Paulo Jannig

Publications
CV
Public outreach and news

Articles

Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2025;328(2):E274-E285
Constitutive loss of kynurenine-3-monooxygenase changes circulating kynurenine metabolites without affecting systemic energy metabolism
Dumont KD; Jannig PR; Porsmyr-Palmertz M; Ruas JL
Article: NATURE COMMUNICATIONS. 2024;15(1):9826
The mitochondrial mRNA-stabilizing protein SLIRP regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
Pham TCP; Raun SH; Havula E; Henriquez-Olguin C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig PR; Andersen NR; Kruse R; Ali MS; Irazoki A; Halling JF; Ringholm S; Needham EJ; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ortenblad N; Hojlund K; Kjaer M; Ruas JL; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
Article: AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 2024;327(3):C516-C524
The rRNA epitranscriptome and myonuclear SNORD landscape in skeletal muscle fibers contributes to ribosome heterogeneity and is altered by a hypertrophic stimulus
Cui M; Jannig P; Halladjian M; Figueiredo VC; Wen Y; Vechetti IJ; Krogh N; Jude B; Edman S; Lanner J; Mccarthy J; Murach KA; Sejersen T; Nielsen H; von Walden F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(34):e2319724121
Zfp697 is an RNA- binding protein that regulates skeletal muscle inflammation and remodeling
Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Praestholm SM; Dias JM; Dumont KD; Liu Z; Liang Q; Edsgaerd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Teixeira AI; Yeo GW; Ruas JL
Article: MOLECULAR METABOLISM. 2024;82:101912
Mustn1 is a smooth muscle cell-secreted microprotein that modulates skeletal muscle extracellular matrix composition
Ducommun S; Jannig PR; Cervenka I; Murgia M; Mittenbuhler MJ; Chernogubova E; Dias JM; Jude B; Correia JC; Van Vranken JG; Ocana-Santero G; Porsmyr-Palmertz M; Haworth SM; Martinez-Redondo V; Liu Z; Carlstrom M; Mann M; Lanner JT; Teixeira AI; Maegdefessel L; Spiegelman BM; Ruas JL
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 2024;103(1):151377
Sustained PGC-1α2 or PGC-1α3 expression induces astrocyte dysfunction and degeneration
Nunes MJ; Carvalho AN; Sa-Lemos C; Colaco M; Cervenka I; Ciraci V; Santos SG; Ribeiro MM; Castanheira M; Jannig PR; Gama MJ; Castro-Caldas M; Rodrigues CMP; Rodrigues E; Ruas JL
Journal article: SCIENTIFIC REPORTS. 2023;13(1):21970
Aerobic exercise training mitigates tumor growth and cancer-induced splenomegaly through modulation of non-platelet platelet factor 4 expression
Tobias GC; Gomes JLP; Fernandes LG; Voltarelli VA; de Almeida NR; Jannig PR; de Souza RWA; Negrao CE; Oliveira EM; Chammas R; Alves CRR; Brum PC
Journal article: JOURNAL OF PHYSIOLOGY-LONDON. 2023;601(21):4659-4660
Understanding the role of sirtuin 1 in muscle physiology during androgen deprivation
Joaquim VHA; da Silva JG; Jannig PR
Article: CELL REPORTS. 2023;42(1):112021
Epiblast-like stem cells established by Wnt/(3-catenin signaling manifest distinct features of formative pluripotency and germline competence
Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Chen X; Petropoulos S; Ruas JL; Wu J; Deng Q
Article: NATURE METABOLISM. 2022;4(6):739-758
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: CELL METABOLISM. 2021;33(11):2215-2230.e8
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Shvaikovskaya D; Zhengye L; Cervenka I; Khan N; Stec M; Oliveira M; Nijssen J; Martinez-Redondo V; Ducommun S; Azzolini M; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Article: NATURE COMMUNICATIONS. 2021;12(1):1026
