BETA- PD: Balance Elderly Training and Activity in Parkinson’s disease.
The BETA-PD project aims to translate knowledge from basic neuroscience into applied research and clinical understanding and implement the evaluation methods and highly-challenging balance training program into clinical practice. Our main hypothesis is that highly challenging exercise will lead to greater gait and balance ability, increased levels of physical activity and an improved health related quality of life. We also hypothesize that neuroplasticity changes will be seen in corresponding areas of the brain, and that exercise will inhibit the degeneration of dopaminergic neurons in the brain through the mediation of neurotrophic factors. Since there is currently no cure for PD, such a finding would revolutionize the way in which we treat the condition and possibly also other neurodegenerative disorders. This would in turn give new hope to patients of improved quality of life through extended years of functional independence and better health.
The BETA-PD study consists of several steps: method development and laboratory studies, an efficacy study, an effectiveness/implementation study and neuroplasticity studies.
David Conradsson, PhD
Niklas Löfgren, Postdoc
Breiffni Leavy, Postdoc
Linda Rennie, PhD student
Håkan Nero, PhD
Hanna Johansson, PhD student
Martin Benka Wallén, Postdoc
Caroline Paquette, Assistant professor
Maria Hagströmer, Associate professor
Per Svenningsson, Professor
Urban Ekman, PhD/Postdoc
Staffan Holmin, Professor
Agneta Ståhle, Professor
Johan Lökk, Professor
Espen Dietrich, Professor
Arve Opheim, PhD
The Swedish research council
National School in Health Care Sciences
Stockholm County Council research funds
StratNeuro, Karolinska Institutet
Swedish Parkinson foundation
Parkinsons Research Foundation
Extrastiftelsen, Helse & Rehabilitering
Conradssson D, Paquette C, Lökk J. Franzén E. Pre- and unplanned walking turns in Parkinson's disease - effects of dopaminergic medication. Accepted in Neuroscience 2016-10-29.
Leavy B, Skavberg Roaldsen K, Nylund K, Hagströmer M, Franzén E. Pushing the Limits’ – Rethinking Motor and Cognitive Resources after a Highly Challenging Balance Training Program for Parkinson’s Disease. Physical Therapy Journal 2016 Aug 11. [Epub ahead of print] PMID: 27515945
Nero H, Benka-Wallén M, Franzén E, Conradsson D, Ståhle A, Hagströmer M. Objectively assessed physical activity and its association with balance, physical function and dyskinesia in Parkinson’s disease. Accepted in Journal of Parkinson’s Disease 2016-07-26.
Löfgren N, Benka-Wallén M, Sorjonen K, Conradsson D, Franzén E. Investigating the Mini-BESTest's construct validity in elderly with Parkinson’s disease. Accepted Acta Neurologica Scandinavica 2016-06-23
Franzén E, Conradsson D, Hagströmer M, Nilsson MH Depressive symptoms associated with concerns about falling in Parkinson’s disease. Brain and Behavior 2016 Jul 21;6 (10).
Benka Wallén M, Sorjonen K, Löfgren N, Franzén E. Structural validity of the Mini-BESTest in people with mild to moderate Parkinson’s disease. Physical Therapy Journal 2016 Nov;96(11):1799-1806
Nero H, Benka Wallén M, Ståhle A, Franzén E, Hagströmer M. Accelerometer cut points for physical activity assessment of older adults with Parkinson´s disease. Plos One 2015; 10(9)
Conradsson D, Löfgren N, Nero H, Hagströmer M, Ståhle A, Lökk J, Franzén E. The Effects of Highly Challenging Balance Training in Elderly with Parkinson's Disease: A Randomized Controlled Trial. Neurorehabilitation and Neural Repair 2015 Oct;29(9):827-36.
Benka Wallén M, Nero M, Franzén E, Hagströmer M. Levels and patterns of physical activity and sedentary behavior in elderly with Parkinson’s disease. Physical Therapy 2015 Aug;95(8):1135-41.
Löfgren N, Lenholm E, Conradsson D, Ståhle A, Franzén E The Mini-BESTest - a clinically reliable tool for balance evaluations in mild to moderate Parkinson's disease? BMC Neurology 2014, 14:235
Conradsson D, Löfgren N, Ståhle A, Hagströmer M, Franzén E. A novel conceptual framework for balance training in Parkinson's disease-study protocol for a randomised controlled trial. BMC Neurol. 2012 Sep 27;12:111. PMID:23017069, JIF(2011) 2.167
Conradsson D, Löfgren N, Ståhle A, Franzén E. Is Highly Challenging and Progressive Balance Training Feasible in Elderly with Parkinson's Disease? Archives of Physical Medicine and Rehabilitation. 2014 May;95(5):1000-3. PMID: 24239585
Benka Wallén M, Dohrn I-M, Ståhle A, Franzén E, Hagströmer M. Comparison of pedometer and accelerometer derived steps in elderly individuals with Parkinson’s disease or osteoporosis under free-living conditions. Journal of Aging and Physical Activity. 2014 Oct;22(4):550-6.
Benka Wallén M, Nero M, Franzén E, Hagströmer M. Comparison of two accelerometer filter settings in individuals with Parkinson’s disease. Physiological Measurement 2014 Nov;35(11):2287-96.