Mattias Carlström group research

Using a translational approach (in vitro and in vivo microperfusion systems, genetically modified mice, and clinical trials) our projects aim to further characterize mechanisms for reactive oxygen species and nitric oxide formation, interaction and influence on renal, cardiovascular and metabolic functions in health and disease.

Research picture
NADPH oxidase (NOX) is the major source of superoxide (O2-) in the vasculature. Oxidative stress (due to increased O2-), and interaction with NO, lead to NO deficiency, which we suggest play a key role in the development and progression of cardiovascular, renal and metabolic disease. Increased sympathetic nerve activity and angiotensin II (ANG II) signaling as well as abnormal mitochondria function may also contribute to oxidative stress and proinflammatory processes. Conversely, new strategies that boost NO (i.e. nitrate and nitrite) may inhibit NOX, ANG II signaling and sympathetic activity.

Purpose and aims

Cardiovascular, metabolic and renal diseases are major global health problems that are interrelated suggesting common pathological mechanism(s). This translational project aims to explore and characterize the role of NADPH oxidase (NOX)-derived oxidative stress and nitric oxide (NO) deficiency in the triad of reno-cardio-metabolic disorders, and specifically investigate the therapeutic value of boosting the nitrate-nitrite-NO pathway (Fig 1).

Experimental Approaches

We have accesses to a broad and advanced methodological platform, and combine experimental and clinical studies, which will result in novel mechanistic insights and the ability to rapidly translate this understanding into practice.

Picture of summary of Mattias Carlström forskning
MC
Content reviewer:
Mattias Carlström
Aline Lantz
03-06-2024