Sebastien Talbot
Principal Researcher
E-mail: sebastien.talbot@ki.se
Visiting address: Solnavägen 9, Biomedicum, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa M Neuroimmunologi, 171 77 Stockholm
About me
My laboratory integrates neuroscience and immunology, which is a novel and highly dynamic field, and combines techniques of molecular and cell biology, optogenetics, tissue clearance and imaging, electrophysiology, neuroanatomy, behavior, and genetics. My goal is to identify the mechanisms and molecules that regulate the interplay between the immune and sensory nervous systems in physiology and pathology. Among the others, I will investigate the role of nociceptor neurons in cancer immunosurveillance.
Selected publications
- Article: NATURE. 2022;611(7935):405-412Balood M; Ahmadi M; Eichwald T; Ahmadi A; Majdoubi A; Roversi K; Roversi K; Lucido CT; Restaino AC; Huang S; Ji L; Huang K-C; Semerena E; Thomas SC; Trevino AE; Merrison H; Parrin A; Doyle B; Vermeer DW; Spanos WC; Williamson CS; Seehus CR; Foster SL; Dai H; Shu CJ; Rangachari M; Thibodeau J; Del RSV; Drapkin R; Rafei M; Ghasemlou N; Vermeer PD; Woolf CJ; Talbot S
Articles
- Journal article: CELL REPORTS. 2025;44(9):116258Thiel V; Sur D; Picoli CC; Mcerlain T; Couto K; Simon DJ; Pan Y; Dixon KO; Kulkarni RP; Talbot S; Birbrair A
- Journal article: NEURON. 2025;113(17):2760-2790Sur D; Zeng Y; Kobayashi H; Zhi X; Goetz MR; Muller CM; Zavitsanou A-M; Picoli CC; Matos AAM; Pareja J; Savita BK; Lee T; Cunha-Junior JP; Amorim JH; Nikpoor AR; Dory A; Thanabalasuriar A; Galante PAF; Ma VT; James AW; Shepherd AJ; Oudin MJ; Bunimovich YL; Scheff NN; D'Silva NJ; Dixon KO; Abdus-Saboor I; Wang TC; Talbot S; Birbrair A
- Journal article: NATURE. 2025;:1-12Baruch EN; Gleber-Netto FO; Nagarajan P; Rao X; Akhter S; Eichwald T; Xie T; Balood M; Adewale A; Naara S; Sathishkumar HN; Islam S; McCarthy W; Mattson BJ; Ferrarotto R; Wong MK; Davies MA; Jindal S; Basu S; Roversi K; Nikpoor AR; Ahmadi M; Ahmadi A; Harwood C; Leigh I; Gong D; Tallon de Lara P; Tao DL; Davidson TM; Ajami NJ; Futreal A; Rai K; Kochat V; Castillo M; Gunaratne P; Goepfert RP; Hernandez SD; Khushalani NI; Wang J; Watowich SS; Calin GA; Migden MR; Yuan M; Liu N; Ye Y; Hwang WL; Vermeer PD; D'Silva NJ; Bunimovich YL; Yaniv D; Burks JK; Gomez J; Dougherty PM; Tsai KY; Allison JP; Sharma P; Wargo JA; Myers JN; Talbot S; Gross ND; Amit M
- Journal article: NATURE REVIEWS CANCER. 2025;25(8):573-589Amit M; Eichwald T; Roger A; Anderson J; Chang A; Vermeer PD; Dixon KO; Scheff NN; Talbot S
- Article: CELL REPORTS. 2024;43(12):115045Crosson T; Bhat S; Wang J-C; Salaun C; Fontaine E; Roversi K; Herzog H; Rafei M; Blunck R; Talbot S
- Article: JOURNAL FOR IMMUNOTHERAPY OF CANCER. 2024;12(11):e009962Mcilvried LA; Martel Matos AA; Yuan MM; Atherton MA; Obuekwe F; Nilsen ML; Nikpoor AR; Talbot S; Bruno TC; Taggart DN; Johnson LK; Ferris RL; Zandberg DP; Scheff NN
- Article: BIORXIV. 2024;:2023.10.18.562990Barr J; Walz A; Restaino AC; Amit M; Barclay SM; Vichaya EG; Spanos WC; Dantzer R; Talbot S; Vermeer PD
