Joseph Bruton

Publications
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Public outreach and news

Articles

Article: TOXICOLOGY IN VITRO. 2025;103:105975
The impact of bisphenol AF on skeletal muscle function and differentiation in vitro
Cui M; Tzioufa F; Bruton J; Westerblad H; Kos VM
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167377
Hierarchical S-adenosylmethionine dependency in mitochondria in heart and skeletal muscle
Rumyantseva A; Rosenberg F; Moedas M; Glasgow R; Pironti G; Bruton J; Wedell A; Hinze Y; Freyer C; Wredenberg A
Article: SCIENTIFIC REPORTS. 2024;14(1):689
Ca²⁺ and force during dynamic contractions in mouse intact skeletal muscle fibers
Fukutani A; Westerblad H; Jardemark K; Bruton J
Article: FASEB JOURNAL. 2023;37(6):e22978
Increased tetanic calcium in early fatigue of mammalian muscle fibers is accompanied by accelerated force development despite a decreased force
Leijding C; Viken I; Bruton JDD; Andersson DCC; Cheng AJJ; Westerblad H
Article: STAR PROTOCOLS. 2023;4(2):102260
Calcium measurements in enzymatically dissociated or mechanically microdissected mouse primary skeletal muscle fibers
Youhanna S; Bruton J; Jardemark K; Westerblad H; Lauschke VM
Article: ISCIENCE. 2022;25(12):105654
Enzymatically dissociated muscle fibers display rapid dedifferentiation and impaired mitochondrial calcium control
Gineste C; Youhanna S; Vorrink SU; Henriksson S; Hernandez A; Cheng AJ; Chaillou T; Buttgereit A; Schneidereit D; Friedrich O; Hultenby K; Bruton JD; Ivarsson N; Sandblad L; Lauschke VM; Westerblad H
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2022;13(5):2551-2561
Sphingomyelinase activity promotes atrophy and attenuates force in human muscle fibres and is elevated in heart failure patients
Olsson K; Cheng AJ; Al-Ameri M; Tardif N; Melin M; Rooyackers O; Lanner JT; Westerblad H; Gustafsson T; Bruton JD; Rullman E
Article: SCIENCE ADVANCES. 2021;7(16):eabe6397
Rational antibody design for undruggable targets using kinetically controlled biomolecular probes
Trkulja CL; Jungholm O; Davidson M; Jardemark K; Marcus MM; Hagglund J; Karlsson A; Karlsson R; Bruton J; Ivarsson N; Srinivasa SP; Cavallin A; Svensson P; Jeffries GDM; Christakopoulou M-N; Reymer A; Ashok A; Willman G; Papadia D; Johnsson E; Orwar O
Journal article: PHYSIOLOGY NEWS. 2021;(Spring 2021)
Obituary: Jan Lännergren (1939 – 2020)
Westerblad H; Bruton J
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2020;598(4):773-787
Impaired sarcoplasmic reticulum Ca²⁺ release is the major cause of fatigue-induced force loss in intact single fibres from human intercostal muscle
Olsson K; Cheng AJ; Al-Ameri M; Wyckelsma VL; Rullman E; Westerblad H; Lanner JT; Gustafsson T; Bruton JD
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2020;1131:7-26
Measuring Ca²⁺ in Living Cells
Bruton J; Cheng AJ; Westerblad H
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2019;4(4):509-523
A Mechanism for Statin-Induced Susceptibility to Myopathy
Lotteau S; Ivarsson N; Yang Z; Restagno D; Colyer J; Hopkins P; Weightman A; Himori K; Yamada T; Bruton J; Steele D; Westerblad H; Calaghan S
Article: JOURNAL OF GENERAL PHYSIOLOGY. 2019;151(4):567-577
SR Ca²⁺ leak in skeletal muscle fibers acts as an intracellular signal to increase fatigue resistance
Ivarsson N; Mattsson CM; Cheng AJ; Bruton JD; Ekblom B; Lanner JT; Westerblad H
Article: CELL CALCIUM. 2018;76:87-100
STIM1 R304W causes muscle degeneration and impaired platelet activation in mice
Gamage TH; Gunnes G; Lee RH; Louch WE; Holmgren A; Bruton JD; Lengle E; Kolstad TRS; Revold T; Amundsen SS; Dalen KT; Holme PA; Tjonnfjord GE; Christensen G; Westerblad H; Klungland A; Bergmeier W; Misceo D; Frengen E
Article: FASEB JOURNAL. 2017;31(11):4809-4820
Prolonged force depression after mechanically demanding contractions is largely independent of Ca²⁺ and reactive oxygen species
Kamandulis S; Leite FDS; Hernandez A; Katz A; Brazaitis M; Bruton JD; Venckunas T; Masiulis N; Mickeviciene D; Eimantas N; Subocius A; Rassier DE; Skurvydas A; Ivarsson N; Westerblad H
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1601:79-87
Assaying Mitochondrial Respiration as an Indicator of Cellular Metabolism and Fitness.
