With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation.
Growth Factor Receptor Signaling and Biology in Nervous System Development and Metabolic Regulation
With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation. Currently, our studies center on three different ligand/receptor systems:
- p75 neurotrophin receptor and neurotrophin family ligands
- GFRα1, Ret and NCAM receptors and GDNF family ligands
- TGF-β superfamily receptors ALK7 and ALK4 and their ligands Activins and GDFs.
Using these signaling systems as entry points, our goal is to discover novel, general biological principles of broad importance for nervous system development and metabolic functions.
Current topics of investigation
- Mechanism of p75NTR activation
- Generation and functional characterization of p75NTR signaling mutants
- Genetic approaches to elucidate p75NTR signaling functions in mutant mice
- Role of GDNF family signaling in the development of the mammalian olfactory system
- Role of GDNF family signaling in the development of the mammalian cerebellum
- Development and differentiation of cortical GABAergic interneurons
- Roles of activin signaling in brown and white adipocyte differentiation and fat homeostasis
- A chemical-genetic approach to study ALK4 and ALK7 signaling in metabolic regulation
Annika Andersson – Research assistant
Diana Fernandez Suarez – Postdoc
Carlos Ibanez – Professor
Claire Elizabeth Kelly – Postdoc
Favio Krapacher – Postdoc
Annalena Moliner – Laboratory engineer
Patricia Mármol Carrasco – Postdoc
Critical role of GFRα1 in the development and function of the main olfactory system.
Marks C, Belluscio L, Ibáñez CF
J. Neurosci. 2012 Nov;32(48):17306-20
Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor.
Charalampopoulos I, Vicario A, Pediaditakis I, Gravanis A, Simi A, Ibáñez CF
Cell Rep 2012 Dec;2(6):1563-70
Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.
Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, et al
Elife 2014 Aug;3():e03245
Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq.
Zechel S, Zajac P, Lönnerberg P, Ibáñez CF, Linnarsson S
Genome Biol. 2014 ;15(10):486
Structural basis of death domain signaling in the p75 neurotrophin receptor.
Lin Z, Tann JY, Goh ET, Kelly C, Lim KB, Gao JF, et al
Elife 2015 Dec;4():e11692