Qiaolin Deng
About me
2001 Bachelor in Medicine, Shanghai Medical College, Fudan University, China
2010 Ph.D in Medical Science, Dept. Cell and Molecular Biology, Karolinska Institutet2010-2014 Postdoc in single-cell biology at Ludwig Institute of Cancer Research, Stockholm
2019 Docent in Developmental Biology, Karolinska InstitutetQiaolin Deng received her professional training in developmental neurobiology, stem cell biology, and single-cell technology, focusing on the molecular mechanisms involved in cell fate specification and transcriptional regulation during embryonic development. She established her lab in 2015 with the support of Young Investigator grants from several prominent funding agencies, including the Swedish Society for Medical Research, the Swedish Medical Research Council, and the Karolinska Institutet Central Faculty Fund. Currently, her lab is funded by prestigious grants such as the VR Consolidator Grant and the Wallenberg Academy Fellow Grant, along with several other grants. Qiaolin also serves as a Board Member of StratRegen
Research
Our lab investigates the developmental principles of germline specification in health and disease using mouse models and human stem cell cultures. Moreover, we investigate how maternal diseases impact the health outcomes of future offspring through developmental programming by placentas and germline modulation, a process known as developmental origins of health and disease. Our current research focuses on polycystic ovary syndrome (PCOS) and diabetes in women.
We use single-cell sequencing on human placentas to elucidate the molecular mechanisms underlying disease. We study germ cell specification processes with disease-derived human iPSCs differentiation system to investigate both developmental and disease mechanisms. We also develop disease-specific trophoblast organoids to examine the placenta's role in fetal development and maternal-fetal interactions underlying developmental programming. Our lab has also established microfluidic coculture systems to better mimic physiological and pathological uterine conditions on organogenesis in humans. Furthermore, our disease modeling of PCOS and diabetes in mice offers a valuable in vivo system to investigate molecular and physiological mechanisms in offspring's reproductive and metabolic functions. We aim to translate these findings into humans by leveraging our human cohort and biobank resources through collaboration.
More information at www.thedenglab.org
Publications @PubMed:https://bit.ly/4cq3qFO @Google Scholar:https://bit.ly/43syS1P
Teaching
- Scientific organizer of the EMBO practical course on “Single Cell Omics” Heidelberg, Germany 2014-2019 and 2022
- Biomedicine undergraduate program, Advanced physiology, Karolinska Institutet, 2020-now
- Biomedical engineering and Health system program, Advanced Physiology, Royal Institute of Technology, 2020-now
- Medical program, BV5 endocrinology, and reproduction, Karolinska Institutet, 2021-now
- Lecturer of doctoral course “Clinical achievements of reproductive medicine”, 2019, 2021, 2022
- Lecturer of doctoral course “Endothelial Cell Function and its Relevance in Cardiovascular Disease” 2020
- Lecturer of Master Program courses “Frontier in translational science”, 2018-2020
- Lecturer of Developmental Biology for Regenerative Medicine research school, 2015-2016Organizer of doctoral courses: “DNA sequencing and bioinformatic analysis” 9-13 May 2016, “From germ cell to neuronal cell 12-16 September 2016
