Jorge Ruas
Professor
E-mail: jorge.ruas@ki.se
Telephone: +46852487261
Visiting address: Solnavägen 9, Biomedicum C5, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Molekylär och cellulär arbetsfysiologi, 171 77 Stockholm
About me
- Professor of Molecular Physiology and Principal Investigator of the Molecular and Cellular Exercise Physiology research group.
After receiving my Pharm.D. degree from the University of Lisbon, I moved to Karolinska Institutet (KI) for my doctoral studies. During that time I investigated how cellular oxygen levels can regulate adaptive gene expression, and in 2005 received my Ph.D. in Medical Sciences.
In 2006 I moved to Boston to pursue postdoctoral studies at the Division of Metabolism and Chronic Disease at the Dana-Farber Cancer Institute and Harvard Medical School. During this period I focused on the study of transcriptional networks that control skeletal muscle physiology.
In July 2011 I setup my research group at the Department of Physiology and Pharmacology at KI, became Associate Professor in 2016, and Professor of Molecular Physiology in 2020. My group aims to identify the molecular mediators of the health benefits of exercise and to use this knowledge to develop novel disease therapies.
Academic honours, awards and prizes
2022 The Med. Dr. Axel Hirsch Prize 2022
2019 Novo Nordisk Foundation Ascending Investigator, Endocrinology and Metabolism
2017 The Leif C. Groop Award for Outstanding Diabetes Research
2016 Swedish Research Council Consolidator Grant
2015 Senior Researcher Award from Karolinska Institutet
2014 Human Frontier Science Program Young Investigator Award
2013 Malin and Lennart Philipson Prize (link to ki.se/news)
Jorge Ruas - award winner 2013-2015 (link to Malin and Lennart Philipson's foundation website)
2012 Novo Nordisk Fonden Excellence Project Award
2012 Marie Curie Career Integration Grant
2011 Assistant Professor Grant from the Swedish Research Council
2011 Young Investigator Award in Diabetes. Strategic Research Programme in Diabetes at Karolinska Institutet (Sweden).
2006 Wenner Gren Fellow
Research
- Research in our laboratory is aimed at understanding the molecular mechanisms that mediate skeletal muscle adaptations to diverse challenges and their local and systemic consequences. We are particularly interested in understanding how exercised or sedentary skeletal muscle can crosstalk with other organs, and how it can affect individual health and disease.
Teaching
- I teach several subjects to the Medicine and Biomedicine programs at KI, and participate as lecturer in diverse doctoral courses. I am also an invited professor at the Faculty of Pharmacy, University of Lisbon.
Articles
- Article: SKELETAL MUSCLE. 2025;15(1):9Horwath O; Cornet L; Stroemlind H; Moberg M; Edman S; Soederlund K; Checa A; Ruas JL; Blomstrand E
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2025;328(2):E274-E285Dumont KD; Jannig PR; Porsmyr-Palmertz M; Ruas JL
- Article: ACTA DERMATO-VENEREOLOGICA. 2024;104:adv40796Tayefi M; Svedbom A; Ivert LU; Lundqvist M; Ruas JL; Bradley M; Johansson EK
- Article: NATURE COMMUNICATIONS. 2024;15(1):9826Pham TCP; Raun SH; Havula E; Henriquez-Olguin C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig PR; Andersen NR; Kruse R; Ali MS; Irazoki A; Halling JF; Ringholm S; Needham EJ; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ortenblad N; Hojlund K; Kjaer M; Ruas JL; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
- Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2024;224:s9-s10Alves ES; van Deventer A; Jude B; Shorter E; Smith J; Steinz M; Gustafsson T; Rullman E; von Walden F; Svensson C; Zierath JR; Ruas JL; Lanner J
- Article: AGING CELL. 2024;23(11):e14295Dedic B; Westerberg L; Solis AM; Dumont KD; Ruas JL; Thorell A; Naslund E; Spalding KL
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2024;56(10):2007-2015Kamandulis S; Lukonaitiene I; Snieckus A; Brazaitis M; Mickevicius M; Cernych M; Ruas J; Schwieler L; Louvrou V; Erhardt S; Westerblad H; Venckunas T
- Journal article: ELIFE. 2024;12Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
- Article: ELIFE. 2024;12:rp92707Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Karppinen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(34):e2319724121Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Praestholm SM; Dias JM; Dumont KD; Liu Z; Liang Q; Edsgaerd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Teixeira AI; Yeo GW; Ruas JL
- Article: MOLECULAR METABOLISM. 2024;82:101912Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbuhler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; Haworth SM; Martinez-Redondo V; Liu Z; Carlstrom M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
- Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2024;103(1):151377Nunes MJ; Carvalho AN; Sa-Lemos C; Colaco M; Cervenka I; Ciraci V; Santos SG; Ribeiro MM; Castanheira M; Jannig PR; Gama MJ; Castro-Caldas M; Rodrigues CMP; Rodrigues E; Ruas JL
- Journal article: NATURE NANOTECHNOLOGY. 2024;19(2)Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
- Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(2):166980Caria I; Nunes MJ; Ciraci V; Carvalho AN; Ranito C; Santos SG; Gama MJ; Castro-Caldas M; Rodrigues CMP; Ruas JL; Rodrigues E
- Article: NATURE NANOTECHNOLOGY. 2024;19(2):237-245Spratt J; Dias JM; Kolonelou C; Kiriako G; Engstrom E; Petrova E; Karampelias C; Cervenka I; Papanicolaou N; Lentini A; Reinius B; Andersson O; Ambrosetti E; Ruas JL; Teixeira AI
- Journal article: TOXICOLOGY LETTERS. 2023;384(Front. Cell Dev. Biol. 9 2021):s188-S193Rodrigues JS; Faria-Pereira A; Camões SP; Serras AS; Morais VA; Ruas JL; Miranda JP
- Article: CELL REPORTS. 2023;42(1):112021Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
- Article: FRONTIERS IN ENDOCRINOLOGY. 2023;13:1043543Rodrigues JS; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
- Article: CELLS. 2022;11(19):2944Tuomainen T; Naumenko N; Mutikainen M; Shakirzyanova A; Sczelecki S; Estall JL; Ruas JL; Tavi P
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2022;298(9):102328Schihada H; Klompstra TM; Humphrys LJ; Cervenka I; Dadvar S; Kolb P; Ruas JL; Schulte G
- Article: BMC BIOLOGY. 2022;20(1):169Oehler D; Spychala A; Godecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
- Article: NATURE METABOLISM. 2022;4(6):739-758Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
- Article: CARDIOVASCULAR RESEARCH. 2022;118(6):1520-1534Naumenko N; Mutikainen M; Holappa L; Ruas JL; Tuomainen T; Tavi P
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2022;14(638):eaba9112Ilegems E; Bryzgalova G; Correia J; Yesildag B; Berra E; Ruas JL; Pereira TS; Berggren P-O
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2022;322(1):C49-C62Jonsson WO; Ponette J; Horwath O; Rydenstam T; Soderlund K; Ekblom B; Azzolini M; Ruas JL; Blomstrand E
