Oscar Fernandez-Capetillo

About me
Publications
Public outreach and news

About me

Professor of Cancer Therapy.

Articles

Article: MOLECULAR THERAPY. 2024;32(9):3012-3024

Discovery of a novel inhibitor of macropinocytosis with antiviral activity.

Porebski B; Christ W; Corman A; Haraldsson M; Barz M; Lidemalm L; Häggblad M; Ilmain J; Wright SC; Murga M; Schlegel J; Jarvius M; Lapins M; Sezgin E; Bhabha G; Lauschke VM; Carreras-Puigvert J; Lafarga M; Klingström J; Hühn D; Fernandez-Capetillo O
Article: EBIOMEDICINE. 2024;103:105124

The anti-leprosy drug clofazimine reduces polyQ toxicity through activation of PPARγ γ

Li X; Hernandez I; Koyuncu S; Haeggblad M; Lidemalm L; Abbas AA; Bendeguz S; Goebloes A; Brautigam L; Lucas JJ; Carreras-Puigvert J; Huehn D; Pircs K; Vilchez D; Fernandez-Capetillo O
Journal article: TRENDS IN BIOCHEMICAL SCIENCES. 2023;48(3):274-287

Targeting the nucleolus as a therapeutic strategy in human disease

Corman A; Sirozh O; Lafarga V; Fernandez-Capetillo O
Article: SCIENTIFIC REPORTS. 2022;12(1):1626

An in silico analysis identifies drugs potentially modulating the cytokine storm triggered by SARS-CoV-2 infection

Sanchez-Burgos L; Gomez-Lopez G; Al-Shahrour F; Fernandez-Capetillo O
Article: BLOOD. 2022;139(2):228-239

Distinct roles for PARP-1 and PARP-2 in c-Myc-driven B-cell lymphoma in mice

Galindo-Campos MA; Lutfi N; Bonnin S; Martinez C; Velasco-Hernandez T; Garcia-Hernandez V; Martin-Caballero J; Ampurdanes C; Gimeno R; Colomo L; Roue G; Guilbaud G; Dantzer F; Navarro P; Murga M; Fernandez-Capetillo O; Bigas A; Menendez P; Sale JE; Yelamos J
Article: NATURE COMMUNICATIONS. 2022;13(1):155

A bispecific monomeric nanobody induces spike trimer dimers and neutralizes SARS-CoV-2 in vivo

Hanke L; Das H; Sheward DJ; Vidakovics LP; Urgard E; Moliner-Morro A; Kim C; Karl V; Pankow A; Smith NL; Porebski B; Fernandez-Capetillo O; Sezgin E; Pedersen GK; Coquet JM; Hallberg BM; Murrell B; McInerney GM
Article: MOLECULAR ONCOLOGY. 2022;16(1):148-165

Prolonged estrogen deprivation triggers a broad immunosuppressive phenotype in breast cancer cells

Huhn D; Marti-Rodrigo P; Mouron S; Hansel C; Tschapalda K; Porebski B; Haggblad M; Lidemalm L; Quintela-Fandino M; Carreras-Puigvert J; Fernandez-Capetillo O
Article: CELL REPORTS. 2021;37(2):109819

USP7 and VCP^FAF1 define the SUMO/Ubiquitin landscape at the DNA replication fork

Franz A; Valledor P; Ubieto-Capella P; Pilger D; Galarreta A; Lafarga V; Fernandez-Llorente A; de la Vega-Barranco G; den Brave F; Hoppe T; Fernandez-Capetillo O; Lecona E
Article: EMBO JOURNAL. 2021;40(13):e103311

Widespread displacement of DNA- and RNA-binding factors underlies toxicity of arginine-rich cell-penetrating peptides