Smolina N; Bruton J; Kostareva A; Sejersen T
Article: CRITICAL CARE. 2016;20(1):254
Impaired Ca²⁺ release contributes to muscle weakness in a rat model of critical illness myopathy
Llano-Diez M; Cheng AJ; Jonsson W; Ivarsson N; Westerblad H; Sun V; Cacciani N; Larsson L; Bruton J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(50):15492-15497
Ryanodine receptor fragmentation and sarcoplasmic reticulum Ca²⁺ leak after one session of high-intensity interval exercise
Place N; Ivarsson N; Venckunas T; Neyroud D; Brazaitis M; Cheng AJ; Ochala J; Kamandulis S; Girard S; Volungevicius G; Pauzas H; Mekideche A; Kayser B; Martinez-Redondo V; Ruas JL; Bruton J; Truffert A; Lanner JT; Skurvydas A; Westerblad H
Article: HUMAN MOLECULAR GENETICS. 2015;24(23):6580-6587
Cyclophilin D, a target for counteracting skeletal muscle dysfunction in mitochondrial myopathy
Gineste C; Hernandez A; Ivarsson N; Cheng AJ; Naess K; Wibom R; Lesko N; Bruhn H; Wedell A; Freyer C; Zhang S-J; Carlstrom M; Lanner JT; Andersson DC; Bruton JD; Wredenberg A; Westerblad H
Article: SKELETAL MUSCLE. 2015;5:26
Intracellular Ca²⁺-handling differs markedly between intact human muscle fibers and myotubes
Olsson K; Cheng AJ; Alam S; Al-Ameri M; Rullman E; Westerblad H; Lanner JT; Bruton JD; Gustafsson T
Article: SKELETAL MUSCLE. 2015;5:20
Muscle dysfunction associated with adjuvant-induced arthritis is prevented by antioxidant treatment
Yamada T; Abe M; Lee J; Tatebayashi D; Himori K; Kanzaki K; Wada M; Bruton JD; Westerblad H; Lanner JT
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2015;593(2):457-472
Antioxidant treatments do not improve force recovery after fatiguing stimulation of mouse skeletal muscle fibres
Cheng AJ; Bruton JD; Lanner JT; westerblad H
Article: BIOMED RESEARCH INTERNATIONAL. 2015;2015:594751-12
Primary Murine Myotubes as a Model for Investigating Muscular Dystrophy
Smolina N; Kostareva A; Bruton J; Karpushev A; Sjoberg G; Sejersen T
Article: CELL CALCIUM. 2014;56(4):269-275
Aggregate-prone desmin mutations impair mitochondrial calcium uptake in primary myotubes
Smolina N; Bruton J; Sjoberg G; Kostareva A; Sejersen T
Article: PLOS ONE. 2014;9(9):e108601
Usage of a Localised Microflow Device to Show that Mitochondrial Networks Are Not Extensive in Skeletal Muscle Fibres
Bruton J; Jeffries GDM; Westerblad H
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2014;466(3):577-585
Effects of N-acetylcysteine on isolated mouse skeletal muscle: contractile properties, temperature dependence, and metabolism
Katz A; Hernandez A; Ramos Caballero DM; Bonilla Briceno JF; Rivera Amezquita LV; Kosterina N; Bruton JD; Westerblad H
Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(8):1390-1399
TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis
Zong M; Bruton JD; Grundtman C; Yang H; Li JH; Alexanderson H; Palmblad K; Andersson U; Harris HE; Lundberg IE; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2013;591(15):3739-3748
Doublet discharge stimulation increases sarcoplasmic reticulum Ca²⁺ release and improves performance during fatiguing contractions in mouse muscle fibres
Cheng AJ; Place N; Bruton JD; Holmberg H-C; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2012;590(23):6187-6197
Impaired mitochondrial respiration and decreased fatigue resistance followed by severe muscle weakness in skeletal muscle of mitochondrial DNA mutator mice
Yamada T; Ivarsson N; Hernandez A; Fahlstrom A; Cheng AJ; Zhang S-J; Bruton JD; Ulfhake B; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2012;590(15):3575-3583
Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscle
Hernandez A; Schiffer TA; Ivarsson N; Cheng AJ; Bruton JD; Lundberg JO; Weitzberg E; Westerblad H
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2012;32(6):403-409
Non-crossbridge calcium-dependent stiffness in slow and fast skeletal fibres from mouse muscle
Nocella M; Colombini B; Bagni MA; Bruton J; Cecchi G
Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2012;740:27-43
Methods to Detect Ca²⁺ in Living Cells
Bruton JD; Cheng AJ; Westerblad H
Journal article: PHYSIOLOGY NEWS. 2011;(Summer 2011):18-20
Endurance training–overtraining: a fine-tuned balance that depends on Ca2+
Ivarsson N; Bruton J; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2011;589(13):3371-3381