Distinct subtypes of proprioceptive dorsal root ganglion neurons regulate adaptive proprioception in mice
Wu H; Petitpre C; Fontanet P; Sharma A; Bellardita C; Quadros RM; Jannig PR; Wang Y; Heimel JA; Cheung KKY; Wanderoy S; Xuan Y; Meletis K; Ruas J; Gurumurthy CB; Kiehn O; Hadjab S; Lallemend F
Journal article: CELLS. 2021;10(1):146
β₂-Adrenergic Signaling Modulates Mitochondrial Function and Morphology in Skeletal Muscle in Response to Aerobic Exercise
Azevedo Voltarelli V; Coronado M; Goncalves Fernandes L; Cruz Campos J; Jannig PR; Batista Ferreira JC; Fajardo G; Chakur Brum P; Bernstein D
Article: MOLECULAR METABOLISM. 2020;39:101012
Exercise training reverses cancer-induced oxidative stress and decrease in muscle COPS2/TRIP15/ALIEN
Alves CRR; das Neves W; de Almeida NR; Eichelberger EJ; Jannig PR; Voltarelli VA; Tobias GC; Bechara LRG; Faria DDP; Alves MJN; Hagen L; Sharma A; Slupphaug G; Moreira JBN; Wisloff U; Hirshman MF; Negrao CE; de CGJ; Chammas R; Swoboda KJ; Ruas JL; Goodyear LJ; Brum PC
Article: MOLECULAR METABOLISM. 2020;34:72-84
PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
Leveille M; Besse-Patin A; Jouvet N; Gunes A; Sczelecki S; Jeromson S; Khan NP; Baldwin C; Dumouchel A; Correia JC; Jannig PR; Boulais J; Ruas JL; Estall JL
Article: FRONTIERS IN ENDOCRINOLOGY. 2020;11:591476
Comparative Analysis of Skeletal Muscle Transcriptional Signatures Associated With Aerobic Exercise Capacity or Response to Training in Humans and Rats
Kelahmetoglu Y; Jannig PR; Cervenka I; Koch LG; Britton SL; Zhou J; Wang H; Robinson MM; Nair KS; Ruas JL
Journal article: EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY. 2018;118(12):2607-2616
Resistance training in young men induces muscle transcriptome-wide changes associated with muscle structure and metabolism refining the response to exercise-induced stress
Damas F; Ugrinowitsch C; Libardi CA; Jannig PR; Hector AJ; McGlory C; Lixandrao ME; Vechin FC; Montenegro H; Tricoli V; Roschel H; Phillips SM
Article: CELL METABOLISM. 2018;27(2):378-392.e5
Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation
Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martinez-Redondo V; Ueland PM; Midttun O; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
Article: LIFE SCIENCES. 2017;191:46-51
Effects of N-acetylcysteine on isolated skeletal muscle contractile properties after an acute bout of aerobic exercise
Jannig PR; Alves CRR; Voltarelli VA; Bozi LHM; Vieira JS; Brum PC; Bechara LRG
Article: AUTOPHAGY. 2017;13(8):1304-1317
Exercise reestablishes autophagic flux and mitochondrial quality control in heart failure
Campos JC; Queliconi BB; Bozi LHM; Bechara LRG; Dourado PMM; Andres AM; Jannig PR; Gomes KMS; Zambelli VO; Rocha-Resende C; Guatimosim S; Brum PC; Mochly-Rosen D; Gottlieb RA; Kowaltowski AJ; Ferreira JCB
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2017;122(4):817-827
Exercise training decreases NADPH oxidase activity and restores skeletal muscle mass in heart failure rats
Cunha TF; Bechara LRG; Bacurau AVN; Jannig PR; Voltarelli VA; Dourado PM; Vasconcelos AR; Scavone C; Ferreira JCB; Brum PC
Article: LASERS IN MEDICAL SCIENCE. 2017;32(2):317-325
Strength training prior to muscle injury potentiates low-level laser therapy (LLLT)-induced muscle regeneration
