Publications from the Germ cell biology, developmental programming and epigenetic inheritance of disease research group

Selected publications

Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome.
Risal S, Pei Y, Lu H, Manti M, Fornes R, Pui HP, Zhao Z, Massart J, Ohlsson C, Lindgren E, Crisosto N, Maliqueo M, Echiburú B, Ladrón de Guevara A, Sir-Petermann T, Larsson H, Rosenqvist MA, Cesta CE, Benrick A, Deng Q, Stener-Victorin E
Nat Med 2019 Dec;25(12):1894-1904

Single-Cell RNA-Seq Reveals Cellular Heterogeneity of Pluripotency Transition and X Chromosome Dynamics during Early Mouse Development.
Cheng S, Pei Y, He L, Peng G, Reinius B, Tam PPL, Jing N, Deng Q
Cell Rep 2019 Mar;26(10):2593-2607.e3

A genome-wide cross-trait analysis identifies shared loci and causal relationships of type 2 diabetes and glycaemic traits with polycystic ovary syndrome.
Liu Q, Tang B, Zhu Z, Kraft P, Deng Q, Stener-Victorin E, Jiang X
Diabetologia 2022 Sep;65(9):1483-1494

ZnT8 loss-of-function accelerates functional maturation of hESC-derived β cells and resists metabolic stress in diabetes.
Ma Q, Xiao Y, Xu W, Wang M, Li S, Yang Z, Xu M, Zhang T, Zhang ZN, Hu R, Su Q, Yuan F, Xiao T, Wang X, He Q, Zhao J, Chen ZJ, Sheng Z, Chai M, Wang H, Shi W, Deng Q, Cheng X, Li W
Nat Commun 2022 Jul;13(1):4142

Genomic correlation, shared loci, and causal relationship between obesity and polycystic ovary syndrome: a large-scale genome-wide cross-trait analysis.
Liu Q, Zhu Z, Kraft P, Deng Q, Stener-Victorin E, Jiang X
BMC Med 2022 Feb;20(1):66

Epigenetic inheritance of polycystic ovary syndrome - challenges and opportunities for treatment.
Stener-Victorin E, Deng Q
Nat Rev Endocrinol 2021 Sep;17(9):521-533

Transmission of Polycystic Ovary Syndrome via Epigenetic Inheritance.
Stener-Victorin E, Deng Q
Trends Mol Med 2021 Aug;27(8):723-724

Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice.
Manti M, Pui HP, Edström S, Risal S, Lu H, Lindgren E, Ohlsson C, Jerlhag E, Benrick A, Deng Q, Stener-Victorin E
FASEB J 2020 Nov;34(11):14440-14457

Single-cell analyses of X Chromosome inactivation dynamics and pluripotency during differentiation.
Chen G, Schell JP, Benitez JA, Petropoulos S, Yilmaz M, Reinius B, Alekseenko Z, Shi L, Hedlund E, Lanner F, Sandberg R, Deng Q
Genome Res 2016 Oct;26(10):1342-1354

Single-cell RNA-seq reveals dynamic, random monoallelic gene expression in mammalian cells.
Deng Q, Ramsköld D, Reinius B, Sandberg R
Science 2014 Jan;343(6167):193-6