Lafarga V; Sirozh O; Diaz-Lopez I; Galarreta A; Hisaoka M; Zarzuela E; Boskovic J; Jovanovic B; Fernandez-Leiro R; Munoz J; Stoecklin G; Ventoso I; Fernandez-Capetillo O
Article: EMBO JOURNAL. 2021;40(11):e99692

USP7 limits CDK1 activity throughout the cell cycle

Galarreta A; Valledor P; Ubieto-Capella P; Lafarga V; Zarzuela E; Munoz J; Malumbres M; Lecona E; Fernandez-Capetillo O
Article: PLOS BIOLOGY. 2021;19(5):e3001263

A chemical screen for modulators of mRNA translation identifies a distinct mechanism of toxicity for sphingosine kinase inhibitors

Corman A; Kanellis DC; Michalska P; Haggblad M; Lafarga V; Bartek J; Carreras-Puigvert J; Fernandez-Capetillo O
Article: AGING-US. 2020;12(7):5612-5624

Supraphysiological protection from replication stress does not extend mammalian lifespan.

Albers E; Avram A; Sbroggio M; Fernandez-Capetillo O; Lopez-Contreras AJ
Article: ELIFE. 2020;9:e54756

ATR expands embryonic stem cell fate potential in response to replication stress

Atashpaz S; Shams SS; Gonzalez JM; Sebestyen E; Arghavanifard N; Gnocchi A; Albers E; Minardi S; Faga G; Soffientini P; Allievi E; Cancila V; Bachi A; Fernandez-Capetillo O; Tripodo C; Ferrari F; Lopez-Contreras AJ; Costanzo V
Article: CELL REPORTS. 2019;28(3):597-604.e4

A Chemical Screen Identifies Compounds Capable of Selecting for Haploidy in Mammalian Cells

Olbrich T; Vega-Sendino M; Murga M; de Carcer G; Malumbres M; Ortega S; Ruiz S; Fernandez-Capetillo O
Article: CELL CHEMICAL BIOLOGY. 2019;26(2):235-243.e5

A Chemical Screen Identifies Compounds Limiting the Toxicity of C9ORF72 Dipeptide Repeats

Corman A; Jung B; Haggblad M; Brautigam L; Lafarga V; Lidemalm L; Huhn D; Carreras-Puigvert J; Fernandez-Capetillo O
Article: EMBO REPORTS. 2019;20(1):e46224

TIAR marks nuclear G2/M transition granules and restricts CDK1 activity under replication stress

Lafarga V; Sung H-M; Haneke K; Roessig L; Pauleau A-L; Bruer M; Rodriguez-Acebes S; Lopez-Contreras AJ; Gruss OJ; Erhardt S; Mendez J; Fernandez-Capetillo O; Stoecklin G
Article: NATURE COMMUNICATIONS. 2018;9(1):2622

ATR is required to complete meiotic recombination in mice

Pacheco S; Maldonado-Linares A; Marcet-Ortega M; Rojas C; Martinez-Marchal A; Fuentes-Lazaro J; Lange J; Jasin M; Keeney S; Fernandez-Capetillo O; Garcia-Caldes M; Roig I
Article: GENES & DEVELOPMENT. 2018;32(7-8):568-576

ERF deletion rescues RAS deficiency in mouse embryonic stem cells

Mayor-Ruiz C; Olbrich T; Drosten M; Lecona E; Vega-Sendino M; Ortega S; Dominguez O; Barbacid M; Ruiz S; Fernandez-Capetillo O
Article: CELL REPORTS. 2018;22(2):396-410

The RNA Polymerase II Factor RPAP1 Is Critical for Mediator-Driven Transcription and Cell Identity

Lynch CJ; Bernad R; Calvo I; Nobrega-Pereira S; Ruiz S; Ibarz N; Martinez-Val A; Grana-Castro O; Gomez-Lopez G; Andres-Leon E; Angarica VE; del Sol A; Ortega S; Fernandez-Capetillo O; Rojo E; Munoz J; Serrano M
Article: JOURNAL OF MOLECULAR BIOLOGY. 2017;429(18):2780-2789

