Paediatrics - Inger Kull

The overall focus in the research group is to identify factors of importance for improved care of allergic disease, with a special focus on the transition from childhood to adulthood. The research is performed in a multidisciplinary environment, with a mix of researchers, pre- and post-doctoral students from various research fields, and clinically active health care professionals.

Inger Kull

Professor

Email: inger.kull@ki.se

Group members

Charlotta Flodström, MD, PhD-student

Marina Jonsson, PhD, Specialist nurse

Susanne Lundin, PhD, Specialist nurse

Maria Ödling, PhD, Specialist nurse, Assistant Professor

Niklas Andersson, Statistician

Elin Dahlén, Post doc, Pharmacist

Ida Mogensen, Post doc, MD

Sandra Ekström, Post doc, Nutritionist

Birgitta Lagercrantz, Research nurse

Collaborations

The group have established extensive national and international collaborations in the asthma and allergy field.

Projects

BAMSE- Children, Allergy, Environment, in Stockholm, an epidemiological study

A part of the research from the group is based on data from the birth cohort BAMSE The cohort was initially designed to study risk factors for asthma and allergic diseases in childhood, and to study factors of importance for prognosis at already established disease. The ongoing cohort have followed the participants since birth with repeated follow-ups up to young adulthood. PIs Erik Melén, Anna Bergström, Antonios Georgelis and Inger Kull. Web page BAMSE Project.

Transition and transfer for adolescents and young adults with asthma and allergic disease

Previous research from our group shows that a large majority of adolescents and young adults (AYA) have uncontrolled asthma, limited contact with healthcare and few dispensations of asthma medication. Therefore, we propose a new model aiming to strengthen AYA with asthma during the transition to adult healthcare. The model is based on national and international guidelines and design to be user friendly and to be used in both primary care and in pediatric outpatient clinics. The model will be implemented, and effects evaluated.

Covid-19

Based on data from the BAMSE cohort we have published several papers based on experiences from the pandemic. For example, we found that young adults with asthma reports higher stress and anxiety than peers without asthma during the covid-19 pandemic. Moreover, we did not find evidence for a covid-19–associated impairment in lung function in young adults with or without asthma. In an ongoing study we are investigating factors associated with willingness to be vaccinated against covid-19 infection.

Living with allergic disease in young adulthood

In our research group we have published and have ongoing papers with focus on how it is to live with an allergic disease in young adulthood. For example, in a recent published paper we investigated if treatment with peanut oral immunotherapy in combination with omalizumab improves self-reported health-related quality of life (HRQoL) among adolescents with severe peanut allergy. Where results showed that HRQoL improved, and the difference from start were clinically relevant. To further shred light and to increase the knowledge of what it is like to live with food allergy, we are planning to investigate what it is like to live with a severe food allergy to possible improve care and treatment for AYA with food allergy. Moreover, in an ongoing qualitative study with participants from BAMSE, we are aiming to gain in-depth knowledge about experiences and thoughts about drug treatment in young adults with asthma.

Perinatal dietary interventions and allergic outcome in the child – long term follow-ups and transgenerational effects

The overall purpose of the project is to evaluate the importance of food allergen exposure during the last trimester and the development of allergic diseases during childhood to early adulthood. Furthermore, to evaluate the development of allergic diseases over three generations. The follow up is based on data from questionnaires, clinical examinations, and analysis of IgE - sensitization in blood tests.

Research support

Swedish Heart-Lung Foundation

Swedish Asthma and Allergy Association

The Swedish Research Council

The Konsul Th C Bergh's Foundation

The Samariten Foundation for Paediatric Research

Ellen, Walter and Lennart Hesselman Foundation for Scientific Research

Articles

Peanut oral immunotherapy may improve health-related quality of life among severe peanut allergic adolescents.
Ödling M, Sundqvist AC, Brandström J, Nopp A, Andersson N, Nilsson C, Kull I
Clin Transl Allergy 2023 Feb;13(2):e12225

Health-related quality of life decreases in young people with asthma during the transition from adolescence to young adulthood: a birth cohort study.
Ödling M, Andersson N, Janson C, Melén E, Bergström A, Kull I
BMC Pulm Med 2023 Jan;23(1):34

A Gap Between Asthma Guidelines and Management for Adolescents and Young Adults.
Ödling M, Andersson N, Hallberg J, Almqvist C, Janson C, Bergström A, Melén E, Kull I
J Allergy Clin Immunol Pract 2020 Oct;8(9):3056-3065.e2

Characterization of Asthma Trajectories from Infancy to Young Adulthood.
Ödling M, Wang G, Andersson N, Hallberg J, Janson C, Bergström A, Melén E, Kull I
J Allergy Clin Immunol Pract 2021 Jun;9(6):2368-2376.e3

Lung function before and after COVID-19 in young adults: A population-based study.
Mogensen I, Hallberg J, Björkander S, Du L, Zuo F, Hammarström L, Pan-Hammarström Q, Ekström S, Georgelis A, Palmberg L, Janson C, Bergström A, Melén E, Kull I,
J Allergy Clin Immunol Glob 2022 May;1(2):37-42

General Stress Among Young Adults with Asthma During the COVID-19 Pandemic.
Ekström S, Mogensen I, Georgelis A, Westman M, Almqvist C, Melén E, Bergström A, Kull I,
J Allergy Clin Immunol Pract 2022 Jan;10(1):108-115

Lung function in young adulthood: differences between males and females with asthma.
Mogensen I, Hallberg J, Palmberg L, Ekström S, Georgelis A, Melén E, Bergström A, Kull I
ERJ Open Res 2022 Apr;8(2):

Non-adherence and sub-optimal treatment with asthma medications in young adults: a population-based cohort study.
Dahlén E, Bergström A, Ödling M, Ekström S, Melén E, Kull I
J Asthma 2022 Aug;59(8):1661-1669

Living with Atopic Dermatitis as a Young Adult in Relation to Health-related Quality of Life and Healthcare Contacts: A Population-based Study.
Lundin S, Bergström A, Wahlgren CF, Johansson EK, Andersson N, Ballardini N, Jonsson M, Melén E, Kull I
Acta Derm Venereol 2022 May;102():adv00702

Egg and milk exposure during pregnancy and food reactions in grandchildren.
Mogensen I, Flodström C, Nopp A, Melén E, Bergström A, Kull I
Allergy 2023 Feb;78(2):569-571