Mariette Lengquist

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CV
Public outreach and news

Articles

Article: VASCULAR PHARMACOLOGY. 2023;150:107167
Mast cells participate in smooth muscle cell reprogramming and atherosclerotic plaque calcification
Skenteris NT; Hemme E; Delfos L; Karadimou G; Karlof E; Lengquist M; Kronqvist M; Zhang X; Maegdefessel L; Schurgers LJ; Arnardottir H; Biessen EAL; Bot I; Matic L
Article: BIOMOLECULES. 2023;13(6):882
Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis
Chemaly M; Marlevi D; Iglesias M-J; Lengquist M; Kronqvist M; Bos D; van Dam-Nolen DHK; van der Kolk A; Hendrikse J; Kassem M; Matic L; Odeberg J; de Vries MR; Kooi ME; Hedin U
Article: ATHEROSCLEROSIS. 2023;371:41-53
Interleukin-6 trans-signaling induced laminin switch contributes to reduced trans-endothelial migration of granulocytic cells
Zegeye MM; Matic L; Lengquist M; Hayderi A; Grenegard M; Hedin U; Sirsjo A; Ljungberg LU; Kumawat AK
Article: COMPUTERS IN BIOLOGY AND MEDICINE. 2023;152:106364
In silico model of atherosclerosis with individual patient calibration to enable precision medicine for cardiovascular disease
Buckler AJ; Marlevi D; Skenteris NT; Lengquist M; Kronqvist M; Matic L; Hedin U
Article: JVS - VASCULAR SCIENCE. 2023;4:100111
Transcriptomic and physiological analyses reveal temporal changes contributing to the delayed healing response to arterial injury in diabetic rats.
Narayanan S; Röhl S; Lengquist M; Kronqvist M; Matic L; Razuvaev A
Article: ISCIENCE. 2022;25(5):104219
Clinical risk scores for stroke correlate with molecular signatures of vulnerability in symptomatic carotid patients
Waden K; Karlof E; Narayanan S; Lengquist M; Hansson GK; Hedin U; Roy J; Matic L
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2022;42(5):659-676
Plaque Evaluation by Ultrasound and Transcriptomics Reveals BCLAF1 as a Regulator of Smooth Muscle Cell Lipid Transdifferentiation in Atherosclerosis
Rykaczewska U; Zhao Q; Saliba-Gustafsson P; Lengquist M; Kronqvist M; Bergman O; Huang Z; Lund K; Waden K; Pons Vila Z; Caidahl K; Skogsberg J; Vukojevic V; Lindeman JHN; Roy J; Hansson GK; Treuter E; Leeper NJ; Eriksson P; Ehrenborg E; Razuvaev A; Hedin U; Matic L
Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(2):e682
Osteomodulin attenuates smooth muscle cell osteogenic transition in vascular calcification
Skenteris NT; Seime T; Witasp A; Karlof E; Wasilewski GB; Heuschkel MA; Jaminon AMG; Oduor L; Dzhanaev R; Kronqvist M; Lengquist M; Peeters FECM; Soderberg M; Hultgren R; Roy J; Maegdefessel L; Arnardottir H; Bengtsson E; Goncalves I; Quertermous T; Goettsch C; Stenvinkel P; Schurgers LJ; Matic L
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:988561
Therapeutic potential of the Proprotein Convertase Subtilisin/Kexin family in vascular disease
Suur BE; Chemaly M; Liljeqvist ML; Djordjevic D; Stenemo M; Bergman O; Karlof E; Lengquist M; Odeberg J; Hurt-Camejo E; Eriksson P; Ketelhuth DFJ; Roy J; Hedin U; Nyberg M; Matic L
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2021;62(5):716-726
Carotid Plaque Phenotyping by Correlating Plaque Morphology from Computed Tomography Angiography with Transcriptional Profiling
Karlof E; Buckler A; Liljeqvist ML; Lengquist M; Kronqvist M; Toonsi MA; Maegdefessel L; Matic LP; Hedin U
Article: CELLS. 2021;10(6):1276
Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification
