Martin Hällberg

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Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):6338
Multi-compartmental diversification of neutralizing antibody lineages dissected in SARS-CoV-2 spike-immunized macaques
Mandolesi M; Das H; de Vries L; Yang Y; Kim C; Dhinakaran M; Castro Dopico X; Fischbach J; Kim S; Guryleva MV; Adori M; Chernyshev M; Stalmarck A; Hanke L; Mcinerney GM; Sheward DJ; Corcoran M; Haellberg BM; Murrell B; Karlsson Hedestam GB
Journal article: NUCLEIC ACIDS RESEARCH (NAR). 2024;52(12):7292-7304
Dynamics of the Herpes simplex virus DNA polymerase holoenzyme during DNA synthesis and proof-reading revealed by Cryo-EM
Gustavsson E; Gruenewald K; Elias P; Haellberg BM
Article: NATURE COMMUNICATIONS. 2024;15(1):5664
GTPBP8 plays a role in mitoribosome formation in human mitochondria
Cipullo M; Gese GV; Gopalakrishna S; Krueger A; Lobo V; Pirozhkova MA; Marks J; Palenikova P; Shiriaev D; Liu Y; Misic J; Cai Y; Nguyen MD; Abdelbagi A; Li X; Minczuk M; Hafner M; Benhalevy D; Sarshad AA; Atanassov I; Hallberg BM; Rorbach J
Article: CELL REPORTS MEDICINE. 2024;5(6):101577
Structural basis of broad SARS-CoV-2 cross-neutralization by affinity-matured public antibodies
Sheward DJ; Pushparaj P; Das H; Greaney AJ; Kim C; Kim S; Hanke L; Hyllner E; Dyrdak R; Lee J; Dopico XC; Dosenovic P; Peacock TP; McInerney GM; Albert J; Corcoran M; Bloom JD; Murrell B; Hedestam GBK; Hallberg BM
Article: JOURNAL OF MOLECULAR BIOLOGY. 2024;436(9):168547
Structural and Functional Characterization of a Gene Cluster Responsible for Deglycosylation of C-glucosyl Flavonoids and Xanthonoids by Deinococcus aerius
Furlanetto V; Kalyani DC; Kostelac A; Puc J; Haltrich D; Hallberg BM; Divne C
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2023;145(19):10659-10668
Mass Spectrometry of RNA-Binding Proteins during Liquid-Liquid Phase Separation Reveals Distinct Assembly Mechanisms and Droplet Architectures
Sahin C; Motso A; Gu X; Feyrer H; Lama D; Arndt T; Rising A; Gese GV; Haellberg BM; Marklund EG; Schafer NP; Petzold K; Teilum K; Wolynes PG; Landreh M
Article: PNAS NEXUS. 2023;2(2):pgac303
A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1
Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmae M; Chen G; Elofsson A; Allison TM; Arsenian-Henriksson M; Johansson J; Lane DP; Hallberg BM; Landreh M
Article: IMMUNITY. 2023;56(1):193-206.e7
Immunoglobulin germline gene polymorphisms influence the function of SARS-CoV-2 neutralizing antibodies
Pushparaj P; Nicoletto A; Sheward DJ; Das H; Dopico XC; Vidakovics LP; Hanke L; Chernyshev M; Narang S; Kim S; Fischbach J; Ekstrom S; McInerney G; Hallberg BM; Murrell B; Corcoran M; Hedestam GBK
Article: CELL. 2022;185(13):2309-2323.e24
Non-coding 7S RNA inhibits transcription via mitochondrial RNA polymerase dimerization
Zhu X; Xie X; Das H; Tan BG; Shi Y; Al-Behadili A; Peter B; Motori E; Valenzuela S; Posse V; Gustafsson CM; Haellberg BM; Falkenberg M
Article: NATURE COMMUNICATIONS. 2022;13(1):155
A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo
Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM
Article: NATURE COMMUNICATIONS. 2021;12(1):3673
Structural basis for late maturation steps of the human mitoribosomal large subunit
Cipullo M; Gese GV; Khawaja A; Haellberg BM; Rorbach J
Article: SCIENCE. 2021;371(6530):eabe6230
Structure-guided multivalent nanobodies block SARS-CoV-2 infection and suppress mutational escape
Koenig P-A; Das H; Liu H; Kuemmerer BM; Gohr FN; Jenster L-M; Schiffelers LDJ; Tesfamariam YM; Uchima M; Wuerth JD; Gatterdam K; Ruetalo N; Christensen MH; Fandrey CI; Normann S; Toedtmann JMP; Pritzl S; Hanke L; Boos J; Yuan M; Zhu X; Schmid-Burgk JL; Kato H; Schindler M; Wilson IA; Geyer M; Ludwig KU; Hallberg BM; Wu NC; Schmidt FI
