Neuroimmunology of cancer – Sébastien Talbot

Publications

All publications from group members

• Journal article: CELL REPORTS. 2025;44(9):116258

  Next-gen tools in cancer neuroscience.

  Thiel V; Sur D; Picoli CC; McErlain T; Couto K; Simon DJ; Pan Y; Dixon KO; Kulkarni RP; Talbot S; Birbrair A
• Journal article: NEURON. 2025;113(17):2760-2790

  Entangled cellular and molecular relationships at the sensory neuron-cancer interface.

  Sur D; Zeng Y; Kobayashi H; Zhi X; Goetz MR; Müller CM; Zavitsanou A-M; Picoli CC; Martel Matos AA; Pareja J; Savita BK; Lee T; Cunha-Junior JP; Amorim JH; Nikpoor AR; Dory A; Thanabalasuriar A; Galante PAF; Ma VT; James AW; Shepherd AJ; Oudin MJ; Bunimovich YL; Scheff NN; D'Silva NJ; Dixon KO; Abdus-Saboor I; Wang TC; Talbot S; Birbrair A
• Journal article: NATURE. 2025;:1-12

  Cancer-induced nerve injury promotes resistance to anti-PD-1 therapy

  Baruch EN; Gleber-Netto FO; Nagarajan P; Rao X; Akhter S; Eichwald T; Xie T; Balood M; Adewale A; Naara S; Sathishkumar HN; Islam S; McCarthy W; Mattson BJ; Ferrarotto R; Wong MK; Davies MA; Jindal S; Basu S; Roversi K; Nikpoor AR; Ahmadi M; Ahmadi A; Harwood C; Leigh I; Gong D; Tallon de Lara P; Tao DL; Davidson TM; Ajami NJ; Futreal A; Rai K; Kochat V; Castillo M; Gunaratne P; Goepfert RP; Hernandez SD; Khushalani NI; Wang J; Watowich SS; Calin GA; Migden MR; Yuan M; Liu N; Ye Y; Hwang WL; Vermeer PD; D'Silva NJ; Bunimovich YL; Yaniv D; Burks JK; Gomez J; Dougherty PM; Tsai KY; Allison JP; Sharma P; Wargo JA; Myers JN; Talbot S; Gross ND; Amit M
• Journal article: SCIENCE SIGNALING. 2025;18(898):eads7889

  Tumor-infiltrating nociceptor neurons promote immunosuppression

  Restaino AC; Ahmadi M; Eichwald T; Nikpoor AR; Walz A; Balood M; Talbot S; Vermeer PD
• Journal article: NATURE REVIEWS CANCER. 2025;25(8):573-589

  Neuro-immune cross-talk in cancer

  Amit M; Eichwald T; Roger A; Anderson J; Chang A; Vermeer PD; Dixon KO; Scheff NN; Talbot S
• Preprint: BIORXIV. 2025;BIORXIV

  NOCICEPTOR NEURONS CONTROL POLLUTION-MEDIATED NEUTROPHILIC ASTHMA.

  Wang J-C; Kulle A; Crosson T; Nikpoor AR; Gupta S; Roger A; Rafei M; Thanabalasuriar A; Talbot S
• Journal article: BRAIN SCIENCES. 2025;15(6):646

  Pain Hypersensitivity and Increased Urinary Tetrahydrobiopterin Levels in Mice Submitted to High-Fat Diet

  Eichwald T; Scheffer DDL; Barros L; Solano A; Menegassi VDS; Staats Pires AC; Spivakoski CS; Da Silva RA; Gaspar JM; Ronsoni MF; Latini A
• Journal article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2025;1871(5):167824

  Aminolevulinate/iron exposure elicited Nrf-2-mediated cytoprotection in DARS2 deficient fibroblasts with impaired energy and antioxidant metabolisms.

  Huang W-L; Eichwald T; Stover A; Gazanfari M; Schwartz PH; Latini A; Abdenur JE
• Journal article: ANESTHESIA AND ANALGESIA. 2025;140(5):1073-1082

  Detection and Evaluation of Procalcitonin Variants As Diagnostic Tools in Systemic Inflammation

  Kintrup S; Brabenec L; Zurek-Leffers F-M; Hellenthal KEM; Cyran L; Meybohm P; Gerke V; Wagner N-M
• Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2025;25(5):318

  Macrophages promote nerve growth in both tumours and spinal cord

  Baleviciute A; Talbot S
• Editorial comment: CANCER CELL. 2025;43(1):1-5

  Integrating priorities at the intersection of cancer and neuroscience

  Hwang WL; Perrault EN; Birbrair A; Mattson BJ; Gutmann DH; Mabbott DJ; Cukierman E; Repasky EA; Sloan EK; Zong H; Demir IE; Saloman JL; Borniger JC; Hu J; Dietrich J; Breunig JJ; Cifcibas K; Kasm KAA; Valiente M; Wintermark M; Acharya MM; Scheff NN; D'Silva NJ; Vermeer PD; Wong RJ; Talbot S; Hervey-Jumper SL; Wang TC; Ye Y; Pan Y; Bunimovich YL; Amit M
• Article: CELL REPORTS. 2024;43(12):115045

