Leo Hanke

Publications
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):6338
Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques
Mandolesi M; Das H; de Vries L; Yang Y; Kim C; Dhinakaran M; Castro Dopico X; Fischbach J; Kim S; Guryleva MV; Adori M; Chernyshev M; Stalmarck A; Hanke L; Mcinerney GM; Sheward DJ; Corcoran M; Haellberg BM; Murrell B; Karlsson Hedestam GB
Article: CELL REPORTS MEDICINE. 2024;5(6):101577
Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies
Sheward DJ; Pushparaj P; Das H; Greaney AJ; Kim C; Kim S; Hanke L; Hyllner E; Dyrdak R; Lee J; Dopico XC; Dosenovic P; Peacock TP; McInerney GM; Albert J; Corcoran M; Bloom JD; Murrell B; Hedestam GBK; Hallberg BM
Article: NATURE BIOTECHNOLOGY. 2024;42(4):587-590
High-throughput measurement of the content and properties of nano-sized bioparticles with single-particle profiler
Sych T; Schlegel J; Barriga HMG; Ojansivu M; Hanke L; Weber F; Bostancioglu RB; Ezzat K; Stangl H; Plochberger B; Laurencikiene J; El Andaloussi S; Fuerth D; Stevens MM; Sezgin E
Article: JCI INSIGHT. 2023;8(17):e167656
Antigen receptor stimulation induces purifying selection against pathogenic mitochondrial tRNA mutations
Zhang J; Koolmeister C; Han J; Filograna R; Hanke L; Adori M; Sheward DJ; Teifel S; Gopalakrishna S; Shao Q; Liu Y; Zhu K; Harris RA; Mcinerney G; Murrell B; Aoun M; Baeckdahl L; Holmdahl R; Pekalski M; Wedell A; Engvall M; Wredenberg A; Hedestam GBK; Dopico XC; Rorbach J
Article: NANO LETTERS. 2023;23(9):3701-3707
A Multiparametric and High-Throughput Platform for Host-Virus Binding Screens
Schlegel J; Porebski B; Andronico L; Hanke L; Edwards S; Brismar H; Murrell B; McInerney GM; Fernandez-Capetillo O; Sezgin E
Article: OPEN BIOLOGY. 2023;13(5):220369
Caprin-1 binding to the critical stress granule protein G3BP1 is influenced by pH
Schulte T; Panas MD; Han X; Williams L; Kedersha N; Fleck JS; Tan TJC; Dopico XC; Olsson A; Morro AM; Hanke L; Nilvebrant J; Giang KA; Nygren P-A; Anderson P; Achour A; McInerney GM
Article: EUROSURVEILLANCE. 2023;28(13):2200432
At-home sampling to meet geographical challenges for serological assessment of SARS-CoV-2 exposure in a rural region of northern Sweden, March to May 2021: a retrospective cohort study
Bystrom JW; Vikstrom L; Rosendal E; Groning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Hedestam GBK; Thunberg T; Monsen T; Elgh F; Evander M; Johansson AF; Overby AK; Ahim C; Normark J; Forsell MNE
Article: IMMUNITY. 2023;56(1):193-206.e7
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
Pushparaj P; Nicoletto A; Sheward DJ; Das H; Dopico XC; Vidakovics LP; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekstrom S; McInerney G; Hallberg BM; Murrell B; Corcoran M; Hedestam GBK
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:941281
SARS-CoV-2 spike HexaPro formulated in aluminium hydroxide and administered in an accelerated vaccination schedule partially protects Syrian Hamsters against viral challenge despite low neutralizing antibody responses
Christensen D; Polacek C; Sheward DJ; Hanke L; McInerney G; Murrell B; Hartmann KT; Jensen HE; Zimmermann J; Jungersen G; Illigen KE; Isling LK; Fernandez-Antunez C; Ramirez S; Bukh J; Pedersen GK
Article: EBIOMEDICINE. 2022;84:104248
Protection against SARS-CoV-2 transmission by a parenteral prime-Intranasal boost vaccine strategy
Christensen D; Polacek C; Sheward DJ; Hanke L; Moliner-Morro A; McInerney G; Murrell B; Hartmann KT; Jensen HE; Jungersen G; Illigen K; Isling LK; Jensen RF; Hansen JS; Rosenkrands I; Fernandez-Antunez C; Ramirez S; Follmann F; Bukh J; Pedersen GK
Article: SCIENCE ADVANCES. 2022;8(12):eabm0220
