Structural basis of RNA biogenesis – Martin Hällberg's research group

The Hällberg group investigates molecular mechanisms of mitochondrial and viral gene expression. For mitochondrial gene expression we are working on the aspects of early RNA processing, mitoribosome biogenesis and genome segregation. For viral replication we are primarily interested in the Herpesviral replication machinery as a target for better antiviral therapies.

During the Covid-19 pandemic the group has collaborated to help develop therapeutic interventions towards active viral infection, primarily using nanobodies against the SARS-CoV-2 spike protein.

We are using an integrative structural cell biology approach using a combination of cryoelectron tomography, single-particle cryo-electron microscopy, cryoconfocal microscopy, biochemistry, X-ray crystallography and small-angle-X-ray scattering.

Publications

Selected publications