Photo: Karolinska InstitutetResearch group leader
Professor Ulf Hedin is research group leader of the group Vascular Surgery at the Department of Molecular Medicine and Surgery
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Vascular Surgery – Ulf Hedin's research group
Vascular disease is the leading cause of death and disability in the western world. In order to prevent disease development and develop preventive strategies, a complete understanding of basic cellular and molecular mechanisms is necessary. Our research is focused on basic mechanisms both in the development of vascular disease as well as in the response of the vessel wall to vascular interventions for limb ischemia, carotid disease and stroke and aneurysms.
Part of the Department of Molecular Medicine and Surgery
Photo: Karolinska Institutet
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Event list Vascular Surgery
News Vascular Surgery
Research Area
Our research is focused on basic mechanisms both in the development of vascular disease as well as in the response of the vessel wall to vascular interventions for limb ischemia, carotid disease and stroke and aneurysms. The advanced molecular research conducted in the group and the close proximity to clinical vascular surgery, create a unique platform for the resolution of issues of immediate concern for clinical care as well as breeding of future clinical academic leadership.
The group is headed by Professor Ulf Hedin and belongs to the Department of molecular medicine and surgery, and is also the main research team at the clinical department of vascular surgery at the Karolinska University Hospital. We have established collaborations with the cardiovascular research groups at CMM and the departments of Clinical Physiology, Neurology, Cardiology, Nuclear Medicine, Clinical Chemistry, and Clinical Pharmacology at the hospital. The group also collaborate with CMB, MBB and SciLifeLab at Karolinska Institutet, as well as with researchers at the Royal School of Technology and Uppsala University, and research groups in Sweden and in Norway, Germany, Netherlands, England, USA and Canada.
Address
Vascular Surgery, Department of Molecular Medicine and Surgery
Karolinska Institutet
BioClinicum J8:20
Karolinska University Hospital, Solna
171 76 Stockholm
Research group leader
Ulf Hedin
Professor/Senior PhysicianResearch teams
Vascular disease is the leading cause of death and disability in the western world. In order to prevent disease development and develop preventive strategies, a complete understanding of basic cellular and molecular mechanisms is necessary. Our group utilizes a translational platform with advanced cell- and molecular biology, animal models in combination with patient centred research to resolve target processes in peripheral vascular disease such as mechanisms related to thromboembolic carotid disease and stroke, pathogenesis of abdominal aortic aneurysms, vascular repair processes and inflammation in association with interventional procedures and pulmonary hypertension. The close proximity between clinical vascular surgery and advanced molecular research creates a unique platform for the resolution of issues of immediate concern for clinical care as well as breeding of future clinical academic leadership.
Photo: Karolinska Institutet PI: Ulf Hedin
Carotistenosis and stroke
The project aims to identify biological processes and central molecules in the case of instability in atherosclerosis plaques, which can be used to, among other things, develop biomarkers for unstable atherosclerosis in patients at risk. The project can provide new knowledge about the causes of unstable atherosclerosis in patients with narrowings of the carotid artery, and help prevent stroke.
Photo: Tintin Vidhammer PI: Ljubica Matic
Translational Vascular Medicine
The Translational Vascular Medicine team is a translational Team composed of basic researchers with expertise in molecular biology and pharmacology, and clinically active vascular surgeons. The team applies integrative analyses combining bioinformatic and clinical data studies with murine models of vascular injury and disease, while in vitro systems based on primary cells and tissue explants are utilized for functional and mechanistic investigations.
Photo: Privat PI: Jenny Löfgren
Global Surgery
Lack of surgical healthcare costs lives and money. Five billion people do not have access to quality surgical services at an affordable cost when needed. Still, surgical conditions account for 30% of the global burden of disease and causes the loss of 16.9 million lives every year. This is more than the number of deaths from tuberculosis, HIV/AIDS and malaria combined. The burden of surgical disease is highest in sub-Saharan Africa where access to surgery is most limited.
Staff and contact
Group leader
- Ulf HedinProfessor/Senior Physician
All members of the group
- Mary Margaret AjikoAffiliated to Research
- Patricia AnderssonAffiliated to Research
- Anton AxelssonPhd Student
- Olof BladinPhd Student
- Marko BogdanovicPhd Student
- Melody ChemalyPostdoctoral Researcher
- Corinne CurryAffiliated to Research
- Alireza DaryapeymaAffiliated to Research
- Tove Ekdahl HjelmPhd Student
- Siw FrebeliusResearch Coordinator
- Sari HammoPhd Student
- Ulf HedinProfessor/Senior Physician
- Rebecka HultgrenAdjunct Professor | Docent
- Eva Hurt-CamejoAdjunct Professor
- Mårten HussPhd Student
- Eva Jaldeborg KarlöfPostdoctoral Studies
- Hong JinSenior Research Specialist
- Magnus JonssonAffiliated to Research | Docent
- Glykeria KaradimouPostdoctoral Researcher
- Niki Khatibi ShahidiAffiliated to Teaching/Tutoring
- Arisa KitagishiAffiliated to Research | Phd Student
- Malin KronqvistBiomedical Scientist
- Mariette LengquistLaboratory Manager
- Malin LindbergPhd Student
- Moritz Lindquist LiljeqvistAffiliated to Research
- Jenny LöfgrenAffiliated to Research | Docent
- Ljubica MaticPrincipal Researcher | Docent
- Alphonsus MatovuPhd Student
- Olga NilssonAffiliated to Research
- Anton RazuvaevAffiliated to Research
- Joy RoyAffiliated to Research | Docent
- Samuel RöhlAffiliated to Research
- Antti SiikaPostdoctoral Researcher
- Helen SinabulyaAffiliated to Teaching/Tutoring
- Mareia TalvitieAffiliated to Research
- Zin Min Thet LwinPhd Student
- Ove ThottPhd Student
- Sofija VuckovicPhd Student
- Katarina WadénPhd Student
- Carl Magnus WahlgrenAdjunct Professor | Docent
- Marcus WannbergPhd Student
- David del Rio AledoAffiliated to Research
Histo-Core
Histo-core core facility
Dehydration Service
We can dehydrate any type of tissue in regular or mega cassettes. The dehydration program can be adjusted to match different tissues type and size.
Equipment Milestone Logos (2019)
Embedding Stations
After the dehydration we have two embedding stations for self-service.
Equipment Kunz WD-4 (2018)
New equipment
We can scan any slide in the new Slide-scanner
Software is free
Olympus VS200 (2021)
Price dehydration
Dehydration: 15 SEK per paraffin block
Embedding: Free self-service. 400 SEK/hour if the Histo-core staff takes care of it.
If you do not have your own cassettes and pad’s you can buy them from us.
Price Slide-scanning (2021): Brightfield 40kr/slide, Fluorescence 60kr/slide
Equipment Rental
Microtome 50 SEK/hour - Equipment Microm HM360
Pressure- boiler 20 SEK/run, Equipment BIOCARE Decloaking Chamber Nx Gen
Users of our Dehydration service have priority and can use the microtome for free.
Training
Training is required for all first-time users at the cost of 400 SEK/hour and is limited to instructions on how to operate the equipment and software. Training does not include supervision in assay setup, assay preparation or staining. The fee includes the costs related to the first run. To schedule training contact us directly!
Booking and further information
Contact Mariette Lengquist mariette.lengquist@ki.se for booking, further information and introductions.