Renal glomerulus biology and diseases – Jaakko Patrakka group

Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney.

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Glomerular diseases are the most common cause of end-stage renal disease. We investigate the molecular profile of healthy and diseased glomeruli with the aim to discover molecular pathways that drive the progression of glomerular disorders. We use transgenic mouse and zebrafish models to understand the role of identified pathways in the biology and diseases of the kidney.

Publication accepted in Nature Communications

Single cell sequencing unravels molecular identity of rare renal cell types
Photo of Jaakko Patrakka, researcher at the Department of Laboratory Medicine. Photo: Private

Single cell sequencing unravels molecular identity of rare renal cell types

Jaakko Patrakka and his research group at the Department of Laboratory Medicine have together with Professor Rickard Sandberg's group at the Department of Cell and Molecular Biology got a publication accepted in Nature Communications about single cell sequencing unravels molecular identity of rare renal cell types.

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Research techniques

  • Generation and characterization of transgenic mouse lines.
  • Morpholino and CRISPR/Cas-9 technology in zebrafish. Phenotypic analysis of zebrafish.
  • Cell culture.
  • RNA sequencing.
  • Expressional profiling by RNAscope, qPCR, immunohistochemistry, Western blot.