- Journal article: CANCER RESEARCH. 2024;84(7_Supplement):sy31-02-sy31-02Eichwald T; Balood M; Ahmadi M; Roversi K; Wong D; Mandl J; Rafei M; Ghasemlou N; Vermeer P; Amit M; Talbot S
- Article: CANCER SCIENCE. 2024;115(4):1102-1113Bikorimana J-P; Abusarah J; Gonçalves M; Farah R; Saad W; Talbot S; Stanga D; Beaudoin S; Plouffe S; Rafei M
- Article: ISCIENCE. 2024;27(3):109248Gonçalves MP; Farah R; Bikorimana J-P; Abusarah J; El-Hachem N; Saad W; Talbot S; Stanga D; Beaudoin S; Plouffe S; Rafei M
- Article: SCIENCE ADVANCES. 2023;9(19):eade4443Restaino AC; Walz A; Vermeer SJ; Barr J; Kovacs A; Fettig RR; Vermeer DW; Reavis H; Williamson CS; Lucido CT; Eichwald T; Omran DK; Jung E; Schwartz LE; Bell M; Muirhead DM; Hooper JE; Spanos WC; Drapkin R; Talbot S; Vermeer PD
- Article: CELLS. 2023;12(8):1189Foster SL; Dutton AJ; Yerzhan A; March LB; Barry K; Seehus CR; Huang X; Talbot S; Woolf CJ
- Article: ISCIENCE. 2022;25(12):105537Bikorimana J-P; El-Hachem N; Abusarah J; Eliopoulos N; Talbot S; Shammaa R; Rafei M
- Article: BIO-PROTOCOL. 2022;12(19):e4527Roversi K; Orimi HE; Erfanian M; Talbot S; Boutopoulos C
- Article: CELLS. 2022;11(15):2263Bikorimana J-P; Saad W; Abusarah J; Lahrichi M; Talbot S; Shammaa R; Rafei M
- Article: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY. 2022;67(1):e1-18Rahimi RA; Cho JL; Jakubzick CV; Khader SA; Lambrecht BN; Lloyd CM; Molofsky AB; Talbot S; Bonham CA; Drake WP; Sperling AI; Singer BD
- Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2022;(184)Ahmadi A; Balood M; Roversi K; Ahmadi M; Rafei M; Talbot S
- Article: CELLS. 2022;11(11):1816Mardani F; Saad W; El-Hachem N; Bikorimana J-P; Kurdi M; Shammaa R; Talbot S; Rafei M
- Article: BIOELECTRONIC MEDICINE. 2022;8(1):7Crosson T; Talbot S
- Article: SMALL. 2022;18(14):e2103364Roversi K; Tabatabaei M; Desjardins-Lecavalier N; Balood M; Crosson T; Costantino S; Griffith M; Talbot S; Boutopoulos C
- Article: CELL REPORTS MEDICINE. 2022;3(3):100534Bikorimana J-P; Salame N; Beaudoin S; Balood M; Crosson T; Abusarah J; Talbot S; Lobenberg R; Plouffe S; Rafei M
- Article: METHODS IN MOLECULAR BIOLOGY. 2022;2506:297-314Wang J-C; Crosson T; Talbot S
- Article: JCI INSIGHT. 2021;6(24):e148510Mathur S; Wang J-C; Seehus CR; Poirier F; Crosson T; Hsieh Y-C; Doyle B; Lee S; Woolf CJ; Foster SL; Talbot S
- Article: CELL REPORTS MEDICINE. 2021;2(12):100455Abusarah J; Khodayarian F; El-Hachem N; Salame N; Olivier M; Balood M; Roversi K; Talbot S; Bikorimana J-P; Chen J; Jolicoeur M; Trudeau L-E; Kamyabiazar S; Annabi B; Robert F; Pelletier J; El-Kadiry A-E; Shammaa R; Rafei M
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2021;178(19):3905-3923Tochitsky I; Jo S; Andrews N; Kotoda M; Doyle B; Shim J; Talbot S; Roberson D; Lee J; Haste L; Jordan SM; Levy BD; Bean BP; Woolf CJ
- Article: MICROMACHINES. 2021;12(8):865Roversi K; Ebrahimi Orimi H; Falchetti M; Lummertz da Rocha E; Talbot S; Boutopoulos C
