Ibáñez Laboratory

With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation.

Pro-apoptotic and pro-survival pathways mapped onto non-overlapping epitopes, demonstrating that different signalling outputs can be genetically separated in the p75 receptor.

Research Focus

Growth Factor Receptor Signaling and Biology in Nervous System Development and Metabolic Regulation

With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation. Currently, our studies center on three different ligand/receptor systems:

  • p75 neurotrophin receptor and neurotrophin family ligands
  • GFRα1, Ret and NCAM receptors and GDNF family ligands
  • TGF-β superfamily receptors ALK7 and ALK4 and their ligands Activins and GDFs.

Using these signaling systems as entry points, our goal is to discover novel, general biological principles of broad importance for nervous system development and metabolic functions.

    Current topics of investigation

    • Mechanism of p75NTR activation
    • Generation and functional characterization of p75NTR signaling mutants
    • Genetic approaches to elucidate p75NTR signaling functions in mutant mice
    • Role of GDNF family signaling in the development of the mammalian olfactory system
    • Role of GDNF family signaling in the development of the mammalian cerebellum
    • Development and differentiation of cortical GABAergic interneurons
    • Roles of activin signaling in brown and white adipocyte differentiation and fat homeostasis
    • A chemical-genetic approach to study ALK4 and ALK7 signaling in metabolic regulation

    Group  members

    Publications

    Control of brown adipose tissue adaptation to nutrient stress by the activin receptor ALK7.
    Marmol P, Krapacher F, Ibáñez CF
    Elife 2020 May;9():

    CD137 negatively affects "browning" of white adipose tissue during cold exposure.
    Srivastava RK, Moliner A, Lee ES, Nickles E, Sim E, Liu C, et al
    J. Biol. Chem. 2020 Feb;295(7):2034-2042

    ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons.
    Göngrich C, Krapacher FA, Munguba H, Fernández-Suárez D, Andersson A, Hjerling-Leffler J, et al
    J. Cell Biol. 2020 01;219(1):

    Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing.
    Tann JY, Wong LW, Sajikumar S, Ibáñez CF
    EMBO J. 2019 03;38(5):

    A Small Molecule Targeting the Transmembrane Domain of Death Receptor p75NTR Induces Melanoma Cell Death and Reduces Tumor Growth.
    Goh ETH, Lin Z, Ahn BY, Lopes-Rodrigues V, Dang NH, Salim S, et al
    Cell Chem Biol 2018 12;25(12):1485-1494.e5

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