Simon Elsässer Group

Laboratory of Synthetic Stem Cell and Chromatin Biology

Our laboratory will focus on applying new synthetic and chemical biology methods to understand chromatin structure and function. We will be developing tools to engineer proteins in living cells based on genetic code expansion and unnatural amino acid mutagenesis. We will, for example, control and probe chromatin proteins using light-activated and bioorthogonal chemistries. These methods, combined with quantitative, high-throughput, proteomic and genomic read-outs, will allow us to dissect the complex mechanisms governing chromatin dynamics, histone modifications and epigenetic inheritance.

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