Force decline during fatigue is due to both a decrease in the force per individual cross-bridge and the number of cross-bridges
Nocella M; Colombini B; Benelli G; Cecchi G; Bagni MA; Bruton J
Journal article: BIOPHYSICAL JOURNAL. 2011;100(3):127a
Static Stiffness in Slow and Fast Mouse Muscle Fibers Expressing Different Titin Isoforms
Bagni MA; Colombini B; Nocella M; Benelli G; Bruton J; Cecchi G
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2010;588(21):4275-4288
Increased fatigue resistance linked to Ca²⁺-stimulated mitochondrial biogenesis in muscle fibres of cold-acclimated mice
Bruton JD; Aydin J; Yamada T; Shabalina IG; Ivarsson N; Zhang S-J; Wada M; Tavi P; Nedergaard J; Katz A; Westerblad H
Article: JOURNAL OF CELLULAR PHYSIOLOGY. 2010;223(2):376-383
Myogenic Skeletal Muscle Satellite Cells Communicate by Tunnelling Nanotubes
Tavi P; Korhonen T; Hanninen SL; Bruton JD; Loof S; Simon A; Westerblad H
Article: FASEB JOURNAL. 2010;24(2):570-578
Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies
Grundtman C; Bruton J; Yamada T; Ostberg T; Pisetsky DS; Harris HE; Andersson U; Lundberg IE; Westerblad H
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2009;107(6):1935-1942
Doxorubicin acts through tumor necrosis factor receptor subtype 1 to cause dysfunction of murine skeletal muscle
Gilliam LAA; Ferreira LF; Bruton JD; Moylan JS; Westerblad H; Clair DKS; Reid MB
Article: ARTHRITIS & RHEUMATOLOGY. 2009;60(11):3280-3289
Impaired Myofibrillar Function in the Soleus Muscle of Mice With Collagen-Induced Arthritis
Yamada T; Place N; Kosterina N; Ostberg T; Zhang S-J; Grundtman C; Erlandsson-Harris H; Lundberg IE; Glenmark B; Bruton JD; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2009;587(19):4717-4724
High temperature does not alter fatigability in intact mouse skeletal muscle fibres
Place N; Yamada T; Zhang S-J; Westerblad H; Bruton JD
Article: FASEB JOURNAL. 2009;23(6):1728-1738
Knockdown of TRPC3 with siRNA coupled to carbon nanotubes results in decreased insulin-mediated glucose uptake in adult skeletal muscle cells
Lanner JT; Bruton JD; Assefaw-Redda Y; Andronache Z; Zhang S-J; Severa D; Zhang Z-B; Melzer W; Zhang S-L; Katz A; Westerblad H
Article: HUMAN MOLECULAR GENETICS. 2009;18(2):278-288
Increased mitochondrial Ca²⁺ and decreased sarcoplasmic reticulum Ca²⁺ in mitochondrial myopathy
Aydin J; Andersson DC; Hanninen SL; Wredenberg A; Tavi P; Park CB; Larsson N-G; Bruton JD; Westerblad H
Article: FASEB JOURNAL. 2008;22(11):3919-3924
Nonshivering thermogenesis protects against defective calcium handling in muscle
Aydin J; Shabalina IG; Place N; Reiken S; Zhang S-J; Bellinger AM; Nedergaard J; Cannon B; Marks AR; Bruton JD; Westerblad H
Article: NEUROSCIENCE LETTERS. 2008;444(3):275-279
The APP670/671 mutation alters calcium signaling and response to hyperosmotic stress in rat primary hippocampal neurons
Kloskowska E; Bruton JD; Winblad B; Benedikz E
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_23):t744-t745
P4‐250: The APP670/671 mutation alters calcium signaling and response to hyperosmotic stress in rat primary hippocampal neurons
Kloskowska E; Benedikz E; Winblad B; Bruton JD
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2008;586(11):2799-2805
Interpolated twitches in fatiguing single mouse muscle fibres: implications for the assessment of central fatigue
Place N; Yamada T; Bruton JD; Westerblad H
Article: NEUROSCIENCE LETTERS. 2008;436(2):250-254
APPswe mutation increases the frequency of spontaneous Ca²⁺ -oscillations in rat hippocampal neurons
Kloskowska E; Malkiewicz K; Winblad B; Benedikz E; Bruton JD
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2008;29(1):25-36
Mice expressing L345P mutant desmin exhibit morphological and functional changes of skeletal and cardiac mitochondria
Kostareva A; Sjoberg G; Bruton J; Zhang S-J; Balogh J; Gudkova A; Hedberg B; Edstrom L; Westerblad H; Sejersen T
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2008;586(1):175-184
Reactive oxygen species and fatigue-induced prolonged low-frequency force depression in skeletal muscle fibres of rats, mice and SOD2 overexpressing mice
Bruton JD; Place N; Yamada T; Silva JP; Andrade FH; Dahlstedt AJ; Zhang S-J; Katz A; Larsson N-G; Westerblad H
Journal article: MITOCHONDRION. 2007;7(6):406-407
9 Single fibers from myopathic Tfam−/− mice display alterations in Ca2+ handling
