Kent Jardemark

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Articles

Article: SCIENTIFIC REPORTS. 2024;14(1):689
Ca²⁺ and force during dynamic contractions in mouse intact skeletal muscle fibers
Fukutani A; Westerblad H; Jardemark K; Bruton J
Article: STAR PROTOCOLS. 2023;4(2):102260
Calcium measurements in enzymatically dissociated or mechanically microdissected mouse primary skeletal muscle fibers
Youhanna S; Bruton J; Jardemark K; Westerblad H; Lauschke VM
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2022;62:22-35
Lumateperone-mediated effects on prefrontal glutamatergic receptor-mediated neurotransmission: A dopamine D₁ receptor dependent mechanism
Titulaer J; Radhe O; Danielsson K; Dutheil S; Marcus MM; Jardemark K; Svensson TH; Snyder GL; Ericson M; Davis RE; Konradsson-Geuken A
Article: SCIENCE ADVANCES. 2021;7(16):eabe6397
Rational antibody design for undruggable targets using kinetically controlled biomolecular probes
Trkulja CL; Jungholm O; Davidson M; Jardemark K; Marcus MM; Hagglund J; Karlsson A; Karlsson R; Bruton J; Ivarsson N; Srinivasa SP; Cavallin A; Svensson P; Jeffries GDM; Christakopoulou M-N; Reymer A; Ashok A; Willman G; Papadia D; Johnsson E; Orwar O
Article: INTERNATIONAL JOURNAL OF TRYPTOPHAN RESEARCH. 2021;14:11786469211041368
Blockade of KAT II Facilitates LTP in Kynurenine 3-Monooxygenase Depleted Mice
Imbeault S; Gubert Olive M; Jungholm O; Erhardt S; Wigstrom H; Engberg G; Jardemark K
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2019;216(8):1904-1924
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons
Farinotti AB; Wigerblad G; Nascimento D; Bas DB; Urbina CM; Nandakumar KS; Sandor K; Xu B; Abdelmoaty S; Hunt MA; Moller KA; Baharpoor A; Sinclair J; Jardemark K; Lanner JT; Khmaladze I; Borm LE; Zhang L; Wermeling F; Cragg MS; Lengqvist J; Chabot-Dore A-J; Diatchenko L; Belfer I; Collin M; Kultima K; Heyman B; Miguel Jimenez-Andrade J; Codeluppi S; Holmdahl R; Svensson CI
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27(4):411-417
The novel antipsychotic drug brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism
Bjorkholm C; Marcus MM; Konradsson-Geuken A; Jardemark K; Svensson TH
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(9):1401-1411
Alpha7 nicotinic acetylcholine receptor agonists and PAMs as adjunctive treatment in schizophrenia. An experimental study
Marcus MM; Bjorkholm C; Malmerfelt A; Moller A; Pahlsson N; Konradsson-Geuken A; Feltmann K; Jardemark K; Schilstrom B; Svensson TH
Article: PLOS ONE. 2016;11(12):e0167090
The Role of Reactive Oxygen Species in β-Adrenergic Signaling in Cardiomyocytes from Mice with the Metabolic Syndrome
Llano-Diez M; Sinclair J; Yamada T; Zong M; Fauconnier J; Zhang S-J; Katz A; Jardemark K; Westerblad H; Andersson DC; Lanner JT
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2015;25(10):1842-1847
Ketamine-like effects of a combination of olanzapine and fluoxetine on AMPA and NMDA receptor-mediated transmission in the medial prefrontal cortex of the rat
Bjorkholm C; Jardemark K; Schilstrom B; Svensson TH
Article: NEUROPSYCHOPHARMACOLOGY. 2015;40(5):1130-1140
Evaluation of Guanfacine as a Potential Medication for Alcohol Use Disorder in Long-Term Drinking Rats: Behavioral and Electrophysiological Findings
Fredriksson I; Jayaram-Lindstrom N; Wirf M; Nylander E; Nystrom E; Jardemark K; Steensland P
Article: JOURNAL OF NEUROSCIENCE METHODS. 2015;241:132-136
Spatial characterization of a multifunctional pipette for drug delivery in hippocampal brain slices
Ahemaiti A; Wigstrom H; Ainla A; Jeffries GDM; Orwar O; Jesorka A; Jardemark K
Article: ANALYTICAL CHEMISTRY. 2015;87(1):381-387
A Heating-Superfusion Platform Technology for the Investigation of Protein Function in Single Cells
Xu S; Ainla A; Jardemark K; Jesorka A; Jeffries GDM
