Juan Pablo Lopez

About me
Publications
Public outreach and news

About me

Dr. Juan Pablo Lopez is an Assistant Professor in the Department of Neuroscience. Pablo received his undergraduate degrees in Psychology and Biology from Florida International University in Miami (USA). He received his doctoral degree (Ph.D.) from McGill University in Montreal (Canada), under the supervision of Dr. Gustavo Turecki, where he studied the role of non-coding RNA in major depression, suicide, and antidepressant treatment response. In 2016, Pablo moved to Munich (Germany) for a postdoctoral fellowship in the laboratory of Dr. Alon Chen, at the Max Planck Institute of Psychiatry. During his postdoc, he investigated the neurobiology of stress responses, using single-cell transcriptomics.

In 2022, Pablo was recruited by the Department of Neuroscience at the Karolinska Institutet (Sweden). His laboratory seeks to understand and characterize the molecular mechanisms, cellular circuits, and behavioral correlates, associated with stress-related psychiatric disorders and their treatments, using animal models.

Articles

Journal article: NEUROSCIENCE APPLIED. 2024;3:103929
Knowledge gaps in psychedelic medicalisation: Preclinical and neuroimaging mechanisms
McCulloch DE-W; Lopez JP; Dalla C; Castrén E; Erritzoe D; Frokjaer VG; Lundberg J; Preller KH; Fisher PM; Knudsen GM
Article: SCIENCE ADVANCES. 2023;9(48):eadj3793
Early life adversity shapes social subordination and cell type-specific transcriptomic patterning in the ventral hippocampus
Kos A; Lopez JP; Bordes J; de Donno C; Dine J; Brivio E; Karamihalev S; Luecken MD; Almeida-Correa S; Gasperoni S; Dick A; Miranda L; Buettner M; Stoffel R; Flachskamm C; Theis FJ; Schmidt MV; Chen A
Article: CELL REPORTS. 2023;42(8):112874
Sex shapes cell-type-specific transcriptional signatures of stress exposure in the mouse hypothalamus
Brivio E; Kos A; Ulivi AF; Karamihalev S; Ressle A; Stoffel R; Hirsch D; Stelzer G; Schmidt MV; Lopez JP; Chen A
Article: ELIFE. 2023;12:e85316
SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants
Lin R; Kos A; Lopez JP; Dine J; Fiori LM; Yang J; Ben-Efraim Y; Aouabed Z; Ibrahim P; Mitsuhashi H; Wong TP; Ibrahim EC; Belzung C; Blier P; Farzan F; Frey BN; Lam RW; Milev R; Muller DJ; Parikh SV; Soares C; Uher R; Nagy C; Mechawar N; Foster JA; Kennedy SH; Chen A; Turecki G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2023;120(23):e2300722120
Sex-specific and opposed effects of FKBP51 in glutamatergic and GABAergic neurons: Implications for stress susceptibility and resilience
van Doeselaar L; Stark T; Mitra S; Yang H; Bordes J; Stolwijk L; Engelhardt C; Kovarova V; Narayan S; Brix LM; Springer M; Deussing JM; Lopez JP; Czisch M; Schmidt MV
Article: STRESS. 2023;26(1):2186141
Increasing resolution in stress neurobiology: from single cells to complex group behaviors
Miranda L; Bordes J; Gasperoni S; Lopez JP
Article: NEURON. 2022;110(14):2283-2298.e9
Ketamine exerts its sustained antidepressant effects via cell-type-specific regulation of Kcnq2
Lopez JP; Luecken MD; Brivio E; Karamihalev S; Kos A; De Donno C; Benjamin A; Yang H; Dick ALW; Stoffel R; Flachskamm C; Ressle A; Roeh S; Huettl R-E; Parl A; Eggert C; Novak B; Yan Y; Yeoh K; Holzapfel M; Hauger B; Harbich D; Schmid B; Di Giaimo R; Turck CW; Schmidt MV; Deussing JM; Eder M; Dine J; Theis FJ; Chen A
Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):629
Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder
Lin R; Lopez JP; Cruceanu C; Pierotti C; Fiori LM; Squassina A; Chillotti C; Dieterich C; Mellios N; Turecki G
Journal article: MOLECULAR PSYCHIATRY. 2021;26(8):4191-4204
