Ocular Oncology and Pathology

We conduct clinical and preclinical research to expand knowledge, improve survival and reduce suffering in eye cancer.

A variety of different tumors can arise in the eye, in the eyelids and in the orbit. Some of these are benign, while others are malignant and very aggressive.

Uveal melanoma is the most common primary intraocular tumor in adults. Almost half of all patients develop metastases even if the eye has been removed. This is believed to be due to so-called micrometastases that leave the primary tumor very early. These micrometastases can remain dormant in their metastatic niche, including the bone marrow and liver, for several years. Once they leave dormancy and start growing, the patient’s prognosis is poor. Uveal melanoma is thereby a cancer disease with unpredictable, high mortality and limited treatment options. We would like to help remedy this. To this aim, we extend current knowledge in the field with clinical and preclinical research. We also develop prognostic test with high accuracy and conduct clinical trials with the aim to prevent the development of metastases.

 

The most common tumor in children is Retinoblastoma. In national and international collaboration, we research genetic aspects of the disease and evaluate the results of novel treatment regimens.

Research Projects

We perform translational research in clinical environments and laboratories. As both the affiliated researchers and the infrastructure are exclusively dedicated to ocular oncology and pathology, we aim to achieve and maintain excellence in this area.

Selected publications

Presenting Symptoms Are Associated with Uveal Melanoma-Related Death

Maria Fili, Stefan Seregard, Gustav Stålhammar

Ophthalmology. 2020 Nov 27;S0161-6420(20)31118-0.doi: 10.1016/j.ophtha.2020.11.023. Online ahead of print.

Expression of immune checkpoint receptors Indoleamine 2,3-dioxygenase and T cell Ig and ITIM domain in metastatic versus nonmetastatic choroidal melanoma

Gustav Stålhammar, Stefan Seregard, Hans E Grossniklaus

Cancer Med. 2019 Jun;8(6):2784-2792.doi: 10.1002/cam4.2167. Epub 2019 Apr 16.

Prediction of BAP1 Expression in Uveal Melanoma Using Densely-Connected Deep Classification Networks

Muyi Sun, Wei Zhou, Xingqun Qi, Guanhong Zhang, Leonard Girnita, Stefan Seregard, Hans E Grossniklaus, Zeyi Yao, Xiaoguang Zhou, Gustav Stålhammar

Cancers (Basel). 2019 Oct 16;11(10):1579.doi: 10.3390/cancers11101579.

Subfoveal fibrovascular membranes in age-related macular degeneration express vascular endothelial growth factor

A Kvanta, P V Algvere, L Berglin, S Seregard

Invest Ophthalmol Vis Sci. 1996 Aug;37(9):1929-34.

A 10-year experience of outcome in chemotherapy-treated hereditary retinoblastoma

Katarina Bartuma, Niklas Pal, Sonja Kosek, Stefan Holm, Charlotta All-Ericsson

Acta Ophthalmol. 2014 Aug;92(5):404-11.doi: 10.1111/aos.12282. Epub 2013 Oct 7.

Group leaders

Gustav Stålhammar

Research group leader

Stefan Seregard

Research group leader

Research team members

Charlotta All Ericsson, Affiliated to research

Katarina Bartuma, Affiliated to research

Maria Fili, Affiliated to research

Louise Ramsköld Cabaca, PhD

Christina Herrspiegel, PhD

Shiva Sabazade, PhD

Viktor Gill, PhD

Alexander Berg Rendahl, Affiliated to research