  Cytokines reprogram airway sensory neurons in asthma

  Crosson T; Bhat S; Wang J-C; Salaun C; Fontaine E; Roversi K; Herzog H; Rafei M; Blunck R; Talbot S
• Review: CURRENT OPINION IN IMMUNOLOGY. 2024;91:102507

  Decoding the neuroimmune axis in the atopic march: mechanisms and implications

  Brabenec L; Gupta S; Eichwald T; Rafei M; Talbot S
• Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2024;12(11):e009962

  Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma

  Mcilvried LA; Martel Matos AA; Yuan MM; Atherton MA; Obuekwe F; Nilsen ML; Nikpoor AR; Talbot S; Bruno TC; Taggart DN; Johnson LK; Ferris RL; Zandberg DP; Scheff NN
• Review: NATURE REVIEWS DRUG DISCOVERY. 2024;23(10):780-796

  Targeting the peripheral neural-tumour microenvironment for cancer therapy

  Yaniv D; Mattson B; Talbot S; Gleber-Netto FO; Amit M
• Preprint: BIORXIV. 2024;BIORXIV

  Cytokines reprogram airway sensory neurons in asthma.

  Crosson T; Bhat S; Wang J-C; Salaun C; Fontaine E; Roversi K; Herzog H; Rafei M; Blunck R; Talbot S
• Preprint: BIORXIV. 2024;BIORXIV

  TUMOR-INFILTRATING NOCICEPTOR NEURONS PROMOTE IMMUNOSUPPRESSION.

  Restaino AC; Ahmadi M; Nikpoor AR; Walz A; Balood M; Eichwald T; Talbot S; Vermeer PD
• Editorial comment: TRENDS IN IMMUNOLOGY. 2024;45(8):574-576

  Aching to defend: spleen innervation drives humoral immunity

  Eichwald T; Talbot S
• Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;154(1):11-19

  Interactions between skin-resident dendritic and Langerhans cells and pain-sensing neurons.

  Wilcox NC; Taheri G; Halievski K; Talbot S; Silva JR; Ghasemlou N
• Preprint: BIORXIV. 2024;BIORXIV

  BASOPHILS ACTIVATE PRURICEPTOR-LIKE VAGAL SENSORY NEURONS.

  Wang J-C; Nikpoor AR; Crosson T; Kaufmann E; Rafei M; Talbot S
• Article: BIORXIV. 2024;:2023.10.18.562990

  Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a male mouse model of head-and-neck cancer.

  Barr J; Walz A; Restaino AC; Amit M; Barclay SM; Vichaya EG; Spanos WC; Dantzer R; Talbot S; Vermeer PD
• Journal article: CANCER RESEARCH. 2024;84(7_Supplement):sy31-02-sy31-02

  Abstract SY31-02: Nociceptor neurons control anti-tumor immunity

  Eichwald T; Balood M; Ahmadi M; Roversi K; Wong D; Mandl J; Rafei M; Ghasemlou N; Vermeer P; Amit M; Talbot S
• Editorial comment: CANCER DISCOVERY. 2024;14(4):669-673

  Next Directions in the Neuroscience of Cancers Arising outside the CNS

  Amit M; Anastasaki C; Dantzer R; Demir IE; Deneen B; Dixon KO; Egeblad M; Gibson EM; Hervey-Jumper SL; Hondermarck H; Magnon C; Monje M; Na'ara S; Pan Y; Repasky EA; Scheff NN; Sloan EK; Talbot S; Tracey KJ; Trotman LC; Valiente M; Van Aelst L; Venkataramani V; Venkatesh HS; Vermeer PD; Winkler F; Wong RJ; Gutmann DH; Borniger JC
• Journal article: MOLECULAR GENETICS AND METABOLISM. 2024;141(4):108187

  Bioenergetics and antioxidant status in human TFAM deficient fibroblasts

  Gazanfari M; Huang W-L; Eichwald T; Stover A; Schwartz PH; Latini A; Abdenur J
• Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;153(4):924-938

  Navigating the blurred path of mixed neuroimmune signaling

  Gupta S; Viotti A; Eichwald T; Roger A; Kaufmann E; Othman R; Ghasemlou N; Rafei M; Foster SL; Talbot S
• Article: CANCER SCIENCE. 2024;115(4):1102-1113

  An engineered Accum-E7 protein-based vaccine with dual anti-cervical cancer activity.

  Bikorimana J-P; Abusarah J; Gonçalves M; Farah R; Saad W; Talbot S; Stanga D; Beaudoin S; Plouffe S; Rafei M
• Article: ISCIENCE. 2024;27(3):109248

  A1-reprogrammed mesenchymal stromal cells prime potent antitumoral responses.

