CarlenLab - Publications

Publications from the CarlenLab, in reverse chronological order.
*) equal contribution.

Robust derivation of transplantable dopamine neurons from human pluripotent stem cells by timed reinoic acid delivery
Alekseenko Z, Dias JM, Adler AF, Kozhevnikova M, van Lunteren JA, Nolbrant S, Jeggari A, Vasylovska S, Yoshitake T, Kehr J, Carlén M, Alexyenko A, Parmar M, Ericson J.
(2022), Nature Communications, 13:3046, https://doi.org/10.1038/s41467-022-30777-8

Spatial transcriptomics: molecular maps of the Mammalian Brain. Review
Ortiz C, Carlén M, Meletis K.
(2021). Annual Reviews Neuroscience. Jul 8;44:547-562

The mouse prefrontal cortex: unity in diversity. Perspective
Le Merre P*/Ährlund-Richter S*, Carlén M.
(2021) Neuron. Jun 16;109(12):1925-1944

Adult trkB Signaling in Parvalbumin Interneurons is Essential to Prefrontal Network Dynamics
Guyon N, Rakauskas Zacharias L, van Lunteren JA, Immenschuh J, Fuzik J, Märtin A, Xuan Y, Zilberter M, Kim H, Meletis K, Lopes-Aguiar C, Carlén M
(2021) Journal of Neuroscience. Apr 7;41(14):3120-3141

Network asynchrony underlying increased broadband gamma power
Guyon N, Rakauskas Zacharias L, Rermino de Oliveira E, Kim H, Pereria Leite J, Lopes-Aguiar C*/Carlén M*
(2021) Journal of Neuroscience. Mar 31;41(13):2944-2963

Neuronal oscillations and the mouse prefrontal cortex. Book chapter
Jung F, Carlén M.
(2021) International Review of Neurobiology. 158:337-372. ISSN 0074-7742. Elsevier Inc. 

A latent lineage potential in resident neural stem cells enables spinal cord repair.
Llorens-Bobadilla E, Chell JM, Le Merre P, Wu Y, Zomboni M, Bergenstråhle J, Stenudd M, Sopova E, Lundeberg J, Shupliakov O, Carlén M, Frisén J
(2020) Science. 2020 Oct 2;370(6512):eabb8795

The DMCdrive: practical 3D-printable micro-drive system for reliable chronic multitetrode recording and optogenetic application in freely behaving rodents.
Kim H*/Brünner H*, Carlén M.
(2020) Scientific Reports. Jul 16;10(1):11838

A hypothalamus-habenula circuit controls aversion.
Lazaridis I, Tzortzi O, Weglage M, Märtin A, Xuan Y, Parent M, Johansson Y, Fuzik J, Fürth D, Fenno LE, Ramakrishnan C, Silberberg G, Deisseroth K, Carlén M, Meletis, K.
(2019) Molecular Psychiatry. Sep;24(9):1351-1368

A whole-brain atlas of the monosynaptic input targeting four different cell-types in the prefrontal cortex of the mouse.
Ährlund-Richter S*/Xuan Y*, van Lunteren JA, Kim H, Ortiz C, Pollak Dorocic I, Meletis K, Carlén M.
(2019) Nature Neuroscience. Apr;22(4):657-668.

Reducing pericyte-derived scarring promotes recovery after spinal cord injury.
Dias DO, Kim H, Holl D, Solnestam BW, Lundeberg J, Carlén M, Göritz C*/Frisén J*.
(2018) Cell. Mar 22;173(1):153-165.e22.

An interactive framework for whole-brain maps at cellular resolution.
Fürth D, Vaissière T, Tzortzi O, Xuan Y, Lazaridis I, Spigolon G, Fisone G, Tomer R, Deissoerth K, Carlén M, Miller C, Rumbaugh G. Meletis K.
(2018) Nature Neuroscience. Jan;21(1):139-149

What constitutes the prefrontal cortex? Review
Carlén, M.
(2017) Science. Oct 27; 285(6362):478-82.

Prefrontal parvalbumin neurons in control of attention.
Kim H, Ährlund-Richter S, Wang X, Deisseroth K, Carlén M.
(2016) Cell. Jan 14:164(1-2):208-218

Structural foundations of optogenetics: Determinants of channelrhodopsin ion selectivity.
Berndt A, Lee SY, Wietek J, Ramakrishnan C, Steinberg EE, Rashid AJ, Kim H, Park S, Santoro A, Frankland PW, Iyer SM, Pak S, Ährlund-Richter S, Delp SL, Malenka RC, Josselyn SA, Carlén M, Hegemann P, Deisseroth K.
(2016) Proc Natl Acad Sci U S A. Jan 26;113(4):822-9

The Diameter of Cortical Axons and Their Relevance to Neural Computing. Book chapter
Innocenti GM, Carlén M, Dyrby TB.
(2015) Axons and Brain Architecture. Dec 15. ISBN: 978-0-12-801393-9. Elsevier Inc.