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;18(3):pyu068
Adjunctive Treatment with Asenapine Augments the Escitalopram-Induced Effects on Monoaminergic Outflow and Glutamatergic Neurotransmission in the Medial Prefrontal Cortex of the Rat
Bjorkholm C; Franberg O; Malmerfelt A; Marcus MM; Konradsson-Geuken A; Schilstrom B; Jardemark K; Svensson TH
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2014;136(42):14875-14882
Probing Structure and Function of Ion Channels Using Limited Proteolysis and Microfluidics
Trkulja CL; Jansson ET; Jardemark K; Orwar O
Article: JOURNAL OF NEUROSCIENCE METHODS. 2013;219(2):292-296
A multifunctional pipette for localized drug administration to brain slices
Ahemaiti A; Ainla A; Jeffries GDM; Wigstrom H; Orwar O; Jesorka A; Jardemark K
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2013;23(7):709-720
Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine
Bjorkholm C; Jardemark K; Marcus MM; Malmerfelt A; Nyberg S; Schilstrom B; Svensson TH
Article: MOLECULAR PAIN. 2013;9:1
Effect of cholesterol depletion on the pore dilation of TRPV1
Jansson ET; Trkulja CL; Ahemaiti A; Millingen M; Jeffries GDM; Jardemark K; Orwar O
Journal article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2012;22:s276
P.2.d.016 Add-on administration of olanzapine to fluoxetine facilitates cortical AMPA receptor-mediated responses like ketamine and scopolamine
Björkholm C; Jardemark K; Svensson TH
Article: PSYCHOPHARMACOLOGY. 2012;221(1):115-131
Differential effects of AMPA receptor potentiators and glycine reuptake inhibitors on antipsychotic efficacy and prefrontal glutamatergic transmission
Jardemark K; Marcus MM; Malmerfelt A; Shahid M; Svensson TH
Article: SYNAPSE. 2012;66(4):277-290
Augmentation by escitalopram, but not citalopram or R-citalopram, of the effects of low-dose risperidone: Behavioral, biochemical, and electrophysiological evidence
Marcus MM; Jardemark K; Malmerfelt A; Gertow J; Konradsson-Geuken A; Svensson TH
Article: SYNAPSE. 2011;65(5):357-367
Effects of S-Citalopram, Citalopram, and R-Citalopram on the Firing Patterns of Dopamine Neurons in the Ventral Tegmental Area, N-methyl-D-aspartate Receptor-Mediated Transmission in the Medial Prefrontal Cortex and Cognitive Function in the Rat
Schilstrom B; Konradsson-Geuken A; Ivanov V; Gertow J; Feltmann K; Marcus MM; Jardemark K; Svensson TH
Article: SYNAPSE. 2010;64(11):870-874
Effects of Asenapine on Prefrontal N-methyl-D-Aspartate Receptor-Mediated Transmission: Involvement of Dopamine D1 Receptors
Jardemark K; Marcus MM; Shahid M; Svensson TH
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2010;13(7):891-903
Adjunctive α₂-adrenoceptor blockade enhances the antipsychotic-like effect of risperidone and facilitates cortical dopaminergic and glutamatergic, NMDA receptor-mediated transmission
Marcus MM; Wiker C; Franberg O; Konradsson-Geuken A; Langlois X; Jardemark K; Svensson TH
Article: NEUROPSYCHOPHARMACOLOGY. 2010;35(9):1952-1961
Reboxetine Enhances the Olanzapine-Induced Antipsychotic-Like Effect, Cortical Dopamine Outflow and NMDA Receptor-Mediated Transmission
Marcus MM; Jardemark K; Malmerfelt A; Bjorkholm C; Svensson TH
Article: SYNAPSE. 2009;63(10):913-920
Differential Effects of Topiramate on Prefrontal Glutamatergic Transmission When Combined With Raclopride or Clozapine
Jardemark KE; Konradsson A; Schilstrom B; Marcus MM; Svensson TH
Article: PSYCHOPHARMACOLOGY. 2008;196(3):417-429
Asenapine, a novel psychopharmacologic agent:: preclinical evidence for clinical effects in schizophrenia
Franberg O; Wiker C; Marcus MM; Konradsson A; Jardemark K; Schilstrom B; Shahid M; Wong EHF; Svensson TH
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(3):315-327
Combined alpha2 and D2/3 receptor blockade enhances cortical glutamatergic transmission and reverses cognitive impairment in the rat.
