Christian Göritz's Group
We are studying homeostasis and tissue repair mechanisms in the mammalian system with a focus on pericytes, perivascular cells of the microvasculature.
Commonly, tissue damage triggers a wound closure reaction that can lead to pathological tissue formation, causing functional impairment and blocking regeneration.
We discovered that a specific subpopulation of pericytes participate in the wound closure reaction and following scar formation after spinal cord injury.
Pericytes are abundant throughout the body and have a great potential to be a general source for scar formation and fibrosis in different injuries and diseases. We are aiming to understand the nature of these cells, their heterogeneity, stem cell potential and functions.
|David Dias||PhD student|
|Christian Göritz||Senior researcher|
|Wing Fung Hau||PhD student, Graduate Student|
|Daniel Holl||PhD student, Graduate Student|
|Jannis Kalkitsas||PhD student, Graduate Student|
|Yildiz Kelahmetoglu||PhD student, Graduate Student|
Glutamate transporter Slc1a3 mediates inter-niche stem cell activation during skin growth.
EMBO J. 2018 May;37(9):
Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury.
Cell 2018 Mar;173(1):153-165.e22
Fibrotic scarring following lesions to the central nervous system.
Matrix Biol. 2018 Aug;68-69():561-570
A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse.
Science 2014 Oct;346(6206):237-41
Resident neural stem cells restrict tissue damage and neuronal loss after spinal cord injury in mice.
Science 2013 Nov;342(6158):637-40
Neural stem cells and neurogenesis in the adult.
Cell Stem Cell 2012 Jun;10(6):657-9
A pericyte origin of spinal cord scar tissue.
Science 2011 Jul;333(6039):238-42
EphB signaling controls lineage plasticity of adult neural stem cell niche cells.
Cell Stem Cell 2010 Dec;7(6):730-43
Origin of new glial cells in intact and injured adult spinal cord.
Cell Stem Cell 2010 Oct;7(4):470-82