Research group for Cancer evolution

We study structural aspects of cancer proteins that make them targets for disease-causing mutations as well as their function in cancer cells. We also study how cellular interactions in micro-environments affect the function of cancer proteins

Cancer is an evolutionary disease. Disease-causing genetic or epigenetic changes often alter the functional characteristics of regulatory proteins leading to survival and proliferation of cancer cells at the expense of normal cells. The cancer-driving properties of cancer cells are selected for in specific cellular micro-environments by Darwinian natural selection. We study structural aspects of cancer proteins that make them targets for disease-causing mutations as well as their function in cancer cells. We also study how cellular interactions in micro-environments affect the function of cancer proteins. The work is relevant for understanding cancer development as well as development of resistance to chemotherapy. The work is focused on cancers involving blood cells.

Research group leader Anthony Wright

Group members

Research techniques

  • Molecular cell biology
  • Cell culture
  • Genomics
  • Bioinformatics

External funding

Cancerfonden

Selected publications

A Protein Intrinsic Disorder Approach for Characterising Differentially Expressed Genes in Transcriptome Data: Analysis of Cell-Adhesion Regulated Gene Expression in Lymphoma Cells.
Arvidsson G, Wright APH
Int J Mol Sci 2018 Oct;19(10):

A subset of functional adaptation mutations alter propensity for α-helical conformation in the intrinsically disordered glucocorticoid receptor tau1core activation domain.
Salamanova E, Costeira-Paulo J, Han KH, Kim DH, Nilsson L, Wright APH
Biochim Biophys Acta Gen Subj 2018 06;1862(6):1452-1461

Impact of Sox11 over-expression in Ba/F3 cells.
Lord M, Arvidsson G, Wasik AM, Christensson B, Wright AP, Grandien A, et al
Haematologica 2018 12;103(12):e594-e597

Mixed-species RNAseq analysis of human lymphoma cells adhering to mouse stromal cells identifies a core gene set that is also differentially expressed in the lymph node microenvironment of mantle cell lymphoma and chronic lymphocytic leukemia patients.
Arvidsson G, Henriksson J, Sander B, Wright AP
Haematologica 2018 04;103(4):666-678

Origins of Myc proteins--using intrinsic protein disorder to trace distant relatives.
Mahani A, Henriksson J, Wright AP
PLoS ONE 2013 ;8(9):e75057

Proteome-wide evidence for enhanced positive Darwinian selection within intrinsically disordered regions in proteins.
Nilsson J, Grahn M, Wright AP
Genome Biol. 2011 Jul;12(7):R65