About us- Germ cell biology, developmental programming and epigenetic inheritance of disease

The germline cycle.

Germ cells are often considered immortal. They are sole messengers to relay genetic and epigenetic information across generations to perpetuate life. The germline cycle is long with specification starting from early gastrulation to gametogenesis continuing after birth. Errors occurring at any stage during this process can lead to devastating and long-lasting effects. With recent technological advances in single-cell sequencing, our knowledge of germline development in mammals has expanded considerably in recent times but some questions are remained. Among them, we aim to answer (1) what regulate progenitor competence and then define cell quality to opt into germline specification? (2) How is migration correlated with epigenetic remodeling? (3) How certain genetic mutations affect gametogenesis? Read more about our research and ongoing projects here.

Group members

Qiaolin Deng

PI /Associate professor

Email: qiaolin.deng@ki.se

Eva Lindgren

Lab manager

Email: eva.lindgren@ki.se

Sanjiv Risal

Research specialist, PhD

Email: sanjiv.risal@ki.se

Jian Zhao

Email: jian.zhao@ki.se

Emilie Derisoud

Postdoc researcher

Email: emilie.derisoud@ki.se

Wenteng He

Email: wenteng.he@ki.se

Qing Luo

Doctoral student

Email: qing.luo@ki.se

Hong Jiang

Email: hong.jiang@ki.se

Allan Zhao

Email: allan.zhao@ki.se

Alumni

Han Hui-Pin (postdoc)
Ahmed Reda (postdoc)
Veeramohan Veerapandian (postdoc)
Menghan Wang (postdoc)
Shangli Cheng (postdoc)
Julio Agulia Benitez (postdoc)
Geng Chen (postdoc)
Yu Pei (PhD student)
Alice Larsson (master student)
Christina An Binh Nordentoft (master student)
Alisa Luo (biomedicine student)
Tom van Leeuwen (master student)
Hannah Schöler (master student)
Mathias Ahlqvist (master student)
Olli Ainasoja (master student)

Our collaborators

Elisabet Stener-Victorin, Dept. Physiology and Pharmacology, KI
Jan-Bernd Stukenborg, Dept. Women and Children’s health, KI
Martin Enge, Dept. Oncology and Pathology, KI
Kenny Rodriguez-Wallberg, Dept. Clinical Science, Intervention and Technology, KI
Sergiu-Bogdan Catrina, Dept. Molecular Medicine and Surgery, KI
Eva Hedlund, Dept. Biochemistry and Biophysics, Stockholm University
Xingqi Chen, Dept. Immunology, Genetics and Pathology, Uppsala University
Jun Wu, UT Southwestern Medical center, USA
Jiayu Cheng, School of Life Sciences, Tongji University, China
Weida Li, School of Life Sciences, Tongji University, China
Eszter Vanky, Institute for Clinical and Molecular Medicine, NTNU, Norway
Sandra Haider, Reproductive Biology Unit, Medical University of Vienna