Martin Hällberg's Group

Structural basis of RNA biogenesis

The Hällberg group investigates molecular mechanisms of mitochondrial and viral gene expression. For mitochondrial gene expression we are working on the aspects of early RNA processing, mitoribosome biogenesis and genome segregation. For viral replication we are primarily interested in the Herpesviral replication machinery as a target for better antiviral therapies.

During the Covid-19 pandemic the group has collaborated to help develop therapeutic interventions towards active viral infection, primarily using nanobodies against the SARS-CoV-2 spike protein.

We are using an integrative structural cell biology approach using a combination of cryoelectron tomography, single-particle cryo-electron microscopy, cryoconfocal microscopy, biochemistry, X-ray crystallography and small-angle-X-ray scattering.

Group members

Selected Publications

An alpaca nanobody neutralizes SARS-CoV-2 by blocking receptor interaction.
Hanke L, Vidakovics Perez L, Sheward DJ, Das H, Schulte T, Moliner-Morro A, et al
Nat Commun 2020 09;11(1):4420

The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria.
Reinhard L, Sridhara S, Hällberg BM
Nucleic Acids Res. 2017 Dec;45(21):12469-12480

Structure of mitochondrial poly(A) RNA polymerase reveals the structural basis for dimerization, ATP selectivity and the SPAX4 disease phenotype.
Lapkouski M, Hällberg BM
Nucleic Acids Res. 2015 Oct;43(18):9065-75

Structure of the nuclease subunit of human mitochondrial RNase P.
Reinhard L, Sridhara S, Hällberg BM
Nucleic Acids Res. 2015 Jun;43(11):5664-72

TEFM is a potent stimulator of mitochondrial transcription elongation in vitro.
Posse V, Shahzad S, Falkenberg M, Hällberg BM, Gustafsson CM
Nucleic Acids Res. 2015 Mar;43(5):2615-24