Perioperative assessment of patients with obstructive sleep apnea
Research in our group revolves around perioperative assessment of patients with obstructive sleep apnea, with focus on pathophysiological mechanisms behind intermittent hypoxia and drugs used in anesthesia.
Patients with obstructive sleep apnea (OSA) have repeated episodes with hypoxia during sleep leading to hypertension and cardiovascular morbidities. Among patients at risk for complications after surgery, OSA has been identified as one of the most important risk factors.
The overall aim with this translational project is to describe respiratory control in OSA from bed to bench in relation to effects of anesthetic drugs, and to evaluate the effect of continuous positive airway pressure treatment and postoperative risk-assessment and outcome in these high-risk patients. We will use a combination of epidemiology, advanced physiological monitoring of patients combined with modern molecular and imaging techniques.
|Malin Jonsson Fagerlund||MD, PhD, Docent|
|Eva Christensson||MD, doctoral student|
|Åse Danielson||MD, doctoral student|
- Stockholm County Council
- Jeanssons stiftelser (in Swedish)
- Tore Nilssons stiftelse för medicinsk forskning (in Swedish)
- Karolinska Institutet
- The Maquet ESA Anesthesia Grant
- Odd Fellow-logers minnes- och hyllningsfond
Pronounced depression by propofol on carotid body response to CO2 and K+-induced carotid body activation.
Respir Physiol Neurobiol 2008 Feb;160(3):284-8
Distinct pharmacologic properties of neuromuscular blocking agents on human neuronal nicotinic acetylcholine receptors: a possible explanation for the train-of-four fade.
Anesthesiology 2006 Sep;105(3):521-33
Activation and inhibition of human muscular and neuronal nicotinic acetylcholine receptors by succinylcholine.
Anesthesiology 2006 Apr;104(4):724-33