Maria Genander

Our research aims to identify regulatory mechanisms that guide epithelial stem cells in forming and maintaining functional tissue architecture, and how deregulation of these processes leads to disease.

We are also found here:
https://ki.se/en/cmb/maria-genanders-group

The Genander lab investigates the mechanisms of stem cell maintenance, lineage specification, and differentiation during epithelial development, homeostasis, and disease. We explore the cellular complexity of the skin and dissect the seemingly uniform esophageal epithelium to identify stem cell heterogeneity, uncover region-specific stem cell behaviors, and elucidate the molecular pathways that govern tissue architecture and function.

Current Projects

Understanding mechanisms of epithelial regionalization – location matters.

We have characterized the cellular landscape and transcriptional signatures along the esophageal tube, revealing how local stem cell–niche architectures dictate stem cell behavior in vivo. Our current focus is on understanding how these regional differences influence epithelial regeneration and tumor initiation. We aim to map local cell–cell communication circuits and identify signaling pathways that are differentially engaged within specific epithelial regions. Ultimately, our goal is to uncover pro-regenerative or tumor-suppressive mechanisms that may be relevant to human epithelial diseases.

Citrullination – investigating posttranslational protein modifications in regeneration

Citrullination, a post-translational modification of proteins, has been implicated in both stem cell renewal and various disease processes. Our research focuses on elucidating the role of citrullination in regulating stem cell maintenance and lineage commitment during the dynamic process of hair follicle regeneration.

Current Lab Members:

Evelien Eenjes, Research Specialist
Wei Yang, Research Specialist
Li Lei, Post Doc

Kylie Hin-Man Mak, PhD student

Jesse Kuipers, Research Assistant

Interested in joining the lab?

We are looking for highly motivated PhD or postdoctoral candidates who are interested in epithelial stem cell biology. Contact Maria Genander directly to get in touch!