miR-323a regulates ERBB4 and is involved in depression
Fiori LM; Kos A; Lin R; Theroux J-F; Lopez JP; Kuhne C; Eggert C; Holzapfel M; Huettl R-E; Mechawar N; Belzung C; Ibrahim EC; Chen A; Turecki G
Journal article: MOLECULAR PSYCHIATRY. 2021;26(8):3751-3764
Regulation of impulsive and aggressive behaviours by a novel lncRNA
Labonte B; Abdallah K; Maussion G; Yerko V; Yang J; Bittar T; Quessy F; Golden SA; Navarro L; Checknita D; Gigek C; Lopez JP; Neve RL; Russo SJ; Tremblay RE; Cote G; Meaney MJ; Mechawar N; Nestler EJ; Turecki G
Journal article: MOLECULAR PSYCHIATRY. 2021;26(7):3060-3076
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice
Hausl AS; Brix LM; Hartmann J; Pohlmann ML; Lopez J-P; Menegaz D; Brivio E; Engelhardt C; Roeh S; Bajaj T; Rudolph L; Stoffel R; Hafner K; Goss HM; Reul JMHM; Deussing JM; Eder M; Ressler KJ; Gassen NC; Chen A; Schmidt MV
Journal article: SCIENCE ADVANCES. 2021;7(5):eabe4497
Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation
Lopez JP; Brivio E; Santambrogio A; De Donno C; Kos A; Peters M; Rost N; Czamara D; Brueckl TM; Roeh S; Poehlmann ML; Engelhardt C; Ressle A; Stoffel R; Tontsch A; Villamizar JM; Reincke M; Riester A; Sbiera S; Fassnacht M; Mayberg HS; Craighead WE; Dunlop BW; Nemeroff CB; Schmidt MV; Binder EB; Theis FJ; Beuschlein F; Andoniadou CL; Chen A
Journal article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2021;53(2):390-401
Loss of the psychiatric risk factor SLC6A15 is associated with increased metabolic functions in primary hippocampal neurons
Schraut K-G; Kalnytska O; Lamp D; Jastroch M; Eder M; Hausch F; Gassen NC; Moore S; Nagaraj N; Lopez JP; Chen A; Schmidt MV
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2020;34:39-49
MicroRNA expression profiling of lymphoblasts from bipolar disorder patients who died by suicide, pathway analysis and integration with postmortem brain findings
Squassina A; Niola P; Lopez JP; Cruceanu C; Pisanu C; Congiu D; Severino G; Ardau R; Chillotti C; Alda M; Turecki G; Del Zompo M
Journal article: NATURE COMMUNICATIONS. 2020;11(1):1635
GPR56/ADGRG1 is associated with response to antidepressant treatment
Belzeaux R; Gorgievski V; Fiori LM; Lopez JP; Grenier J; Lin R; Nagy C; Ibrahim EC; Gascon E; Courtet P; Richard-Devantoy S; Berlim M; Chachamovich E; Theroux J-F; Dumas S; Giros B; Rotzinger S; Soares CN; Foster JA; Mechawar N; Tall GG; Tzavara ET; Kennedy SH; Turecki G
Journal article: GENES, BRAIN AND BEHAVIOR. 2020;19(3):e12643
Sex differences: Transcriptional signatures of stress exposure in male and female brains
Brivio E; Lopez JP; Chen A
Journal article: JOURNAL OF CLINICAL PSYCHIATRY. 2019;80(3):18m12556
Predicting Worsening Suicidal Ideation With Clinical Features and Peripheral Expression of Messenger RNA and MicroRNA During Antidepressant Treatment
Belzeaux R; Fiori LM; Lopez JP; Boucekine M; Boyer L; Blier P; Farzan F; Frey BN; Giacobbe P; Lam RW; Leri F; MacQueen GM; Milev R; Mueller DJ; Parikh SV; Rotzinger S; Soares CN; Uher R; Foster JA; Kennedy SH; Turecki G
Article: MOLECULAR PSYCHIATRY. 2018;23(10):2050-2056
Rare susceptibility variants for bipolar disorder suggest a role for G protein-coupled receptors
Cruceanu C; Schmouth J-F; Torres-Platas SG; Lopez JP; Ambalavanan A; Darcq E; Gross F; Breton B; Spiegelman D; Rochefort D; Hince P; Petite JM; Gauthier J; Lafreniere RG; Dion PA; Greenwood CM; Kieffer BL; Alda M; Turecki G; Rouleau GA
Journal article: STRESS. 2018;21(5):384-388
Preclinical stress research: where are we headed? An early career investigator's perspective
Gururajan A; Kos A; Lopez JP
Journal article: NATURE MEDICINE. 2018;24(5):591-597
Antidepressive effects of targeting ELK-1 signal transduction
