Sebastien Talbot

About me
Publications
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About me

My laboratory integrates neuroscience and immunology, which is a novel and highly dynamic field, and combines techniques of molecular and cell biology, optogenetics, tissue clearance and imaging, electrophysiology, neuroanatomy, behavior, and genetics. My goal is to identify the mechanisms and molecules that regulate the interplay between the immune and sensory nervous systems in physiology and pathology. Among the others, I will investigate the role of nociceptor neurons in cancer immunosurveillance.

Articles

Journal article: NATURE REVIEWS CANCER. 2025;25(8):573-589
Neuro-immune cross-talk in cancer
Amit M; Eichwald T; Roger A; Anderson J; Chang A; Vermeer PD; Dixon KO; Scheff NN; Talbot S
Article: CELL REPORTS. 2024;43(12):115045
Cytokines reprogram airway sensory neurons in asthma
Crosson T; Bhat S; Wang J-C; Salaun C; Fontaine E; Roversi K; Herzog H; Rafei M; Blunck R; Talbot S
Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2024;12(11):e009962
Morphine treatment restricts response to immunotherapy in oral squamous cell carcinoma
Mcilvried LA; Martel Matos AA; Yuan MM; Atherton MA; Obuekwe F; Nilsen ML; Nikpoor AR; Talbot S; Bruno TC; Taggart DN; Johnson LK; Ferris RL; Zandberg DP; Scheff NN
Article: BIORXIV. 2024;:2023.10.18.562990
Tumor-infiltrating nerves functionally alter brain circuits and modulate behavior in a male mouse model of head-and-neck cancer.
Barr J; Walz A; Restaino AC; Amit M; Barclay SM; Vichaya EG; Spanos WC; Dantzer R; Talbot S; Vermeer PD
Journal article: CANCER RESEARCH. 2024;84(7_Supplement):sy31-02-sy31-02
Abstract SY31-02: Nociceptor neurons control anti-tumor immunity
Eichwald T; Balood M; Ahmadi M; Roversi K; Wong D; Mandl J; Rafei M; Ghasemlou N; Vermeer P; Amit M; Talbot S
Article: CANCER SCIENCE. 2024;115(4):1102-1113
An engineered Accum-E7 protein-based vaccine with dual anti-cervical cancer activity.
Bikorimana J-P; Abusarah J; Gonçalves M; Farah R; Saad W; Talbot S; Stanga D; Beaudoin S; Plouffe S; Rafei M
Article: ISCIENCE. 2024;27(3):109248
A1-reprogrammed mesenchymal stromal cells prime potent antitumoral responses.
Gonçalves MP; Farah R; Bikorimana J-P; Abusarah J; El-Hachem N; Saad W; Talbot S; Stanga D; Beaudoin S; Plouffe S; Rafei M
Article: SCIENCE ADVANCES. 2023;9(19):eade4443
Functional neuronal circuits promote disease progression in cancer
Restaino AC; Walz A; Vermeer SJ; Barr J; Kovacs A; Fettig RR; Vermeer DW; Reavis H; Williamson CS; Lucido CT; Eichwald T; Omran DK; Jung E; Schwartz LE; Bell M; Muirhead DM; Hooper JE; Spanos WC; Drapkin R; Talbot S; Vermeer PD
Article: CELLS. 2023;12(8):1189
A Preliminary Study of Mild Heat Stress on Inflammasome Activation in Murine Macrophages
Foster SL; Dutton AJ; Yerzhan A; March LB; Barry K; Seehus CR; Huang X; Talbot S; Woolf CJ
Article: ISCIENCE. 2022;25(12):105537
The CIt protocol: A blueprint to potentiate the immunogenicity of immunoproteasome-reprogrammed mesenchymal stromal cells
Bikorimana J-P; El-Hachem N; Abusarah J; Eliopoulos N; Talbot S; Shammaa R; Rafei M
Article: BIO-PROTOCOL. 2022;12(19):e4527
LIST: A Newly Developed Laser-assisted Cell Bioprinting Technology
Roversi K; Orimi HE; Erfanian M; Talbot S; Boutopoulos C
Article: CELLS. 2022;11(15):2263
CD146 Defines a Mesenchymal Stromal Cell Subpopulation with Enhanced Suppressive Properties
Bikorimana J-P; Saad W; Abusarah J; Lahrichi M; Talbot S; Shammaa R; Rafei M
Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2022;67(1):e1-18
Advancing Lung Immunology Research An Official American Thoracic Society Workshop Report
Rahimi RA; Cho JL; Jakubzick CV; Khader SA; Lambrecht BN; Lloyd CM; Molofsky AB; Talbot S; Bonham CA; Drake WP; Sperling AI; Singer BD
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2022;(184)
Teasing Out the Interplay Between Natural Killer Cells and Nociceptor Neurons
Ahmadi A; Balood M; Roversi K; Ahmadi M; Rafei M; Talbot S
Article: CELLS. 2022;11(11):1816
LSD1 Inhibition Enhances the Immunogenicity of Mesenchymal Stromal Cells by Eliciting a dsRNA Stress Response
Mardani F; Saad W; El-Hachem N; Bikorimana J-P; Kurdi M; Shammaa R; Talbot S; Rafei M
Article: BIOELECTRONIC MEDICINE. 2022;8(1):7
Anatomical differences in nociceptor neurons sensitivity.