Article: GENETICS. 2020;216(4):1009-1022
Post-translational Regulation of DNA Polymerase η, a Connection to Damage-Induced Cohesion in Saccharomyces cerevisiae
Wu P-S; Enervald E; Joelsson A; Palmberg C; Rutishauser D; Hallberg BM; Strom L
Article: NATURE COMMUNICATIONS. 2020;11(1):5588
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
Custodio TF; Das H; Sheward DJ; Hanke L; Pazicky S; Pieprzyk J; Sorgenfrei M; Schroer MA; Gruzinov AY; Jeffries CM; Graewert MA; Svergun DI; Dobrev N; Remans K; Seeger MA; McInerney GM; Murrell B; Haellberg BM; Loew C
Article: NATURE COMMUNICATIONS. 2020;11(1):4420
An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction
Hanke L; Perez LV; Sheward DJ; Das H; Schulte T; Moliner-Morro A; Corcoran M; Achour A; Hedestam GBK; Haellberg BM; Murrell B; McInerney GM
Article: NUCLEIC ACIDS RESEARCH (NAR). 2017;45(21):12469-12480
The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria
Reinhard L; Sridhara S; Haellberg BM
Article: SCIENTIFIC REPORTS. 2017;7:46370
SnoN Stabilizes the SMAD3/SMAD4 Protein Complex
Wallden K; Nyman T; Hallberg BM
Article: NUCLEIC ACIDS RESEARCH (NAR). 2015;43(18):9065-9075
Structure of mitochondrial poly(A) RNA polymerase reveals the structural basis for dimerization, ATP selectivity and the SPAX4 disease phenotype
Lapkouski M; Haellberg BM
Article: NATURE COMMUNICATIONS. 2015;6:7542
Structural basis for cellobiose dehydrogenase action during oxidative cellulose degradation
Tan T-C; Kracher D; Gandini R; Sygmund C; Kittl R; Haltrich D; Hallberg BM; Ludwig R; Divne C
Article: NUCLEIC ACIDS RESEARCH (NAR). 2015;43(11):5664-5672
Structure of the nuclease subunit of human mitochondrial RNase P
Reinhard L; Sridhara S; Haellberg BM
Article: NUCLEIC ACIDS RESEARCH (NAR). 2015;43(5):2615-2624
TEFM is a potent stimulator of mitochondrial transcription elongation in vitro
Posse V; Shahzad S; Falkenberg M; Hallberg BM; Gustafsson CM
Article: NUCLEIC ACIDS RESEARCH (NAR). 2014;42(6):3638-3647
The amino terminal extension of mammalian mitochondrial RNA polymerase ensures promoter specific transcription initiation
Posse V; Hoberg E; Dierckx A; Shahzad S; Koolmeister C; Larsson N-G; Wilhelmsson LM; Hallberg BM; Gustafsson CM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(38):15253-15258
Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis
Spahr H; Habermann B; Gustafsson CM; Larsson N-G; Hallberg BM
Article: CELL METABOLISM. 2011;13(5):527-539
MTERF4 Regulates Translation by Targeting the Methyltransferase NSUN4 to the Mammalian Mitochondrial Ribosome
Camara Y; Asin-Cayuela J; Park CB; Metodiev MB; Shi Y; Ruzzenente B; Kukat C; Habermann B; Wibom R; Hultenby K; Franz T; Erdjument-Bromage H; Tempst P; Hallberg BM; Gustafsson CM; Larsson N-G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(6):4511-4516
Structural Basis of Tumor Suppressor in Lung Cancer 1 (TSLC1) Binding to Differentially Expressed in Adenocarcinoma of the Lung (DAL-1/4.1B)
Busam RD; Thorsell A-G; Flores A; Hammarstrom M; Persson C; Obrink B; Hallberg BM
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;397(3):386-390
Structure of mitochondrial transcription termination factor 3 reveals a novel nucleic acid-binding domain
Spahr H; Samuelsson T; Hallberg BM; Gustafsson CM
Article: PROTEINS: STRUCTURE, FUNCTION AND BIOINFORMATICS. 2009;77(1):242-246
Crystal structure of human diphosphoinositol phosphatase 1
Thorsell A-G; Persson C; Graslund S; Hammarstrom M; Busam RD; Hallberg BM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(11):6600-6604