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;147(6):2330-2342Crosson T; Wang J-C; Doyle B; Merrison H; Balood M; Parrin A; Pascal M; Mindt BC; Seehus CR; Ozcan A; Huang X; Semenara E; Lai NYY; Majdoubi A; Abdulnour R-EE; Rajchgot T; Rafei M; Foster SL; Thibodeau J; Fritz JH; Levy BD; Woolf CJ; Talbot S
- Article: NATURE BIOTECHNOLOGY. 2021;39(2):179-185Michoud F; Seehus C; Schoenle P; Brun N; Taub D; Zhang Z; Jain A; Furfaro I; Akouissi O; Moon R; Meier P; Galan K; Doyle B; Tetreault M; Talbot S; Browne LE; Huang Q; Woolf CJ; Lacour SP
- Article: FRONTIERS IN IMMUNOLOGY. 2020;11:1953Majdoubi A; Lee JS; Kishta OA; Balood M; Moulefera MA; Ishido S; Talbot S; Cheong C; Alquier T; Thibodeau J
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2020;145(6):1693-1696.e4Talbot S; Doyle B; Huang J; Wang J-C; Ahmadi M; Roberson DP; Yekkirala A; Foster SL; Browne LE; Bean BP; Levy BD; Woolf CJ
- Article: FRONTIERS IN PHARMACOLOGY. 2020;11:237El-Kadiry AE-H; Abusarah J; Cui YE; El-Hachem N; Hammond-Martel I; Wurtele H; Thomas S; Ahmadi M; Balood M; Talbot S; Rafei M
- Article: FRONTIERS IN IMMUNOLOGY. 2020;10:3115Yeola AP; Doss PMIA; Baillargeon J; Akbar I; Mailhot B; Balood M; Talbot S; Anderson AC; Lacroix S; Rangachari M
- Article: JOURNAL OF IMMUNOLOGY. 2019;203(11):2887-2898Majdoubi A; Lee JS; Balood M; Sabourin A; DeMontigny A; Kishta OA; Moulefera MA; Galbas T; Yun TJ; Talbot S; Ishido S; Cheong C; Thibodeau J
- Article: ELIFE. 2019;8:e48118Lee S; Jo S; Talbot S; Zhang H-XB; Kotoda M; Andrews NA; Puopolo M; Liu PW; Jacquemont T; Pascal M; Heckman LM; Jain A; Lee J; Woolf CJ; Bean BP
- Journal article: JOURNAL OF INTERNAL MEDICINE. 2019;286(3):268-289Crosson T; Roversi K; Balood M; Othman R; Ahmadi M; Wang J-C; Pereira PJS; Tabatabaei M; Couture R; Eichwald T; Latini A; Prediger RD; Rangachari M; Seehus CR; Fosters SL; Talbot S
- Article: STEM CELL REPORTS. 2019;12(1):29-41Korecka JA; Talbot R; Osborn TM; de Leeuw SM; Levy SA; Ferrari EJ; Moskites A; Atkinson E; Jodelka FM; Hinrich AJ; Hastings ML; Woolf CJ; Hallett PJ; Isacson O
- Article: NATURE. 2018;563(7732):564-568Cronin SJF; Seehus C; Weidinger A; Talbot S; Reissig S; Seifert M; Pierson Y; McNeill E; Longhi MS; Turnes BL; Kreslavsky T; Kogler M; Hoffmann D; Ticevic M; Scheffer DDL; Tortola L; Cikes D; Jais A; Rangachari M; Rao S; Paolino M; Novatchkova M; Aichinger M; Barrett L; Latremoliere A; Wirnsberger G; Lametschwandtner G; Busslinger M; Zicha S; Latini A; Robson SC; Waisman A; Andrews N; Costigan M; Channon KM; Weiss G; Kozlov AV; Tebbe M; Johnsson K; Woolf CJ; Penninger JM
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(2):447-453.e3Azimi E; Reddy VB; Seadi Pereira PJ; Talbot S; Woolf CJ; Lerner EA
- Article: JCI INSIGHT. 2016;1(16):e89362Azimi E; Reddy VB; Shade K-TC; Anthony RM; Talbot S; Pereira PJS; Lerner EA
- Article: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY. 2016;94(7):752-757Talbot S; Dias JP; El Midaoui A; Couture R
- Article: BIOELECTRONIC MEDICINE. 2016;3:18-28Hanes WM; Olofsson PS; Talbot S; Tsaava T; Ochani M; Imperato GH; Levine YA; Roth J; Pascal MA; Foster SL; Wang P; Woolf C; Chavan SS; Tracey KJ
