Sebastien Talbot

Sebastien Talbot

Principal Researcher
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa M Neuroimmunologi, 171 77 Stockholm

About me

  • My laboratory integrates neuroscience and immunology, which is a novel and highly dynamic field, and combines techniques of molecular and cell biology, optogenetics, tissue clearance and imaging, electrophysiology, neuroanatomy, behavior, and genetics. My goal is to identify the mechanisms and molecules that regulate the interplay between the immune and sensory nervous systems in physiology and pathology. Among the others, I will investigate the role of nociceptor neurons in cancer immunosurveillance.

Selected publications

  • Article: NATURE. 2022;611(7935):405-412
    Balood M; Ahmadi M; Eichwald T; Ahmadi A; Majdoubi A; Roversi K; Roversi K; Lucido CT; Restaino AC; Huang S; Ji L; Huang K-C; Semerena E; Thomas SC; Trevino AE; Merrison H; Parrin A; Doyle B; Vermeer DW; Spanos WC; Williamson CS; Seehus CR; Foster SL; Dai H; Shu CJ; Rangachari M; Thibodeau J; Del RSV; Drapkin R; Rafei M; Ghasemlou N; Vermeer PD; Woolf CJ; Talbot S

Articles

All other publications

Grants

  • Swedish Research Council
    1 January 2023 - 31 December 2027
    Pain is a common feature of various cancers. Cancer cells actively secrete factors promoting the neuronal infiltration of tumors. Stopping the electrical signals of tumor-infiltrating neurons helps decrease tumor growth, but the specific means through which neurons regulate cancer cell survival have yet to be determined. I discovered that cancer cells drive major changes in the gene expression profiles of tumor-infiltrating noxious-detecting neurons. I now hypothesize that cancer cells sustain their growth and survival by exploiting neuro-immunity. To investigate this, I aim to study:1) Characterize how nociceptor innervation shapes the immune landscape of skin cancer2) If silencing tumor-innervating nociceptors affect the clinical response to cancer therapeutics. 3) How nociceptor innervation blunts cancer immunosurveillance beyond neuropeptide release. This proposal will uncover how tumor-innervating nociceptors, which are typically considered as bystanders, control malignant cells´ immune escape behaviors and their resistance to therapy. It represents the first attempt to amplify the immune system´s capacity to fight cancer cells by harnessing the nervous and immune systems’ interplay. It will highlight a novel strategy to safeguard the host immunosurveillance, one focussed on silencing tumor-innervating nociceptors. The role played by tumor neo-innervation may be of similar importance to oncology as the one now appreciated for neo-angiogenesis
  • Swedish Research Council
    1 January 2023
    Pain is a common feature of various cancers. Cancer cells actively secrete factors promoting the neuronal infiltration of tumors. Stopping the electrical signals of tumor-infiltrating neurons helps decrease tumor growth, but the specific means through which neurons regulate cancer cell survival have yet to be determined. I discovered that cancer cells drive major changes in the gene expression profiles of tumor-infiltrating noxious-detecting neurons. I now hypothesize that cancer cells sustain their growth and survival by exploiting neuro-immunity. To investigate this, I aim to study:1) Characterize how nociceptor innervation shapes the immune landscape of skin cancer2) If silencing tumor-innervating nociceptors affect the clinical response to cancer therapeutics. 3) How nociceptor innervation blunts cancer immunosurveillance beyond neuropeptide release. This proposal will uncover how tumor-innervating nociceptors, which are typically considered as bystanders, control malignant cells´ immune escape behaviors and their resistance to therapy. It represents the first attempt to amplify the immune system´s capacity to fight cancer cells by harnessing the nervous and immune systems’ interplay. It will highlight a novel strategy to safeguard the host immunosurveillance, one focussed on silencing tumor-innervating nociceptors. The role played by tumor neo-innervation may be of similar importance to oncology as the one now appreciated for neo-angiogenesis

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