Research team Monika Ehnman

Cells of the tumor microenvironment control tumor growth, metastasis and response to treatment. These aspects of tumor biology are well studied in tumors derived from epithelial cells, but much less described in sarcomas. These malignant tumors of mesenchymal origin can be found almost anywhere in the body and include subtypes like rhabdomyosarcoma, Ewing sarcoma and osteosarcoma.

The sarcoma tumor microenvironment (TME) team focuses on understanding how malignant and non-malignant cells communicate and educate each other during sarcoma progression.

We have currently developed several distinct in vitro and in vivo model systems for sarcoma TME studies. Methods used in the lab, or together with our national or international collaborators, include advanced cell culture, flow cytometry, qPCR and gene expression analysis (including bioinformatics), immunostaining (including multiplexing) of human or mouse tissue material, and microscopy/image analysis. Our projects are translational and involve collaborations with bioinformaticians, pathologists, oncologists and surgeons.

For further information and Publications, see https://staff.ki.se/people/monika-ehnman

Group members

Monika Ehnman, Assistant Professor
Yue Zhang, postdoc
Yanhong Su, MD, PhD student
Binbin Zhao, PhD student

Visiting researchers and affiliated

Wei Ouyang, PhD, postdoc
Maya Nisancioglu Hestnes, MD, PhD
Liu Zhen Meng, master student
Martin Andersson, MD student

Alumni

Master students: Aditi Kallai, Ioanna Tsea, Shanlin Tong
Bachelor students: Karim Katkhada, Nike Olabiyi

Grants

  • Barncancerfonden
  • Cancerföreningen
  • Åke Wibergs stiftelse