Multivariate mining of an alpaca immune repertoire identifies potent cross-neutralizing SARS-CoV-2 nanobodies
Hanke L; Sheward DJ; Pankow A; Vidakovics LP; Karl V; Kim C; Urgard E; Smith NL; Astorga-Wells J; Ekstrom S; Coquet JM; McInerney GM; Murrell B
Article: NATURE COMMUNICATIONS. 2022;13(1):155
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM
Article: FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 2022;10:1083232
Silver nanoparticles with excellent biocompatibility block pseudotyped SARS-CoV-2 in the presence of lung surfactant
Gupta G; Hamawandi B; Sheward DJ; Murrell B; Hanke L; McInerney G; Blosi M; Costa AL; Toprak MS; Fadeel B
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2022;11(3):e1379
Probabilistic classification of anti-SARS-CoV-2 antibody responses improves seroprevalence estimates
Dopico XC; Muschiol S; Grinberg NF; Aleman S; Sheward DJ; Hanke L; Ahl M; Vikstrom L; Forsell M; Coquet JM; McInerney G; Dillner J; Bogdanovic G; Murrell B; Albert J; Wallace C; Hedestam GBK
Article: CELL REPORTS MEDICINE. 2021;2(11):100450
Beta RBD boost broadens antibody-mediated protection against SARS-CoV-2 variants in animal models
Sheward DJ; Mandolesi M; Urgard E; Kim C; Hanke L; Vidakovics LP; Pankow A; Smith NL; Dopico XC; McInerney GM; Coquet JM; Hedestam GBK; Murrell B
Article: JOURNAL OF INTERNAL MEDICINE. 2021;290(3):666-676
Seropositivity in blood donors and pregnant women during the first year of SARS-CoV-2 transmission in Stockholm, Sweden
Castro Dopico X; Muschiol S; Christian M; Hanke L; Sheward DJ; Grinberg NF; Rorbach J; Bogdanovic G; Mcinerney GM; Allander T; Wallace C; Murrell B; Albert J; Karlsson Hedestam GB
Article: NATURE COMMUNICATIONS. 2021;12(1):3695
Multianalyte serology in home-sampled blood enables an unbiased assessment of the immune response against SARS-CoV-2
Roxhed N; Bendes A; Dale M; Mattsson C; Hanke L; Dodig-Crnkovic T; Christian M; Meineke B; Elsasser S; Andrell J; Havervall S; Thalin C; Eklund C; Dillner J; Beck O; Thomas CE; McInerney G; Hong M-G; Murrell B; Fredolini C; Schwenk JM
Article: CELL REPORTS MEDICINE. 2021;2(4):100252
SARS-CoV-2 protein subunit vaccination of mice and rhesus macaques elicits potent and durable neutralizing antibody responses
Mandolesi M; Sheward DJ; Hanke L; Ma J; Pushparaj P; Vidakovics LP; Kim C; Adori M; Lenart K; Lore K; Dopico XC; Coquet JM; McInerney GM; Hedestam GBK; Murrell B
Article: SCIENCE. 2021;371(6530):eabe6230
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
Koenig P-A; Das H; Liu H; Kuemmerer BM; Gohr FN; Jenster L-M; Schiffelers LDJ; Tesfamariam YM; Uchima M; Wuerth JD; Gatterdam K; Ruetalo N; Christensen MH; Fandrey CI; Normann S; Toedtmann JMP; Pritzl S; Hanke L; Boos J; Yuan M; Zhu X; Schmid-Burgk JL; Kato H; Schindler M; Wilson IA; Geyer M; Ludwig KU; Hallberg BM; Wu NC; Schmidt FI
Article: SCIENTIFIC REPORTS. 2021;11(1):3125
DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice
Szurgot I; Hanke L; Sheward DJ; Vidakovics LP; Murrell B; McInerney GM; Liljestrom P
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(7):e1312
Systematic evaluation of SARS-CoV-2 antigens enables a highly specific and sensitive multiplex serological COVID-19 assay
Hober S; Hellstrom C; Olofsson J; Andersson E; Bergstrom S; Jernbom Falk A; Bayati S; Mravinacova S; Sjoberg R; Yousef J; Skoglund L; Kanje S; Berling A; Svensson A-S; Jensen G; Enstedt H; Afshari D; Xu LL; Zwahlen M; von Feilitzen K; Hanke L; Murrell B; McInerney G; Karlsson Hedestam GB; Lendel C; Roth RG; Skoog I; Svenungsson E; Olsson T; Fogdell-Hahn A; Lindroth Y; Lundgren M; Maleki KT; Lagerqvist N; Klingstrom J; Da Silva Rodrigues R; Muschiol S; Bogdanovic G; Arroyo Muhr LS; Eklund C; Lagheden C; Dillner J; Sivertsson A; Havervall S; Thalin C; Tegel H; Pin E; Manberg A; Hedhammar M; Nilsson P
