The Agneta Richter-Dahlfors group

Infections are multifaced phenomena difficult to recreate and study. By integrating knowledge and techniques of medical and engineering science, the Agneta Richter-Dahlfors group uses advanced techniques when studying the integrated pathophysiology of bacterial infections. Acknowledging the need for better analytical tools to advance research, the research group develops, tests and disseminates novel methods and technologies.

Research focus

Richter-Dahlfors’ research group embraces scientists with expertise in micro­biology/infection, neuroscience, and medicine as well as chemistry, organic- and micro­electronics. Via extensive engagement in national and international multidisciplinary collaborations, we focus on defining the integrated pathophysiology of bacterial infections, and on generating novel technologies for neuromodulation.

Controlled release of acetylcholine (ACh) from a conducting polymer matrix.

Tissue microbiology reveals the integrated pathophysiology of infection

By applying a panel of intravital techniques (e.g. intravital 2-photon microscopy, amperometric bio­sensors), we study the real-time dynamics of the infection process within the organ at high resolution using uropathogenic E. coli-induced pyelonephritis as a model.

Our work

  1. aids in establishing the emerging field 'tissue micro­biology'
  2. advances the development of biomimetic tools for complementary in vitro studies
  3. focuses on developing bio­sensors for hospital-acquired infections
  4. producing smart materials for use in the clinic

Organic bioelectronics in nanomedicine

We recently demonstrated the use of conducting polymers for precise, non-convective, electrophoretic delivery of signal substances, such as ions and neurotransmitters. Analogously to the function of neurons, the device mimics the action potential causing the release of chemical substances into the synaptic cleft. We currently focus on integrating this technology as a novel machine-to-brain interface and as an implantable neuromodulation technology.

Group members

Selected publications

An organic electronic biomimetic neuron enables auto-regulated neuromodulation.
Simon DT, Larsson KC, Nilsson D, Burström G, Galter D, Berggren M, et al
Biosens Bioelectron 2015 Sep;71():359-364

Biomimetic interfaces reveal activation dynamics of C-reactive protein in local microenvironments.
Goda T, Kjall P, Ishihara K, Richter-Dahlfors A, Miyahara Y
Adv Healthc Mater 2014 Nov;3(11):1733-8

Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function.
Simon DT, Kurup S, Larsson KC, Hori R, Tybrandt K, Goiny M, et al
Nat Mater 2009 Sep;8(9):742-6

Tissue microbiology provides a coherent picture of infection.
Richter-Dahlfors A, Rhen M, Udekwu K
Curr. Opin. Microbiol. 2012 Feb;15(1):15-22

Multiphoton microscopy applied for real-time intravital imaging of bacterial infections in vivo.
Choong FX, Sandoval RM, Molitoris BA, Richter-Dahlfors A
Meth. Enzymol. 2012 ;506():35-61

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