- Article: JOURNAL OF NEUROSCIENCE. 2015;35(49):16272-16281Pereira PJS; Machado GDB; Danesi GM; Canevese FF; Reddy VB; Pereira TCB; Bogo MR; Cheng Y-C; Laedermann C; Talbot S; Lerner EA; Campos MM
- Article: NEURON. 2015;87(2):341-354Talbot S; Abdulnour R-EE; Burkett PR; Lee S; Cronin SJF; Pascal MA; Laedermann C; Foster SL; Tran JV; Lai N; Chiu IM; Ghasemlou N; DiBiase M; Roberson D; Von Hehn C; Agac B; Haworth O; Seki H; Penninger JM; Kuchroo VK; Bean BP; Levy BD; Woolf CJ
- Article: J DIABETES METAB. 2015;6(6):1-7Midaoui AE; Talbot S; Lahjouji K; Dias JP; Fantus IG; Couture R
- Article: BEHAVIOURAL BRAIN RESEARCH. 2013;241:17-26Gariepy HDB; Talbot S; Senecal J; Couture R
- Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:214Talbot S; Gariepy HDB; Saint-Denis J; Couture R
- Article: EXPERIMENTAL NEUROLOGY. 2012;234(2):373-381Talbot S; Couture R
- Article: PLOS ONE. 2012;7(3):e33864Pouliot M; Talbot S; Senecal J; Dotigny F; Vaucher E; Couture R
- Article: TOXICOLOGY. 2012;293(1-3):125-131Lin JC-J; Roy J-P; Verreault J; Talbot S; Cote F; Couture R; Morin A
- Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:16Talbot S; Dias JP; Lahjouji K; Bogo MR; Campos MM; Gaudreau P; Couture R
- Article: PEPTIDES. 2011;32(7):1447-1456Talbot S; Lin JC-J; Lahjouji K; Roy J-P; Senecal J; Morin A; Couture R
- Article: PEPTIDES. 2010;31(10):1940-1945Lin JC-J; Talbot S; Lahjouji K; Roy J-P; Senecal J; Couture R; Morin A
- Article: PLOS ONE. 2010;5(9):e12622Dias JP; Talbot S; Senecal J; Carayon P; Couture R
- Article: JOURNAL OF NEUROINFLAMMATION. 2010;7(1):36Talbot S; Chahmi E; Dias JP; Couture R
- Article: JOURNAL OF NEUROINFLAMMATION. 2009;6:11Talbot S; Theberge-Turmel P; Liazoghli D; Senecal J; Gaudreau P; Couture R
- Article: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY. 2008;52(3):278-285Richard C; Lauzier B; Delemasure S; Talbot S; Ghibu S; Collin B; Senecal J; Menetrier F; Vergely C; Couture R; Rochette L
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2008;589(1-3):66-72Ismael MA; Talbot S; Carbonneau CL; Beausejour CM; Couture R
- Article: BRITISH JOURNAL OF PHARMACOLOGY. 2008;154(1):136-143Abdouh M; Talbot S; Couture R; Hassessian HM
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2007;557(2-3):115-123Gallant MA; Slipetz D; Hamelin E; Rochdi MD; Talbot S; de Brum-Fernandes AJ; Parent J-L
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All other publications
- Preprint: BIORXIV. 2025;BIORXIVWang J-C; Kulle A; Crosson T; Nikpoor AR; Gupta S; Roger A; Rafei M; Thanabalasuriar A; Talbot S
- Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2025;25(5):318Baleviciute A; Talbot S
- Editorial comment: CANCER CELL. 2025;43(1):1-5Hwang WL; Perrault EN; Birbrair A; Mattson BJ; Gutmann DH; Mabbott DJ; Cukierman E; Repasky EA; Sloan EK; Zong H; Demir IE; Saloman JL; Borniger JC; Hu J; Dietrich J; Breunig JJ; Cifcibas K; Kasm KAA; Valiente M; Wintermark M; Acharya MM; Scheff NN; D'Silva NJ; Vermeer PD; Wong RJ; Talbot S; Hervey-Jumper SL; Wang TC; Ye Y; Pan Y; Bunimovich YL; Amit M
- Review: CURRENT OPINION IN IMMUNOLOGY. 2024;91:102507Brabenec L; Gupta S; Eichwald T; Rafei M; Talbot S
