Christian Göritz's Group

We are studying homeostasis and tissue repair mechanisms in the mammalian system with a focus on pericytes, perivascular cells of the microvasculature.

Commonly, tissue damage triggers a wound closure reaction that can lead to pathological tissue formation, causing functional impairment and blocking regeneration.

We discovered that a specific subpopulation of pericytes participate in the wound closure reaction and following scar formation after spinal cord injury.

Pericytes are abundant throughout the body and have a great potential to be a general source for scar formation and fibrosis in different injuries and diseases. We are aiming to understand the nature of these cells, their heterogeneity, stem cell potential and functions.

Group members

David DiasPhD student
Eduardo GuimaraesPostdoc
Christian GöritzSenior researcher
Wing Fung HauPhD student, Graduate Student
Daniel HollPhD student, Graduate Student
Jannis KalkitsasPhD student, Graduate Student
Yildiz KelahmetogluPhD student, Graduate Student
Bettina ReichenbachPostdoc
Soniya SavantPostdoc

Selected Publications

A pericyte origin of spinal cord scar tissue.
Göritz C, Dias D, Tomilin N, Barbacid M, Shupliakov O, Frisén J
Science 2011 Jul;333(6039):238-42

EphB signaling controls lineage plasticity of adult neural stem cell niche cells.
Nomura T, Göritz C, Catchpole T, Henkemeyer M, Frisén J
Cell Stem Cell 2010 Dec;7(6):730-43

RBPJkappa-dependent signaling is essential for long-term maintenance of neural stem cells in the adult hippocampus.
Ehm O, Göritz C, Covic M, Schäffner I, Schwarz T, Karaca E, et al
J. Neurosci. 2010 Oct;30(41):13794-807

Origin of new glial cells in intact and injured adult spinal cord.
Barnabé-Heider F, Göritz C, Sabelström H, Takebayashi H, Pfrieger F, Meletis K, et al
Cell Stem Cell 2010 Oct;7(4):470-82

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke.
Carlén M, Meletis K, Göritz C, Darsalia V, Evergren E, Tanigaki K, et al
Nat. Neurosci. 2009 Mar;12(3):259-67

Developmental BiologyStem Cell BiologyStem cells