Renal glomerulus biology and diseases – Jaakko Patrakka group

Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney.

Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney.

Publication accepted in Nature Communications

Publications

Selected publications

Members and contact

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Research techniques

  • Generation and characterization of transgenic mouse lines.
  • Morpholino and CRISPR/Cas-9 technology in zebrafish. Phenotypic analysis of zebrafish.
  • Cell culture.
  • RNA sequencing.
  • Expressional profiling by RNAscope, qPCR, immunohistochemistry, Western blot.