Andras Simon's Group
We try to understand regeneration mechanisms in newts, which are semiaquatic salamanders, and have the widest repertoire of regenerative abilities among vertebrates.
We sequenced a gigantic newt genome, established stable transgenesis, and created means for in vivo genome-editing. To harness these technological developments, we are now combining cell tracking studies, massive parallel sequencing and molecular manipulations in various lesion/regeneration paradigms.
We also carry out cross-species comparisons by which we aim to gain insights into regulatory programs whose appropriate targeting could impose regenerative traits to mammals. We hope that our results will lead to novel regenerative strategies as well as provide explanatory models for the evolutionarily uneven distribution of regenerative capacities.
Reading and editing the Pleurodeles waltl genome reveals novel features of tetrapod regeneration.
Elewa A, Wang H, Talavera-López C, Joven A, Brito G, Kumar A, et al
Nat Commun 2017 12;8(1):2286
MARCKS-like protein is an initiating molecule in axolotl appendage regeneration.
Sugiura T, Wang H, Barsacchi R, Simon A, Tanaka EM
Nature 2016 Mar;531(7593):237-40
Environmental changes in oxygen tension reveal ROS-dependent neurogenesis and regeneration in the adult newt brain.
Hameed LS, Berg DA, Belnoue L, Jensen LD, Cao Y, Simon A
Elife 2015 Oct;4():
Turning terminally differentiated skeletal muscle cells into regenerative progenitors.
Wang H, Lööf S, Borg P, Nader GA, Blau HM, Simon A
Nat Commun 2015 Aug;6():7916
Fundamental differences in dedifferentiation and stem cell recruitment during skeletal muscle regeneration in two salamander species.
Sandoval-Guzmán T, Wang H, Khattak S, Schuez M, Roensch K, Nacu E, et al
Cell Stem Cell 2014 Feb;14(2):174-87
Dopamine controls neurogenesis in the adult salamander midbrain in homeostasis and during regeneration of dopamine neurons.
Berg DA, Kirkham M, Wang H, Frisén J, Simon A
Cell Stem Cell 2011 Apr;8(4):426-33