Recent publications - Jorge Ruas laboratory

On this page you will find a list of recent publications from the Ruas Lab.

Exercised cytokines promote endurance.
Correia JC, Ruas JL
Science 2020 05;368(6490):470-471
This article can be downloaded for free at

LIM and cysteine-rich domains 1 (LMCD1) regulates skeletal muscle hypertrophy, calcium handling, and force.
Ferreira DMS, Cheng AJ, Agudelo LZ, Cervenka I, Chaillou T, Correia JC, et al
Skelet Muscle 2019 10;9(1):26

Skeletal muscle PGC-1α1 reroutes kynurenine metabolism to increase energy efficiency and fatigue-resistance.
Agudelo LZ, Ferreira DMS, Dadvar S, Cervenka I, Ketscher L, Izadi M, et al
Nat Commun 2019 06;10(1):2767

Small molecule PGC-1α1 protein stabilizers induce adipocyte Ucp1 expression and uncoupled mitochondrial respiration.
Pettersson-Klein AT, Izadi M, Ferreira DMS, Cervenka I, Correia JC, Martinez-Redondo V, et al
Mol Metab 2018 03;9():28-42

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation (free to download)
Agudelo L, Ferreira D, Cervenka I, Bryzgalova G, Dadvar S, Jannig P, Pettersson-Klein A, Lakshmikanth T, Sustarsic E, Porsmyr-Palmertz M, Correia J, Izadi M, Martínez-Redondo V, Ueland P, Midttun Ø, Gerhart-Hines Z, Brodin P, PereiraT, Berggren P-O, Ruas J.
Cell Metabolism Volume 27, Issue 2, 6 February 2018, Pages 378–392.e5

Kynurenines: Tryptophan's metabolites in exercise, inflammation, and mental health.
Cervenka I, Agudelo LZ, Ruas JL
Science 2017 Jul;357(6349):

Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes.
Martínez-Redondo V, Jannig PR, Correia JC, Ferreira DM, Cervenka I, Lindvall JM, et al
J. Biol. Chem. 2016 07;291(29):15169-84

Bioenergetic cues shift FXR splicing towards FXRα2 to modulate hepatic lipolysis and fatty acid metabolism.
Correia JC, Massart J, de Boer JF, Porsmyr-Palmertz M, Martínez-Redondo V, Agudelo LZ, et al
Mol Metab 2015 Dec;4(12):891-902

The hitchhiker's guide to PGC-1α isoform structure and biological functions.
Martínez-Redondo V, Pettersson AT, Ruas JL
Diabetologia 2015 Sep;58(9):1969-77

Intercellular: local and systemic actions of skeletal muscle PGC-1s.
Correia JC, Ferreira DM, Ruas JL
Trends Endocrinol. Metab. 2015 Jun;26(6):305-14

Skeletal muscle PGC-1α1 modulates kynurenine metabolism and mediates resilience to stress-induced depression.
Agudelo LZ, Femenía T, Orhan F, Porsmyr-Palmertz M, Goiny M, Martinez-Redondo V, et al
Cell 2014 Sep;159(1):33-45

Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation.
Sczelecki S, Besse-Patin A, Abboud A, Kleiner S, Laznik-Bogoslavski D, Wrann CD, et al
Am. J. Physiol. Endocrinol. Metab. 2014 Jan;306(2):E157-67

Full list of publications