- Review: NATURE REVIEWS DRUG DISCOVERY. 2024;23(10):780-796Yaniv D; Mattson B; Talbot S; Gleber-Netto FO; Amit M
- Preprint: BIORXIV. 2024;BIORXIVCrosson T; Bhat S; Wang J-C; Salaun C; Fontaine E; Roversi K; Herzog H; Rafei M; Blunck R; Talbot S
- Preprint: BIORXIV. 2024;BIORXIVRestaino AC; Ahmadi M; Nikpoor AR; Walz A; Balood M; Eichwald T; Talbot S; Vermeer PD
- Editorial comment: TRENDS IN IMMUNOLOGY. 2024;45(8):574-576Eichwald T; Talbot S
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;154(1):11-19Wilcox NC; Taheri G; Halievski K; Talbot S; Silva JR; Ghasemlou N
- Preprint: BIORXIV. 2024;BIORXIVWang J-C; Nikpoor AR; Crosson T; Kaufmann E; Rafei M; Talbot S
- Editorial comment: CANCER DISCOVERY. 2024;14(4):669-673Amit M; Anastasaki C; Dantzer R; Demir IE; Deneen B; Dixon KO; Egeblad M; Gibson EM; Hervey-Jumper SL; Hondermarck H; Magnon C; Monje M; Na'ara S; Pan Y; Repasky EA; Scheff NN; Sloan EK; Talbot S; Tracey KJ; Trotman LC; Valiente M; Van Aelst L; Venkataramani V; Venkatesh HS; Vermeer PD; Winkler F; Wong RJ; Gutmann DH; Borniger JC
- Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;153(4):924-938Gupta S; Viotti A; Eichwald T; Roger A; Kaufmann E; Othman R; Ghasemlou N; Rafei M; Foster SL; Talbot S
- Editorial comment: IMMUNITY. 2023;56(5):906-908Crosson T; Talbot S
- Review: FRONTIERS IN IMMUNOLOGY. 2021;12:759679Roversi K; Callai-Silva N; Roversi K; Griffith M; Boutopoulos C; Prediger RD; Talbot S
- Review: FRONTIERS IN HUMAN NEUROSCIENCE. 2020;14:181Eichwald T; Talbot S
- Preprint: BIORXIV. 2020Kovacs A; Vermeer D; Madeo M; Reavis H; Vermeer S; Williamson C; Rickel A; Stamp J; Lucido C; Cain J; Bell M; Morgan M; Yoon J-Y; Mitchell M; Tulina N; Stuckelberger S; Budina A; Omran D; Jung E; Schwartz L; Eichwald T; Hong Z; Weimer J; Hooper J; Godwin A; Talbot S; Drapkin R; Vermeer P
- Editorial comment: FRONTIERS IN NEUROSCIENCE. 2020;14:56Gaspar JM; Talbot S; Latini A
- Corrigendum: NATURE. 2019;572(7769):E18Cronin SJF; Seehus C; Weidinger A; Talbot S; Reissig S; Seifert M; Pierson Y; McNeill E; Longhi MS; Turnes BL; Kreslavsky T; Kogler M; Hoffmann D; Ticevic M; da Luz Scheffer D; Tortola L; Cikes D; Jais A; Rangachari M; Rao S; Paolino M; Novatchkova M; Aichinger M; Barrett L; Latremoliere A; Wirnsberger G; Lametschwandtner G; Busslinger M; Zicha S; Latini A; Robson SC; Waisman A; Andrews N; Costigan M; Channon KM; Weiss G; Kozlov AV; Tebbe M; Johnsson K; Woolf CJ; Penninger JM
- Review: FRONTIERS IN NEUROSCIENCE. 2019;13:25Rajchgot T; Thomas SC; Wang J-C; Ahmadi M; Balood M; Crosson T; Dias JP; Couture R; Claing A; Talbot S
- Editorial comment: OXIDATIVE MEDICINE AND CELLULAR LONGEVITY. 2019;2019:2715326-2Latini A; Pereira PJS; Couture R; Campos MM; Talbot S
- Review: FRONTIERS IN IMMUNOLOGY. 2017;8:1463Foster SL; Seehus CR; Woolf CJ; Talbot S
- Review: ANNUAL REVIEW OF IMMUNOLOGY. 2016;34:421-447Talbot S; Foster SL; Woolf CJ
- Editorial comment: IMMUNITY. 2015;42(3):403-405Foster SL; Talbot S; Woolf CJ
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Grants