  Gonçalves MP; Farah R; Bikorimana J-P; Abusarah J; El-Hachem N; Saad W; Talbot S; Stanga D; Beaudoin S; Plouffe S; Rafei M
• Journal article: NEUROTOXICOLOGY. 2023;97:12-24

  ALDH2 inhibition by lead and ethanol elicits redox imbalance and mitochondrial dysfunction in SH-SY5Y human neuroblastoma cell line: Reversion by Alda-1.

  Deza-Ponzio R; Albrecht PA; Fernandez-Hubeid LE; Eichwald T; Cejas RB; Garay YC; Rivera-Meza M; Latini A; Irazoqui FJ; Virgolini MB
• Journal article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2023;11(1):31

  A model of porcine polymicrobial septic shock

  Zurek-Leffers FM; Lehmann F; Brabenec L; Kintrup S; Hellenthal KEM; Mersjann K; Kneifel F; Hessler M; Arnemann P-H; Kampmeier T-G; Ertmer C; Kellner P; Wagner N-M
• Article: SCIENCE ADVANCES. 2023;9(19):eade4443

  Functional neuronal circuits promote disease progression in cancer

  Restaino AC; Walz A; Vermeer SJ; Barr J; Kovacs A; Fettig RR; Vermeer DW; Reavis H; Williamson CS; Lucido CT; Eichwald T; Omran DK; Jung E; Schwartz LE; Bell M; Muirhead DM; Hooper JE; Spanos WC; Drapkin R; Talbot S; Vermeer PD
• Editorial comment: IMMUNITY. 2023;56(5):906-908

  Decoding nociceptor-DC dialogues

  Crosson T; Talbot S
• Journal article: ANTIOXIDANTS. 2023;12(5):1037

  Tetrahydrobiopterin: Beyond Its Traditional Role as a Cofactor.

  Eichwald T; da Silva LDB; Staats Pires AC; Niero L; Schnorrenberger E; Filho CC; Espíndola G; Huang W-L; Guillemin GJ; Abdenur JE; Latini A
• Article: CELLS. 2023;12(8):1189

  A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages

  Foster SL; Dutton AJ; Yerzhan A; March LB; Barry K; Seehus CR; Huang X; Talbot S; Woolf CJ
• Journal article: MOLECULAR GENETICS AND METABOLISM. 2023;138(3):107440

  ENHANCED ENERGY METABOLISM AND CYTOPROTECTION IN AMINOLEVULINATE/IRON-EXPOSED DARS2 DEFICIENT FIBROBLASTS

  Latini A; Huang W-L; Eichwald T; Stover A; Schwartz P; Abdenur J
• Journal article: ANTIOXIDANTS. 2023;12(3):554

  Anti-Inflammatory Effect of Caffeine on Muscle under Lipopolysaccharide-Induced Inflammation

  Eichwald T; Solano AF; Souza J; de Miranda TB; Carvalho LB; Sanna PLDS; da Silva RAF; Latini A
• Journal article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(3):e163735

  A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodents

  He S; Zambelli VO; Sinharoy P; Brabenec L; Bian Y; Rwere F; Hell RCR; Neto BS; Hung B; Yu X; Zhao M; Luo Z; Wu C; Xu L; Svensson KJ; McAllister SL; Stary CM; Wagner N-M; Zhang Y; Gross ER
• Article: ISCIENCE. 2022;25(12):105537

  The CIt protocol: A blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells

  Bikorimana J-P; El-Hachem N; Abusarah J; Eliopoulos N; Talbot S; Shammaa R; Rafei M
• Article: NATURE. 2022;611(7935):405-412

  Nociceptor neurons affect cancer immunosurveillance

  Balood M; Ahmadi M; Eichwald T; Ahmadi A; Majdoubi A; Roversi K; Roversi K; Lucido CT; Restaino AC; Huang S; Ji L; Huang K-C; Semerena E; Thomas SC; Trevino AE; Merrison H; Parrin A; Doyle B; Vermeer DW; Spanos WC; Williamson CS; Seehus CR; Foster SL; Dai H; Shu CJ; Rangachari M; Thibodeau J; Del RSV; Drapkin R; Rafei M; Ghasemlou N; Vermeer PD; Woolf CJ; Talbot S
• Journal article: FREE RADICAL BIOLOGY AND MEDICINE. 2022;192:85

  Tetrahydrobiopterin metabolism is impaired in chemically-induced, idiopathic and genetic mitochondrial deficiencies

  Cruz L; Pasa T; Scheffer D; Eichwald T; Stover A; Schwartz P; Huang W-L; Walz R; De Paul AL; Abdenur J; Latini A
• Journal article: LIFE SCIENCES. 2022;307:120889

  Procalcitonin mediates vascular dysfunction in obesity

  Brabenec L; Hellenthal KEM; Mueller M; Kintrup S; Zurek-Leffers F; Kardell M; Otto M; Wagner N-M
• Article: BIO-PROTOCOL. 2022;12(19):e4527

  LIST: A Newly Developed Laser-assisted Cell Bioprinting Technology

  Roversi K; Orimi HE; Erfanian M; Talbot S; Boutopoulos C
• Journal article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;206(4):488-500

