Stine Marie Præstholm
Affiliated to Research
E-mail: stine.marie.praestholm@ki.se
Visiting address: Solnavägen 9, Biomedicum C5, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa Molekylär och cellulär arbetsfysiologi, 171 77 Stockholm
About me
- Stine Marie Præstholm obtained her PhD from the University of Southern
Denmark in April 2021. During her doctoral studies she investigated
transcriptional regulation mediated by nuclear receptors: the thyroid hormone
receptor and the glucocorticoid receptor, in mouse liver. Specifically, she
looked into enhancers regulated by the thyroid hormone receptor identifying
different types of enhancers differential bound by coregulators. Later, she
studied the role of the glucocorticoid receptor in regulating hepatic gene
transcription in the transition from fasting to feeding in a circadian
context.
PhD | 2021 | Biochemistry and Molecular Biology, University of Southern
Denmark
MSc | 2018 | Biochemistry and Molecular Biology, University of Southern
Denmark
BSc | 2015 | Biochemistry and Molecular Biology, University of Southern
Denmark
Research
- In October 2021, I started my SRP Diabetes Postdoctoral Fellowship at
Karolinska Institutet under the supervision of Professor Jorge Ruas at the
Department of Physiology and Pharmacology. In our project we investigate how
a protein, newly discovered to be a major regulator of inflammation,
extracellular matrix remodeling and fibrogenesis, called TRAIN, promotes
NAFLD/NASH and elucidate the molecular mechanism. Moreover, we will evaluate
the TRAIN-driven secretome to identify diagnostic tools for NAFLD/NASH and
investigate TRAIN levels and candidate biomarkers in NAFLD/NASH patient
samples. The findings of this project could potentially form a basis of a new
class of pharmacological therapies for NASH.
Articles
- Journal article: ENDOCRINOLOGY. 2023;164(10):bqad128Correia CM; Praestholm SM; Havelund JF; Pedersen FB; Siersbaek MS; Ebbesen MF; Gerhart-Hines Z; Heeren J; Brewer J; Larsen S; Blagoev B; Faergeman NJ; Grontved L
- Journal article: CELL REPORTS. 2021;37(5):109938Praestholm SM; Correia CM; Goitea VE; Siersbaek MS; Jorgensen M; Havelund JF; Pedersen TA; Faergeman NJ; Grontved L
- Journal article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:572981Praestholm SM; Correia CM; Grontved L
- Journal article: SCIENTIFIC REPORTS. 2020;10(1):14052Siersbaek MS; Ditzel N; Hejbol EK; Praestholm SM; Markussen LK; Avolio F; Li L; Lehtonen L; Hansen AK; Schroder HD; Krych L; Mandrup S; Langhorn L; Bollen P; Grontved L
- Journal article: PLOS GENETICS. 2020;16(5):e1008770Praestholm SM; Siersbaek MS; Nielsen R; Zhu X; Hollenberg A; Cheng S-Y; Grontved L
- Journal article: PLOS BIOLOGY. 2018;16(12):e2006249Kalvisa A; Siersbaek MS; Praestholm SM; Christensen LJL; Nielsen R; Stohr O; Vettorazzi S; Tuckermann J; White M; Mandrup S; Grontved L
- Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(52):E11323-E11332Hoenes GS; Rakov H; Logan J; Liao X-H; Werbenko E; Pollard AS; Praestholm SM; Siersbaek MS; Rijntjes E; Gassen J; Latteyer S; Engels K; Strucksberg K-H; Kleinbongard P; Zwanziger D; Rozman J; Gailus-Durner V; Fuchs H; de Angelis MH; Klein-Hitpass L; Koehrle J; Armstrong DL; Grontved L; Bassett JHD; Williams GR; Refetoff S; Fuehrer D; Moeller LC
All other publications
- Preprint: BIORXIV. 2023;BIORXIVCorreia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Præstholm SM; Dumont K; Liu Z; Liang Q; Edsgärd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Yeo GW; Ruas JL
Employments
- Affiliated to Research, Department of Physiology and Pharmacology, Karolinska Institutet, 2025-2025
- Postdoctoral Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2021-2025