Article: EBIOMEDICINE. 2021;63:103197
Adjuvanted SARS-CoV-2 spike protein elicits neutralizing antibodies and CD4 T cell responses after a single immunization in mice
Worzner K; Sheward DJ; Schmidt ST; Hanke L; Zimmermann J; McInerney G; Hedestam GBK; Murrell B; Christensen D; Pedersen GK
Article: BIOMOLECULES. 2020;10(12):E1661-1661
Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs
Moliner-Morro A; J. Sheward D; Karl V; Perez Vidakovics L; Murrell B; McInerney GM; Hanke L
Article: NATURE COMMUNICATIONS. 2020;11(1):5588
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
Custodio TF; Das H; Sheward DJ; Hanke L; Pazicky S; Pieprzyk J; Sorgenfrei M; Schroer MA; Gruzinov AY; Jeffries CM; Graewert MA; Svergun DI; Dobrev N; Remans K; Seeger MA; McInerney GM; Murrell B; Haellberg BM; Loew C
Article: NATURE COMMUNICATIONS. 2020;11(1):5064
SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden
Rudberg A-S; Havervall S; Manberg A; Jernbom Falk A; Aguilera K; Ng H; Gabrielsson L; Salomonsson A-C; Hanke L; Murrell B; McInerney G; Olofsson J; Andersson E; Hellstrom C; Bayati S; Bergstrom S; Pin E; Sjoberg R; Tegel H; Hedhammar M; Phillipson M; Nilsson P; Hober S; Thalin C
Article: NATURE COMMUNICATIONS. 2020;11(1):4420
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
Hanke L; Perez LV; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GBK; Haellberg BM; Murrell B; McInerney GM
Article: EMBO REPORTS. 2017;18(6):1027-1037
Vesicular stomatitis virus N protein-specific single-domain antibody fragments inhibit replication
Hanke L; Schmidt FI; Knockenhauer KE; Morin B; Whelan SPJ; Schwartz TU; Ploegh HL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(2):E152-E160
Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response
Truttmann MC; Zheng X; Hanke L; Damon JR; Grootveld M; Krakowiak J; Pincus D; Ploegh HL
Article: JOURNAL OF IMMUNOLOGY. 2016;197(12):4838-4847
Generation of Immunity against Pathogens via Single-Domain Antibody-Antigen Constructs
Duarte JN; Cragnolini JJ; Swee LK; Bilate AM; Bader J; Ingram JR; Rashidfarrokhi A; Fang T; Schiepers A; Hanke L; Ploegh HL
Article: MBIO. 2016;7(6):e01569-e01516
The Antiviral Mechanism of an Influenza A Virus Nucleoprotein-Specific Single-Domain Antibody Fragment
Hanke L; Knockenhauer KE; Brewer RC; van Diest E; Schmidt FI; Schwartz TU; Ploegh HL
Article: NATURE MICROBIOLOGY. 2016;1(8):16080
Phenotypic lentivirus screens to identify functional single domain antibodies
Schmidt FI; Hanke L; Morin B; Brewer R; Brusic V; Whelan SPJ; Ploegh HL
Article: JOURNAL OF VIROLOGY. 2015;89(5):2792-2800
Intracellular Expression of Camelid Single-Domain Antibodies Specific for Influenza Virus Nucleoprotein Uncovers Distinct Features of Its Nuclear Localization
Ashour J; Schmidt FI; Hanke L; Cragnolini J; Cavallari M; Altenburg A; Brewer R; Ingram J; Shoemaker C; Ploegh HL
Show more

All other publications

Review: JOURNAL OF GENERAL VIROLOGY. 2022;103(5)
Nanobodies in the limelight: Multifunctional tools in the fight against viruses
Moliner-Morro A; McInerney GM; Hanke L
Preprint: MEDRXIV. 2022;MEDRXIV
Serological assessment of SARS-CoV-2 exposure in northern Sweden by the use of at-home sampling to meet geographical challenges in rural regions.
Byström JW; Vikström L; Rosendal E; Gröning R; Gwon Y-D; Nilsson E; Sharma A; Espaillat A; Hanke L; McInerney G; Puhar A; Cava F; Karlsson Hedestam GB; Thunberg T; Monsen T; Elgh F; Evander M; Johansson A; Överby AK; Ahlm C; Normark J; Forsell MN

Articles

All other publications

News from KI

Events from KI