Recent publications - Jorge Ruas laboratory

Recent publications from the Ruas Lab.

SnapShot: Regulation and biology of PGC-1α.
Jannig PR, Dumesic PA, Spiegelman BM, Ruas JL
Cell 2022 Apr;185(8):1444-1444.e1

Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity.
Correia JC, Kelahmetoglu Y, Jannig PR, Schweingruber C, Shvaikovskaya D, Zhengye L, Cervenka I, Khan N, Stec M, Oliveira M, Nijssen J, Martínez-Redondo V, Ducommun S, Azzolini M, Lanner JT, Kleiner S, Hedlund E, Ruas JL
Cell Metab 2021 11;33(11):2215-2230.e8

Effects of Tryptophan Supplementation and Exercise on the Fate of Kynurenine Metabolites in Mice and Humans.
Valente-Silva P, Cervenka I, Ferreira DMS, Correia JC, Edman S, Horwath O, Heng B, Chow S, Jacobs KR, Guillemin GJ, Blomstrand E, Ruas JL
Metabolites 2021 Aug;11(8):

The kynurenine pathway in chronic diseases: a compensatory mechanism or a driving force?
Joisten N, Ruas JL, Braidy N, Guillemin GJ, Zimmer P
Trends Mol Med 2021 10;27(10):946-954

Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats
Kelahmetoglu Y, Jannig PR, Cervenka I, Koch LG, Britton SL, Zhou J, Wang H, Robinson MM, Nair KS, and Ruas, JL.Front. Endocrinol. 2020 Oct 26; 11:591476.

Exercised cytokines promote endurance.
Correia JC, Ruas JL
Science 2020 05;368(6490):470-471
This article can be downloaded for free at

LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force.
Ferreira DMS, Cheng AJ, Agudelo LZ, Cervenka I, Chaillou T, Correia JC, et al
Skelet Muscle 2019 10;9(1):26

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.
Agudelo LZ, Ferreira DMS, Dadvar S, Cervenka I, Ketscher L, Izadi M, et al
Nat Commun 2019 06;10(1):2767

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration.
Pettersson-Klein AT, Izadi M, Ferreira DMS, Cervenka I, Correia JC, Martinez-Redondo V, et al
Mol Metab 2018 03;9():28-42

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation (free to download)
Agudelo L, Ferreira D, Cervenka I, Bryzgalova G, Dadvar S, Jannig P, Pettersson-Klein A, Lakshmikanth T, Sustarsic E, Porsmyr-Palmertz M, Correia J, Izadi M, Martínez-Redondo V, Ueland P, Midttun Ø, Gerhart-Hines Z, Brodin P, PereiraT, Berggren P-O, Ruas J.
Cell Metabolism Volume 27, Issue 2, 6 February 2018, Pages 378–392.e5

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.
Cervenka I, Agudelo LZ, Ruas JL
Science 2017 Jul;357(6349):

Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes.
Martínez-Redondo V, Jannig PR, Correia JC, Ferreira DM, Cervenka I, Lindvall JM, et al
J. Biol. Chem. 2016 07;291(29):15169-84

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.
Correia JC, Massart J, de Boer JF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, et al
Mol Metab 2015 Dec;4(12):891-902

The hitchhiker's guide to PGC-1α isoform structure and biological functions.
Martínez-Redondo V, Pettersson AT, Ruas JL
Diabetologia 2015 Sep;58(9):1969-77

Intercellular: local and systemic actions of skeletal muscle PGC-1s.
Correia JC, Ferreira DM, Ruas JL
Trends Endocrinol. Metab. 2015 Jun;26(6):305-14

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.
Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, et al
Cell 2014 Sep;159(1):33-45

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.
Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, et al
Am. J. Physiol. Endocrinol. Metab. 2014 Jan;306(2):E157-67

Full list of publications

Content reviewer:
Ida Monstedt