- Article: FASEB JOURNAL. 2021;35(12):e22010Liu Z; Chaillou T; Santos Alves E; Mader T; Jude B; Ferreira DMS; Hynynen H; Cheng AJ; Jonsson WO; Pironti G; Andersson DC; Kenne E; Ruas JL; Tavi P; Lanner JT
- Article: CELL METABOLISM. 2021;33(11):2215-2230.e8Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Shvaikovskaya D; Zhengye L; Cervenka I; Khan N; Stec M; Oliveira M; Nijssen J; Martinez-Redondo V; Ducommun S; Azzolini M; Lanner JT; Kleiner S; Hedlund E; Ruas JL
- Article: NATURE COMMUNICATIONS. 2021;12(1):5948Massart J; Sjogren RJO; Egan B; Garde C; Lindgren M; Gu W; Ferreira DMS; Katayama M; Ruas JL; Barres R; O'Gorman DJ; Zierath JR; Krook A
- Article: METABOLITES. 2021;11(8):508Valente-Silva P; Cervenka I; Ferreira DMS; Correia JC; Edman S; Horwath O; Heng B; Chow S; Jacobs KR; Guillemin GJ; Blomstrand E; Ruas JL
- Article: BIOTECHNOLOGY AND BIOENGINEERING. 2021;118(6):2234-2242Song K-Y; Correia JC; Ruas JL; Teixeira AI
- Article: BMC BIOLOGY. 2021;19(1):57Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fao L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
- Article: SCIENTIFIC REPORTS. 2021;11(1):6453Moberg M; Apro W; Cervenka I; Ekblom B; van Hall G; Holmberg H-C; Ruas JL; Blomstrand E
- Article: NATURE COMMUNICATIONS. 2021;12(1):1026Wu H; Petitpre C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
- Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:591476Kelahmetoglu Y; Jannig PR; Cervenka I; Koch LG; Britton SL; Zhou J; Wang H; Robinson MM; Nair KS; Ruas JL
- Article: COMMUNICATIONS BIOLOGY. 2020;3(1):541Hahn M; van Krieken PP; Nord C; Alanentalo T; Morini F; Xiong Y; Eriksson M; Mayer J; Kostromina E; Ruas JL; Sharpe J; Pereira T; Berggren P-O; Ilegems E; Ahlgren U
- Article: MOLECULAR METABOLISM. 2020;39:101012Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIENAlves CRR; das Neves W; de Almeida NR; Eichelberger EJ; Jannig PR; Voltarelli VA; Tobias GC; Bechara LRG; Faria DDP; Alves MJN; Hagen L; Sharma A; Slupphaug G; Moreira JBN; Wisloff U; Hirshman MF; Negrao CE; de CGJ; Chammas R; Swoboda KJ; Ruas JL; Goodyear LJ; Brum PC
- Article: NURSING OPEN. 2020;7(5):1446-1452Cronfalk BS; Akesson E; Nygren J; Nystrom A; Strandell A-M; Ruas J; von Euler M
- Article: MOLECULAR METABOLISM. 2020;34:72-84Leveille M; Besse-Patin A; Jouvet N; Gunes A; Sczelecki S; Jeromson S; Khan NP; Baldwin C; Dumouchel A; Correia JC; Jannig PR; Boulais J; Ruas JL; Estall JL
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
- Article: REDOX BIOLOGY. 2020;28:101387Peleli M; Ferreira DMS; Tarnawski L; Haworth SM; Xuechen L; Zhuge Z; Newton PT; Massart J; Chagin AS; Olofsson PS; Ruas JL; Weitzberg E; Lundberg JO; Carlstrom M
- Article: SKELETAL MUSCLE. 2019;9(1):26Ferreira DMS; Cheng AJ; Agudelo LZ; Cervenka I; Chaillou T; Correia JC; Porsmyr-Palmertz M; Izadi M; Hansson A; Martinez-Redondo V; Valente-Silva P; Pettersson-Klein AT; Estall JL; Robinson MM; Nair KS; Lanner JT; Ruas JL
- Article: NATURE COMMUNICATIONS. 2019;10(1):2767Agudelo LZ; Ferreira DMS; Dadyar S; Cervenka I; Ketscher L; Izadi M; Liu Z; Furrer R; Handschin C; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Ruas JL
- Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13Carvalho A; Ranito C; Tavares C; Castro-Caldas M; Rodrigues E; Ruas J; Van Horssen J; Gama M
- Journal article: FRONTIERS IN CELLULAR NEUROSCIENCE. 2019;13Nunes M; Caria I; Carvalho A; Costa D; Castro-Caldas M; Gama M; Rodrigues E; Ruas J