Lourenco Morais SR; Goya AG; Urias U; Jannig PR; Nova Bacurau AV; Mello WG; Faleiros PL; Penha Oliveira SH; Garcia VG; Ervolino E; Chakur Brum P; Menegati Dornelles RC
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2016;20(11):2208-2212
Aerobic exercise training rescues cardiac protein quality control and blunts endoplasmic reticulum stress in heart failure rats
Bozi LHM; Jannig PR; Rolim N; Voltarelli VA; Dourado PMM; Wisloff U; Brum PC
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(18):5209-5222
Resistance training-induced changes in integrated myofibrillar protein synthesis are related to hypertrophy only after attenuation of muscle damage
Damas F; Phillips SM; Libardi CA; Vechin FC; Lixandrao ME; Jannig PR; Costa LAR; Bacurau AV; Snijders T; Parise G; Tricoli V; Roschel H; Ugrinowitsch C
Article: SCIENCE TRANSLATIONAL MEDICINE. 2016;8(350):350ra103
The chaperone co-inducer BGP-15 alleviates ventilation-induced diaphragm dysfunction
Salah H; Li M; Cacciani N; Gastaldello S; Ogilvie H; Akkad H; Namuduri AV; Morbidoni V; Artemenko KA; Balogh G; Martinez-Redondo V; Jannig P; Hedstrom Y; Dworkin B; Bergquist J; Ruas J; Vigh L; Salviati L; Larsson L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(29):15169-15184
Peroxisome Proliferator-activated Receptor γ Coactivator-1 α Isoforms Selectively Regulate Multiple Splicing Events on Target Genes
Martinez-Redondo V; Jannig PR; Correia JC; Ferreira DMS; Cervenka I; Lindvall JM; Sinha I; Izadi M; Pettersson-Klein AT; Agudelo LZ; Gimenez-Cassina A; Brum PC; Dahlman-Wright K; Ruas JL
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2016;214:137-147
Akt/mTOR pathway contributes to skeletal muscle anti-atrophic effect of aerobic exercise training in heart failure mice
Bacurau AVN; Jannig PR; de Moraes WMAM; Cunha TF; Medeiros A; Barberi L; Coelho MA; Bacurau RFP; Ugrinowitsch C; Musaro A; Brum PC
Journal article: FASEB JOURNAL. 2015;29(S1)
Time Course of Mitophagy‐Related Signals in Skeletal Muscle Following a Single Bout of Aerobic Exercise in Mice
Jannig P; Voltarelli V; Bozi L; Brum P
Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2014;175(3):499-507
NADPH oxidase hyperactivity induces plantaris atrophy in heart failure rats
Bechara LRG; Moreira JBN; Jannig PR; Voltarelli VA; Dourado PM; Vasconcelos AR; Scavone C; Ramires PR; Brum PC
Article: PLOS ONE. 2014;9(1):e85820
Autophagy Signaling in Skeletal Muscle of Infarcted Rats
Jannig PR; Moreira JBN; Bechara LRG; Bozi LHM; Bacurau AV; Monteiro AWA; Dourado PM; Wisloff U; Brum PC
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2013;114(8):1029-1041
High- versus moderate-intensity aerobic exercise training effects on skeletal muscle of infarcted rats
Moreira JBN; Bechara LRG; Bozi LHM; Jannig PR; Monteiro AWA; Dourado PM; Wisloff U; Brum PC
Article: CLINICS. 2013;68(1):107-114
Exercise training prevents skeletal muscle damage in an experimental sepsis model
Coelho CW; Jannig PR; de Souza AB; Fronza HJ; Westphal GA; Petronilho F; Constantino L; Dal-Pizzol F; Ferreira GK; Streck EE; Silva E
Journal article: CRITICAL CARE. 2011;15(Suppl 2):p2
Exercise training reduces oxidative damage in skeletal muscle of septic rats
Coelho C; Jannig P; Souza A; Fronza H; Westphal G; Petronilho F; Silva P; Dal-Pizzol F; Silva E
Article: REVISTA BRASILEIRA DE MEDICINA DO ESPORTE. 2009;15(5):338-341
Influence of Resistance Exercises Order Performance on Post-exercise Hypotension in Hypertensive Elderly
Jannig PR; Cardoso AC; Fleischmann E; Coelho CW; de Carvalho T
Show more