RNA-Protein Mutually Induced Fit STRUCTURE OF ESCHERICHIA COLI ISOPENTENYL-tRNA TRANSFERASE IN COMPLEX WITH tRNA(Phe)
Seif E; Hallberg BM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(22):15209-15216
Structural and biophysical characterization of human myo-inositol oxygenase
Thorsell A-G; Persson C; Voevodskaya N; Busam RD; Hammarstrom M; Graslund S; Graslund A; Hallberg BM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(27):19644-19652
Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site
Bakali HMA; Herman MD; Johnson KA; Kelly AA; Wieslander A; Hallberg BM; Nordlund P
Article: JOURNAL OF MOLECULAR BIOLOGY. 2007;369(4):1079-1086
Crystal structure of the major Malassezia sympodialis allergen mala s 1 reveals a β-propeller fold:: A novel fold among allergens
Vilhelmsson M; Zargari A; Crameri R; Rasool O; Achour A; Scheynius A; Hallberg BM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(46):35104-35115
Structural basis for substrate binding and regioselective oxidation of monosaccharides at C3 by pyranose 2-oxidase
Kujawa M; Ebner H; Leitner C; Hallberg BM; Prongjit M; Sucharitakul J; Ludwig R; Rudsander U; Peterbauer C; Chaiyen P; Haltrich D; Divne C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(45):33830-33834
First structure of a eukaryotic phosphohistidine phosphatase
Busam RD; Thorsell A-G; Flores A; Hammarstrom M; Persson C; Hallberg BM
Article: ANALYTICAL BIOCHEMISTRY. 2006;357(2):289-298
Thermofluor-based high-throughput stability optimization of proteins for structural studies
Ericsson UB; Hallberg BM; DeTitta GT; Dekker N; Nordlund P
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;360(4):774-787
The structure of the RNA m⁵C methyltransferase YebU from Escherichia coli reveals a C-terminal RNA-recruiting PUA domain
Hallberg BM; Ericsson UB; Johnson KA; Andersen NM; Douthwaite S; Nordlund P; Beuscher AE; Erlandsen H
Article: EMBO JOURNAL. 2006;25(9):1977-1986
The closed structure of presequence protease PreP forms a unique 10 000 A³ chamber for proteolysis
Johnson KA; Bhushan S; Stahl A; Hallberg BM; Frohn A; Glaser E; Eneqvist T
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2006;62(Pt 3):295-297
Expression, purification, crystallization and preliminary diffraction studies of the mammalian DAG kinase homologue YegS from Escherichia coli
Bakali HMA; Nordlund P; Hallberg BM
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2006;62(Pt 2):97-99
Crystallization and preliminary crystallographic study of the yeast Malassezia sympodialis allergen Mala s 1
Vilhelmsson M; Hallberg BM; Rasool O; Zargari A; Scheynius A; Achour A
Article: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 2005;127(41):14339-14347
Catalytic mechanism of limonene epoxide hydrolase, a theoretical study
Hopmann KH; Hallberg BM; Himo F
Article: GENE. 2004;338(1):1-14
Ancestral gene fusion in cellobiose dehydrogenases reflects a specific evolution of GMC oxidoreductases in fungi
Zámocky M; Hallberg M; Ludwig R; Divne C; Haltrich D
Article: JOURNAL OF MOLECULAR BIOLOGY. 2004;341(3):781-796
Crystal structure of the 270 kDa homotetrameric lignin-degrading enzyme pyranose 2-oxidase
Hallberg BM; Leitner C; Haltrich D; Divne C
Article: FEBS LETTERS. 2004;565(1-3):59-64
X-ray structure of tRNA pseudouridine synthase TruD reveals an inserted domain with a novel fold
Ericsson UB; Nordlund P; Hallberg BM
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2004;60(Pt 4):775-776
Expression, purification, crystallization and preliminary diffraction studies of the tRNA pseudouridine synthase TruD from Escherichia coli
