Kristoffer Strålin Group - Sepsis and COVID-19

Our group performs clinical and translational research on sepsis, community-acquired pneumonia, and COVID-19.

Group leader

Kristoffer Strålin

Affiliated to research
H7 Department of Medicine, Huddinge

Kristoffer Strålin is a Senior Consultant in Infectious Diseases at the Karolinska University Hospital. Within national healthcare projects, he is currently building up a strategy to monitor the Swedish sepsis population and he is involved in the national COVID-19 monitoring.

Together with other groups and within international collaboration projects, he works with precision diagnostics, with the goal to improve prognostication and enable new therapeutical strategies in sepsis and COVID-19.

Research support

  • ALF
  • Innovationsfonden
  • Vetenskapsrådet
  • Nordforsk
  • EIT Health (EU)


  1. Plasma calprotectin as an indicator of need of transfer to intensive care in patients with suspected sepsis at the emergency department.
    Parke Å, Unge C, Yu D, Sundén-Cullberg J, Strålin KBMC Emerg Med 2023 Feb;23(1):16
  2. Targeted plasma proteomics reveals signatures discriminating COVID-19 from sepsis with pneumonia.
    Palma Medina LM, Babačić H, Dzidic M, Parke Å, Garcia M, Maleki KT, Unge C, Lourda M, Kvedaraite E, Chen P, Muvva JR, Cornillet M, Emgård J, Moll K, , Michaëlsson J, Flodström-Tullberg M, Brighenti S, Buggert M, Mjösberg J, Malmberg KJ, Sandberg JK, Gredmark-Russ S, Rooyackers O, Svensson M, Chambers BJ, Eriksson LI, Pernemalm M, Björkström NK, Aleman S, Ljunggren HG, Klingström J, Strålin K*, Norrby-Teglund A*, * Equal contribution
    Respir Res 2023 Feb;24(1):62 
  3. The Karolinska KI/K COVID-19 Immune Atlas: An open resource for immunological research and educational purposes.
    Ljunggren HG, Ask EH, Cornillet M, Strunz B, Chen P, Rao Muvva J, Akber M, Buggert M, Chambers BJ, Cuapio A, Dzidic M, Filipovic I, Flodström-Tullberg M, Garcia M, Gorin JB, Gredmark-Russ S, Hertwig L, Klingström J, Kokkinou E, Kvedaraite E, Lourda M, Mjösberg J, Maucourant C, Norrby-Teglund A, Palma Medina LM, Parrot T, Perez-Potti A, Ponzetta A, Ringqvist E, Rivera-Ballesteros O, Rooyackers O, Sandberg JK, Sandberg JT, Sekine T, Svensson M, Varnaite R, Wullimann D, , Eriksson LI, Aleman S, Malmberg KJ, Strålin K, Björkström NK
    Scand J Immunol 2022 Jun;96(1):e13195
  4. Mortality in hospitalized COVID-19 patients was associated with the COVID-19 admission rate during the first year of the pandemic in Sweden.
    Strålin K, Wahlström E, Walther S, Bennet-Bark AM, Heurgren M, Lindén T, Holm J, Hanberger H
    Infect Dis (Lond) 2022 Feb;54(2):145-151
  5. Mortality trends among hospitalised COVID-19 patients in Sweden: A nationwide observational cohort study.
    Strålin K, Wahlström E, Walther S, Bennet-Bark AM, Heurgren M, Lindén T, Holm J, Hanberger H
    Lancet Reg Health Eur 2021 May;4():100054
  6. Performance of PCR/Electrospray Ionization-Mass Spectrometry on Whole Blood for Detection of Bloodstream Microorganisms in Patients with Suspected Sepsis.
    Strålin K, Rothman RE, Özenci V, Barkataki K, Brealey D, Dhiman N, Poling L, Kurz MC, Limaye AP, LoVecchio F, Lowery K, Miller LG, Moran GJ, Overcash JS, Parekh A, Peacock WF, Rivers EP, Sims M, Stubbs AM, Sundqvist M, Ullberg M, Carroll KC
    J Clin Microbiol 2020 Aug;58(9):
  7. Single-Sampling Strategy vs. Multi-Sampling Strategy for Blood Cultures in Sepsis: A Prospective Non-inferiority Study.
    Yu D, Larsson A, Parke Å, Unge C, Henning C, Sundén-Cullberg J, Somell A, Strålin K*, Özenci V*, Equal contribution. Front Microbiol 2020 ;11():1639 
  8. High nuc DNA load in whole blood is associated with sepsis, mortality and immune dysregulation in Staphylococcus aureus bacteraemia.
    Ziegler I, Cajander S, Rasmussen G, Ennefors T, Mölling P, Strålin K
    Infect Dis (Lond) 2019 Mar;51(3):216-226
  9. High HMGB1 levels in sputum are related to pneumococcal bacteraemia but not to disease severity in community-acquired pneumonia.
    Alpkvist H, Athlin S, Mölling P, Norrby-Teglund A, Strålin K
    Sci Rep 2018 Sep;8(1):13428
  10. Clinical and Microbiological Factors Associated with High Nasopharyngeal Pneumococcal Density in Patients with Pneumococcal Pneumonia.
    Alpkvist H, Athlin S, Nauclér P, Herrmann B, Abdeldaim G, Slotved HC, Hedlund J, Strålin K
    PLoS One 2015 ;10(10):e0140112
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