All other publications

Preprint: RESEARCH SQUARE. 2024
The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
Sylow L; Pham TCP; Raun S; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen A; Jannig P; Andersen N; Kruse R; Ali M; Halling J; Ringholm S; Needham E; Hansen S; Lemminger A; Schjerling P; Petersen M; de Almeida M; Jensen T; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski J; Nielsen J; Qvortrup K; Pilegaard H; Richter E
Preprint: BIORXIV. 2023
The mitochondrial mRNA stabilizing protein, SLIRP, regulates skeletal muscle mitochondrial structure and respiration by exercise-recoverable mechanisms
Pham TCP; Raun SH; Havula E; Henriquez-Olguín C; Rubalcava-Gracia D; Frank E; Fritzen AM; Jannig P; Andersen NR; Kruse R; Ali MS; Halling JF; Ringholm S; Needham E; Hansen S; Lemminger AK; Schjerling P; Petersen MH; de Almeida ME; Jensen TE; Kiens B; Hostrup M; Larsen S; Ørtenblad N; Højlund K; Kjær M; Ruas J; Trifunovic A; Wojtaszewski JFP; Nielsen J; Qvortrup K; Pilegaard H; Richter EA; Sylow L
Preprint: BIORXIV. 2023;BIORXIV
Zfp697 is an RNA-binding protein that regulates skeletal muscle inflammation and regeneration.
Correia JC; Jannig PR; Gosztyla ML; Cervenka I; Ducommun S; Præstholm SM; Dumont K; Liu Z; Liang Q; Edsgärd D; Emanuelsson O; Gregorevic P; Westerblad H; Venckunas T; Brazaitis M; Kamandulis S; Lanner JT; Yeo GW; Ruas JL
Editorial comment: CELL. 2022;185(8):1444-1444.e1
Regulation and biology of PGC-1α
Jannig PR; Dumesic PA; Spiegelman BM; Ruas JL
Preprint: SSRN ELECTRONIC JOURNAL. 2022
Epiblast-Like Stem Cells Established by Wnt/β-Catenin Signaling Manifest Distinct Features of Formative Pluripotency
Luo Q; Pui H-P; Chen J; Yu L; Jannig PR; Pei Y; Zhao L; Petropoulos S; Chen X; Ruas JL; Wu J; Deng Q
Preprint: BIORXIV. 2021
Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity
Correia JC; Kelahmetoglu Y; Jannig PR; Schweingruber C; Svaikovskaya D; Zhengye L; Cervenka I; Oliveira M; Nijssen J; Martínez-Redondo V; Stec M; Khan N; Lanner JT; Kleiner S; Hedlund E; Ruas JL
Preprint: BIORXIV. 2019
PGC-1α isoforms coordinate to balance hepatic metabolism and apoptosis in inflammatory environments
Léveillé M; Besse-Patin A; Jouvet N; Gunes A; Jeromson S; Khan NP; Sczelecki S; Baldwin C; Dumouchel A; Correia J; Jannig P; Boulais J; Ruas JL; Estall JL
Editorial comment: ACTA PHYSIOLOGICA. 2017;219(1):14-16
Targeting mitochondrial mRNA translation to tackle obesity-induced insulin resistance: thumbs up for exercise
Jannig PR; Ruas JL
Meeting abstract: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2016;48(5):900
Muscle Damage Over A Resistance-training Period: Repeated Bout Effect Analysed Through Direct And Indirect Markers
Damas F; Phillips SM; Libardi CA; Vechin FC; Lixandrao ME; Jannig PR; Roschel H; Costa LAR; Tricoli V; Ugrinowitsch C
Editorial comment: JOURNAL OF PHYSIOLOGY-LONDON. 2016;594(2):265-266
Age-dependent effects of bed rest in human skeletal muscle: exercise to the rescue
Moreira JBN; Wohlwend M; Amellem I; Jannig PR
Review: AUTOPHAGY. 2016;12(2):1-222
Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition) (vol 12, pg 1, 2015)
Kliosnky D
Book chapter: THE CARDIOVASCULAR ADRENERGIC SYSTEM. 2015;p. 77-96
The Cardiovascular Adrenergic System and Physical Exercise
Voltarelli VA; Jannig PR; Costa DG; Bozi LHM; Júnior CRB; Brum PC

Employments

Research Specialist, Department of Physiology and Pharmacology, Karolinska Institutet, 2024-
Postdoctoral Researcher, C3 Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2023

Articles

All other publications

Employments

News from KI

Events from KI