  Targeting Procalcitonin Protects Vascular Barrier Integrity

  Brabenec L; Mueller M; Hellenthal KEM; Karsten OS; Pryvalov H; Otto M; Holthenrich A; Matos ALL; Weiss R; Kintrup S; Hessler M; Dell'Aquila A; Thomas K; Nass J; Margraf A; Nottebaum AF; Rossaint J; Zarbock A; Vestweber D; Gerke V; Wagner N-M
• Article: CELLS. 2022;11(15):2263

  CD146 Defines a Mesenchymal Stromal Cell Subpopulation with Enhanced Suppressive Properties

  Bikorimana J-P; Saad W; Abusarah J; Lahrichi M; Talbot S; Shammaa R; Rafei M
• Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2022;67(1):e1-18

  Advancing Lung Immunology Research An Official American Thoracic Society Workshop Report

  Rahimi RA; Cho JL; Jakubzick CV; Khader SA; Lambrecht BN; Lloyd CM; Molofsky AB; Talbot S; Bonham CA; Drake WP; Sperling AI; Singer BD
• Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2022;(184)

  Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons

  Ahmadi A; Balood M; Roversi K; Ahmadi M; Rafei M; Talbot S
• Journal article: CELLS. 2022;11(12):1935

  Regulation and Dysregulation of Endothelial Permeability during Systemic Inflammation

  Hellenthal KEM; Brabenec L; Wagner N-M
• Article: CELLS. 2022;11(11):1816

  LSD1 Inhibition Enhances the Immunogenicity of Mesenchymal Stromal Cells by Eliciting a dsRNA Stress Response

  Mardani F; Saad W; El-Hachem N; Bikorimana J-P; Kurdi M; Shammaa R; Talbot S; Rafei M
• Article: BIOELECTRONIC MEDICINE. 2022;8(1):7

  Anatomical differences in nociceptor neurons sensitivity.

  Crosson T; Talbot S
• Article: SMALL. 2022;18(14):e2103364

  Nanophotonics Enable Targeted Photothermal Silencing of Nociceptor Neurons

  Roversi K; Tabatabaei M; Desjardins-Lecavalier N; Balood M; Crosson T; Costantino S; Griffith M; Talbot S; Boutopoulos C
• Article: CELL REPORTS MEDICINE. 2022;3(3):100534

  Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity

  Bikorimana J-P; Salame N; Beaudoin S; Balood M; Crosson T; Abusarah J; Talbot S; Lobenberg R; Plouffe S; Rafei M
• Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(2):ab12

  Nociceptor Neurons Control Pollution-exacerbated Asthma

  Crosson T; Eichwald T; Roversi K; Ahmadi M; Ahmadi A; Balood M; Talbot S
• Journal article: NEUROTOXICITY RESEARCH. 2022;40(1):276-285

  Protective Effects of Probucol on Different Brain Cells Exposed to Manganese

  da Silva EB; Eichwald T; Glaser V; Varela KG; Baptistella AR; de Carvalho D; Remor AP
• Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(2):ab132

  Nociceptor neurons protect from allergen-induced anaphylaxis

  Eichwald T; Wang J-C; Poirier F; Crosson T; Ahmadi M; Balood M; Ahmadi A; Roversi K; Talbot S
• Article: METHODS IN MOLECULAR BIOLOGY. 2022;2506:297-314

  Analysis of Airway Vagal Neurons.

  Wang J-C; Crosson T; Talbot S
• Article: JCI INSIGHT. 2021;6(24):e148510

  Nociceptor neurons promote IgE class switch in B cells

  Mathur S; Wang J-C; Seehus CR; Poirier F; Crosson T; Hsieh Y-C; Doyle B; Lee S; Woolf CJ; Foster SL; Talbot S
• Article: CELL REPORTS MEDICINE. 2021;2(12):100455

  Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice

  Abusarah J; Khodayarian F; El-Hachem N; Salame N; Olivier M; Balood M; Roversi K; Talbot S; Bikorimana J-P; Chen J; Jolicoeur M; Trudeau L-E; Kamyabiazar S; Annabi B; Robert F; Pelletier J; El-Kadiry A-E; Shammaa R; Rafei M
• Review: FRONTIERS IN IMMUNOLOGY. 2021;12:759679

  Neuro-Immunity and Gut Dysbiosis Drive Parkinson's Disease-Induced Pain

  Roversi K; Callai-Silva N; Roversi K; Griffith M; Boutopoulos C; Prediger RD; Talbot S
• Journal article: LIFE SCIENCES. 2021;284:119925

  Development of heart failure with preserved ejection fraction in type 2 diabetic mice is ameliorated by preserving vascular function

  Otto M; Brabenec L; Mueller M; Kintrup S; Hellenthal KEM; Holtmeier R; Steinbuch SC; Karsten OS; Pryvalov H; Rossaint J; Gross ER; Wagner N-M
• Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(19):3905-3923

  Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker

  Tochitsky I; Jo S; Andrews N; Kotoda M; Doyle B; Shim J; Talbot S; Roberson D; Lee J; Haste L; Jordan SM; Levy BD; Bean BP; Woolf CJ
• Journal article: BIOMOLECULES. 2021;11(10):1401

  TRP Channels as Sensors of Aldehyde and Oxidative Stress

  Hellenthal KEM; Brabenec L; Gross ER; Wagner N-M
• Article: MICROMACHINES. 2021;12(8):865

  Bioprinting of Adult Dorsal Root Ganglion (DRG) Neurons Using Laser-Induced Side Transfer (LIST)

  Roversi K; Ebrahimi Orimi H; Falchetti M; Lummertz da Rocha E; Talbot S; Boutopoulos C
• Journal article: PLANTA MEDICA. 2021;87(08):611-619

  BNO 1095, a Standardized Dry Extract from the Fruits of Vitex agnus-castus , Impairs Angiogenesis-related Endothelial Cell Functions In Vitro

  Bischoff-Kont I; Brabenec L; Ingelfinger R; Nausch B; Fuerst R
• Preprint: RESEARCH SQUARE. 2021

  Nociceptor neurons impair cancer immunosurveillance

  Talbot S; Balood M; Ahmadi M; Eichwald T; Majdoubi A; Merrison H; Parrin A; Doyle B; Lucido C; Vermeer D; Huang S; Ji L; Dai H; Shu C; Roversi K; Thomas S; Seehus C; Foster S; Ahmadi A; Rafei M; Rangachari M; Thibodeau J; Ghasemlou N; Rincon SD; Drapkin R; Vermeer P; Woolf C
• Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(6):2330-2342

  FcεR1-expressing nociceptors trigger allergic airway inflammation

  Crosson T; Wang J-C; Doyle B; Merrison H; Balood M; Parrin A; Pascal M; Mindt BC; Seehus CR; Ozcan A; Huang X; Semenara E; Lai NYY; Majdoubi A; Abdulnour R-EE; Rajchgot T; Rafei M; Foster SL; Thibodeau J; Fritz JH; Levy BD; Woolf CJ; Talbot S
• Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(2):ab149

  Nociceptor Neurons Control Pollution-exacerbated Asthma

  Wang J-C; Crosson T; Eichwald T; Roversi K; Ahmadi M; Balood M; Talbot S
• Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(2):ab54

  Vagal sensory neurons sense allergens to regulate Type 2 inflammation

  Crosson T; WANG J-C; Roversi K; Eichwald T; Balood M; Ahmadi M; Talbot S
• Article: NATURE BIOTECHNOLOGY. 2021;39(2):179-185

  Epineural optogenetic activation of nociceptors initiates and amplifies inflammation

  Michoud F; Seehus C; Schoenle P; Brun N; Taub D; Zhang Z; Jain A; Furfaro I; Akouissi O; Moon R; Meier P; Galan K; Doyle B; Tetreault M; Talbot S; Browne LE; Huang Q; Woolf CJ; Lacour SP
• Journal article: ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH. 2020;27(36):45874-45882

  Exposure to the herbicide 2,4-dichlorophenoxyacetic acid impairs mitochondrial function, oxidative status, and behavior in adult zebrafish

  Thiel NA; Sachett A; Schneider SE; Garbinato C; Decui L; Eichwald T; Conterato GMM; Latini A; Piato A; Siebel AM
• Article: FRONTIERS IN IMMUNOLOGY. 2020;11:1953

  Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice

  Majdoubi A; Lee JS; Kishta OA; Balood M; Moulefera MA; Ishido S; Talbot S; Cheong C; Alquier T; Thibodeau J
• Review: FRONTIERS IN HUMAN NEUROSCIENCE. 2020;14:181

  Neuro-Immunity Controls Obesity-Induced Pain

  Eichwald T; Talbot S
• Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(6):1693-1696.e4

  Vagal sensory neurons drive mucous cell metaplasia

  Talbot S; Doyle B; Huang J; Wang J-C; Ahmadi M; Roberson DP; Yekkirala A; Foster SL; Browne LE; Bean BP; Levy BD; Woolf CJ
• Preprint: BIORXIV. 2020

  Tumor-infiltrating nerves create an electro-physiologically active microenvironment and contribute to treatment resistance

  Kovacs A; Vermeer D; Madeo M; Reavis H; Vermeer S; Williamson C; Rickel A; Stamp J; Lucido C; Cain J; Bell M; Morgan M; Yoon J-Y; Mitchell M; Tulina N; Stuckelberger S; Budina A; Omran D; Jung E; Schwartz L; Eichwald T; Hong Z; Weimer J; Hooper J; Godwin A; Talbot S; Drapkin R; Vermeer P
• Article: FRONTIERS IN PHARMACOLOGY. 2020;11:237

  A Novel Sulfonyl-Based Small Molecule Exhibiting Anti-cancer Properties

  El-Kadiry AE-H; Abusarah J; Cui YE; El-Hachem N; Hammond-Martel I; Wurtele H; Thomas S; Ahmadi M; Balood M; Talbot S; Rafei M
• Editorial comment: FRONTIERS IN NEUROSCIENCE. 2020;14:56