- Article: CARDIOVASCULAR RESEARCH. 2019;115(1):107-118Karkkainen O; Tuomainen T; Mutikainen M; Lehtonen M; Ruas JL; Hanhineva K; Tavi P
- Article: PHYSIOLOGICAL GENOMICS. 2018;50(12):1071-1082Blackwell TA; Cervenka I; Khatri B; Brown JL; Rosa-Caldwell ME; Lee DE; Perry RAJ; Brown LA; Haynie WS; Wiggs MP; Bottje WG; Washington TA; Kong BC; Ruas JL; Greene NP
- Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(5):519-533Dadvar S; Ferreira DMS; Cervenka I; Ruas JL
- Article: EMBO MOLECULAR MEDICINE. 2018;10(8):e8613Bayindir-Buchhalter I; Wolff G; Lerch S; Sijmonsma T; Schuster M; Gronych J; Billeter AT; Babaei R; Krunic D; Ketscher L; Spielmann N; de Angelis MH; Ruas JL; Mueller-Stich BP; Heikenwalder M; Lichter P; Herzig S; Vegiopoulos A
- Journal article: IBJ PLUS. 2018Agró M; Díaz Nido J; Giménez Cassina A; Katsu Jiménez Y; da Silva P; Ruas J
- Article: MOLECULAR METABOLISM. 2018;9:28-42Pettersson-Klein AT; Izadi M; Ferreira DMS; Cervenka I; Correia JC; Martinez-Redondo V; Southern M; Cameron M; Kamenecka T; Agudelo LZ; Porsmyr-Palmertz M; Martens U; Lundgren B; Otrocka M; Jenmalm-Jensen A; Griffin PR; Ruas JL
- Article: CELL METABOLISM. 2018;27(2):378-392.e5Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
- Journal article: ANNALS OF RESEARCH IN SPORT AND PHYSICAL ACTIVITY. 2018;(ex2018):79-80Ruas JL
- Article: MOLECULAR METABOLISM. 2018;7:12-22Mills R; Taylor-Weiner H; Correia JC; Agudelo LZ; Allodi I; Kolonelou C; Martinez-Redondo V; Ferreira DMS; Nichterwitz S; Comley LH; Lundin V; Hedlund E; Ruas JL; Teixeira AI
- Journal article: EUROPEAN JOURNAL OF TRANSLATIONAL MYOLOGY. 2017;27(4):7218Gabellini D; Musarò A
- Article: ARCHIVES OF TOXICOLOGY. 2017;91(6):2469-2489Cipriano M; Correia JC; Camoes SP; Oliveira NG; Cruz P; Cruz H; Castro M; Ruas JL; Santos JM; Miranda JP
- Article: CELL REPORTS. 2017;18(3):636-646Ruby MA; Massart J; Hunerdosse DM; Schonke M; Correia JC; Louie SM; Ruas JL; Naslund E; Nomura DK; Zierath JR
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(23):7049-7071Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Laidinen S; Kokki K; Hynynen H; Yla-Herttuala S; Heinaniemi M; Ruas JL; Tavi P
- Article: SCIENTIFIC REPORTS. 2016;6:30928Moutinho M; Nunes MJ; Correia JC; Gama MJ; Castro-Caldas M; Cedazo-Minguez A; Rodrigues CMP; Bjorkhem I; Ruas JL; Rodrigues E
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2016;8(350):350ra103Salah H; Li M; Cacciani N; Gastaldello S; Ogilvie H; Akkad H; Namuduri AV; Morbidoni V; Artemenko KA; Balogh G; Martinez-Redondo V; Jannig P; Hedstrom Y; Dworkin B; Bergquist J; Ruas J; Vigh L; Salviati L; Larsson L
- Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(15):4371-4388Kalamgi RC; Salah H; Gastaldello S; Martinez-Redondo V; Ruas JL; Fury W; Bai Y; Gromada J; Sartori R; Guttridge DC; Sandri M; Larsson L
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2016;310(10):C836-C840Schlittler M; Goiny M; Agudelo LZ; Venckunas T; Brazaitis M; Skurvydas A; Kamandulis S; Ruas JL; Erhardt S; Westerblad H; Andersson DC
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(50):15492-15497Place N; Ivarsson N; Venckunas T; Neyroudard D; Brazaitis M; Cheng AJ; Ochala J; Kamandulis S; Girard S; Volungevicius G; Pauzas H; Mekideche A; Kayser B; Martinez-Redondo V; Ruas JL; Bruton J; Truffert A; Lanner JT; Skurvydas A; Westerblad H
- Article: MOLECULAR METABOLISM. 2015;4(12):891-902Correia JC; Massart J; de Boer JF; Porsmyr-Palmertz M; Martinez-Redondo V; Agudelo LZ; Sinha I; Meierhofer D; Ribeiro V; Bjornholm M; Sauer S; Dahlman-Wright K; Zierath JR; Groen AK; Ruas JL
