Department of Cell and Molecular Biology

The Department of Cell and Molecular Biology at Karolinska Institutet is a nationally leading academic research center of high international standard where science comes first and foremost. CMB researchers publish regularly in the best international science journals, a result of a long-term in-house culture that promotes real impact and key breakthroughs.

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Capturing the onset of stem cell differentiation in the skin

Capturing the onset of stem cell differentiation in the skin

Researchers at Karolinska Institutet and at Yale University in USA have uncovered how stem cells behave in real-time while adapting their gene expression for differentiation. The study is published in the scientific journal Nature Cell Biology.

Skin is essential for protecting our body from outside harm, such as injury, microbes, and radiation. This protective skin function is maintained by the tireless effort of resident stem cells to self-renew (remain stem cells) and differentiate (produce specialized cells) throughout our lifetime.

Epigenetic control of transcriptional stability maintains identity and function in dopaminergic and serotonergic neurons

Epigenetic control of transcriptional stability maintains identity and function in dopaminergic and serotonergic neurons

New study from researchers from the Department of Cell and Molecular Biology published in Science Advances show that inactivation of a protein complex that controls gene repression leads to loss of neuronal identity of dopamine-producing cells and to motor symptoms typical of Parkinson's disease.

In vivo drug discovery for increasing incretin-expressing cells in diabetes

In vivo drug discovery for increasing incretin-expressing cells in diabetes

A new study published in Cell Chemical Biology describes an alternative approach to treat diabetes by identifying drugs directly increasing the number of incretin-expressing cells. The work results from researchers at the Department of Cell and Molecular Biology.

There is an alternative strategy to regenerate the heart muscle

There is an alternative strategy to regenerate the heart muscle

Heart progenitors spontaneously regenerate cardiac muscle via a tight junction “honeycomb” in salamanders.

Whether there are endogenous adult heart progenitors that can replenish damaged muscle cells remained controversial. Now researchers at Karolinska Institute in Sweden show that the outermost layer of the heart, called epicardium acts as a source of cardiac muscle cells through formation of an intriguing honeycomb-like structure.

The study, published in Nature Cell Biology, identifies a new paradigm for heart regeneration by studying a salamander model for heart regeneration and reports an important role for tight junctions in the process.

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