  Editorial: Obesity and Diabetes: Implications for Brain-Immunometabolism

  Gaspar JM; Talbot S; Latini A
• Article: FRONTIERS IN IMMUNOLOGY. 2020;10:3115

  Endogenous T Cell Receptor Rearrangement Represses Aggressive Central Nervous System Autoimmunity in a TcR-Transgenic Model on the Non-Obese Diabetic Background

  Yeola AP; Doss PMIA; Baillargeon J; Akbar I; Mailhot B; Balood M; Talbot S; Anderson AC; Lacroix S; Rangachari M
• Preprint: SSRN ELECTRONIC JOURNAL. 2020

  Nociceptor Neurons Decrease Cancer Immunosurveillance

  Balood M; Ahmadi M; Majdoubi A; Eichwald T; Merrison H; Parrin A; Doyle B; Vermeer D; Wang C-C; Thanawala M; Roversi K; Thomas SC; Seehus CR; Foster SL; Latini A; Rafei M; Rangachari M; Del Rincon S; Shu CJ; Drapkin R; Thibodeau J; Woolf CJ; Vermeer PD; Talbot S
• Journal article: REVISTA BRASILEIRA DE SAÚDE OCUPACIONAL. 2020;45:e1

  Ação interinstitucional e participação social na atuação da Comissão Intersetorial de Saúde do Trabalhador e da Trabalhadora: relato de caso

  Steffani JA; Wames MMM; Eichwald T; Dallacosta FM; Rossoni C; Cetolin SF
• Article: JOURNAL OF IMMUNOLOGY. 2019;203(11):2887-2898

  Downregulation of MHC Class II by Ubiquitination Is Required for the Migration of CD206⁺ Dendritic Cells to Skin-Draining Lymph Nodes

  Majdoubi A; Lee JS; Balood M; Sabourin A; DeMontigny A; Kishta OA; Moulefera MA; Galbas T; Yun TJ; Talbot S; Ishido S; Cheong C; Thibodeau J
• Article: ELIFE. 2019;8:e48118

  Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation

  Lee S; Jo S; Talbot S; Zhang H-XB; Kotoda M; Andrews NA; Puopolo M; Liu PW; Jacquemont T; Pascal M; Heckman LM; Jain A; Lee J; Woolf CJ; Bean BP
• Journal article: JOURNAL OF INTERNAL MEDICINE. 2019;286(3):268-289

  Profiling of how nociceptor neurons detect danger - new and old foes

  Crosson T; Roversi K; Balood M; Othman R; Ahmadi M; Wang J-C; Pereira PJS; Tabatabaei M; Couture R; Eichwald T; Latini A; Prediger RD; Rangachari M; Seehus CR; Fosters SL; Talbot S
• Corrigendum: NATURE. 2019;572(7769):E18

  Publisher Correction: The metabolite BH4 controls T cell proliferation in autoimmunity and cancer.

  Cronin SJF; Seehus C; Weidinger A; Talbot S; Reissig S; Seifert M; Pierson Y; McNeill E; Longhi MS; Turnes BL; Kreslavsky T; Kogler M; Hoffmann D; Ticevic M; da Luz Scheffer D; Tortola L; Cikes D; Jais A; Rangachari M; Rao S; Paolino M; Novatchkova M; Aichinger M; Barrett L; Latremoliere A; Wirnsberger G; Lametschwandtner G; Busslinger M; Zicha S; Latini A; Robson SC; Waisman A; Andrews N; Costigan M; Channon KM; Weiss G; Kozlov AV; Tebbe M; Johnsson K; Woolf CJ; Penninger JM
• Journal article: REGULATORY TOXICOLOGY AND PHARMACOLOGY. 2019;104:98-107

  Sex differences in subacute manganese intoxication: Oxidative parameters and metal deposition in peripheral organs of adult Wistar rats

  Richter Schmitz CR; Eichwaldd T; Branco Flores MV; Varela KG; Mantovani A; Steffani JA; Glaser V; de Carvalho D; Remor AP
• Journal article: PHYSIOLOGY & BEHAVIOR. 2019;204:309-323

  Epigenetic modifications induced by exercise: Drug-free intervention to improve cognitive deficits associated with obesity

  Barros L; Eichwald T; Solano AF; Scheffer D; da Silva RA; Gaspar JM; Latini A
• Journal article: FRONTIERS IN NEUROSCIENCE. 2019;13:323

  Deep Brain Stimulation for Obesity: A Review and Future Directions

  Formolo DA; Gaspar JM; Melo HM; Eichwald T; Zepeda RJ; Latini A; Okun MS; Walz R
• Review: FRONTIERS IN NEUROSCIENCE. 2019;13:25

  Neurons and Microglia; A Sickly-Sweet Duo in Diabetic Pain Neuropathy

  Rajchgot T; Thomas SC; Wang J-C; Ahmadi M; Balood M; Crosson T; Dias JP; Couture R; Claing A; Talbot S
• Article: STEM CELL REPORTS. 2019;12(1):29-41