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(44):15756-15761White JP; Wrann CD; Rao RR; Nair SK; Jedrychowski MP; You J-S; Martinez-Redondo V; Gygi SP; Ruas JL; Hornberger TA; Wu Z; Glass DJ; Piao X; Spiegelman BM
- Article: CELL. 2014;159(1):33-45Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson AT; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
- Article: CELL. 2014;157(6):1279-1291Rao RR; Long JZ; White JP; Svensson KJ; Lou J; Lokurkar I; Jedrychowski MP; Ruas JL; Wrann CD; Lo JC; Camera DM; Lachey J; Gygi S; Seehra J; Hawley JA; Spiegelman BM
- Article: MOLECULAR CANCER. 2014;13:54Aesoy R; Gradin K; Aasrud KS; Hoivik EA; Ruas JL; Poellinger L; Bakke M
- Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(2):E157-E167Sczelecki S; Besse-Patin A; Abboud A; Kleiner S; Laznik-Bogoslavski D; Wrann CD; Ruas JL; Haibe-Kains B; Estall JL
- Journal article: FASEB JOURNAL. 2013;27(S1):940.18White J; Ruas J; Rao R; Kleiner S; Wu J; Spiegelman B
- Article: CELL. 2012;151(6):1319-1331Ruas JL; White JP; Rao RR; Kleiner S; Brannan KT; Harrison BC; Greene NP; Wu J; Estall JL; Irving BA; Lanza IR; Rasbach KA; Okutsu M; Nair KS; Yan Z; Leinwand LA; Spiegelman BM
- Article: GENES & DEVELOPMENT. 2011;25(12):1232-1244Lustig Y; Ruas JL; Estall JL; Lo JC; Devarakonda S; Laznik D; Choi JH; Ono H; Olsen JV; Spiegelman BM
- Article: CELL METABOLISM. 2011;13(2):160-169Wu J; Ruas JL; Estall JL; Rasbach KA; Choi JH; Ye L; Bostroem P; Tyra HM; Crawford RW; Campbell KP; Rutkowski DT; Kaufman RJ; Spiegelman BM
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(50):21866-21871Rasbach KA; Gupta RK; Ruas JL; Wu J; Naseri E; Estall JL; Spiegelman BM
- Article: DEVELOPMENT. 2010;137(20):3489-3499Chakkalakal JV; Nishimune H; Ruas JL; Spiegelman BM; Sanes JR
- Article: NATURE. 2010;466(7305):451-456Choi JH; Banks AS; Estall JL; Kajimura S; Bostroem P; Laznik D; Ruas JL; Chalmers MJ; Kamenecka TM; Blueher M; Griffin PR; Spiegelman BM
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(4):2601-2609Ruas JL; Berchner-Pfannschmidt U; Malik S; Gradin K; Fandrey J; Roeder RG; Pereira T; Poellinger L
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(52):22510-22515Estall JL; Ruas JL; Choi CS; Laznik D; Badman M; Maratos-Flier E; Shulman GI; Spiegelman BM
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(50):21401-21406Chinsomboon J; Ruas J; Gupta RK; Thom R; Shoag J; Rowe GC; Sawada N; Raghuram S; Arany Z
- Article: GENES & DEVELOPMENT. 2008;22(10):1397-1409Kajimura S; Seale P; Tomaru T; Erdjument-Bromage H; Cooper MP; Ruas JL; Chin S; Tempst P; Lazar MA; Spiegelman BM
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2008;105(9):3368-3373Zheng X; Linke S; Dias JM; Zheng X; Gradin K; Wallis TP; Hamilton BR; Gustafsson M; Ruas JL; Wilkins S; Bilton RL; Brismar K; Whitelaw ML; Pereira T; Gorman JJ; Ericson J; Peet DJ; Lendahl U; Poellinger L
- Article: NATURE. 2008;451(7181):1008-1012Arany Z; Foo S-Y; Ma Y; Ruas JL; Bommi-Reddy A; Girnun G; Cooper M; Laznik D; Chinsomboon J; Rangwala SM; Baek KH; Rosenzweig A; Spiegelman BM
- Article: FASEB JOURNAL. 2007;21(8):1821-1830Ronkainen V-P; Ronkainen JJ; Hannninen SL; Leskinen H; Ruas JL; Pereira T; Poellinger L; Vuolteenaho O; Tavi P
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(12):4628-4641Zheng X; Ruas JL; Cao R; Salomons FA; Cao Y; Poellinger L; Pereira T