Crosson T; Talbot S
Article: SMALL. 2022;18(14):e2103364
Nanophotonics Enable Targeted Photothermal Silencing of Nociceptor Neurons
Roversi K; Tabatabaei M; Desjardins-Lecavalier N; Balood M; Crosson T; Costantino S; Griffith M; Talbot S; Boutopoulos C
Article: CELL REPORTS MEDICINE. 2022;3(3):100534
Promoting antigen escape from dendritic cell endosomes potentiates anti-tumoral immunity
Bikorimana J-P; Salame N; Beaudoin S; Balood M; Crosson T; Abusarah J; Talbot S; Lobenberg R; Plouffe S; Rafei M
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2506:297-314
Analysis of Airway Vagal Neurons.
Wang J-C; Crosson T; Talbot S
Article: JCI INSIGHT. 2021;6(24):e148510
Nociceptor neurons promote IgE class switch in B cells
Mathur S; Wang J-C; Seehus CR; Poirier F; Crosson T; Hsieh Y-C; Doyle B; Lee S; Woolf CJ; Foster SL; Talbot S
Article: CELL REPORTS MEDICINE. 2021;2(12):100455
Engineering immunoproteasome-expressing mesenchymal stromal cells: A potent cellular vaccine for lymphoma and melanoma in mice
Abusarah J; Khodayarian F; El-Hachem N; Salame N; Olivier M; Balood M; Roversi K; Talbot S; Bikorimana J-P; Chen J; Jolicoeur M; Trudeau L-E; Kamyabiazar S; Annabi B; Robert F; Pelletier J; El-Kadiry A-E; Shammaa R; Rafei M
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(19):3905-3923
Inhibition of inflammatory pain and cough by a novel charged sodium channel blocker
Tochitsky I; Jo S; Andrews N; Kotoda M; Doyle B; Shim J; Talbot S; Roberson D; Lee J; Haste L; Jordan SM; Levy BD; Bean BP; Woolf CJ
Article: MICROMACHINES. 2021;12(8):865
Bioprinting of Adult Dorsal Root Ganglion (DRG) Neurons Using Laser-Induced Side Transfer (LIST)
Roversi K; Ebrahimi Orimi H; Falchetti M; Lummertz da Rocha E; Talbot S; Boutopoulos C
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(6):2330-2342
FcεR1-expressing nociceptors trigger allergic airway inflammation
Crosson T; Wang J-C; Doyle B; Merrison H; Balood M; Parrin A; Pascal M; Mindt BC; Seehus CR; Ozcan A; Huang X; Semenara E; Lai NYY; Majdoubi A; Abdulnour R-EE; Rajchgot T; Rafei M; Foster SL; Thibodeau J; Fritz JH; Levy BD; Woolf CJ; Talbot S
Article: NATURE BIOTECHNOLOGY. 2021;39(2):179-185
Epineural optogenetic activation of nociceptors initiates and amplifies inflammation
Michoud F; Seehus C; Schoenle P; Brun N; Taub D; Zhang Z; Jain A; Furfaro I; Akouissi O; Moon R; Meier P; Galan K; Doyle B; Tetreault M; Talbot S; Browne LE; Huang Q; Woolf CJ; Lacour SP
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(6):1693-1696.e4
Vagal sensory neurons drive mucous cell metaplasia
Talbot S; Doyle B; Huang J; Wang J-C; Ahmadi M; Roberson DP; Yekkirala A; Foster SL; Browne LE; Bean BP; Levy BD; Woolf CJ
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:237
A Novel Sulfonyl-Based Small Molecule Exhibiting Anti-cancer Properties
El-Kadiry AE-H; Abusarah J; Cui YE; El-Hachem N; Hammond-Martel I; Wurtele H; Thomas S; Ahmadi M; Balood M; Talbot S; Rafei M
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:1953
Lack of the E3 Ubiquitin Ligase March1 Affects CD8 T Cell Fate and Exacerbates Insulin Resistance in Obese Mice
Majdoubi A; Lee JS; Kishta OA; Balood M; Moulefera MA; Ishido S; Talbot S; Cheong C; Alquier T; Thibodeau J
Article: JOURNAL OF IMMUNOLOGY. 2019;203(11):2887-2898
Downregulation of MHC Class II by Ubiquitination Is Required for the Migration of CD206⁺ Dendritic Cells to Skin-Draining Lymph Nodes
Majdoubi A; Lee JS; Balood M; Sabourin A; DeMontigny A; Kishta OA; Moulefera MA; Galbas T; Yun TJ; Talbot S; Ishido S; Cheong C; Thibodeau J
