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Maria Genander's group

We are interested in understanding how stem cells are regulated to form a functional tissue during development and how these processes go wrong in i.e. cancer.

To generate a tissue and to restore its integrity after injury, tissues maintains self-renewing, long-term stem cells. Stem cells are defined by their ability to self-renew and to give rise to differentiated cell types that form the adult tissues. We are using the mouse skin as our main model system to define both intrinsic transcriptional programs and environmental signaling cues that are key for epidermal and hair follicle stem cell establishment and maintenance.

Using development as a roadmap, we want to understand how and if developmental signaling patterns are mimicked in tumor imitation and progression. Certain cutaneous tumors harbour a subpopulation of cells with tumor initiating capacities, thus acting as stem cells. We are interested in identifying characteristics that will allow for the specific targeting of these cells.

Group Members

Maria GenanderForskarassistent, Forskare
David GrommischDoktorand, Forskarstuderande
Christina KantzerPostdoc
Srivathsa MagadiPostdoc
Vera ShirokovaPostdoc
Kim Vikhe PatilDoktorand, Forskarstuderande
Débora Lucia Joppi Master student
Katrin Schätzmüller Master student

Selected Publications

29615452

25834110

25312496

19914164

16777604