- Article: DEVELOPMENTAL CELL. 2005;9(5):617-628Gustafsson MV; Zheng XW; Pereira T; Gradin K; Jin SB; Lundkvist J; Ruas JL; Poellinger L; Lendahl U; Bondesson M
- Article: JOURNAL OF CELL SCIENCE. 2005;118(2):301-311Ruas JL; Poellinger L; Pereira T
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):6816-6823Pereira T; Zheng XW; Ruas JL; Tanimoto K; Poellinger L
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(41):38723-38730Ruas JL; Poellinger L; Pereira T
- Article: PHARMACOGENETICS AND GENOMICS. 1997;7(4):333-335Ruas JL; Lechner MC
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All other publications
- Conference publication: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(8):167373Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Juhlin CC; von Kriegsheim A; Cao Y; Schlisio S
- Preprint: BIORXIV. 2024Horwath O; Cornet L; Strömlind H; Moberg M; Edman S; Söderlund K; Checa A; Ruas JL; Blomstrand E
- Preprint: RESEARCH SQUARE. 2024Sylow L; Pham TCP; Raun S; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen A; Jannig P; Andersen N; Kruse R; Ali M; Halling J; Ringholm S; Needham E; Hansen S; Lemminger A; Schjerling P; Petersen M; de Almeida M; Jensen T; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski J; Nielsen J; Qvortrup K; Pilegaard H; Richter E
- Conference publication: WOUND REPAIR AND REGENERATION. 2023;31:S19Rodrigues JS; Faria-Pereira A; Camoes SP; Serras AS; Jannig PR; Morais VA; Ruas JL; Miranda JP
- Preprint: BIORXIV. 2023Pham TCP; Raun SH; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig P; Andersen NR; Kruse R; Ali MS; Halling JF; Ringholm S; Needham E; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
- Preprint: BIORXIV. 2023Wadsworth B; Leiwe M; Minogue E; Cunha P; Engman V; Brombach C; Asvestis C; Sah-Teli S; Marklund E; Koivunen P; Ruas J; Rundqvist H; Lanner J; Johnson R
- Conference publication: ACTA PHYSIOLOGICA. 2023;239Jude B; Tagadirt L; Santos-Alves E; Mader T; Chibalin AV; Ducommun S; Zierath JR; Von Walden F; Krook A; Ruas JL; Lanner JT
- Conference publication: TOXICOLOGY LETTERS. 2023;384:S188Saraiva Rodrigues J; Faria-Pereira A; Camoes SP; Serras AS; Morais VA; Ruas JL; Miranda JP
- Conference publication: ACTA PHYSIOLOGICA. 2023;239Ruas J
- Conference publication: ANNALS OF NUTRITION AND METABOLISM. 2023;79:85Ruas JL
- Preprint: BIORXIV. 2023;BIORXIVCorreia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Præstholm SM; Dumont K; Liu Z; Liang Q; Edsgärd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Yeo GW; Ruas JL
- Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:839Jude B; Chibalin A; Ducommun S; Zierath J; Von Walden F; Ruas J; Krook A; Lanner J
- Conference publication: JOURNAL OF HEPATOLOGY. 2023;78:S741Praestholm SM; Correia J; Ruas J
- Corrigendum: NATURE METABOLISM. 2022;4(10):1421Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
- Conference publication: FEBS OPEN BIO. 2022;12:34Ruas J
- Conference publication: FASEB JOURNAL. 2022;36Addinsall AB; Cacciani N; Akkad H; Moruzzi N; Maestri A; Shevchenko G; Bergquist J; Ruas J; Larsson L
- Editorial comment: CELL. 2022;185(8):1444-1444.e1Jannig PR; Dumesic PA; Spiegelman BM; Ruas JL
- Preprint: BIORXIV. 2022Oehler D; Spychala A; Gödecke A; Lang A; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
- Preprint: SSRN ELECTRONIC JOURNAL. 2022Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Petropoulos S; Chen X; Ruas JL; Wu J; Deng Q
