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Ibáñez Laboratory

With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation.

Pro-apoptotic and pro-survival pathways mapped onto non-overlapping epitopes, demonstrating that different signalling outputs can be genetically separated in the p75 receptor.
Ibañez laboratory research focus

Research Focus

Growth Factor Receptor Signaling and Biology in Nervous System Development and Metabolic Regulation

With a focus on growth factor receptor signaling, we investigate different aspects of nervous system development and metabolic regulation. Currently, our studies center on three different ligand/receptor systems:

  • p75 neurotrophin receptor and neurotrophin family ligands
  • GFRα1, Ret and NCAM receptors and GDNF family ligands
  • TGF-β superfamily receptors ALK7 and ALK4 and their ligands Activins and GDFs.

Using these signaling systems as entry points, our goal is to discover novel, general biological principles of broad importance for nervous system development and metabolic functions.

    Current topics of investigation

    • Mechanism of p75NTR activation
    • Generation and functional characterization of p75NTR signaling mutants
    • Genetic approaches to elucidate p75NTR signaling functions in mutant mice
    • Role of GDNF family signaling in the development of the mammalian olfactory system
    • Role of GDNF family signaling in the development of the mammalian cerebellum
    • Development and differentiation of cortical GABAergic interneurons
    • Roles of activin signaling in brown and white adipocyte differentiation and fat homeostasis
    • A chemical-genetic approach to study ALK4 and ALK7 signaling in metabolic regulation

    Group Members

    Annika Andersson – Research assistant

    Diana Fernandez Suarez – Postdoc

    Carlos Ibanez – Professor

    Claire Elizabeth Kelly – Postdoc

    Favio Krapacher – Postdoc

    Annalena Moliner – Laboratory engineer

    Patricia Mármol Carrasco – Postdoc

    Publications

    Critical role of GFRα1 in the development and function of the main olfactory system.
    Marks C, Belluscio L, Ibáñez CF
    J. Neurosci. 2012 Nov;32(48):17306-20

    Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor.
    Charalampopoulos I, Vicario A, Pediaditakis I, Gravanis A, Simi A, Ibáñez CF
    Cell Rep 2012 Dec;2(6):1563-70

    Adipocyte ALK7 links nutrient overload to catecholamine resistance in obesity.
    Guo T, Marmol P, Moliner A, Björnholm M, Zhang C, Shokat KM, et al
    Elife 2014 Aug;3():e03245

    Topographical transcriptome mapping of the mouse medial ganglionic eminence by spatially resolved RNA-seq.
    Zechel S, Zajac P, Lönnerberg P, Ibáñez CF, Linnarsson S
    Genome Biol. 2014 ;15(10):486

    Structural basis of death domain signaling in the p75 neurotrophin receptor.
    Lin Z, Tann JY, Goh ET, Kelly C, Lim KB, Gao JF, et al
    Elife 2015 Dec;4():e11692

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