Ericsson UB; Andersson ME; Engvall B; Nordlund P; Hallberg BM
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2004;60(Pt 1):197-199
Crystallization and preliminary X-ray diffraction analysis of pyranose 2-oxidase from the white-rot fungus Trametes multicolor
Hallberg BM; Leitner C; Haltrich D; Divne C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(35):33224-33231
Biophysical and structural analysis of a novel heme b iron ligation in the flavocytochrome cellobiose dehydrogenase
Rotsaert FAJ; Hallberg BM; de Vries S; Moenne-Loccoz P; Divne C; Renganathan V; Gold MH
Article: EMBO JOURNAL. 2003;22(11):2583-2592
Structure of Rhodococcus erythropolis limonene-1,2-epoxide hydrolase reveals a novel active site
Arand M; Hallberg BM; Zou JY; Bergfors T; Oesch F; van der Werf MJ; de Bont JAM; Jones TA; Mowbray SL
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(9):5069-5074
Moth chernosensory protein exhibits drastic conformational changes and cooperativity on ligand binding
Campanacci V; Lartigue A; Hällberg BM; Jones TA; Giudici-Orticoni MT; Tegoni M; Cambillau C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2003;1604(1):47-54
The heme domain of cellobiose oxidoreductase: a one-electron reducing system
Mason MG; Nicholls P; Divne C; Hallberg BM; Henriksson G; Wilson MT
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(9):7160-7166
Mechanism of the reductive half-reaction in cellobiose dehydrogenase
Hallberg BM; Henriksson G; Pettersson G; Vasella A; Divne C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2002;1576(1-2):15-22
Cellobiose quinone oxidoreductase from the white rot fungus Phanerochaete chrysosporium is produced by intracellular proteolysis of cellobiose dehydrogenase
Raíces M; Montesino R; Cremata J; García B; Perdomo W; Szabó I; Henriksson G; Hallberg BM; Pettersson G; Johansson G
Article: JOURNAL OF MOLECULAR BIOLOGY. 2002;315(3):421-434
Crystal structure of the flavoprotein domain of the extracellular flavocytochrome cellobiose dehydrogenase
Hallberg BM; Henriksson G; Pettersson G; Divne C
Article: BIOSCIENCE, BIOTECHNOLOGY AND BIOCHEMISTRY. 2001;65(9):2050-2057
Production and characterization of recombinant Phanerochaete chrysosporium cellobiose dehydrogenase in the methylotrophic yeast Pichia pastoris
Yoshida M; Ohira T; Igarashi K; Nagasawa H; Aida K; Hallberg BM; Divne C; Nishino T; Samejima M
Article: STRUCTURE. 2000;8(2):111-122
Structure of Aspergillus niger epoxide hydrolase at 1.8 Å resolution:: implications for the structure and function of the mammalian microsomal class of epoxide hydrolases
Zou JY; Hallberg BM; Bergfors T; Oesch F; Arand M; Mowbray SL; Jones TA
Article: STRUCTURE. 2000;8(1):79-88
A new scaffold for binding haem in the cytochrome domain of the extracellular flavocytochrome cellobiose dehydrogenase
Hallberg BM; Bergfors T; Bäckbro K; Pettersson G; Henriksson G; Divne C
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All other publications

Preprint: BIORXIV. 2024
Structural basis of 3′-tRNA maturation by the human mitochondrial RNAse Z complex
Gesé GV; Martin Hällberg B
Preprint: BIORXIV. 2024
Engineering multivalent Fc display for FcγR blockade
Petrova E; Kiriako G; Rebetz J; Johansson K; Wennmalm S; Meijer NEJ; Hällberg M; André I; Ambrosetti E; Semple J; Teixeira A
Conference publication: PROTEIN SCIENCE. 2023;32(12)
Mass Spectrometry and Molecular Dynamics Simulations Untangles Structure and Function of Protein Condensates
Sahin C; Motso A; Gu X; Feyrer H; Lama D; Arndt T; Rising A; Gese GV; Hallberg M; Marklund EG; Schafer NP; Petzold K; Teilum K
Review: CELL METABOLISM. 2014;20(2):226-240
Making proteins in the powerhouse.