Marcus MM; Jardemark KE; Wadenberg M-L; Langlois X; Hertel P; Svensson TH
Article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2005;8(2):157-162
The combination of nicotine with the D₂ antagonist raclopride or the weak D₄ antagonist L-745,870 generates a clozapine-like facilitation of NMDA receptor-mediated neurotransmission in pyramidal cells of the rat medial prefrontal cortex
Jardemark K; Marcus MM; Konradsson Å; Svensson TH
Article: NEUROSCIENCE. 2004;125(4):957-964
Nitric oxide is involved in nicotine-induced burst firing of rat ventral tegmental area dopamine neurons
Schilström B; Mameli-Engvall M; Rawal N; Grillner P; Jardemark K; Svensson TH
Article: SYNAPSE. 2003;48(2):66-79
Differential effects of atypical and typical antipsychotic drugs on N-methyl-D-aspartate- and electrically evoked responses in the pyramidal cells of the rat medial prefrontal cortex.
Ninan I; Jardemark KE; Wang RY
Article: SYNAPSE. 2003;47(4):285-294
Calcium/calmodulin-dependent kinase II is involved in the facilitating effect of clozapine on NMDA- and electrically evoked responses in the medial prefrontal cortical pyramidal cells.
Ninan I; Jardemark KE; Liang X; Wang RY
Article: NEUROPHARMACOLOGY. 2003;44(4):462-472
Olanzapine and clozapine but not haloperidol reverse subchronic phencyclidine-induced functional hyperactivity of N-methyl-D-aspartate receptors in pyramidal cells of the rat medial prefrontal cortex.
Ninan I; Jardemark KE; Wang RY
Article: NEUROSCIENCE. 2003;118(2):501-512
Protein kinase C is involved in clozapine's facilitation of N-methyl-D-aspartate- and electrically evoked responses in pyramidal cells of the medial prefrontal cortex.
Jardemark KE; Ninan I; Liang X; Wang RY
Article: ANALYTICAL CHEMISTRY. 2002;74(24):6133-6138
A cell-based bar code reader for high-throughput screening of ion channel-ligand interactions
Sinclair J; Pihl J; Olofsson J; Karlsson M; Jardemark K; Chiu DT; Orwar O
Article: SYNAPSE. 2001;41(4):294-300
Biphasic modulation of NMDA-induced responses in pyramidal cells of the medial prefrontal cortex by Y-931, a potential atypical antipsychotic drug.
Jardemark KE; Ai J; Ninan I; Wang RY
Article: ANALYTICAL CHEMISTRY. 2001;73(6):1228-1233
Screening of ion channel receptor agonists using capillary electrophoresis-patch clamp detection with resensitized detector cells.
Farre C; Sjöberg A; Jardemark K; Jacobson I; Orwar O
Article: NEUROCHEMISTRY INTERNATIONAL. 2001;38(3):269-276
Activation of beta-adrenoceptors opens calcium-activated potassium channels in astroglial cells.
Muyderman H; Sinclair J; Jardemark K; Hansson E; Nilsson M
Article: BIOPHYSICAL JOURNAL. 2000;79(4):1993-2001
Characterization of single-cell electroporation by using patch-clamp and fluorescence microscopy.
Ryttsén F; Farre C; Brennan C; Weber SG; Nolkrantz K; Jardemark K; Chiu DT; Orwar O
Article: NEUROSCIENCE. 2000;100(1):1-9
Subchronic treatment with either clozapine, olanzapine or haloperidol produces a hyposensitive response of the rat cortical cells to N-methyl-D-aspartate.