Loss of cyclin-dependent kinase 5 from parvalbumin interneurons leads to hyperinhibition, decreased anxiety, and memory impairment.
Rudenko A, Seo J, Hu J, Su SC, de Anda FC, Durak o, Ericsson m, Carlén M, Tsai L-H.
(2015) Journal of Neuroscience. Feb 11;35(6):2372-83.

A whole-brain atlas of inputs to serotonergic neurons of the dorsal and median raphe nuclei.
Pollak Dorocic I, Fürth D, Xuan Y, Johansson Y, Pozzi L, Silberberg G, Carlén M, Meletis K.
(2014) Neuron. Aug 6;83(3):663-78.

Mice lacking NMDA receptors in parvalbumin neurons display normal depression-related behavior and response to antidepressant action of NMDAR antagonists.
Pozzi L, Dorocic IP, Wang X, Carlén M, Meletis K.
(2014) PLoS One. Jan 16;9(1):e83879.

Target selectivity of feedforward inhibition by striatal fast-spiking interneurons.
Szydlowski SN, Pollak Dorocic I, Planert H, Carlén M, Meletis K*/Silberberg G*.
(2013) Journal of Neuroscience. Jan 23;33(4):1678-83.

A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior.
Carlén M*/Meletis K*, Siegle J, Cardin J, Futai K, Vierling-Claasen D, Ruhlmann C, Jones S, Deisseroth K, Sheng M, Moore C, Tsai LH.
(2012) Molecular Psychiatry. May; 17(5)537-48

Optogenetic dissection of cortical information processing – shining light on schizophrenia. Review
Wang X, Carlén M.
(2012) Brain Research. Oct 2; 1476: 31-7. 

Chronically implanted hyperdrive for cortical recording and optogenetic control in behaving mice.
Siegle JH, Carlén M, Meletis K, Tsai LH, Moore CI, Ritt J.
(2011) Conf Proc IEEE Eng Med Biol Soc.:7529-32.

Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene.
Forsberg M*/Carlén M*, Meletis K, Yeung MS, Barnabé-Heider F, Persson MA, Aarum J, Frisén J.
(2010) Proc Natl Acad Sci U S A. Aug 17;107(33):14657-61.

Targeted optogenetic stimulation and recording of neurons in vivo using cell-type-specific expression of Channelrhodopsin-2.
Cardin JA*/Carlén M*, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore C.
(2010) Nature Protocols. Jan 21 5(2):247-254

Neocortical Interneurons: From Diversity, Strength. Review
Moore CI, Carlén M, Knoblich U, Cardin J.
(2010) Cell. Jul 21; 142(2):184-88. 

Driving fast-spiking cells induces gamma rhythm and controls sensory responses.
Cardin JA*/Carlén M*, Meletis K, Knoblich U, Zhang F, Deisseroth K, Tsai LH, Moore C.
(2009) Nature. Jun 4;459(7247):663-7.

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.
Carlén M, Meletis K, Göritz C, Darsalia V, Evergren E, Tanigaki K, Amendola M, Barnabé-Heider F, Yeung MSY, Naldini L, Honjo T, Kokaia Z, Shupliakov O, Cassidy RM, Lindvall O, Frisén J.
(2009) Nature Neuroscience. Mar;12(3):259-67.

Spinal Cord Injury Reveals Multilineage Differentiation of Ependymal Cells.
Meletis K*/Barnabé-Heider F*/Carlén M*, Evergren E, Tomilin N, Shupliakov O, Frisén J.
(2008) PLoS Biology. Jul 22;6(7)

Genetic visualization of neurogenesis.
Carlén M, Meletis K, Barnabé-Heider F, Frisén J.
(2006) Exp Cell Res. Sep 10;312(15):2851-9.

Evidence for neurogenesis in the adult mammalian substantia nigra.
Zhao M*/Momma S*, Delfani K, Carlén M, Cassidy RM, Johansson CB, Brismar H, Shupliakov O, Frisen J, Janson AM.
(2003) Proc Natl Acad Sci U S A. Jun 24;100(13): 7925-30.

Gene delivery to adult neural stem cells.
Falk A*/Holmström N*, Carlén M, Cassidy R, Lundberg C, Frisén J.
(2002) Exp Cell Res. Sep 10; 279(1): 34-9.

Functional integration of adult born neurons.
Carlén M*/Cassidy RM*, Brismar H, Smith GA, Enquist LW, Frisén J.
(2002) Current Biology. Apr 2, 12(7): 606-08