Articles
- Article: NATURE MEDICINE. 2025;31(6):1925-1938Eriksson G; Li C; Sparovec TG; Dekanski A; Torstensson S; Risal S; Ohlsson C; Hirschberg AL; Petropoulos S; Deng Q; Stener-Victorin E
- Journal article: CELL REPORTS MEDICINE. 2025;6(5):102089Su Y; Sun J; Li X; Huang F; Kong Y; Chen Z; Zhang J; Qin D; Chen X; Wang Z; Pei Y; Gong M; Yang K; Xu M; Dong Y; He Q; Zhang Z-N; Sheng Z; Deng Q; Wang H; Wang G; Hu P; Le R; Gao S; Li W
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2025;135(10):e180900Collado A; Humoud R; Kontidou E; Eldh M; Swaich J; Zhao A; Yang J; Jiao T; Domingo E; Carlestal E; Mahdi A; Tengbom J; Vegvari A; Deng Q; Alvarsson M; Gabrielsson S; Eriksson P; Zhou Z; Pernow J
- Article: ADVANCED SCIENCE. 2025;12(15):e2410533He W; Luo Q; Zhao J; Wang M; Zhao A; Feng L; Reda A; Lindgren E; Stukenborg J-B; Chen J; Deng Q
- Journal article: PLACENTA. 2025;160:147Jiang H; Derisoud E; Parreira D; Jannig PR; Vanky E; Stener-Victorin E; Deng Q
- Article: NATURE COMMUNICATIONS. 2024;15(1):8894Zhong T; Li X; Lei K; Tang R; Deng Q; Love PE; Zhou Z; Zhao B; Li X
- Article: ADVANCED SCIENCE. 2024;11(36):e2309429Lu H; Jiang H; Li C; Derisoud E; Zhao A; Eriksson G; Lindgren E; Pui H-P; Risal S; Pei Y; Maxian T; Ohlsson C; Benrick A; Haider S; Stener-Victorin E; Deng Q
- Article: CELL REPORTS MEDICINE. 2024;5(5):101515Shen S; Wang M; Li X; Wang B; Hong W; Li W; Xu B; Guo Z; Han R; Yi S; Wu Z; He X; Wang L; Zhu Q; Yang G; Wang H; Deng Q; Chen J; Gao S; Jiang C; Gao R
- Article: DEVELOPMENTAL CELL. 2024;59(10):1269-1283.e6Grommisch D; Wang M; Eenjes E; Svetlicic M; Deng Q; Giselsson P
- Article: EMBO REPORTS. 2024;25(4):1752-1772Zhao A; Jiang H; Palomares AR; Larsson A; He W; Grunler J; Zheng X; Wallberg KAR; Catrina S-B; Deng Q
- Article: BMC BIOLOGY. 2023;21(1):277Birgersson M; Indukuri R; Lindquist L; Stepanauskaite L; Luo Q; Deng Q; Archer A; Williams C
- Article: CELL REPORTS MEDICINE. 2023;4(5):101035Risal S; Li C; Luo Q; Fornes R; Lu H; Eriksson G; Manti M; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; Recabarren S; Petermann TS; Benrick A; Brusselaers N; Qiao J; Deng Q; Stener-Victorin E
- Article: CELL DISCOVERY. 2023;9(1):14Gao R; Zeng S; Yang D; Li X; Liu W; Gao Y; Bai D; Zhang L; Chen C; Kang Y; Wang B; Hong W; Wang M; Yin J; Wang H; Deng Q; Gao S; Zhang Y; Chen J
- Article: CELL REPORTS. 2023;42(1):112021Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
- Article: COMMUNICATIONS BIOLOGY. 2023;6(1):69Pei Y; Risal S; Jiang H; Lu H; Lindgren E; Stener-Victorin E; Deng Q
- Article: DIABETOLOGIA. 2022;65(9):1483-1494Liu Q; Tang B; Zhu Z; Kraft P; Deng Q; Stener-Victorin E; Jiang X
- Article: NATURE COMMUNICATIONS. 2022;13(1):4142Ma Q; Xiao Y; Xu W; Wang M; Li S; Yang Z; Xu M; Zhang T; Zhang Z-N; Hu R; Su Q; Yuan F; Xiao T; Wang X; He Q; Zhao J; Chen Z-J; Sheng Z; Chai M; Wang H; Shi W; Deng Q; Cheng X; Li W
- Article: NATURE COMMUNICATIONS. 2022;13(1):1854Lentini A; Cheng H; Noble JC; Papanicolaou N; Coucoravas C; Andrews N; Deng Q; Enge M; Reinius B
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(3 PT A):705-716Li D; Cheng S; Pei Y; Sommar P; Karner J; Herter EK; Toma MA; Zhang L; Pham K; Cheung YT; Liu Z; Chen X; Eidsmo L; Deng Q; Landen NX
- Article: BMC MEDICINE. 2022;20(1):66Liu Q; Zhu Z; Kraft P; Deng Q; Stener-Victorin E; Jiang X