Article: ELIFE. 2019;8:e48118
Novel charged sodium and calcium channel inhibitor active against neurogenic inflammation
Lee S; Jo S; Talbot S; Zhang H-XB; Kotoda M; Andrews NA; Puopolo M; Liu PW; Jacquemont T; Pascal M; Heckman LM; Jain A; Lee J; Woolf CJ; Bean BP
Journal article: JOURNAL OF INTERNAL MEDICINE. 2019;286(3):268-289
Profiling of how nociceptor neurons detect danger - new and old foes
Crosson T; Roversi K; Balood M; Othman R; Ahmadi M; Wang J-C; Pereira PJS; Tabatabaei M; Couture R; Eichwald T; Latini A; Prediger RD; Rangachari M; Seehus CR; Fosters SL; Talbot S
Article: STEM CELL REPORTS. 2019;12(1):29-41
Neurite Collapse and Altered ER Ca²⁺ Control in Human Parkinson Disease Patient iPSC-Derived Neurons with LRRK2 G2019S Mutation
Korecka JA; Talbot R; Osborn TM; de Leeuw SM; Levy SA; Ferrari EJ; Moskites A; Atkinson E; Jodelka FM; Hinrich AJ; Hastings ML; Woolf CJ; Hallett PJ; Isacson O
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:3115
Endogenous T Cell Receptor Rearrangement Represses Aggressive Central Nervous System Autoimmunity in a TcR-Transgenic Model on the Non-Obese Diabetic Background
Yeola AP; Doss PMIA; Baillargeon J; Akbar I; Mailhot B; Balood M; Talbot S; Anderson AC; Lacroix S; Rangachari M
Article: NATURE. 2018;563(7732):564-568
The metabolite BH4 controls T cell proliferation in autoimmunity and cancer
Cronin SJF; Seehus C; Weidinger A; Talbot S; Reissig S; Seifert M; Pierson Y; McNeill E; Longhi MS; Turnes BL; Kreslavsky T; Kogler M; Hoffmann D; Ticevic M; Scheffer DDL; Tortola L; Cikes D; Jais A; Rangachari M; Rao S; Paolino M; Novatchkova M; Aichinger M; Barrett L; Latremoliere A; Wirnsberger G; Lametschwandtner G; Busslinger M; Zicha S; Latini A; Robson SC; Waisman A; Andrews N; Costigan M; Channon KM; Weiss G; Kozlov AV; Tebbe M; Johnsson K; Woolf CJ; Penninger JM
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(2):447-453.e3
Substance P activates Mas-related G protein-coupled receptors to induce itch
Azimi E; Reddy VB; Seadi Pereira PJ; Talbot S; Woolf CJ; Lerner EA
Article: JCI INSIGHT. 2016;1(16):e89362
Dual action of neurokinin-1 antagonists on Mas-related GPCRs
Azimi E; Reddy VB; Shade K-TC; Anthony RM; Talbot S; Pereira PJS; Lerner EA
Article: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 2016;94(7):752-757
Beneficial effects of kinin B1 receptor antagonism on plasma fatty acid alterations and obesity in Zucker diabetic fatty rats
Talbot S; Dias JP; El Midaoui A; Couture R
Article: BIOELECTRONIC MEDICINE. 2016;3:18-28
Neuronal Circuits Modulate Antigen Flow Through Lymph Nodes.
Hanes WM; Olofsson PS; Talbot S; Tsaava T; Ochani M; Imperato GH; Levine YA; Roth J; Pascal MA; Foster SL; Wang P; Woolf C; Chavan SS; Tracey KJ
Article: JOURNAL OF NEUROSCIENCE. 2015;35(49):16272-16281
GRPR/PI3Kγ: Partners in Central Transmission of Itch
Pereira PJS; Machado GDB; Danesi GM; Canevese FF; Reddy VB; Pereira TCB; Bogo MR; Cheng Y-C; Laedermann C; Talbot S; Lerner EA; Campos MM
Article: NEURON. 2015;87(2):341-354
Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation
Talbot S; Abdulnour R-EE; Burkett PR; Lee S; Cronin SJF; Pascal MA; Laedermann C; Foster SL; Tran JV; Lai N; Chiu IM; Ghasemlou N; DiBiase M; Roberson D; Von Hehn C; Agac B; Haworth O; Seki H; Penninger JM; Kuchroo VK; Bean BP; Levy BD; Woolf CJ
Article: J DIABETES METAB. 2015;6(6):1-7
Effects of Alpha-Lipoic Acid on Oxidative Stress and Kinin Receptor Expression in Obese Zucker Diabetic Fatty Rats.