Apazoglou K; Farley S; Gorgievski V; Belzeaux R; Lopez JP; Grenier J; Ibrahim EC; El Khoury M-A; Tse YC; Mongredien R; Barbe A; de Macedo CEA; Jaworski W; Bochereau A; Orrico A; Isingrini E; Guinaudie C; Mikasova L; Louis F; Gautron S; Groc L; Massaad C; Yildirim F; Vialou V; Dumas S; Marti F; Mechawar N; Morice E; Wong TP; Caboche J; Turecki G; Giros B; Tzavara ET
Journal article: CURRENT OPINION IN PSYCHIATRY. 2018;31(1):7-16
Major depression and its treatment: microRNAs as peripheral biomarkers of diagnosis and treatment response
Lopez JP; Kos A; Turecki G
Journal article: NEUROPSYCHOPHARMACOLOGY. 2017;42(10):2043-2051
Co-Variation of Peripheral Levels of miR-1202 and Brain Activity and Connectivity During Antidepressant Treatment
Lopez JP; Pereira F; Richard-Devantoy S; Berlim M; Chachamovich E; Fiori LM; Niola P; Turecki G; Jollant F
Article: JOURNAL OF MOLECULAR NEUROSCIENCE. 2017;62(3-4):304-308
Evidence towards RNA Binding Motif (RNP1, RRM) Protein 3 (RBM3) as a Potential Biomarker of Lithium Response in Bipolar Disorder Patients
Papadima EM; Niola P; Melis C; Pisanu C; Congiu D; Cruceanu C; Lopez JP; Turecki G; Ardau R; Severino G; Chillotti C; Del Zompo M; Squassina A
Journal article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2017;20(8):619-623
Investigation of miR-1202, miR-135a, and miR-16 in Major Depressive Disorder and Antidepressant Response
Fiori LM; Lopez JP; Richard-Devantoy S; Berlim M; Chachamovich E; Jollant F; Foster J; Rotzinger S; Kennedy SH; Turecki G
Article: NATURE COMMUNICATIONS. 2017;8:15497
MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes
Lopez JP; Fiori LM; Cruceanu C; Lin R; Labonte B; Cates HM; Heller EA; Vialou V; Ku SM; Gerald C; Han M-H; Foster J; Frey BN; Soares CN; Muller DJ; Farzan F; Leri F; MacQueen GM; Feilotter H; Tyryshkin K; Evans KR; Giacobbe P; Blier P; Lam RW; Milev R; Parikh SV; Rotzinger S; Strother SC; Lewis CM; Aitchison KJ; Wittenberg GM; Mechawar N; Nestler EJ; Uher R; Kennedy SH; Turecki G
Journal article: BIOLOGICAL PSYCHIATRY. 2017;81(4):306-315
DCC Confers Susceptibility to Depression-like Behaviors in Humans and Mice and Is Regulated by miR-218
Torres-Berrio A; Lopez JP; Bagot RC; Nouel D; Dal Bo G; Cuesta S; Zhu L; Manitt C; Eng C; Cooper HM; Storch K-F; Turecki G; Nestler EJ; Flores C
Article: BMC PSYCHIATRY. 2016;16(1):286
DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression
Cruceanu C; Kutsarova E; Chen ES; Checknita DR; Nagy C; Lopez JP; Alda M; Rouleau GA; Turecki G
Article: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2016;26(7):1241-1247
Leukocyte telomere length positively correlates with duration of lithium treatment in bipolar disorder patients
Squassina A; Pisanu C; Congiu D; Caria P; Frau D; Niola P; Melis C; Baggiani G; Lopez JP; Cruceanu C; Turecki G; Severino G; Bocchetta A; Vanni R; Chillotti C; Del Zompo M
Article: AMERICAN JOURNAL OF PSYCHIATRY. 2015;172(11):1131-1140
Transcriptome Sequencing of the Anterior Cingulate in Bipolar Disorder: Dysregulation of G Protein-Coupled Receptors
Cruceanu C; Tan PPC; Rogic S; Lopez JP; Torres-Platas SG; Gigek CO; Alda M; Rouleau GA; Pavlidis P; Turecki G
Article: BMC MEDICAL GENOMICS. 2015;8:35
Biomarker discovery: quantification of microRNAs and other small non-coding RNAs using next generation sequencing
Lopez JP; Diallo A; Cruceanu C; Fiori LM; Laboissiere S; Guillet I; Fontaine J; Ragoussis J; Benes V; Turecki G; Ernst C
Journal article: TRANSLATIONAL PSYCHIATRY. 2015;5(5):e565
A molecular model for neurodevelopmental disorders
Gigek CO; Chen ES; Ota VK; Maussion G; Peng H; Vaillancourt K; Diallo AB; Lopez JP; Crapper L; Vasuta C; Chen GG; Ernst C
Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2015;74(5):459-469
Effects of Postmortem Interval on Biomolecule Integrity in the Brain
Nagy C; Maheu M; Lopez JP; Vaillancourt K; Cruceanu C; Gross JA; Arnovitz M; Mechawar N; Turecki G
Journal article: TRANSLATIONAL PSYCHIATRY. 2015;5(2):e511
MicroRNA regulation of central glial cell line-derived neurotrophic factor (GDNF) signalling in depression
Maheu M; Lopez JP; Crapper L; Davoli MA; Turecki G; Mechawar N
Journal article: PSYCHIATRY RESEARCH. 2014;220(3):1167-1168
Lithium-induced differential expression of SAT1 in suicide completers and controls is not correlated with polymorphisms in the promoter region of the gene
Niola P; Squassina A; Gross JA; Lopez JP; Turecki G; Chillotti C; Deiana V; Manchia M; Georgitsi M; Patrinos GP; Alda M; Del Zompo M
Journal article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;95(5):490-508
Molecular Convergence of Neurodevelopmental Disorders
Chen ES; Gigek CO; Rosenfeld JA; Diallo AB; Maussion G; Chen GG; Vaillancourt K; Lopez JP; Crapper L; Poujol R; Shaffer LG; Bourque G; Ernst C
Article: NATURE MEDICINE. 2014;20(7):764-768
miR-1202 is a primate-specific and brain-enriched microRNA involved in major depression and antidepressant treatment
Lopez JP; Lim R; Cruceanu C; Crapper L; Fasano C; Labonte B; Maussion G; Yang JP; Yerko V; Vigneault E; El Mestikawy S; Mechawar N; Pavlidis P; Turecki G
Journal article: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2014;17(1):23-32
Regulatory role of miRNAs in polyamine gene expression in the prefrontal cortex of depressed suicide completers
Lopez JP; Fiori LM; Gross JA; Labonte B; Yerko V; Mechawar N; Turecki G
Journal article: TRANSLATIONAL PSYCHIATRY. 2013;3(12):e338
dcc orchestrates the development of the prefrontal cortex during adolescence and is altered in psychiatric patients
Manitt C; Eng C; Pokinko M; Ryan RT; Torres-Berrio A; Lopez JP; Yogendran SV; Daubaras MJJ; Grant A; Schmidt ERE; Tronche F; Krimpenfort P; Cooper HM; Pasterkamp RJ; Kolb B; Turecki G; Wong TP; Nestler EJ; Giros B; Flores C
Journal article: AMERICAN JOURNAL OF PSYCHIATRY. 2013;170(5):511-520
Genome-Wide Methylation Changes in the Brains of Suicide Completers
Labonte B; Suderman M; Maussion G; Lopez JP; Navarro-Sanchez L; Yerko V; Mechawar N; Szyf M; Meaney MJ; Turecki G
Journal article: MOLECULAR PSYCHIATRY. 2013;18(4):398-399
Epigenetic regulation of BDNF expression according to antidepressant response
Lopez JP; Mamdani F; Labonte B; Beaulieu M-M; Yang JP; Berlim MT; Ernst C; Turecki G
Journal article: JOURNAL OF PSYCHIATRIC RESEARCH. 2013;47(4):513-519
Effects of promoter methylation on increased expression of polyamine biosynthetic genes in suicide
Gross JA; Fiori LM; Labonte B; Lopez JP; Turecki G
Journal article: AMERICAN JOURNAL OF HUMAN GENETICS. 2012;91(6):1128-1134
Disruption of a Large Intergenic Noncoding RNA in Subjects with Neurodevelopmental Disabilities
Talkowski ME; Maussion G; Crapper L; Rosenfeld JA; Blumenthal I; Hanscom C; Chiang C; Lindgren A; Pereira S; Ruderfer D; Diallo AB; Lopez JP; Turecki G; Chen ES; Gigek C; Harris DJ; Lip V; An Y; Biagioli M; MacDonald ME; Lin M; Haggarty SJ; Sklar P; Purcell S; Kellis M; Schwartz S; Shaffer LG; Natowicz MR; Shen Y; Morton CC; Gusella JF; Ernst C
Journal article: JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING. 2011;31(2):87-92
A New System and Paradigm for Chronic Stimulation of Denervated Rat Muscle
Willand MP; Lopez JP; de Bruin H; Fahnestock M; Holmes M; Bain JR
Journal article: ANIMAL COGNITION. 2009;12(4):559-565
Bobwhite quail (Colinus virginianus) hatchlings track the direction of human gaze
Jaime M; Lopez JP; Lickliter R
Show more