Trap ^seq: An RNA Sequencing-Based Pipeline for the Identification of Gene-Trap Insertions in Mammalian Cells

Mayor-Ruiz C; Dominguez O; Fernandez-Capetillo O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(35):9367-9372

A p53-dependent response limits the viability of mammalian haploid cells

Olbrich T; Mayor-Ruiz C; Vega-Sendino M; Gomez C; Ortega S; Ruiz S; Fernandez-Capetillo O
Article: BIOESSAYS. 2016;38(12):1209-1217

A SUMO and ubiquitin code coordinates protein traffic at replication factories

Lecona E; Fernandez-Capetillo O
Article: SCIENCE SIGNALING. 2016;9(445):ra91

Targeting the kinase activities of ATR and ATM exhibits antitumoral activity in mouse models of MLL-rearranged AML

Morgado-Palacin I; Day A; Murga M; Lafarga V; Elena Anton M; Tubbs A; Chen H-T; Ergen AV; Anderson R; Bhandoola A; Pike KG; Barlaam B; Cadogan E; Wang X; Pierce AJ; Hubbard C; Armstrong SA; Nussenzweig A; Fernandez-Capetillo O
Article: ONCOTARGET. 2016;7(37):58759-58767

Efficacy of ATR inhibitors as single agents in Ewing sarcoma

Nieto-Soler M; Morgado-Palacin I; Lafarga V; Lecona E; Murga M; Callen E; Azorin D; Alonso J; Lopez-Contreras AJ; Nussenzweig A; Fernandez-Capetillo O
Article: MOLECULAR CELL. 2016;63(5):877-883

POLD3 Is Haploinsufficient for DNA Replication in Mice

Murga M; Lecona E; Kamileri I; Diaz M; Lugli N; Sotiriou SK; Anton ME; Mendez J; Halazonetis TD; Fernandez-Capetillo O
Article: NATURE. 2016;535(7612):382-387

Replication fork stability confers chemoresistance in BRCA-deficient cells

Chaudhuri AR; Callen E; Ding X; Gogola E; Duarte AA; Lee J-E; Wong N; Lafarga V; Calvo JA; Panzarino NJ; John S; Day A; Crespo AV; Shen B; Starnes LM; de Ruiter JR; Daniel JA; Konstantinopoulos PA; Cortez D; Cantor SB; Fernandez-Capetillo O; Ge K; Jonkers J; Rottenberg S; Sharan SK; Nussenzweig A
Article: MOLECULAR CELL. 2016;62(2):307-313

A Genome-wide CRISPR Screen Identifies CDC25A as a Determinant of Sensitivity to ATR Inhibitors

Ruiz S; Mayor-Ruiz C; Lafarga V; Murga M; Vega-Sendino M; Ortega S; Fernandez-Capetillo O
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2016;23(4):270-277

USP7 is a SUMO deubiquitinase essential for DNA replication

Lecona E; Rodriguez-Acebes S; Specks J; Lopez-Contreras AJ; Ruppen I; Murga M; Munoz J; Mendez J; Fernandez-Capetillo O
Article: EMBO JOURNAL. 2015;34(21):2604-2619

NSMCE2 suppresses cancer and aging in mice independently of its SUMO ligase activity

Jacome A; Gutierrez-Martinez P; Schiavoni F; Tenaglia E; Martinez P; Rodriguez-Acebes S; Lecona E; Murga M; Mendez J; Blasco MA; Fernandez-Capetillo O
Article: NATURE COMMUNICATIONS. 2015;6:8548

Replication stress caused by low MCM expression limits fetal erythropoiesis and hematopoietic stem cell functionality

Alvarez S; Diaz M; Flach J; Rodriguez-Acebes S; Lopez-Contreras AJ; Martinez D; Canamero M; Fernandez-Capetillo O; Isern J; Passegue E; Mendez J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2015;35(17):2910-2917