Seime T; Akbulut AC; Liljeqvist ML; Siika A; Jin H; Winski G; van Gorp RH; Karlof E; Lengquist M; Buckler AJ; Kronqvist M; Waring OJ; Lindeman JHN; Biessen EAL; Maegdefessel L; Razuvaev A; Schurgers LJ; Hedin U; Matic L
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2021;41(5):1738-1750
Virtual Transcriptomics Noninvasive Phenotyping of Atherosclerosis by Decoding Plaque Biology From Computed Tomography Angiography Imaging
Buckler AJ; Karlof E; Lengquist M; Gasser TC; Maegdefessel L; Perisic Matic L; Hedin U
Article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2021;8:655869
AMPA-Type Glutamate Receptors Associated With Vascular Smooth Muscle Cell Subpopulations in Atherosclerosis and Vascular Injury
Gallina AL; Rykaczewska U; Wirka RC; Caravaca AS; Shavva VS; Youness M; Karadimou G; Lengquist M; Razuvaev A; Paulsson-Berne G; Quertermous T; Gistera A; Malin SG; Tarnawski L; Matic L; Olofsson PS
Article: ATHEROSCLEROSIS. 2020;314:1-9
A neutralizing antibody against DKK1 does not reduce plaque formation in classical murine models of atherosclerosis: Is the therapeutic potential lost in translation?
Rakipovski G; Rolin B; Barascuk N; Lund HE; Bonde MFB; Djordjevic D; Wulff-Larsen PG; Petersen M; Kirk RK; Hultman K; Manfe V; Blume N; Zahn S; Lengquist M; Maegdefessel L; Hovingh GK; Conde-Knape K; Hedin U; Matic L; Nyberg M
Article: CELLS. 2020;9(4):E1009-1009
Lack of PCSK6 Increases Flow-Mediated Outward Arterial Remodeling in Mice
Rohl S; Suur BE; Lengquist M; Seime T; Caidahl K; Hedin U; Arner A; Matic L; Razuvaev A
Article: CIRCULATION RESEARCH. 2020;126(5):571-585
PCSK6 Is a Key Protease in the Control of Smooth Muscle Cell Function in Vascular Remodeling
Rykaczewska U; Suur BE; Rohl S; Razuvaev A; Lengquist M; Sabater-Lleal M; van der Laan SW; Miller CL; Wirka RC; Kronqvist M; Diez MG; Vesterlund M; Gillgren P; Odeberg J; Lindeman JH; Veglia F; Humphries SE; de Faire U; Baldassarre D; Tremoli E; Lehtio J; Hansson GK; Paulsson-Berne G; Pasterkamp G; Quertermous T; Hamsten A; Eriksson P; Hedin U; Matic L
Article: JVS - VASCULAR SCIENCE. 2020;1:13-27
Transcriptomic profiling of experimental arterial injury reveals new mechanisms and temporal dynamics in vascular healing response.
Röhl S; Rykaczewska U; Seime T; Suur BE; Diez MG; Gådin JR; Gainullina A; Sergushichev AA; Wirka R; Lengquist M; Kronqvist M; Bergman O; Odeberg J; Lindeman JHN; Quertermous T; Hamsten A; Eriksson P; Hedin U; Razuvaev A; Matic LP
Article: ATHEROSCLEROSIS. 2020;292:215-223
Endothelin-1 increases expression and activity of arginase 2 via ETB receptors and is co-expressed with arginase 2 in human atherosclerotic plaques
Rafnsson A; Matic LP; Lengquist M; Mahdi A; Shemyakin A; Paulsson-Berne G; Hansson GK; Gabrielsen A; Hedin U; Yang J; Pernow J
Article: PLOS ONE. 2020;15(1):e0227889
Dipeptidyl peptidase-4 is increased in the abdominal aortic aneurysm vessel wall and is associated with aneurysm disease processes
Liljeqvist ML; Eriksson L; Villard C; Lengquist M; Kronqvist M; Hultgren R; Roy J
Article: THROMBOSIS AND HAEMOSTASIS. 2019;119(12):2014-2024
Early Inhibition of P-Selectin/P-Selectin Glycoprotein Ligand-1 Reduces Intimal Hyperplasia in Murine Vein Grafts through Platelet Adhesion
Tseng C-N; Chang Y-T; Yen C-Y; Lengquist M; Kronqvist M; Eriksson EE; Hedin U
Article: ATHEROSCLEROSIS. 2019;288:175-185
Correlation of computed tomography with carotid plaque transcriptomes associates calcification with lesion-stabilization.
Karlöf E; Seime T; Dias N; Lengquist M; Witasp A; Almqvist H; Kronqvist M; Gådin JR; Odeberg J; Maegdefessel L; Stenvinkel P; Matic LP; Hedin U
