Jaakko Patrakka group
Renal glomerulus biology and diseases
Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney.
Research group leader
Emmanuelle Charrin Postdoc Dina Dabaghie PhD student, R&D trainee Xiang Hua Associated Katja Möller-Hackbarth Assistant professor Jaakko Patrakka Senior researcher Angelina Schwarz PhD student Sonia Zambrano Sevilla Assistant professor
- KI/AZ Integrated Cardio Metabolic Center
- Marianne and Marcus Wallenberg Foundation
- Swedish Research Council
- Swedish Diabetes Foundation
- Swedish Juvenile Diabetes Foundation
- KI Foundations
- Westmans Foundation
- Generation and characterization of transgenic mouse lines
- Morpholino and CRISPR/Cas-9 technology in zebrafish. Phenotypic analysis of zebrafish.
- Cell culture
- RNA sequencing
- Expressional profiling by RNAscope, qPCR, immunohistochemistry, Western blot
Pdlim2 is a novel actin-regulating protein of podocyte foot processes.
Kidney Int. 2011 Nov;80(10):1045-54
New insights into the role of podocytes in proteinuria.
Nat Rev Nephrol 2009 Aug;5(8):463-8
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik.
J. Am. Soc. Nephrol. 2007 Mar;18(3):689-97
Hereditary proteinuria syndromes and mechanisms of proteinuria.
N. Engl. J. Med. 2006 Mar;354(13):1387-401
Proteinuria and prenatal diagnosis of congenital nephrosis in fetal carriers of nephrin gene mutations.
Lancet 2002 May;359(9317):1575-7