- Review: TRENDS IN MOLECULAR MEDICINE. 2021;27(10):946-954Joisten N; Ruas JL; Braidy N; Guillemin GJ; Zimmer P
- Preprint: BIORXIV. 2021Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Svaikovskaya D; Zhengye L; Cervenka I; Oliveira M; Nijssen J; Martínez-Redondo V; Stec M; Khan N; Lanner JT; Kleiner S; Hedlund E; Ruas JL
- Conference publication: EUROPEAN HEART JOURNAL. 2020;41:3582Oehler D; Goedecke A; Spychala A; Lai K; Gerdes N; Ruas J; Kelm M; Szendroedi J; Westenfeld R
- Editorial comment: SCIENCE. 2020;368(6490):470-471Correia JC; Ruas JL
- Review: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2020;318(5):C818-C830Martin KS; Azzolin M; Ruas JL
- Conference publication: TOXICOLOGY LETTERS. 2019;314:S288Rodrigues JS; Cipriano M; Correia J; Camoes SP; Oliveira N; Castro M; Ruas J; Miranda J
- Preprint: BIORXIV. 2019Léveillé M; Besse-Patin A; Jouvet N; Gunes A; Jeromson S; Khan NP; Sczelecki S; Baldwin C; Dumouchel A; Correia J; Jannig P; Boulais J; Ruas JL; Estall JL
- Review: SCIENCE. 2017;357(6349):eaaf9794Cervenka I; Agudelo LZ; Ruas JL
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:20Mutikainen M; Tuomainen T; Naumenko N; Huusko J; Smirin B; Hynynen H; Laidinen S; Yla-Herttuala S; Heinaniemi M; Ruas J; Tavi P
- Conference publication: ACTA PHYSIOLOGICA. 2017;219:16-17Chaillou T; Hynynen H; Ferreira D; Pironti G; Andersson D; Ruas J; Tavi P; Lanner J
- Book chapter: HORMONES, METABOLISM AND THE BENEFITS OF EXERCISE: RESEARCH AND PERSPECTIVES IN ENDOCRINE INTERACTIONS. 2017;p. 83-91Valente-Silva P; Ruas JL
- Editorial comment: ACTA PHYSIOLOGICA. 2017;219(1):14-16Jannig PR; Ruas JL
- Meeting abstract: FREE RADICAL BIOLOGY AND MEDICINE. 2016;100:S186Chaillou T; Hynynen H; Ferreira D; Pironti G; Kenne E; Andersson DC; Ruas JL; Tavi P; Lanner JT
- Letter: ACTA NEUROPSYCHIATRICA. 2016;28(4):244-245Zepf FD; Stewart RM; Guillemin GJ; Ruas JL
- Conference publication: DIABETOLOGIA. 2015;58:S300Mudry JM; Ruas JL; Erhardt S; Caidahl K; Zierath JR; Krook A; Wallberg-Henriksson H
- Review: DIABETOLOGIA. 2015;58(9):1969-1977Martinez-Redondo V; Pettersson AT; Ruas JL
- Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2015;26(6):305-314Correia JC; Ferreira DMS; Ruas JL
- Corrigendum: CELL. 2015;160(1-2):351Agudelo LZ; Femenia T; Orhan F; Porsmyr-Palmertz M; Goiny M; Martinez-Redondo V; Correia JC; Izadi M; Bhat M; Schuppe-Koistinen I; Pettersson A; Ferreira DMS; Krook A; Barres R; Zierath JR; Erhardt S; Lindskog M; Ruas JL
- Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009;29(7):E16-E17Arany ZP; Foo S-Y; Chinsomboon J; Girnun G; Cooper M; Ruas J; Bommi-Reddy A; Rangwala S; Baek KH; Rosenzweig A; Spiegelman B
- Review: CURRENT OPINION IN LIPIDOLOGY. 2007;18(5):508-514Ruas JL; Lendahl U; Poellinger L
- Review: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2005;16(4-5):514-522Ruas JL; Poellinger L
- Doctoral thesis: 2005Ruas JL
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Grants
- Regulation of Adipose Tissue Function by Neuroendocrine CommunicationNovo Nordisk Foundation1 October 2023 - 30 September 2024
- Um outro olhar para a prescrição do exercício: Exercício a diferentes horas do dia e o ciclo circadiano em pessoas com diabetes tipo 2 e aqueles que se encontram em riscoFundação para a Ciência e Tecnologia1 March 2023 - 28 February 2025
