Department of Cell and Molecular Biology
The Department of Cell and Molecular Biology at Karolinska Institutet is a nationally leading academic research center of high international standard where science comes first and foremost. CMB researchers publish regularly in the best international science journals, a result of a long-term in-house culture that promotes real impact and key breakthroughs.
CMB News
New small antibodies show promising effects against COVID-19 infection
New small antibodies show promising effects against COVID-19 infection
Researchers at Karolinska Institutet have developed, in collaboration with researchers in Germany and the U.S., new small antibodies, also known as nanobodies, which prevent the SARS-CoV-2 coronavirus from entering human cells. The research study, published in Science, shows that a combined nanobody had a particularly good effect – even if the virus mutated. According to the researchers, the nanobodies have the potential to be developed into a treatment for COVID-19.
New core facility offers world class imaging technique
New core facility offers world class imaging technique
In the basement of Wargentin House on Solna campus there are several cryo-electron microscopes of the latest models, that can be used by both KI researchers and external customers. Read an interview with Martin Hällberg, director of the new 3D-EM facility.
KI collaboration awarded ERC Synergy Grant of almost SEK 100 million
KI collaboration awarded ERC Synergy Grant of almost SEK 100 million
Professor András Simon of the Department of Cell and Molecular Biology (CMB) and two fellow researchers in Canada and Switzerland have been awarded a grant of almost SEK 100 million by the European Research Council. The aim of the project, which goes under the acronym Salamandra, is to understand how locomotor functions can be restored after damage to the nervous system.
New article in Nature Communications
New article in Nature Communications
Jonas Muhr's lab are now provide evidence for a novel mechanism by which the cell-cycle regulators Cyclin-B1/2 and Cyclin-D1 act in opposition to coordinate self-renewal and lineage commitment of cortical stem cells.
Mapping cell types by single cell sequencing in a Parkinson’s disease cell therapy model
Mapping cell types by single cell sequencing in a Parkinson’s disease cell therapy model
Many severe symptoms in Parkinson’s disease are caused by the degeneration of the brain’s dopamine neurons. Transplantation of stem cell-derived dopamine neurons to patients with Parkinson’s disease is a therapeutic approach that is getting close to clinical application. The strategy uses pluripotent stem cells that are cultured under conditions that will induce them to differentiate into dopamine neuron precursor cells. These precursor cells can then be transplanted into the brains of Parkinson’s disease patients.