Midaoui AE; Talbot S; Lahjouji K; Dias JP; Fantus IG; Couture R
Article: BEHAVIOURAL BRAIN RESEARCH. 2013;241:17-26
Brain kinin B₁ receptor contributes to the onset of stereotypic nocifensive behavior in rat
Gariepy HDB; Talbot S; Senecal J; Couture R
Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:214
Activation of kinin B1 receptor evokes hyperthermia through a vagal sensory mechanism in the rat
Talbot S; Gariepy HDB; Saint-Denis J; Couture R
Article: EXPERIMENTAL NEUROLOGY. 2012;234(2):373-381
Emerging role of microglial kinin B1 receptor in diabetic pain neuropathy
Talbot S; Couture R
Article: TOXICOLOGY. 2012;293(1-3):125-131
An ex vivo approach to the differential parenchymal responses induced by cigarette whole smoke and its vapor phase
Lin JC-J; Roy J-P; Verreault J; Talbot S; Cote F; Couture R; Morin A
Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:16
Activation of TRPV1 by capsaicin induces functional Kinin B₁ receptor in rat spinal cord microglia
Talbot S; Dias JP; Lahjouji K; Bogo MR; Campos MM; Gaudreau P; Couture R
Article: PLOS ONE. 2012;7(3):e33864
Ocular Application of the Kinin B₁ Receptor Antagonist LF22-0542 Inhibits Retinal Inflammation and Oxidative Stress in Streptozotocin-Diabetic Rats
Pouliot M; Talbot S; Senecal J; Dotigny F; Vaucher E; Couture R
Article: PEPTIDES. 2011;32(7):1447-1456
Cigarette smoke-induced kinin B1 receptor promotes NADPH oxidase activity in cultured human alveolar epithelial cells
Talbot S; Lin JC-J; Lahjouji K; Roy J-P; Senecal J; Morin A; Couture R
Article: PEPTIDES. 2010;31(10):1940-1945
Mechanism of cigarette smoke-induced kinin B₁ receptor expression in rat airways
Lin JC-J; Talbot S; Lahjouji K; Roy J-P; Senecal J; Couture R; Morin A
Article: PLOS ONE. 2010;5(9):e12622
Kinin B₁ Receptor Enhances the Oxidative Stress in a Rat Model of Insulin Resistance: Outcome in Hypertension, Allodynia and Metabolic Complications
Dias JP; Talbot S; Senecal J; Carayon P; Couture R
Article: JOURNAL OF NEUROINFLAMMATION. 2010;7(1):36
Key role for spinal dorsal horn microglial kinin B₁ receptor in early diabetic pain neuropathy
Talbot S; Chahmi E; Dias JP; Couture R
Article: JOURNAL OF NEUROINFLAMMATION. 2009;6:11
Cellular localization of kinin B₁ receptor in the spinal cord of streptozotocin-diabetic rats with a fluorescent [N^α-Bodipy]-des-Arg⁹-bradykinin
Talbot S; Theberge-Turmel P; Liazoghli D; Senecal J; Gaudreau P; Couture R
Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2008;52(3):278-285
Effects of angiotensin-1 converting enzyme inhibition on oxidative stress and bradykinin receptor expression during doxorubicin-induced cardiomyopathy in rats
Richard C; Lauzier B; Delemasure S; Talbot S; Ghibu S; Collin B; Senecal J; Menetrier F; Vergely C; Couture R; Rochette L
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;589(1-3):66-72
Blockade of sensory abnormalities and kinin B₁ receptor expression by N-Acetyl-L-Cysteine and ramipril in a rat model of insulin resistance
Ismael MA; Talbot S; Carbonneau CL; Beausejour CM; Couture R
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2008;154(1):136-143
Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B₁ and B₂ receptors
Abdouh M; Talbot S; Couture R; Hassessian HM
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2007;557(2-3):115-123
Differential regulation of the signaling and trafficking of the two prostaglandin D₂ receptors, prostanoid DP receptor and CRTH2
Gallant MA; Slipetz D; Hamelin E; Rochdi MD; Talbot S; de Brum-Fernandes AJ; Parent J-L
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