- Swedish Research Council1 January 2023 - 31 December 2026Nonalcoholic fatty liver disease (NAFLD) is estimated to affect up to one third of the adult population in industrialized countries and 70-80% of obese patients with diabetes. The milder stage, hepatic steatosis, is often asymptomatic and undiagnosed but over 30% of these patients progress to nonalcoholic steatohepatitis (NASH). NASH impairs liver function and is a risk factor for cirrhosis, hepatocellular carcinoma, and cardiovascular disease. Amongst obese patients with diabetes, 30-50% develop NASH. There are no specific pharmacological treatments for NASH and drug development depends on a better understanding of the mechanisms underlying its pathogenesis. In addition, there are no biomarkers to diagnose and monitor NAFLD/NASH progression.We have identified a protein with previously unknown function and discovered that it operates as a major regulator of inflammation, extracellular matrix remodeling, and fibrogenesis. Based on its function, we have named it Tissue Remodeler and Activator of INflammation (TRAIN). TRAIN expression is elevated in human and rodent liver disease. We have observed that increasing TRAIN expression in mouse liver is sufficient to elicit many of the metabolic, morphological, histological, and transcriptional abnormalities characteristic of NASH. Our goal is to understand how TRAIN activation leads to NALFD/NASH, to identify reliable disease biomarkers and to develop novel therapies for NAFLD/NASH by manipulating TRAIN activity.
- Regulation of Adipose Tissue Neuroendocrine Communication by Kynurenine MetabolitesNovo Nordisk Foundation1 October 2021 - 30 September 2023
- T.R.A.I.N., a novel target in Non-Alcoholic Fatty Liver Disease (NAFLD): Disease Mechanisms, Biomarkers, and Therapeutics.Novo Nordisk Foundation1 July 2019 - 30 June 2024
- Research Institute for MedicinesFundação para a Ciência e Tecnologia1 January 2019 - 31 December 2019
- PGC-1alpha Isoforms as novel Therapeutic targets in ParkinsON's DiseaseFundação para a Ciência e Tecnologia1 August 2018 - 31 July 2022
- Molecular Mechanisms Regulating Skeletal Muscle Function and their Systemic ImpactNovo Nordisk Foundation1 January 2017 - 1 January 2020
- Swedish Research Council1 January 2017 - 31 December 2022
- Swedish Research Council1 January 2016 - 31 December 2019
- Japan Society for the Promotion of Science1 April 2015 - 31 March 2017
- Swedish Research Council1 January 2015 - 31 December 2018
- Modeling information flow between tissues during metabolic adaptation and dysfunctionInternational Human Frontier Science Program Organization1 May 2014 - 30 April 2017
- Mechanisms of Skeletal Muscle Adaptations to ExerciseNovo Nordisk Foundation19 March 2012 - 18 March 2017
- Swedish Research Council1 January 2011 - 31 December 2014
- Swedish Research Council1 January 2011 - 31 December 2014
- MECHANISM OF HYPOXIA DEPENDENT TRANSCRIPTION ACTIVATION MEDIATED BY THE HYPOXIA-INDUCIBLE FACTOR-1Fundação para a Ciência e Tecnologia1 July 1999 - 30 June 2003
- STUDY OF THE POLYMORPHISM OF THE CYP2AG AND CYP2C19 GENES IN PORTUGUESE POPULATIONS.Fundação para a Ciência e Tecnologia1 August 1996 - 31 July 1998
Employments
- Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2020-
Degrees and Education
- Docent, Karolinska Institutet, 2016
- Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2005
- Pharm.D., University of Lisbon, 1995
Visiting research fellowships
- Postdoc, Harvard Medical School, Postdoc in Molecular Muscle Physiology, 2006-2011