Aydin J; Andersson D; Wredenberg A; Bruton J; Larsson N-G; Westerblad H
Article: ACTA PHYSIOLOGICA. 2007;191(2):131-137
Activation of Ca²⁺-dependent protein kinase II during repeated contractions in single muscle fibres from mouse is dependent on the frequency of sarcoplasmic reticulum Ca²⁺ release
Aydin J; Korhonen T; Tavi P; Allen DG; Westerblad H; Bruton JD
Journal article: PHYSIOLOGY NEWS. 2007;(Spring 2007):16-17
Reactive oxygen species and glucose transport during exercise
Sandström M; Zhang S-J; Bruton J; Silva J; Reid M; Westerblad H; Katz A
Article: DIABETES. 2007;56(4):1136-1142
Effects of palmitate on Ca²⁺ handling in adult control and ob/ob cardiomyocytes
Fauconnier J; Andersson DC; Zhang S-J; Lanner JT; Wibom R; Katz A; Bruton JD; Westerblad H
Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(2):674-687
Immunolocalization of interleukin-1 receptors in the sarcolemma and nuclei of skeletal muscle in patients with idiopathic inflammatory myopathies
Grundtman C; Salomonsson S; Dorph C; Bruton J; Andersson U; Lundberg IE
Article: CARDIOVASCULAR RESEARCH. 2007;73(2):376-385
Insulin potentiates TRPC3-mediated cation currents in normal but not in insulin-resistant mouse cardiomyocytes
Fauconnier J; Lanner JT; Sultan A; Zhang S-J; Katz A; Bruton JD; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2006;575(1):251-262
Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle
Sandstrom ME; Zhang S-J; Bruton J; Silva JP; Reid MB; Westerblad H; Katz A
Article: DIABETES. 2006;55(7):2077-2083
The role of Ca²⁺ influx for insulin-mediated glucose uptake in skeletal muscle
Lanner JT; Katz A; Tavi P; Sandstrom ME; Zhang S-J; Wretman C; James S; Fauconnier J; Lannergren J; Bruton JD; Westerblad H
Article: CIRCULATION RESEARCH. 2006;98(12):1514-1519
Effects of congestive heart failure on Ca²⁺ handling in skeletal muscle during fatigue
Lunde PK; Sejersted OM; Thorud H-MS; Tonnessen T; Henriksen UL; Christensen G; Westerblad H; Bruton J
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2006;572(2):551-559
Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle
Zhang SJ; Bruton JD; Katz A; Westerblad K
Article: ACTA PHYSIOLOGICA. 2006;186(1):59-66
The effects of the myosin-II inhibitor N-benzyl-p-toluene sulphonamide on fatigue in mouse single intact toe muscle fibres
Bruton J; Pinniger GJ; Lännergren J; Westerblad H
Article: DIABETES. 2005;54(8):2375-2381
Insulin and inositol 1,4,5-trisphosphate trigger abnormal cytosolic Ca²⁺ transients and reveal mitochondrial Ca²⁺ handling defects in cardiomyocytes of ob/ob mice
Fauconnier J; Lanner JT; Zhang SJ; Tavi P; Bruton JD; Katz A; Westerblad H
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2005;26(2-3):135-141
Effects of a myosin-II inhibitor (N-benzyl-p-toluene sulphonamide, BTS) on contractile characteristics of intact fast-twitch mammalian muscle fibres
Pinniger G; Bruton J; Westerblad H; Ranatunga K
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2004;554(2):309-320
Pacing-induced calcineurin activation controls cardiac Ca²⁺ signalling and gene expression
Tavi P; Pikkarainen S; Ronkainen J; Niemelä P; Ilves M; Weckström M; Vuolteenaho O; Bruton J; Westerblad H; Ruskoaho H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2003;552(2):393-402
Mitochondrial function in intact skeletal muscle fibres of creatine kinase deficient mice
Bruton JD; Dahlstedt AJ; Abbate F; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2003;551(1):179-190
Mitochondrial and myoplasmic [Ca²⁺] in single fibres from mouse limb muscles during repeated tetanic contractions
Bruton J; Tavi P; Aydin J; Westerblad H; Lännergren J
Article: FASEB JOURNAL. 2003;16(14):301-303
Ryanodine receptors of pancreatic-cells mediate a distinct context-dependent signal for insulin secretion
Bruton JD; Lemmens R; Shi CL; Persson-Sjögren S; Westerblad H; Ahmed M; Pyne NJ; Frame M; Furman BL; Islam MS
Article: PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2002;444(6):692-699
Regulation of myoplasmic Ca²⁺ in genetically obese (ob/ob) mouse single skeletal muscle fibres
Bruton JD; Katz A; Lännergren J; Abbate F; Westerblad H
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2002;283(1):C42-C47
Prolonged force increase following a high-frequency burst is not due to a sustained elevation of [Ca²⁺]_i
Abbate F; Bruton JD; De Haan A; Westerblad H