- Swedish Research Council1 January 2023 - 31 December 2027Pain is a common feature of various cancers. Cancer cells actively secrete factors promoting the neuronal infiltration of tumors. Stopping the electrical signals of tumor-infiltrating neurons helps decrease tumor growth, but the specific means through which neurons regulate cancer cell survival have yet to be determined. I discovered that cancer cells drive major changes in the gene expression profiles of tumor-infiltrating noxious-detecting neurons. I now hypothesize that cancer cells sustain their growth and survival by exploiting neuro-immunity. To investigate this, I aim to study:1) Characterize how nociceptor innervation shapes the immune landscape of skin cancer2) If silencing tumor-innervating nociceptors affect the clinical response to cancer therapeutics. 3) How nociceptor innervation blunts cancer immunosurveillance beyond neuropeptide release. This proposal will uncover how tumor-innervating nociceptors, which are typically considered as bystanders, control malignant cells´ immune escape behaviors and their resistance to therapy. It represents the first attempt to amplify the immune system´s capacity to fight cancer cells by harnessing the nervous and immune systems’ interplay. It will highlight a novel strategy to safeguard the host immunosurveillance, one focussed on silencing tumor-innervating nociceptors. The role played by tumor neo-innervation may be of similar importance to oncology as the one now appreciated for neo-angiogenesis
- Swedish Research Council1 January 2023Pain is a common feature of various cancers. Cancer cells actively secrete factors promoting the neuronal infiltration of tumors. Stopping the electrical signals of tumor-infiltrating neurons helps decrease tumor growth, but the specific means through which neurons regulate cancer cell survival have yet to be determined. I discovered that cancer cells drive major changes in the gene expression profiles of tumor-infiltrating noxious-detecting neurons. I now hypothesize that cancer cells sustain their growth and survival by exploiting neuro-immunity. To investigate this, I aim to study:1) Characterize how nociceptor innervation shapes the immune landscape of skin cancer2) If silencing tumor-innervating nociceptors affect the clinical response to cancer therapeutics. 3) How nociceptor innervation blunts cancer immunosurveillance beyond neuropeptide release. This proposal will uncover how tumor-innervating nociceptors, which are typically considered as bystanders, control malignant cells´ immune escape behaviors and their resistance to therapy. It represents the first attempt to amplify the immune system´s capacity to fight cancer cells by harnessing the nervous and immune systems’ interplay. It will highlight a novel strategy to safeguard the host immunosurveillance, one focussed on silencing tumor-innervating nociceptors. The role played by tumor neo-innervation may be of similar importance to oncology as the one now appreciated for neo-angiogenesis