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2490:235-249Reda A; Stukenborg J-B; Deng Q
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2490:213-233Pui H-P; Deng Q
- Article: NATURE COMMUNICATIONS. 2021;12(1):5309Bedoya-Reina OC; Li W; Arceo M; Plescher M; Bullova P; Pui H; Kaucka M; Kharchenko P; Martinsson T; Holmberg J; Adameyko I; Deng Q; Larsson C; Juhlin CC; Kogner P; Schlisio S
- Journal article: TRENDS IN MOLECULAR MEDICINE. 2021;27(8):723-724Stener-Victorin E; Deng Q
- Article: HUMAN REPRODUCTION. 2021;36(8):2382-2391Jiang X; Deng Q; Stener-Victorin E
- Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2021;14:699562Aguila J; Cheng S; Kee N; Cao M; Wang M; Deng Q; Hedlund E
- Article: TRANSLATIONAL PSYCHIATRY. 2021;11(1):45Risal S; Manti M; Lu H; Fornes R; Larsson H; Benrick A; Deng Q; Cesta CE; Rosenqvist MA; Stener-Victorin E
- Article: FASEB JOURNAL. 2020;34(11):14440-14457Manti M; Pui H-P; Edstrom S; Risal S; Lu H; Lindgren E; Ohlsson C; Jerlhag E; Benrick A; Deng Q; Stener-Victorin E
- Article: GENOME RESEARCH. 2020;30(8):1083-1096Nichterwitz S; Nijssen J; Storvall H; Schweingruber C; Comley LH; Allodi I; van der Lee M; Deng Q; Sandberg R; Hedlund E
- Article: NATURE MEDICINE. 2019;25(12):1894-1904Risal S; Pei Y; Lu H; Manti M; Fornes R; Pui H-P; Zhao Z; Massart J; Ohlsson C; Lindgren E; Crisosto N; Maliqueo M; Echiburu B; de Guevara AL; Sir-Petermann T; Larsson H; Rosenqvist MA; Cesta CE; Benrick A; Deng Q; Stener-Victorin E
- Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2019;39(7):1402-1418Ali Z; Mukwaya A; Biesemeier A; Ntzouni M; Ramskold D; Giatrellis S; Mammadzada P; Cao R; Lennikov A; Marass M; Gerri C; Hildesjo C; Taylor M; Deng Q; Peebo B; del Peso L; Kvanta A; Sandberg R; Schraermeyer U; Andre H; Steffensen JF; Lagali N; Cao Y; Kele J; Dahl Jensen L
- Article: CELL REPORTS. 2019;26(10):2593-2607.e3Cheng S; Pei Y; He L; Peng G; Reinius B; Tam PPL; Jing N; Deng Q
- Article: EBIOMEDICINE. 2018;30:283-294Bhandage AK; Jin Z; Korol SV; Shen Q; Pei Y; Deng Q; Espes D; Carlsson P-O; Kamali-Moghaddam M; Birnir B
- Article: METHODS IN MOLECULAR BIOLOGY. 2018;1649:95-110Nichterwitz S; Benitez JA; Hoogstraaten R; Deng Q; Hedlund E
- Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2017;90:155-160Benitez JA; Cheng S; Deng Q
- Article: NATURE GENETICS. 2016;48(11):1430-1435Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R
- Article: GENOME RESEARCH. 2016;26(10):1342-1354Chen G; Schell JP; Benitez JA; Petropoulos S; Yilmaz M; Reinius B; Alekseenko Z; Shi L; Hedlund E; Lanner F; Sandberg R; Deng Q
- Journal article: CELL. 2016;167(1):285Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(30):E4387-E4396Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neuronsDoucet-Beaupre H; Gilbert C; Profes MS; Chabrat A; Pacelli C; Giguere N; Rioux V; Charest J; Deng Q; Laguna A; Ericson J; Perlmann T; Ang S-L; Cicchetti F; Parent M; Trudeau L-E; Levesque M
- Article: NATURE COMMUNICATIONS. 2016;7:12139Nichterwitz S; Chen G; Benitez JA; Yilmaz M; Storvall H; Cao M; Sandberg R; Deng Q; Hedlund E
- Article: SCIENTIFIC REPORTS. 2016;6:26448Hedlund E; Belnoue L; Theofilopoulos S; Salto C; Bye C; Parish C; Deng Q; Kadkhodaei B; Ericson J; Arenas E; Perlmann T; Simon A
- Article: STEM CELL REPORTS. 2016;6(5):643-651Braune E-B; Tsoi YL; Phoon YP; Landor S; Cascales HS; Ramskold D; Deng Q; Lindqvist A; Lian X; Sahlgren C; Jin S-B; Lendahl U
