Department of Cell and Molecular Biology
The Department of Cell and Molecular Biology at Karolinska Institutet is a nationally leading academic research center of high international standard where science comes first and foremost. CMB researchers publish regularly in the best international science journals, a result of a long-term in-house culture that promotes real impact and key breakthroughs.
CMB News
Mapping cell types by single cell sequencing in a Parkinson’s disease cell therapy model
Mapping cell types by single cell sequencing in a Parkinson’s disease cell therapy model
Many severe symptoms in Parkinson’s disease are caused by the degeneration of the brain’s dopamine neurons. Transplantation of stem cell-derived dopamine neurons to patients with Parkinson’s disease is a therapeutic approach that is getting close to clinical application. The strategy uses pluripotent stem cells that are cultured under conditions that will induce them to differentiate into dopamine neuron precursor cells. These precursor cells can then be transplanted into the brains of Parkinson’s disease patients.
High-resolution mapping of cell types with improved single-cell sequencing
High-resolution mapping of cell types with improved single-cell sequencing
Single-cell RNA sequencing (scRNA-seq) has revolutionized the ability to characterize cell types and their gene expression programs in organisms and tissues. Although great improvements in cellular throughput have been made, methods generally suffer from low sensitivity and quantification that is limited to short RNA pieces. Now, researchers at Karolinska Institutet have released Smart-seq3 that greatly improves the quality in scRNA-seq. The study is published in Nature Biotechnology.
Bored at work? Fat chance
Bored at work? Fat chance
Who cares about the fate of an annoying fat cell? Kirsty Spalding, PI at KI's Department of Cell and Molecular Biology, has taken on the task with a great deal of energy and a genuine thirst for knowledge.
Sten Eirik Waelgaard Jacobsen new member of The Royal Swedish Academy of Sciences
Sten Eirik Waelgaard Jacobsen new member of The Royal Swedish Academy of Sciences
Sten Eirik Waelgaard Jacobsen, professor at the Department of Medicine Huddinge and the Department of Cell and Molecular Biology is a new member of The Royal Swedish Academy of Sciences.
Maria Genander have been awarded the ERC Starting Grant
Maria Genander have been awarded the ERC Starting Grant
Three researchers at Karolinska Institutet have been awarded the ERC Starting Grant 2019: Jenny Mjösberg, Maria Genander, and newly recruited Pia Dosenovic. Their projects concern inflammatory bowel disease, esophageal cancers, and HIV vaccine, respectively. In all, the ERC will support 408 early-career researchers from around the world with its prestigious starting grant this year.
András Simon appointed Head of Department at CMB
András Simon appointed Head of Department at CMB
The appointment is for a five year period and was signed by the KI Vice President Karin Dahlman-Wright starting June 1, 2019. Professor András Simon has been Acting Head of Department since January 1, 2019 succeeding Christer Höög.