Jardemark KE; Liang X; Arvanov V; Wang RY
Article: METHODS IN ENZYMOLOGY. 1999;294:189-208
Voltage-clamp biosensors for capillary electrophoresis.
Orwar O; Jardemark K; Farre C; Jacobson I; Moscho A; Shear JB; Fishman HA; Lillard SJ; Zare RN
Article: ANALYTICAL CHEMISTRY. 1998;70(13):2468-2474
Screening of receptor antagonists using agonist-activated patch clamp detection in chemical separations.
Jardemark K; Farre C; Jacobson I; Zare RN; Orwar O
Article: ANALYTICAL CHEMISTRY. 1997;69(17):3427-3434
Patch clamp detection in capillary electrophoresis.
Jardemark K; Orwar O; Jacobson I; Moscho A; Zare RN
Article: NEUROCHEMISTRY INTERNATIONAL. 1997;30(3):253-259
Bicarbonate-sensitive cysteine induced elevation of extracellular aspartate and glutamate in rat hippocampus in vitro.
Abbas AK; Jardemark K; Lehmann A; Weber SG; Sandberg M
Article: JOURNAL OF NEUROPHYSIOLOGY. 1997;77(2):702-708
Ca2+ ion permeability properties of (R,S) alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in isolated interneurons from the olfactory bulb of the rat.
Jardemark K; Nilsson M; Muyderman H; Jacobson I
Article: SCIENCE. 1996;272(5269):1779-1782
Patch-clamp detection of neurotransmitters in capillary electrophoresis.
Orwar O; Jardemark K; Jacobson I; Moscho A; Fishman HA; Scheller RH; Zare RN
Article: NEUROSCIENCE LETTERS. 1995;194(1-2):93-96
Expression of Ca(2+)-ion permeable alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors in Xenopus oocytes injected with total RNA from human epileptic temporal lobe.
Jardemark K; Nyström B; Rydenhag B; Hamberger A; Jacobson I
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All other publications

Preprint: ARXIV. 2019
Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons
Farinotti AB; Wigerblad G; Nascimento D; Bas DB; Urbina CM; Nandakumar KS; Sandor K; Xu B; Abdelmoaty S; Hunt MA; Möller KÄ; Baharpoor A; Sinclair J; Jardemark K; Lanner JT; Khmaladze I; Borm LE; Zhang L; Wermeling F; Cragg MS; Lengqvist J; Chabot-Doré A-J; Diatchenko L; Belfer I; Collin M; Kultima K; Heyman B; Jimenez-Andrade JM; Codeluppi S; Holmdahl R; Svensson CI
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26:S235-S236
The novel atypical antipsychotic drug brexpiprazole, alone and in combination with escitalopram, facilitates prefrontal glutamatergic transmission via a dopamine D1 receptor-dependent mechanism
Svensson TH; Bjorkholm C; Konradsson-Geuken A; Jardemark K; Marcus MM
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2015;40:S222-S223
The Novel Atypical Antipsychotic Brexpiprazole, Alone and in Combination with Escitalopram, Facilitates Prefrontal Glutamatergic Transmission via a Dopamine D1 Receptor-Dependent Mechanism
Marcus M; Bjorkholm C; Konradsson-Geuken A; Jardemark K; Svensson T
Conference publication: BIOPHYSICAL JOURNAL. 2014;106(2):191A
A Multifunctional Pipette for Localized Drug Administration to Brain Slices
Ahemaiti A; Ainla A; Jeffries GDM; Wigstrom H; Jesorka A; Jardemark K
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;17:107
NS1738, a positive allosteric modulator of Alpha7 nicotinic receptors, as adjunctive treatment in schizophrenia. An experimental study
Jardemark K; Konradsson-Geuken A; Feltmann K; Ivanov V; Schilstrom B; Marcus MM; Svensson T
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2013;38:S570-S571
NS1738, a Positive Allosteric Modulator of Alpha7 Nicotinic Receptors, as Adjunctive Treatment in Schizophrenia. An Experimental Study
Marcus MM; Konradsson-Geuken A; Feltmann K; Ivanov V; Schilstrom B; Jardemark K; Svensson TH
Conference publication: BIOPHYSICAL JOURNAL. 2012;102(3):342A
Effect of Cholesterol on the Pore Dilation of TRPV1
Jansson ET; Bostrom CL; Ahemaiti A; Millingen M; Jardemark K; Orwar O
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:27