- Article: CELL. 2016;165(4):1012-1026Petropoulos S; Edsgard D; Reinius B; Deng Q; Panula SP; Codeluppi S; Reyes AP; Linnarsson S; Sandberg R; Lanner F
- Article: NATURE BIOTECHNOLOGY. 2016;34(2):199-203Cadwell CR; Palasantza A; Jiang X; Berens P; Deng Q; Yilmaz M; Reimer J; Shen S; Bethge M; Tolias KF; Sandberg R; Tolias AS
- Article: NATURE NEUROSCIENCE. 2015;18(6):826-835Laguna A; Schintu N; Nobre A; Alvarsson A; Volakakis N; Jacobsen JK; Gomez-Galan M; Sopova E; Joodmardi E; Yoshitake T; Deng Q; Kehr J; Ericson J; Svenningsson P; Shupliakov O; Perlmann T
- Article: CANCER CELL. 2014;25(6):794-808Woll PS; Kjallquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstrom-Lindberg E; Linnarsson S; Jacobsen SEW
- Article: SCIENCE. 2014;343(6167):193-196Deng Q; Ramskold D; Reinius B; Sandberg R
- Article: CELL STEM CELL. 2013;13(5):535-548Boiers C; Carrelha J; Lutteropp M; Luc S; Green JCA; Azzoni E; Woll PS; Mead AJ; Hultquist A; Swiers G; Perdiguero EG; Macaulay IC; Melchiori L; Luis TC; Kharazi S; Bouriez-Jones T; Deng Q; Ponten A; Atkinson D; Jensen CT; Sitnicka E; Geissmann F; Godin I; Sandberg R; de Bruijn MFTR; Jacobsen SEW
- Article: NATURE BIOTECHNOLOGY. 2012;30(8):777-782Ramskold D; Luo S; Wang Y-C; Li R; Deng Q; Faridani OR; Daniels GA; Khrebtukova I; Loring JF; Laurent LC; Schroth GP; Sandberg R
- Article: DEVELOPMENT. 2011;138(16):3399-3408Deng Q; Andersson E; Hedlund E; Alekseenko Z; Coppola E; Panman L; Millonig JH; Brunet J-F; Ericson J; Perlmann T
- Article: CELL STEM CELL. 2011;8(6):663-675Panman L; Andersson E; Alekseenko Z; Hedlund E; Kee N; Mong J; Uhde CW; Deng Q; Sandberg R; Stanton LW; Ericson J; Perlmann T
- Article: CELL. 2006;124(2):393-405Andersson E; Tryggvason U; Deng QL; Friling S; Alekseenko Z; Robert B; Perlmann T; Ericson J
- Show more
All other publications
- Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2025;36(5):472-481Stener-Victorin E; Deng Q
- Preprint: BIORXIV. 2025Jiang H; Derisoud E; Parreira D; Taebnia N; Jannig P; Shafagh RZ; Zhao A; Li C; Ortiz M; Maliqueo MA; Stener-Victorin E; Lauschke V; Deng Q
- Review: HUMAN REPRODUCTION UPDATE. 2024;30(4):410-441Derisoud E; Jiang H; Zhao A; Chavatte-Palmer P; Deng Q
- Review: NATURE REVIEWS ENDOCRINOLOGY. 2021;17(9):521-533Stener-Victorin E; Deng Q
- Review: MOLECULAR ASPECTS OF MEDICINE. 2018;59:36-46Hedlund E; Deng Q
- Corrigendum: CANCER CELL. 2015;27(4):603-605Woll PS; Kjaellquist U; Chowdhury O; Doolittle H; Wedge DC; Thongjuea S; Erlandsson R; Ngara M; Anderson K; Deng Q; Mead AJ; Stenson L; Giustacchini A; Duarte S; Giannoulatou E; Taylor S; Karimi M; Scharenberg C; Mortera-Blanco T; Macaulay IC; Clark S-A; Dybedal I; Josefsen D; Fenaux P; Hokland P; Holm MS; Cazzola M; Malcovati L; Tauro S; Bowen D; Boultwood J; Pellagatti A; Pimanda JE; Unnikrishnan A; Vyas P; Goehring G; Schlegelberger B; Tobiasson M; Kvalheim G; Constantinescu SN; Nerlov C; Nilsson L; Campbell PJ; Sandberg R; Papaemmanuil E; Hellstroem-Lindberg E; Linnarsson S; Jacobsen SEW
- Doctoral thesis: 2010Deng Q
Grants
- A programming perspective of the germline cycle on origin of germ cell tumors and epigenetic inheritance of diseasesSwedish Research Council1 January 2021 - 1 January 2026
Employments
- Principal Researcher, Department of Physiology and Pharmacology, Karolinska Institutet, 2021-
Degrees and Education
- Docent, Karolinska Institutet, 2019
- Degree Of Doctor Of Philosophy, Department of Cell and Molecular Biology, Karolinska Institutet, 2010