  Neurite Collapse and Altered ER Ca²⁺ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation

  Korecka JA; Talbot R; Osborn TM; de Leeuw SM; Levy SA; Ferrari EJ; Moskites A; Atkinson E; Jodelka FM; Hinrich AJ; Hastings ML; Woolf CJ; Hallett PJ; Isacson O
• Editorial comment: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2019;2019:2715326-2

  Oxidative Stress: Neuropathy, Excitability, and Neurodegeneration

  Latini A; Pereira PJS; Couture R; Campos MM; Talbot S
• Journal article: REVISTA INTERDISCIPLINAR DE ESTUDOS EM SAÚDE. 2018;7(2):193-210

  INTOXICAÇÃO SUBAGUDA AO MANGANÊS EM RATOS WISTAR ADULTOS: AVALIAÇÃO DE PARÂMETROS OXIDATIVOS NO SNC E DEPOSIÇÃO DO METAL EM DIFERENTES TECIDOS

  Flores MVB; Eichwald T; Mantovani A; Glaser V; Schimitz CRR; Rossoni C; Steffani JA; Perinetto D; Carvalho D; Remor AP
• Article: NATURE. 2018;563(7732):564-568

  The metabolite BH4 controls T cell proliferation in autoimmunity and cancer

  Cronin SJF; Seehus C; Weidinger A; Talbot S; Reissig S; Seifert M; Pierson Y; McNeill E; Longhi MS; Turnes BL; Kreslavsky T; Kogler M; Hoffmann D; Ticevic M; Scheffer DDL; Tortola L; Cikes D; Jais A; Rangachari M; Rao S; Paolino M; Novatchkova M; Aichinger M; Barrett L; Latremoliere A; Wirnsberger G; Lametschwandtner G; Busslinger M; Zicha S; Latini A; Robson SC; Waisman A; Andrews N; Costigan M; Channon KM; Weiss G; Kozlov AV; Tebbe M; Johnsson K; Woolf CJ; Penninger JM
• Review: FRONTIERS IN IMMUNOLOGY. 2017;8:1463

  Sense and Immunity: Context-Dependent Neuro-Immune Interplay

  Foster SL; Seehus CR; Woolf CJ; Talbot S
• Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(2):447-453.e3

  Substance P activates Mas-related G protein-coupled receptors to induce itch

  Azimi E; Reddy VB; Seadi Pereira PJ; Talbot S; Woolf CJ; Lerner EA
• Article: JCI INSIGHT. 2016;1(16):e89362

  Dual action of neurokinin-1 antagonists on Mas-related GPCRs

  Azimi E; Reddy VB; Shade K-TC; Anthony RM; Talbot S; Pereira PJS; Lerner EA
• Article: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 2016;94(7):752-757

  Beneficial effects of kinin B1 receptor antagonism on plasma fatty acid alterations and obesity in Zucker diabetic fatty rats

  Talbot S; Dias JP; El Midaoui A; Couture R
• Review: ANNUAL REVIEW OF IMMUNOLOGY. 2016;34:421-447

  Neuroimmunity: Physiology and Pathology

  Talbot S; Foster SL; Woolf CJ
• Article: BIOELECTRONIC MEDICINE. 2016;3:18-28

  Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes.

  Hanes WM; Olofsson PS; Talbot S; Tsaava T; Ochani M; Imperato GH; Levine YA; Roth J; Pascal MA; Foster SL; Wang P; Woolf C; Chavan SS; Tracey KJ
• Article: JOURNAL OF NEUROSCIENCE. 2015;35(49):16272-16281

  GRPR/PI3Kγ: Partners in Central Transmission of Itch

  Pereira PJS; Machado GDB; Danesi GM; Canevese FF; Reddy VB; Pereira TCB; Bogo MR; Cheng Y-C; Laedermann C; Talbot S; Lerner EA; Campos MM
• Article: NEURON. 2015;87(2):341-354

  Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation

  Talbot S; Abdulnour R-EE; Burkett PR; Lee S; Cronin SJF; Pascal MA; Laedermann C; Foster SL; Tran JV; Lai N; Chiu IM; Ghasemlou N; DiBiase M; Roberson D; Von Hehn C; Agac B; Haworth O; Seki H; Penninger JM; Kuchroo VK; Bean BP; Levy BD; Woolf CJ
• Article: J DIABETES METAB. 2015;6(6):1-7

  Effects of Alpha-Lipoic Acid on Oxidative Stress and Kinin Receptor Expression in Obese Zucker Diabetic Fatty Rats.