Effects of antipsychotic and antidepressant drugs, alone and in combination, on cortical dopaminergic and glutamatergic transmission and cognitive impairment in schizophrenia
Svensson T; Bjorkholm C; Jardemark K; Marcus M; Schilstrom B
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2012;15:4
Dopamine, D1 receptors and noradrenergic mechanisms in the modes of action of antipsychotic drugs
Svensson T; Bjorkholm C; Jardemark K; Marcus M; Nyberg S; Schilstrom B
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S562-S563
Enhanced cortical dopaminergic and glutamatergic transmission and antipsychotic-like effect of risperidone by idazoxan
Marcus MM; Wiker C; Franberg O; Konradsson-Geuken A; Langlois X; Jardemark K; Svensson TH
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2009;19:S561
Reboxetine enhances cortical dopaminergic and glutamatergic transmission and the anti psychotic-like effect of olanzapine
Svensson TH; Jardemark K; Malmerfelt A; Bjorkholm C; Marcus MM
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S477
Asenapine:: preclinical evidence for clinical effects in schizophrenia and cognitive dysfunction
Svensson TH; Frånberg O; Konradsson A; Jardemark K; Schilstroem B; Wiker C; Ivanov V; Shahid M; Wong EHF; Marcus MM
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2007;17:S20-S21
Asenapine: preclinical evidence for clinical effects in Schizophrenia
Franberg O; Marcus MM; Konradsson A; Jardemark K; Schilstrom B; Wiker C; Shahid M; Wong EHF; Svensson TH
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):339
Asenapine, a novel psychopharmacological agent:: Preclinical evidence for clinical effects in schizophrenia
Oggesjo O; Marcus MM; Konradsson A; Jardemark K; Schilstrom B; Wiker C; Shahid M; Wong EHF; Svensson TH
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):321
Augmentation strategies in schizophrenia
Svensson TH; Hertel P; Marcus MM; Jardemark K; Schilstrom B; Konradsson A; Wadenberg M-L; Langlois X; Wiker C
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2006;31:S239-S240
Asenapine:: Preclinical evidence for clinical effects in schizophrenia
Marcus MM; Franberg O; Konradsson A; Jardemark K; Schilstrom B; Wiker C; Shahid M; Wong EH; Svensson TH
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2006;60(4):331
Escitalopram, in contrast to citalopram, enhances the excitability of the dopaminergic reward system in brain and, in addition, facilitates glutamatergic transmission in the medial prefrontal cortex
Jardemark K; Ivanov V; Konradsson A; Schilstrom B; Arborelius L; Svensson TH
Conference publication: NORDIC JOURNAL OF PSYCHIATRY. 2005;59(5):412-413
The combination of the anticonvulsant drug topiramate and the D2 antagonist raclopride potentiates glutamatergic neurotransmission in the medial prefrontal cortex of the rat.
Jardemark KE; Sitzia F; Marcus MM; Svensson H
Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2003;13:s301
Addition of nicotine to the D₂ antagonist raclopride or the weak D₄ antagonist L-745,870 augments NMDA-induced currents in pyramidal cells from the rat medial prefrontal cortex
Marcus MM; Jardemark KE; Konradsson Å; Svensson TH
Review: CURRENT OPINION IN INVESTIGATIONAL DRUGS. 2002;3(1):101-105
Dopamine D3 and D4 receptor antagonists in the treatment of schizophrenia.
Jardemark K; Wadenberg M-L; Grillner P; Svensson TH
Book chapter: NEUROCHEMISTRY. 1997;p. 1131-1138
Patch Clamp Detection of Neuroreceptor Modulators in Capillary Electrophoresis
Jardemark K; Orwar O; Jacobson I; Moscho A; Fishman HA; Hamberger A; Sandberg M; Scheller RH; Zare RN
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Employments

Senior Lecturer, Department of Physiology and Pharmacology, Karolinska Institutet, 2016-

Degrees and Education

Docent, Karolinska Institutet, 2005

Articles

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