Hällberg BM; Larsson N-G
Editorial comment: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2011;18(11):1179-1181
TFAM forces mtDNA to make a U-turn.
Hallberg BM; Larsson N-G
Review: NATURE METHODS. 2008;5(2):135-146
Protein production and purification
Graslund S; Nordlund P; Weigelt J; Bray J; Hallberg BM; Gileadi O; Knapp S; Oppermann U; Arrowsmith C; Hui R; Ming J; dhe-Paganon S; Park H-W; Savchenko A; Yee A; Edwards A; Vincentelli R; Cambillau C; Kim R; Kim S-H; Rao Z; Shi Y; Terwilliger TC; Kim C-Y; Hung L-W; Waldo GS; Peleg Y; Albeck S; Unger T; Dym O; Prilusky J; Sussman JL; Stevens RC; Lesley SA; Wilson IA; Joachimiak A; Collart F; Dementieva I; Donnelly MI; Eschenfeldt WH; Kim Y; Stols L; Wu R; Zhou M; Burley SK; Emtage JS; Sauder JM; Thompson D; Bain K; Luz J; Gheyi T; Zhang F; Atwell S; Almo SC; Bonanno JB; Fiser A; Swaminathan S; Studier FW; Chance MR; Sali A; Acton TB; Xiao R; Zhao L; Ma LC; Hunt JF; Tong L; Cunningham K; Inouye M; Anderson S; Janjua H; Shastry R; Ho CK; Wang D; Wang H; Jiang M; Montelione GT; Stuart DI; Owens RJ; Daenke S; Schutz A; Heinemann U; Yokoyama S; Bussow K; Gunsalus KC
Review: CURRENT PROTEIN AND PEPTIDE SCIENCE. 2006;7(3):255-280
Cellobiose dehydrogenase - A flavocytochrome from wood-degrading, phytopathogenic and saprotropic fungi
Zamocky M; Ludwig R; Peterbauer C; Hallberg BM; Divne C; Nicholls P; Haltrich D

Grants

HIMBASS – Hierarchical imaging of biofilms at synchrotron sources
Swedish Research Council
1 January 2024 - 31 December 2027
Molecular studies of mitochondrial gene expression
Swedish Research Council
1 January 2023 - 31 December 2026
Molecular studies of mitochondrial gene expression
Swedish Research Council
1 January 2019 - 31 December 2022
Integrative Structural Biology of Herpesvirus Replication - CSSB
Swedish Research Council
4 April 2018 - 31 December 2021
How we can prevent cancer-critical proteins from doing harm
Swedish Cancer Society
1 January 2017
Mitochondrial genome separation and segregation
Knut and Alice Wallenberg Foundation
1 January 2017 - 1 January 2022
Structural-functional basis of tRNA biogenesis
Swedish Research Council
1 January 2014 - 31 December 2017
Structural Basis of Nucleocytoplasmic Transport of Cancer-Critical Transcription Factors
Swedish Research Council
1 January 2012 - 31 December 2014
Structural Basis of Mitochondrial RNA Biogenesis - CSSB
Swedish Research Council
1 January 2011 - 31 December 2015
Structural basis of tRNA biogenesis
Swedish Research Council
1 January 2011 - 31 December 2013

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