Research
Our research focuses on thoracic oncology, mainly lung cancer, and includes both clinical, translational and preclinical studies. We aim to find new treatment targets and biomarkers that are important for prognosis and treatment response, especially in the areas of lung cancer. For this purpose, we have established patient cohorts where we have collected detailed clinical data and associated tumor material for molecular analyses. Resistance to therapy is a common clinical issue in the treatment of lung cancer and is an important reason for poor prognosis. A major focus of our translational and clinical lung cancer research is the identification of mechanisms of resistance to and biomarkers for tyrosine kinase inhibitors, mainly of EGFR and ALK, and immunotherapy. An important aim is to improve diagnostics and treatment using precision cancer medicine. This involves research programs in diagnostics, imaging, treatments and cancer registers as well as preclinical and translational projects. In these projects we are involving patients treated in clinical routine at Karolinska University Hospital as well as in different clinical studies.
Another focus of research is the important clinical issue of brain metastasis in lung cancer, which is a patient group with a poor prognosis. This involves investigation of molecular mechanisms of brain metastasis in lung cancer and development of novel therapeutics. These studies involve analyses of brain metastasis tissue and cerebrospinal fluid (CSF) with a focus on treatment with targeted therapies. We perform exosome analysis in the collected specimens, where exosomes have been shown to be released from tumor cells and to carry DNA and RNA reflecting the molecular profiles of the solid tumor tissues. In another brain metastasis study in lung cancer, we have performed an imaging study of uptake of an EGFR tyrosine kinase inhibitor in the brain using PET imaging and radiolabeled drug with the aim to identify and understand response and resistance in treatment of brain metastasis.
Selected collaborations
Swedish Lung Cancer Study Group, National Lung Cancer Register, Oslo University (PIs Prof Odd Terje Brustugun, Prof Åslaug Helland), University of Copenhagen/Rigshospitalet (PI Prof Jens Benn SØrensen), Uppsala University (PIs Prof Johan Botling, Prof Patrick Micke, Dr Georg Holgersson), Umeå University (PI Prof Michael Bergqvist), University of Manchester/Christie Hospital (PI Dr Raffaele Califano), University of Colorado Denver (PI Prof Fred Hirsch), University of Crete/University General Hospital Heraklion (PI Prof Dimitris Mavroudis).
