Department of Cell and Molecular Biology
The Department of Cell and Molecular Biology at Karolinska Institutet is a nationally leading academic research center of high international standard where science comes first and foremost. CMB researchers publish regularly in the best international science journals, a result of a long-term in-house culture that promotes real impact and key breakthroughs.
CMB News
KI collaboration awarded ERC Synergy Grant of almost SEK 100 million
KI collaboration awarded ERC Synergy Grant of almost SEK 100 million
Professor András Simon of the Department of Cell and Molecular Biology (CMB) and two fellow researchers in Canada and Switzerland have been awarded a grant of almost SEK 100 million by the European Research Council. The aim of the project, which goes under the acronym Salamandra, is to understand how locomotor functions can be restored after damage to the nervous system.
New artical in Nature Communications
New artical in Nature Communications
Jonas Muhr's lab are now provide evidence for a novel mechanism by which the cell-cycle regulators Cyclin-B1/2 and Cyclin-D1 act in opposition to coordinate self-renewal and lineage commitment of cortical stem cells.
Mapping cell types by single cell sequencing in a Parkinson’s disease cell therapy model
Mapping cell types by single cell sequencing in a Parkinson’s disease cell therapy model
Many severe symptoms in Parkinson’s disease are caused by the degeneration of the brain’s dopamine neurons. Transplantation of stem cell-derived dopamine neurons to patients with Parkinson’s disease is a therapeutic approach that is getting close to clinical application. The strategy uses pluripotent stem cells that are cultured under conditions that will induce them to differentiate into dopamine neuron precursor cells. These precursor cells can then be transplanted into the brains of Parkinson’s disease patients.
High-resolution mapping of cell types with improved single-cell sequencing
High-resolution mapping of cell types with improved single-cell sequencing
Single-cell RNA sequencing (scRNA-seq) has revolutionized the ability to characterize cell types and their gene expression programs in organisms and tissues. Although great improvements in cellular throughput have been made, methods generally suffer from low sensitivity and quantification that is limited to short RNA pieces. Now, researchers at Karolinska Institutet have released Smart-seq3 that greatly improves the quality in scRNA-seq. The study is published in Nature Biotechnology.
Bored at work? Fat chance
Bored at work? Fat chance
Who cares about the fate of an annoying fat cell? Kirsty Spalding, PI at KI's Department of Cell and Molecular Biology, has taken on the task with a great deal of energy and a genuine thirst for knowledge.