Selected publications of the Neurobiology of Stress and Treatment Response – Juan Pablo Lopez group

A list of selected publications from the Lopez Laboratory.

# Indicates equal contribution

Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus.
Brivio E, Kos A, Ulivi AF, Karamihalev S, Ressle A, Stoffel R, Hirsch D, Stelzer G, Schmidt MV, Lopez JP, Chen A
Cell Rep 2023 Aug;42(8):112874

Increasing resolution in stress neurobiology: from single cells to complex group behaviors.
Miranda L, Bordes J, Gasperoni S, Lopez JP
Stress 2023 Jan;26(1):2186141

Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2.
Lopez JP, Lücken MD, Brivio E, Karamihalev S, Kos A, De Donno C, Benjamin A, Yang H, Dick ALW, Stoffel R, Flachskamm C, Ressle A, Roeh S, Huettl RE, Parl A, Eggert C, Novak B, Yan Y, Yeoh K, Holzapfel M, Hauger B, Harbich D, Schmid B, Di Giaimo R, Turck CW, Schmidt MV, Deussing JM, Eder M, Dine J, Theis FJ, Chen A
Neuron 2022 07;110(14):2283-2298.e9

Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation.
Lopez JP, Brivio E, Santambrogio A, De Donno C, Kos A, Peters M, Rost N, Czamara D, Brückl TM, Roeh S, Pöhlmann ML, Engelhardt C, Ressle A, Stoffel R, Tontsch A, Villamizar JM, Reincke M, Riester A, Sbiera S, Fassnacht M, Mayberg HS, Craighead WE, Dunlop BW, Nemeroff CB, Schmidt MV, Binder EB, Theis FJ, Beuschlein F, Andoniadou CL, Chen A
Sci Adv 2021 01;7(5):

Sex differences: Transcriptional signatures of stress exposure in male and female brains.
Brivio E, Lopez JP, Chen A
Genes Brain Behav 2020 03;19(3):e12643

Preclinical stress research: where are we headed? An early career investigator's perspective.
Gururajan A, Kos A, Lopez JP
Stress 2018 09;21(5):384-388

Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response.
Lopez JP, Kos A, Turecki G
Curr Opin Psychiatry 2018 Jan;31(1):7-16

MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes.
Lopez JP, Fiori LM, Cruceanu C, Lin R, Labonte B, Cates HM, Heller EA, Vialou V, Ku SM, Gerald C, Han MH, Foster J, Frey BN, Soares CN, Müller DJ, Farzan F, Leri F, MacQueen GM, Feilotter H, Tyryshkin K, Evans KR, Giacobbe P, Blier P, Lam RW, Milev R, Parikh SV, Rotzinger S, Strother SC, Lewis CM, Aitchison KJ, Wittenberg GM, Mechawar N, Nestler EJ, Uher R, Kennedy SH, Turecki G
Nat Commun 2017 05;8():15497

Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response.
Fiori LM#, Lopez JP#, Richard-Devantoy S, Berlim M, Chachamovich E, Jollant F, Foster J, Rotzinger S, Kennedy SH, Turecki G
Int J Neuropsychopharmacol 2017 08;20(8):619-623

Co-Variation of Peripheral Levels of miR-1202 and Brain Activity and Connectivity During Antidepressant Treatment.
Lopez JP, Pereira F, Richard-Devantoy S, Berlim M, Chachamovich E, Fiori LM, Niola P, Turecki G, Jollant F
Neuropsychopharmacology 2017 Sep;42(10):2043-2051

Dysregulation of the glutamatergic receptors after antidepressant treatment in human neural progenitor cells.
Cruceanu C#, Lopez JP#, Tsai WT, Turecki G
Mol Psychiatry 2017 09;22(9):1228-1229

DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218.
Torres-Berrío A#, Lopez JP#, Bagot RC, Nouel D, Dal Bo G, Cuesta S, Zhu L, Manitt C, Eng C, Cooper HM, Storch KF, Turecki G, Nestler EJ, Flores C
Biol Psychiatry 2017 02;81(4):306-315

Biomarker discovery: quantification of microRNAs and other small non-coding RNAs using next generation sequencing.
Lopez JP, Diallo A, Cruceanu C, Fiori LM, Laboissiere S, Guillet I, Fontaine J, Ragoussis J, Benes V, Turecki G, Ernst C
BMC Med Genomics 2015 Jul;8():35

miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment.
Lopez JP, Lim R, Cruceanu C, Crapper L, Fasano C, Labonte B, Maussion G, Yang JP, Yerko V, Vigneault E, El Mestikawy S, Mechawar N, Pavlidis P, Turecki G
Nat Med 2014 Jul;20(7):764-8

Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers.
Lopez JP, Fiori LM, Gross JA, Labonte B, Yerko V, Mechawar N, Turecki G
Int J Neuropsychopharmacol 2014 Jan;17(1):23-32

Epigenetic regulation of BDNF expression according to antidepressant response.
Lopez JP, Mamdani F, Labonte B, Beaulieu MM, Yang JP, Berlim MT, Ernst C, Turecki G
Mol Psychiatry 2013 Apr;18(4):398-9

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