  Midaoui AE; Talbot S; Lahjouji K; Dias JP; Fantus IG; Couture R
• Editorial comment: IMMUNITY. 2015;42(3):403-405

  CNS Injury: IL-33 Sounds the Alarm

  Foster SL; Talbot S; Woolf CJ
• Article: BEHAVIOURAL BRAIN RESEARCH. 2013;241:17-26

  Brain kinin B₁ receptor contributes to the onset of stereotypic nocifensive behavior in rat

  Gariepy HDB; Talbot S; Senecal J; Couture R
• Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:214

  Activation of kinin B1 receptor evokes hyperthermia through a vagal sensory mechanism in the rat

  Talbot S; Gariepy HDB; Saint-Denis J; Couture R
• Article: EXPERIMENTAL NEUROLOGY. 2012;234(2):373-381

  Emerging role of microglial kinin B1 receptor in diabetic pain neuropathy

  Talbot S; Couture R
• Article: PLOS ONE. 2012;7(3):e33864

  Ocular Application of the Kinin B₁ Receptor Antagonist LF22-0542 Inhibits Retinal Inflammation and Oxidative Stress in Streptozotocin-Diabetic Rats

  Pouliot M; Talbot S; Senecal J; Dotigny F; Vaucher E; Couture R
• Article: TOXICOLOGY. 2012;293(1-3):125-131

  An ex vivo approach to the differential parenchymal responses induced by cigarette whole smoke and its vapor phase

  Lin JC-J; Roy J-P; Verreault J; Talbot S; Cote F; Couture R; Morin A
• Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:16

  Activation of TRPV1 by capsaicin induces functional Kinin B₁ receptor in rat spinal cord microglia

  Talbot S; Dias JP; Lahjouji K; Bogo MR; Campos MM; Gaudreau P; Couture R
• Article: PEPTIDES. 2011;32(7):1447-1456

  Cigarette smoke-induced kinin B1 receptor promotes NADPH oxidase activity in cultured human alveolar epithelial cells

  Talbot S; Lin JC-J; Lahjouji K; Roy J-P; Senecal J; Morin A; Couture R
• Article: PEPTIDES. 2010;31(10):1940-1945

  Mechanism of cigarette smoke-induced kinin B₁ receptor expression in rat airways

  Lin JC-J; Talbot S; Lahjouji K; Roy J-P; Senecal J; Couture R; Morin A
• Article: PLOS ONE. 2010;5(9):e12622

  Kinin B₁ Receptor Enhances the Oxidative Stress in a Rat Model of Insulin Resistance: Outcome in Hypertension, Allodynia and Metabolic Complications

  Dias JP; Talbot S; Senecal J; Carayon P; Couture R
• Article: JOURNAL OF NEUROINFLAMMATION. 2010;7(1):36

  Key role for spinal dorsal horn microglial kinin B₁ receptor in early diabetic pain neuropathy

  Talbot S; Chahmi E; Dias JP; Couture R
• Article: JOURNAL OF NEUROINFLAMMATION. 2009;6:11

  Cellular localization of kinin B₁ receptor in the spinal cord of streptozotocin-diabetic rats with a fluorescent [N^α-Bodipy]-des-Arg⁹-bradykinin

  Talbot S; Theberge-Turmel P; Liazoghli D; Senecal J; Gaudreau P; Couture R
• Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2008;52(3):278-285

  Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats

  Richard C; Lauzier B; Delemasure S; Talbot S; Ghibu S; Collin B; Senecal J; Menetrier F; Vergely C; Couture R; Rochette L
• Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;589(1-3):66-72

  Blockade of sensory abnormalities and kinin B₁ receptor expression by N-Acetyl-L-Cysteine and ramipril in a rat model of insulin resistance

  Ismael MA; Talbot S; Carbonneau CL; Beausejour CM; Couture R
• Article: BRITISH JOURNAL OF PHARMACOLOGY. 2008;154(1):136-143

  Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B₁ and B₂ receptors

  Abdouh M; Talbot S; Couture R; Hassessian HM
• Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2007;557(2-3):115-123

  Differential regulation of the signaling and trafficking of the two prostaglandin D₂ receptors, prostanoid DP receptor and CRTH2

  Gallant MA; Slipetz D; Hamelin E; Rochdi MD; Talbot S; de Brum-Fernandes AJ; Parent J-L
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Staff and contact

Group leader

• 

  Sebastien Talbot

  Principal Researcher

  E-mail sebastien.talbot@ki.se

Contact persons

• 

  Tuany Eichwald

  Affiliated to Research

  E-mail tuany.eichwald@ki.se

All members of the group

• 

  Laura Brabenec

  Postdoctoral Studies

  Telephone +46852482374

  E-mail laura.brabenec@ki.se
• 

  Tuany Eichwald

  Affiliated to Research

  E-mail tuany.eichwald@ki.se
• 

  Emilie Linderoth

  Laboratory Coordinator

  E-mail emilie.linderoth@ki.se
• Tamara McErlain

  Postdoctoral Studies

  E-mail tamara.mcerlain@ki.se
• 

  Sebastien Talbot

  Principal Researcher

  E-mail sebastien.talbot@ki.se

Visiting address

Karolinska Intitutet, Physiology and Pharmacology, B5, Solnavägen 9, Solna, 171 65, Sweden

Postal address

Karolinska Development (Sweden), Physiology and Pharmacology, Solnavägen 9, Solna, 171 65, Sweden