Mattias Carlström group research
Using a translational approach (in vitro and in vivo microperfusion systems, genetically modified mice, and clinical trials) our projects aim to further characterize mechanisms for reactive oxygen species and nitric oxide formation, interaction and influence on renal, cardiovascular and metabolic functions in health and disease.
Purpose and aims
Cardiovascular, metabolic and renal diseases are major global health problems that are interrelated suggesting common pathological mechanism(s). This translational project aims to explore and characterize the role of NADPH oxidase (NOX)-derived oxidative stress and nitric oxide (NO) deficiency in the triad of reno-cardio-metabolic disorders, and specifically investigate the therapeutic value of boosting the nitrate-nitrite-NO pathway (Fig 1).
We have accesses to a broad and advanced methodological platform, and combine experimental and clinical studies, which will result in novel mechanistic insights and the ability to rapidly translate this understanding into practice.