Article: CELL BIOLOGY INTERNATIONAL. 2002;26(10):911-920
Dynamic vacuolation in skeletal muscle fibres after fatigue
Lännergren J; Westerblad H; Bruton JD
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2001;18(1):56-67
Neuromuscular junction disassembly and muscle fatigue in mice lacking neurotrophin-4
Belluardo N; Westerblad H; Mudó G; Casabona A; Bruton J; Caniglia G; Pastoris O; Grassi F; Ibáñez CF
Article: CIRCULATION RESEARCH. 2001;88(12):1299-1305
Contraction and intracellular Ca²⁺ handling in isolated skeletal muscle of rats with congestive heart failure
Lunde PK; Dahlstedt AJ; Bruton JD; Lännergren J; Thorén P; Sejersted OM; Westerblad H
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2001;22(3):265-275
Changes in mitochondrial Ca²⁺ detected with Rhod-2 in single frog and mouse skeletal muscle fibres during and after repeated tetanic contractions
Lännergren J; Westerblad H; Bruton JD
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2000;526(3):597-611
Vacuole formation in fatigued skeletal muscle fibres from frog and mouse:: effects of extracellular lactate
Lännergren J; Bruton JD; Westerblad H
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 2000;21(7):621-628
Frog skeletal muscle fibers recovering from fatigue have reduced charge movement
Bruton JD; Szentesi P; Lännergren J; Westerblad H; Kovács L; Csernoch L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(6):3281-3286
Insulin increases near-membrane but not global Ca²⁺ in isolated skeletal muscle
Bruton JD; Katz A; Westerblad H
Article: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 1999;20(1):19-32
Vacuole formation in fatigued single muscle fibres from frog and mouse
Lännergren J; Bruton JD; Westerblad H
Article: JOURNAL OF APPLIED PHYSIOLOGY. 1998;85(2):478-483
Effects of CO₂-induced acidification on the fatigue resistance of single mouse muscle fibers at 28°C
Bruton JD; Lännergren J; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 1997;500(1):193-204
The effect of intracellular pH on contractile function of intact, single fibres of mouse muscle declines with increasing temperature
Westerblad H; Bruton JD; Lannergren J
Article: AMERICAN JOURNAL OF PHYSIOLOGY. 1997;272(3):C870-C874
Increased tetanic force and reduced myoplasmic [P-i] following a brief series of tetani in mouse soleus muscle
Bruton JD; Wretman C; Katz A; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 1996;495(1):15-22
Effects of repetitive tetanic stimulation at long intervals on excitation-contraction coupling in frog skeletal muscle
Bruton JD; Lannergren J; Westerblad H
Article: JOURNAL OF PHYSIOLOGY-LONDON. 1996;493(1):211-217
Augmented force output in skeletal muscle fibres of Xenopus following a preceding bout of activity
Bruton JD; Westerblad H; Katz A; Lannergren J
Article: ACTA PHYSIOLOGICA. 1996;156(4):441-446
Reversible depression of action potentials and force production in frog single muscle fibres by calmodulin-inhibitors
Bruton JD; Westerblad H; Lannergren J
Article: JOURNAL OF PHYSIOLOGY-LONDON. 1995;484(3):737-742
MECANOSENSITIVE LINKAGE IN EXCITATION-CONTRACTION COUPLING IN FROG SKELETAL-MUSCLE
BRUTON JD; LANNERGREN J; WESTERBLAD H
Journal article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1994;1200(2):224-226
LIPASE INHIBITORS ABOLISH CONTRACTIONS AND CAUSE DEPOLARIZATION IN FROG SKELETAL-MUSCLE FIBERS
BRUTON JD; WESTERBLAD H; LANNERGREN J
Journal article: JOURNAL OF PHYSIOLOGICAL SCIENCES. 1991;41(2):189-201
CONTRACTION OF RAT SOLEUS MUSCLE AND THE EFFECTS OF HYPERTONIC TREATMENTS
BRUTON JD
Journal article: QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY. 1989;74(4):565-567
ROLE OF CHLORIDE IN HYPERTONICITY-INDUCED CONTRACTURES OF RAT SOLEUS MUSCLE
BRUTON JD
Journal article: JOURNAL OF PHYSIOLOGICAL SCIENCES. 1988;38(6):897-903
CONTRACTION OF RAT SKELETAL-MUSCLE AFTER GLYCEROL TREATMENTS
BRUTON JD
Journal article: JOURNAL OF PHYSIOLOGICAL SCIENCES. 1988;38(5):735-739
THE EFFECT OF LITHIUM AND NITRATE ON POTASSIUM CONTRACTURES IN A GLYCEROL-TREATED SLOW-TWITCH MUSCLE OF THE RAT
BRUTON JD
Journal article: BRITISH JOURNAL OF ANAESTHESIA. 1986;58(8):915-918
ACTION OF HALOTHANE ON RAT SOLEUS MUSCLE - TEMPERATURE-DEPENDENT INDUCTION OF CONTRACTURES AND MODIFICATION OF CAFFEINE AND POTASSIUM CONTRACTURES
BRUTON JD; ANWYL R; MCLOUGHLIN JV
Journal article: JOURNAL OF THERMAL BIOLOGY. 1985;10(2):71-77