Article: JOURNAL OF ULTRASOUND IN MEDICINE. 2019;38(7):1723-1731
Noninvasive in vivo Assessment of the Re-endothelialization Process Using Ultrasound Biomicroscopy in the Rat Carotid Artery Balloon Injury Model
Rohl S; Eriksson L; Saxelin R; Lengquist M; Ostenson C-G; Hedin U; Caidahl K; Razuvaev A
Article: ATHEROSCLEROSIS. 2019;283:127-136
Dual roles of heparanase in human carotid plaque calcification
Aldi S; Eriksson L; Kronqvist M; Lengquist M; Lofling M; Folkersen L; Matic LP; Maegdefessel L; Grinnemo K-H; Li J-P; Osterholm C; Hedin U
Article: MOLECULAR THERAPY: METHODS & CLINICAL DEVELOPMENT. 2018;10:17-28
Integrated Human Evaluation of the Lysophosphatidic Acid Pathway as a Novel Therapeutic Target in Atherosclerosis
Aldi S; Matic LP; Hamm G; van Keulen D; Tempel D; Holmstrom K; Szwajda A; Nielsen BS; Emilsson V; Ait-Belkacem R; Lengquist M; Paulsson-Berne G; Eriksson P; Lindeman JHN; Gool AJ; Stauber J; Hedin U; Hurt-Camejo E
Article: JACC: BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):464-480
Novel Multiomics Profiling of Human Carotid Atherosclerotic Plaques and Plasma Reveals Biliverdin Reductase B as a Marker of Intraplaque Hemorrhage
Matic LP; Iglesias MJ; Vesterlund M; Lengquist M; Hong M-G; Saieed S; Sanchez-Rivera L; Berg M; Razuvaev A; Kronqvist M; Lund K; Caidahl K; Gillgren P; Ponten F; Uhlen M; Schwenk JM; Hansson GK; Paulsson-Berne G; Fagman E; Roy J; Hultgren R; Bergstrom G; Lehtio J; Odeberg J; Hedin U
Article: THROMBOSIS AND HAEMOSTASIS. 2018;118(2):329-339
Neutrophil Elastase-Derived Fibrin Degradation Products Indicate Presence of Abdominal Aortic Aneurysms and Correlate with Intraluminal Thrombus Volume
Liljeqvist ML; Silveira A; Hultgren R; Frebelius S; Lengquist M; Engstrom J; Gasser TC; Eriksson P; Roy J
Article: JOURNAL OF INTERNAL MEDICINE. 2017;282(5):429-444
Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke
Mahdessian H; Matic LP; Lengquist M; Gertow K; Sennblad B; Baldassarre D; Veglia F; Humphries SE; Rauramaa R; de Faire U; Smit AJ; Giral P; Kurl S; Mannarino E; Tremoli E; Hamsten A; Eriksson P; Hedin U; Malarstig A
Article: HISTOCHEMISTRY AND CELL BIOLOGY. 2017;148(4):425-433
Vessel wall morphology is equivalent for different artery types and localizations of advanced human aneurysms
Busch A; Grimm C; Hartmann E; Paloschi V; Kickuth R; Lengquist M; Otto C; Eriksson P; Kellersmann R; Lorenz U; Maegdefessel L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2017;127(4):1546-1560
Extracellular matrix proteomics identifies molecular signature of symptomatic carotid plaques
Langley SR; Willeit K; Didangelos A; Matic LP; Skroblin P; Barallobre-Barreiro J; Lengquist M; Rungger G; Kapustin A; Kedenko L; Molenaar C; Lu R; Barwari T; Suna G; Yin X; Iglseder B; Paulweber B; Willeit P; Shalhoub J; Pasterkamp G; Davies AH; Monaco C; Hedin U; Shanahan CM; Willeit J; Kiechl S; Mayr M
Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2017;69(2):101-109
Effects of Linagliptin on Vessel Wall Healing in the Rat Model of Arterial Injury Under Normal and Diabetic Conditions
Eriksson L; Rohl S; Saxelin R; Lengquist M; Kronqvist M; Caidahl K; Ostenson C-G; Razuvaev A
Article: MATURITAS. 2017;96:39-44
Differential expression of sex hormone receptors in abdominal aortic aneurysms
Villard C; Eriksson P; Kronqvist M; Lengquist M; Jorns C; Hartman J; Roy J; Hultgren R
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2016;36(9):1947-1961
Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM
Matic LP; Rykaczewska U; Razuvaev A; Sabater-Lleal M; Lengquist M; Miller CL; Ericsson I; Rohl S; Kronqvist M; Aldi S; Magne J; Paloschi V; Vesterlund M; Li Y; Jin H; Diez MG; Roy J; Baldassarre D; Veglia F; Humphries SE; de Faire U; Tremoli E; Odeberg J; Vukojevic V; Lehtio J; Maegdefessel L; Ehrenborg E; Paulsson-Berne G; Hansson GK; Lindeman JHN; Eriksson P; Quertermous T; Hamsten A; Hedin U
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2016;5(5):e003031
NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis
Varghese GP; Folkersen L; Strawbridge RJ; Halvorsen B; Yndestad A; Ranheim T; Krohg-Sorensen K; Skjelland M; Espevik T; Aukrust P; Lengquist M; Hedin U; Jansson J-H; Fransen K; Hansson GK; Eriksson P; Sirsjo A
Article: EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY. 2016;51(4):579-586
The Receptor for Advanced Glycation End Products (Rage) and Its Ligands in Plasma and Infrainguinal Bypass Vein
Malmstedt J; Frebelius S; Lengquist M; Jorneskog G; Wang J; Swedenborg J
Article: JOURNAL OF INTERNAL MEDICINE. 2016;279(3):293-308
Gene expression signatures, pathways and networks in carotid atherosclerosis
Perisic L; Aldi S; Sun Y; Folkersen L; Razuvaev A; Roy J; Lengquist M; Akesson S; Wheelock CE; Maegdefessel L; Gabrielsen A; Odeberg J; Hansson GK; Paulsson-Berne G; Hedin U
Article: CARDIOVASCULAR RESEARCH (CVR). 2015;107(1):20-31
Perlecan heparan sulfate deficiency impairs pulmonary vascular development and attenuates hypoxic pulmonary hypertension
Chang Y-T; Tseng C-N; Tannenberg P; Eriksson L; Yuan K; Perez VADJ; Lundberg J; Lengquist M; Botusan IR; Catrina S-B; Tran P-K; Hedin U; Tran-Lundmark K
Article: THROMBOSIS AND HAEMOSTASIS. 2015;113(4):813-825
Platelet adhesion on endothelium early after vein grafting mediates leukocyte recruitment and intimal hyperplasia in a murine model
Tseng C-N; Chang Y-T; Lengquist M; Kronqvist M; Hedin U; Eriksson EE
Article: PLOS ONE. 2014;9(6):e98904
Contribution of Endothelial Injury and Inflammation in Early Phase to Vein Graft Failure: The Causal Factors Impact on the Development of Intimal Hyperplasia in Murine Models
Tseng C-N; Karlof E; Chang Y-T; Lengquist M; Rotzius P; Berggren P-O; Hedin U; Eriksson EE
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2013;33(10):2432-2443
Profiling of Atherosclerotic Lesions by Gene and Tissue Microarrays Reveals PCSK6 as a Novel Protease in Unstable Carotid Atherosclerosis
Perisic L; Hedin E; Razuvaev A; Lengquist M; Osterholm C; Folkersen L; Gillgren P; Paulsson-Berne G; Ponten F; Odeberg J; Hedin U
Article: ATHEROSCLEROSIS. 2013;226(1):67-73
Increased expression of heparanase in symptomatic carotid atherosclerosis
Osterholm C; Folkersen L; Lengquist M; Ponten F; Renne T; Li JP; Hedin U
Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2012;302(11):L1159-L1166
Antenatal imatinib treatment reduces pulmonary vascular remodeling in a rat model of congenital diaphragmatic hernia
Chang Y-T; Uggla AR; Osterholm C; Phan-Kiet T; Eklof A-C; Lengquist M; Hedin U; Tran-Lundmark K; Frenckner B
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Employments

Laboratory Manager, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2015-

Degrees and Education

Degree Of Bachelor Of Medical Science, Karolinska Institutet, 2009
Degree Of Bachelor Of Science In Nursing, Karolinska Institutet, 2009

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