All other publications

Editorial comment: LANCET NEUROLOGY. 2024;23(1):28-30
Neuropsychiatric research in 2023: mechanisms of stress and therapies
Lopez JP; Chen A
Conference publication: JOURNAL OF PSYCHIATRY & NEUROSCIENCE. 2022;47(3):S15-S16
Role of small nucleolar RNAs in antidepressant treatment
Lin R; Kos A; Dine J; Fiori L; Ben-Efraim Y; Lopez JP; Theroux J-F; Aouabed Z; Ibrahim P; Wong TP; Ibrahim EC; Chen A; Turecki G
Conference publication: BIOLOGICAL PSYCHIATRY. 2021;89(9):S13
Involvement of microRNAs in Lithium Response in Patients With Bipolar Disorder and Related Phenotypes
Pisanu C; Congiu D; Severino G; Niola P; Lopez JP; Cruceanu C; Ardau R; Papadima EM; Loizedda A; Orru N; Calza S; Orru S; Carcassi C; Alda M; Chillotti C; Turecki G; Del Zompo M; Squassina A
Conference publication: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2017;27:S536
MicroRNAs as biomarkers of antidepressant treatment response
Lopez JP; Turecki G
Letter: MOLECULAR PSYCHIATRY. 2017;22(9):1228-1229
Dysregulation of the glutamatergic receptors after antidepressant treatment in human neural progenitor cells
Cruceanu C; Lopez JP; Tsai W-T; Turecki G
Conference publication: EUROPEAN PSYCHIATRY. 2017;41:S167
Peripheral levels of the micro-RNA miR-1202 are correlated with changes in brain activity and connectivity during an antidepressant treatment
Lopez JP; Pereira F; Richard-Devantoy S; Ding Y; Fiori LM; Niola P; Turecki G; Jollant F
Conference publication: NEUROPSYCHOPHARMACOLOGY. 2016;41:S10-S11
Small Non-Coding RNA Targets of Antidepressant Treatment
Lopez JP
Conference publication: INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY. 2016;19:11-12
Regulation of aggressive and impulsive behaviours by a novel lincRNA
Turecki G; Labonte B; Maussion G; Yerko V; Yang J; Golden SA; Suderman M; Navarro L; Checknita D; Gigek C; Lopez JP; Neve R; Russo SJ; Cote G; Meaney MJ; Mechawar N; Nestler EJ
Conference publication: BIOLOGICAL PSYCHIATRY. 2015;77(9):59S
Relative Expression of GDNF Family Receptor Alpha 1 (GFRA1) Isoforms Regulates GDNF Signaling: Implications for Depression
Maheu M; Lopez JP; Crapper L; Davoli MA; Turecki G; Mechawar N
Conference publication: BIOLOGICAL PSYCHIATRY. 2013;73(9):224S
A Primate-Specific and Brain-Enriched miRNA is Involved in Depression and Regulates the Expression of GRM4
Lopez JP; Lim R; Ernst C; Naguib M; Pavlidis P; Turecki G
Conference publication: BIOLOGICAL PSYCHIATRY. 2012;71(8):46S
GDNF Family Receptor Alpha-1 (GFRa1) Expression and Regulation in the Basolateral Amygdala of Depressed Suicides
Maheu M; Lopez JP; Davoli MA; Turecki G; Mechawar N
Conference publication: GENOME. 2012;55(10):725
Rare susceptibility variants for familial bipolar disorder: an exome-sequencing study
Cruceanu C; Gauthier J; Ambalavanan A; Lopez JP; Spiegelman D; Lafreniere RG; Grof P; Alda M; Turecki G; Rouleau GA
Conference publication: BIOLOGICAL PSYCHIATRY. 2011;69(9):132S
The Potential Regulatory Role of miRNAs in Polyamine Gene Expression in the Prefrontal Cortex of Suicide Completers
Lopez JP; Cruceanu C; Fiori LM; Yerko V; Turecki G

About me

Articles

All other publications

News from KI

Events from KI