THE RAPID METABOLIC RESPONSE OF YOUNG LAMBS TO LOW-DOSES OF T3 - INTERACTION WITH RT3
LYNCH MA; BRUTON JD; ANDREWS JF; MOORE RE
Journal article: BRITISH JOURNAL OF PHARMACOLOGY. 1984;82(3):615-621
POTASSIUM CONTRACTURES AND MECHANICAL ACTIVATION IN RAT SKELETAL-MUSCLE - EFFECTS OF MULTIVALENT CATIONS, TEMPERATURE AND TETRACAINE
ANWYL R; BRUTON JD; MCLOUGHLIN JV
Journal article: BRITISH JOURNAL OF PHARMACOLOGY. 1984;82(3):609-614
THE EFFECTS OF EXTERNAL POTASSIUM, MULTIVALENT CATIONS AND TEMPERATURE ON CAFFEINE CONTRACTURES IN RAT SKELETAL-MUSCLE
ANWYL R; BRUTON JD; MCLOUGHLIN JV
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All other publications

Preprint: RESEARCH SQUARE. 2023
A moduli-selective antibody inhibits the pain receptor TRPV1 in cynomolgus monkeys without adverse temperature dysregulation
Jungholm O; Trkulja C; Papadia D; Hägglund J; Davidson M; Stratton J; Tien J; Trinh V; Wilson D; Quigley A; Sriniv S; Vazquez-Juarez E; Freitag F; Balleza-Tapia H; Marcus M; Frumento P; Reymer A; Savvidi P; Willman G; Ashok A; Christakopoulou M-N; Bruton J; Jardemark K; Orwar O
Preprint: BIORXIV. 2021
Disruption of the microphysiological niche alters matrix deposition and causes loss of mitochondrial Ca²⁺control in skeletal muscle fibers
Gineste C; Youhanna S; Vorrink S; Henriksson S; Hernández A; Cheng A; Chaillou T; Buttgereit A; Schneidereit D; Friedrich O; Hultenby K; Bruton J; Ivarsson N; Sandblad L; Lauschke V; Westerblad H
Book chapter: MUSCLE CONTRACTION AND CELL MOTILITY. 2016;p. 137-162
Limitations of in vitro Motility Assay Systems in Studying Molecular Mechanism of Muscle Contraction as Revealed by the Effect of Antibodies to Myosin Head
Colombini B; Nocella M; Bruton JD; Angela Bagni M; Cecchi G
Conference publication: FASEB JOURNAL. 2015;29
Isolated Intercostal Muscle Fibers as a Human Skeletal Muscle Ex Vivo Model
Olsson K; Cheng A; Alam S; Westerblad H; Lanner J; Bruton J; Gustafsson T
Conference publication: EUROPEAN HEART JOURNAL. 2014;35:109
Aggregate prone desmin mutations reduced mitochondrial calcium uptake in primary myotubes upon electrical stimulation
Kostareva A; Smolina N; Bruton J; Sjoberg G; Sejersen T
Conference publication: ACTA PHYSIOLOGICA. 2014;211:59
Changes in calcium handling after enzymatic dissociation of skeletal muscle fibers
Gineste C; Hernandez A; Cheng AJ; Westerblad H; Bruton J
Meeting abstract: CARDIOVASCULAR RESEARCH. 2014;103:s73
Aggregate prone desmin mutations reduced mitochondrial calcium uptake in primary myotubes upon electrical stimulation
Smolina N; Bruton J; Sjoberg G; Kostareva A; Sejersen T
Meeting abstract: BIOPHYSICAL JOURNAL. 2014;106(2):728A
Local Redox Modifications in Skeletal Muscle Differentially Affect Sarcoplasmic Reticulum Calcium Release and Muscle Force Generation
Cheng AJ; Bruton JD; Westerblad H; Lanner JT
Conference publication: BIOPHYSICAL JOURNAL. 2014;106(2):766A
Enzymatic Dissociation Makes Skeletal Muscle Fibers Susceptible to Osmotic Stress and More Prone to Mitochondrial Calcium Uptake
Westerblad H; Hernandez A; Cheng AJ; Bruton JD
Conference publication: FASEB JOURNAL. 2012;26:1078.2
Dietary nitrate dramatically increases force in mouse skeletal muscle
Hernandez A; Schiffer TA; Ivarsson N; Bruton JD; Lundberg JO; Weitzberg E; Westerblad H
Conference publication: FASEB JOURNAL. 2012;26:1078.40
Doublet Discharges Improve Force During Fatigue in Single Fibers
Cheng AJ-H; Bruton JD; Westerblad H
Conference publication: FASEB JOURNAL. 2012;26:1078.20
Impaired calcium handling in skeletal muscles of mitochondrial-DNA-mutator mice
Ivarsson N; Hernandez A; Bruton J; Westerblad H
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a43-a44
CROSSTALK BETWEEN NITROSATIVE STRESS AND ALTERED CA2⁺ HANDLING IN ARTHRITIS-INDUCED SKELETAL MUSCLE DYSFUNCTION
Bruton J; Yamada T; Ivarsson N; Grundtman C; Zhang S-J; Erlandsson-Harris H; Lundberg IE; Lanner JT; Cheng AJ; Westerblad H
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a42-a43
HMGB1 MEDIATES MUSCLE FATIGUE VIA TLR4-A POSSIBLE MECHANISM FOR MUSCLE FATIGUE IN PATIENTS WITH INFLAMMATORY MYOPATHIES
Zong M; Bruton JD; Grundtman C; Yang H; Li JH; Palmblad K; Harris HE; Andersson U; Westerblad H; Lundberg IE
Editorial: JOURNAL OF PHYSIOLOGY-LONDON. 2010;588(22):4333
What does the membrane K_ATP channel really do in skeletal muscle?
