Christian Göritz's Group

Research group picture for Christian Göritz group.

We are studying homeostasis and tissue repair mechanisms in the mammalian system with a focus on pericytes, perivascular cells of the microvasculature.

Commonly, tissue damage triggers a wound closure reaction that can lead to pathological tissue formation, causing functional impairment and blocking regeneration.

We discovered that a specific subpopulation of pericytes participate in the wound closure reaction and following scar formation after spinal cord injury.

Pericytes are abundant throughout the body and have a great potential to be a general source for scar formation and fibrosis in different injuries and diseases. We are aiming to understand the nature of these cells, their heterogeneity, stem cell potential and functions.

Group members

David DiasPhD student
Eduardo GuimaraesSenior lab manager
Christian GöritzSenior researcher
Wing Fung HauPhD student
Daniel HollPhD student, Graduate Student
Jannis KalkitsasPhD student, Graduate Student
Yildiz KelahmetogluPhD student, Graduate Student
Soniya SavantPostdoc

Selected Publications

Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.
Reichenbach B, Classon J, Aida T, Tanaka K, Genander M, Göritz C
EMBO J. 2018 05;37(9):

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.
Dias D, Kim H, Holl D, Werne Solnestam B, Lundeberg J, Carlén M, et al
Cell 2018 03;173(1):153-165.e22

Fibrotic scarring following lesions to the central nervous system.
Dias D, Göritz C
Matrix Biol. 2018 08;68-69():561-570

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.
Magnusson J, Göritz C, Tatarishvili J, Dias D, Smith E, Lindvall O, et al
Science 2014 Oct;346(6206):237-41

Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice.
Sabelström H, Stenudd M, Réu P, Dias D, Elfineh M, Zdunek S, et al
Science 2013 Nov;342(6158):637-40

Neural stem cells and neurogenesis in the adult.
Göritz C, Frisén J
Cell Stem Cell 2012 Jun;10(6):657-659

A pericyte origin of spinal cord scar tissue.
Göritz C, Dias D, Tomilin N, Barbacid M, Shupliakov O, Frisén J
Science 2011 Jul;333(6039):238-42

EphB signaling controls lineage plasticity of adult neural stem cell niche cells.
Nomura T, Göritz C, Catchpole T, Henkemeyer M, Frisén J
Cell Stem Cell 2010 Dec;7(6):730-43

Origin of new glial cells in intact and injured adult spinal cord.
Barnabé-Heider F, Göritz C, Sabelström H, Takebayashi H, Pfrieger F, Meletis K, et al
Cell Stem Cell 2010 Oct;7(4):470-82

Developmental BiologyStem Cell BiologyStem cells