Oscar Fernandez-Capetillo group

The Fernández-Capetillo laboratory focuses on the use of cell-based phenotypic screens for the development of new medicines. Neglected until rather recently, due to a focus on target-oriented drug development, phenotypic screens have yielded some of the most important medical advances to our societies. With the help of automatized microscopes, the laboratory designs phenotypic screens that aim to mimic a disease condition.

Part of the Department of Medical Biochemistry and Biophysics

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Publications
Members and contact

Publications

Selected publications

Article: MICROPUBLICATION BIOLOGY. 2023;2023:10.17912/micropub.biology

A chemical screen underscores the essential role of STAT1-dependent IFNγ signaling to regulate HLA-I expression in cancer cells.

Barz M; Porebski B; Panshikar P; Häggbladd M; Hühn D; Fernandez-Capetillo O
Article: MOLECULAR ONCOLOGY. 2022;16(1):148-165

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells.

Hühn D; Martí-Rodrigo P; Mouron S; Hansel C; Tschapalda K; Porebski B; Häggblad M; Lidemalm L; Quintela-Fandino M; Carreras-Puigvert J; Fernandez-Capetillo O
Article: PLOS BIOLOGY. 2021;19(5):e3001263

A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors.

Corman A; Kanellis DC; Michalska P; Häggblad M; Lafarga V; Bartek J; Carreras-Puigvert J; Fernandez-Capetillo O
Article: CELL CHEMICAL BIOLOGY. 2019;26(2):235-243.e5

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats.

Corman A; Jung B; Häggblad M; Bräutigam L; Lafarga V; Lidemalm L; Hühn D; Carreras-Puigvert J; Fernandez-Capetillo O
Article: MOLECULAR CELL. 2016;62(2):307-313

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors.

Ruiz S; Mayor-Ruiz C; Lafarga V; Murga M; Vega-Sendino M; Ortega S; Fernandez-Capetillo O
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2016;23(4):270-277

USP7 is a SUMO deubiquitinase essential for DNA replication.

Lecona E; Rodriguez-Acebes S; Specks J; Lopez-Contreras AJ; Ruppen I; Murga M; Muñoz J; Mendez J; Fernandez-Capetillo O
Article: EMBO JOURNAL. 2015;34(21):2604-2619

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity.

Jacome A; Gutierrez-Martinez P; Schiavoni F; Tenaglia E; Martinez P; Rodríguez-Acebes S; Lecona E; Murga M; Méndez J; Blasco MA; Fernandez-Capetillo O

Members and contact

Group leader

Oscar Fernandez-Capetillo
Professor

Telephone +46852481262

E-mail oscar.fernandez-capetillo@ki.se

All members of the group

Myriam Barz
Phd Student

E-mail myriam.barz@ki.se
Oscar Fernandez-Capetillo
Professor

Telephone +46852481262

E-mail oscar.fernandez-capetillo@ki.se
Samuele Fisicaro
Research Assistant

E-mail samuele.fisicaro@ki.se
Maria Häggblad
Research Engineer

E-mail maria.haggblad@ki.se
Daniela Hühn
Project Manager

E-mail daniela.huhn@ki.se
Louise Lidemalm
Laboratory Technician

Telephone +46852487220

E-mail louise.lidemalm@ki.se
Bartlomiej Porebski
Postdoctoral Researcher

E-mail bartlomiej.porebski@ki.se