Urban Lendahl's Group
Our long-term goal is to understand how the Notch signaling pathway functions at the molecular level, and how it controls cell fate decisions in normal development as well as when dysregulated in disease.
We work on several aspects of Notch signaling. We study the role of Notch signaling in different organ systems, including the vasculature and the liver. We also address the consequences of Notch dysregulation in disease, notably in vascular disease including CADASIL and in the liver diseases Alagille syndrome and Biliary Atresia. We also study the role of Notch in cancer, with a particular focus on breast cancer.
In addition, we (together with Christer Betsholtz’ research group) use large-scale single cell transcriptomics to gain molecular insights into various vascular cell types (vascular smooth muscle cells, pericytes and endothelial cells) and cells associated with the vasculature, such as perivascular fibroblasts and different classes of brain immune cells.
Notch Signaling in Development, Tissue Homeostasis, and Disease.
Siebel C, Lendahl U
Physiol Rev 2017 10;97(4):1235-1294
Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations.
Andersson ER, Chivukula IV, Hankeova S, Sjöqvist M, Tsoi YL, Ramsköld D, Masek J, Elmansuri A, Hoogendoorn A, Vazquez E, Storvall H, Netušilová J, Huch M, Fischler B, Ellis E, Contreras A, Nemeth A, Chien KC, Clevers H, Sandberg R, Bryja V, Lendahl U
Gastroenterology 2018 03;154(4):1080-1095
A molecular atlas of cell types and zonation in the brain vasculature.
Vanlandewijck M, He L, Mäe MA, Andrae J, Ando K, Del Gaudio F, Nahar K, Lebouvier T, Laviña B, Gouveia L, Sun Y, Raschperger E, Räsänen M, Zarb Y, Mochizuki N, Keller A, Lendahl U, Betsholtz C
Nature 2018 02;554(7693):475-480
Notch signaling promotes a HIF2α-driven hypoxic response in multiple tumor cell types.
Mutvei AP, Landor SK, Fox R, Braune EB, Tsoi YL, Phoon YP, Sahlgren C, Hartman J, Bergh J, Jin S, Lendahl U
Oncogene 2018 11;37(46):6083-6095