Bruton J
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(18):3093-3099
Skeletal muscle: Energy metabolism, fiber types, fatigue and adaptability
Westerblad H; Bruton JD; Katz A
Review: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2010;110(1):1-15
Muscle fatigue: from observations in humans to underlying mechanisms studied in intact single muscle fibres
Place N; Yamada T; Bruton JD; Westerblad H
Conference publication: BIOPHYSICAL JOURNAL. 2010;98(3):712A
Skeletal Muscle Fibers of Cold-Acclimated Mice Display Increases in Basal Calcium, Mitochondrial Content and Fatigue Resistance
Westerblad H; Yamada T; Bruton JD
Published conference paper: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY. 2009;36(3):334-339
MECHANISMS OF FATIGUE INDUCED BY ISOMETRIC CONTRACTIONS IN EXERCISING HUMANS AND IN MOUSE ISOLATED SINGLE MUSCLE FIBRES
Place N; Bruton JD; Westerblad H
Conference publication: JOURNAL OF PHYSIOLOGICAL SCIENCES. 2009;59:240
CALCIUM FLUX THROUGH TRPC3 CHANNELS MODULATES INSULIN-MEDIATED GLUCOSE UPTAKE IN ADULT SKELETAL MUSCLE CELLS
Westerblad H; Lanner JT; Katz A; Bruton JD
Conference publication: JOURNAL OF PHYSIOLOGICAL SCIENCES. 2009;59:215
IMPAIRED MYOFIBRILLAR FUNCTION IN SOLEUS MUSCLE OF MICE WITH COLLAGEN-INDUCED ARTHRITIS
Yamada T; Bruton JD; Place N; Zhang S-J; Kosterina N; Harris HE; Ostberg T; Grundtman C; Glenmark B; Westerblad H
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2008;58(9):S922-S923
The role of the alarmin HMGB-1 in the pathogenesis of inflammatory myopathies
Lundberg IE; Grundtman C; Bruton J; Ostberg T; Pisetsky DS; Harris HE
Conference publication: WIENER KLINISCHE WOCHENSCHRIFT. 2008;120:166
High mobility group box chromosomal protein-1 (HMGB-1), an endogenous alarmin expressed in muscle fibers may induce muscle fatigue in myositis
Grundtman C; Bruton J; Ostberg T; Pisetsky DS; Harris HE; Andersson U; Westerblad H; Lundberg IE
Conference publication: EUROPEAN JOURNAL OF CELL BIOLOGY. 2008;87(7):449-450
L345P desmin transgenic mice exhibit changes in mitochondrial Ca²⁺ handling
Kostareva A; Bruton J; Sjoberg G; Gudkova A; Westerblad H; Sejersen T
Review: CURRENT OPINION IN PHARMACOLOGY. 2008;8(3):339-345
Ca²⁺ and insulin-mediated glucose uptake
Lanner JT; Bruton JD; Katz A; Westerblad H
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2008;40(5):S191
The Twitch Interpolation Technique May Overestimate Central Fatigue
Place N; Yamada T; Bruton JD; Westerblad H
Conference publication: FASEB JOURNAL. 2008;22:1226.5
Knock down of TRPC3 decreases Ca²⁺ influx and insulin-mediated glucose uptake in adult skeletal muscle
Lanner JT; Bruton JD; Assefaw-Redda Y; Zhang S-J; Zhang Z-B; Zhang S-L; Katz A; Westerblad H
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2008;67:A20
High mobility group box chromosomal protein-1 (HMGB-1) is expressed in idiopathic inflammatory myopathies and mediates muscle weakness
Grundtman C; Bruton J; Oestberg T; Erlandsson-Harris H; Andersson U; Westerblad H; Lundberg IE
Conference publication: EUROPEAN HEART JOURNAL. 2007;28:795
L345P desmin transgenic mice exhibit changes in mitochondrial Ca²⁺ handling
Kostareva A; Bruton J; Sjoberg G; Gudkova A; Westerblad H; Sejersen T
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2006;54(9):S662
Reduced force in muscle from conditional MHC class I transgenic mice, an animal model for idiopathic inflammatory myopathies.
