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Katarina Le Blanc group

Experimental and clinical studies of the immunological properties of fetal and adult mesenchymal stem cells (MSC), intracellular mechanisms for differentiation and the use of MSC cell therapy.

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Professor Katarina Le Blanc

Bone marrow derived MSCs suppress immune responses and are anti-inflammatory, although their mode of immunosuppressive function remains largely unconfirmed. In tissue, MSCs reside in niches wrapped around endothelial cells lining capillary and venule walls. Their function is not constitutive or fixed, but the result of micro-environmental cross-talk. With reciprocal communication, MSCs and immune cells regulate each other’s immunomodulatory and antimicrobial properties, self-renewal and differentiation during tissue repair.

We were the first to report that adoptive transfer of MSCs ameliorates treatment-resistant acute graft-versus-host disease (GvHD), a potential life-threatening condition after allogeneic hematopoietic stem cell transplantation (aHSCT). Treatment with MSCs is now approved, or near regulatory approval, in countries, including Japan, Canada and the US. In contrast, MSC treatment of chronic GvHD has been less studied and is currently one of our main research areas. We believe the MSC can shift the patient’s immune system towards a more tolerogenic profile and thereby reducing the symptoms and increasing the quality of life.

In addition to classical GvHD symptoms, chronic fatigue and cognitive dysfunction represent factors of significant morbidity for aHSCT patients. We have recently reported the first battery of neuropsychological tests with the ability to qualitatively and quantitatively evaluate both persistent fatigue and cognitive function after aHSCT. Ongoing clinical studies will further help us to characterize this condition and find possible therapies.

The clinical-grade MSC-product that we have developed since 2003 have been used in several clinical trials for indications such as GvHD, type 1 diabetes, regeneration of vocal fold scarring and multiple sclerosis. The last years we have implemented full GMP in production of the cell products, a requirement since the MSC was classified as ATMP (Advanced Therapeutic Medicinal Products). We are now working on initiating new clinical trials.

Research group leader

Katarina Le Blanc

Professor/specialist physician
Division of Clinical Immunology
Department of Laboratory Medicine (LABMED), H5

Group members

Lili Andersson

Department administrator
Division of Clinical Immunology
Department of Laboratory Medicine (LABMED), H5

Lindsay Davies

Senior researcher
Katarina Le Blancs Group
Department of Laboratory Medicine (LABMED), H5

Cecilia Ström

Laboratory coordinator
Katarina Le Blanc BMA
Department of Laboratory Medicine (LABMED), H5

Tachazi Plym Forshell

Laboratory coordinator
Katarina Le Blancs Group
Department of Laboratory Medicine (LABMED), H5

Anton Törnqvist Andrén

Research technician
Katarina Le Blancs Group
Department of Laboratory Medicine (LABMED), H5
Neuro Brundin
Department of Clinical Neuroscience (CNS), K8

Lena von Bahr

Associated
Katarina Le Blanc Research
Department of Laboratory Medicine (LABMED), H5

Erik Boberg

Graduate Student

Caroline Gavin

PhD student
Division of Clinical Immunology
Department of Laboratory Medicine (LABMED), H5
Division of Clinical Immunology
Department of Laboratory Medicine (LABMED), H5

Find us

Address

The Katarina Le Blanc Research Group and Laboratories are located at the Karolinska Institutet, ANA Futura, level 8, Alfred Nobels Allé 8, Flemingsberg.

Selected publications

Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells.
Le Blanc K, Rasmusson I, Sundberg B, Götherström C, Hassan M, Uzunel M, et al
Lancet 2004 May;363(9419):1439-41

Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement.
Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al
Cytotherapy 2006 ;8(4):315-7

Mesenchymal stem cells for treatment of therapy-resistant graft-versus-host disease.
Ringdén O, Uzunel M, Rasmusson I, Remberger M, Sundberg B, Lönnies H, et al
Transplantation 2006 May;81(10):1390-7

Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study.
Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al
Lancet 2008 May;371(9624):1579-86

Multipotent mesenchymal stromal cells and the innate immune system.
Le Blanc K, Mougiakakos D
Nat. Rev. Immunol. 2012 Apr;12(5):383-96