Salomonsson S; Grundtman C; Zhang S-J; Bruton J; Li C; Kanneboyina N; Wedderburn LR; Lundberg IE; Westerblad H
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2006;65:521
Reduced force and fatigue resistance in muscle from conditional MHC class I transgenic mice, an animal model for idiopathic inflammatory myopathies
Salomonsson S; Grundtman C; Zhang S; Bruton J; Li C; Wedderburn L; Westerblad H; Lundberg IE
Corrigendum: DIABETES. 2005;54(11):3340
Insulin and inositol 1,4,5-trisphosphate trigger abnormal cytosolic Ca²⁺ transients and reveal mitochondrial Ca²⁺ handling defects in cardiomyocytes of ob/ob mice (vol 54, pg 2375, 2005)
Fauconnier J; Lanner JT; Zhang SJ; Tavi P; Bruton JP; Katz A; Westerblad H
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2005;52(9):S310
Marked expression of IL-1 receptors in muscle fiber membrane and muscle fiber nuclei in patients with polymyositis and dermatomyositis.
Lundberg IE; Grundtman C; Dorph C; Bruton J; Andersson U; Salomonsson S
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2005;64:74
IL-1 receptor expression in muscle fibre membrane and muscle cell nuclei in patients with polymyositis or dermatomyositis
Lundberg IE; Grundtman C; Dorph C; Bruton J; Andersson U; Salomonsson S
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2003;538:557-562
Mitochondrial Ca²⁺ in mouse soleus single muscle fibres in response to repeated tetanic contractions
Lannergren J; Bruton JD
Conference publication: JOURNAL OF PHYSIOLOGY-LONDON. 2002;543:102P
Intracellular and mitochondrial Ca²⁺ in mouse intact soleus skeletal muscle fibres during repeated intermittent tetanic stimulation
Bruton JD; Westerblad H; Lännergren J
Conference publication: JOURNAL OF PHYSIOLOGY-LONDON. 2001;533:126P-127P
Triplet potentiation and Ca²⁺ release in single skeletal muscle fibres from the mouse
Bruton JD; Abbate F; de Haan A; Westerblad H
Conference publication: FASEB JOURNAL. 2001;15(5):A1080
TNF-α stimulates contractile dysfunction of murine skeletal muscle via effects on the myofilaments
Reid MB; Lannergren J; Bruton J; Westerblad H
Conference publication: FASEB JOURNAL. 2001;15(5):A816
Accumulation of calcium in mitochondria in living frog skeletal muscle fibres
Bruton J; Westerblad H; Lännergren J
Published conference paper: ACTA PHYSIOLOGICA. 2001;171(3):259-265
The role of Ca²⁺ and calmodulin in insulin signalling in mammalian skeletal muscle
Bruton JD; Katz A; Westerblad H
Review: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2000;83(2-3):166-174
Functional significance of Ca²⁺ in long-lasting fatigue of skeletal muscle
Westerblad H; Bruton JD; Allen DG; Lännergren J
Published conference paper: ACTA PHYSIOLOGICA. 1998;162(3):285-293
Mechanisms underlying the slow recovery of force after fatigue:: importance of intracellular calcium
Bruton JD; Lännergren J; Westerblad H
Published conference paper: ACTA PHYSIOLOGICA. 1998;162(3):253-260
Mechanisms underlying the reduction of isometric force in skeletal muscle fatigue
Westerblad H; Allen DG; Bruton JD; Andrade FH; Lännergren J
Published conference paper: ACTA PHYSIOLOGICA. 1996;156(3):193-202
Slow recovery of force in single skeletal muscle fibres
Lannergren J; Westerblad H; Bruton JD
Conference publication: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 1996;17(1):166
'Warm-up' increases the force output of skeletal muscle by reducing inorganic phosphate
Lannergren J; Bruton JD; Katz A; Westerblad H
Conference publication: JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY. 1996;17(1):135-136
Depression of force production in frog skeletal muscle fibres following long interval tetanic stimulation
Bruton JD; Westerblad H; Lannergren J
Conference publication: JOURNAL OF PHYSIOLOGY-LONDON. 1992;446:P265
RECOVERY FROM FATIGUE IN RAT ISOLATED SKELETAL-MUSCLE
LIU YK; BRUTON JD
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Affiliated to Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2026-2026
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