A Single Conserved Residue Mediates Binding of the Ribonucleotide Reductase Catalytic Subunit RRM1 to RRM2 and Is Essential for Mouse Development

Specks J; Lecona E; Lopez-Contreras AJ; Fernandez-Capetillo O
Article: NATURE COMMUNICATIONS. 2015;6:8036

Limiting replication stress during somatic cell reprogramming reduces genomic instability in induced pluripotent stem cells

Ruiz S; Lopez-Contreras AJ; Gabut M; Marion RM; Gutierrez-Martinez P; Bua S; Ramirez O; Olalde I; Rodrigo-Perez S; Li H; Marques-Bonet T; Serrano M; Blasco MA; Batada NN; Fernandez-Capetillo O
Article: CELL DEATH AND DIFFERENTIATION. 2015;22(7):1144-1157

PARP-2 sustains erythropoiesis in mice by limiting replicative stress in erythroid progenitors

Farres J; Llacuna L; Martin-Caballero J; Martinez C; Lozano JJ; Ampurdanes C; Lopez-Contreras AJ; Florensa L; Navarro J; Ottina E; Dantzer F; Schreiber V; Villunger A; Fernandez-Capetillo O; Yelamos J
Article: GENES & DEVELOPMENT. 2015;29(7):690-695

Increased Rrm2 gene dosage reduces fragile site breakage and prolongs survival of ATR mutant mice

Lopez-Contreras AJ; Specks J; Barlow JH; Ambrogio C; Desler C; Vikingsson S; Rodrigo-Perez S; Green H; Juel Rasmussen L; Murga M; Nussenzweig A; Fernandez-Capetillo O
Article: ONCOGENE. 2014;33(37):4599-4612

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia

Saiz-Ladera C; Lara MF; Garin M; Ruiz S; Santos M; Lorz C; Garcia-Escudero R; Martinez-Fernandez M; Bravo A; Fernandez-Capetillo O; Segrelles C; Paramio JM
Article: NATURE CHEMICAL BIOLOGY. 2014;10(9):768-773

The solute carrier SLC35F2 enables YM155-mediated DNA damage toxicity

Winter GE; Radic B; Mayor-Ruiz C; Blomen VA; Trefzer C; Kandasamy RK; Huber KVM; Gridling M; Chen D; Klampfl T; Kralovics R; Kubicek S; Fernandez-Capetillo O; Brummelkamp TR; Superti-Furga G
Article: CELL CYCLE. 2014;13(12):1980-1986

Fos-dependent induction of Chk1 protects osteoblasts from replication stress

Schulze J; Lopez-Contreras AJ; Uluckan O; Grana-Castro O; Fernandez-Capetillo O; Wagner EF
Article: MOLECULAR BIOLOGY AND EVOLUTION. 2014;31(4):940-961

Emergence and Evolutionary Analysis of the Human DDR Network: Implications in Comparative Genomics and Downstream Analyses

Arcas A; Fernandez-Capetillo O; Cases I; Rojas AM
Article: CELL REPORTS. 2014;6(4):670-683

A Synthetic Lethal Interaction between APC/C and Topoisomerase Poisons Uncovered by Proteomic Screens

Eguren M; Alvarez-Fernandez M; Garcia F; Lopez-Contreras AJ; Fujimitsu K; Yaguchi H; Luis Luque-Garcia J; Fernandez-Capetillo O; Munoz J; Yamano H; Malumbres M
Article: BIOLOGY OPEN. 2013;2(12):1402-1411

Late-replicating CNVs as a source of new genes

Juan D; Rico D; Marques-Bonet T; Fernandez-Capetillo O; Valencia A
Article: PLOS BIOLOGY. 2013;11(12):e1001737

Polycomb Protein SCML2 Regulates the Cell Cycle by Binding and Modulating CDK/CYCLIN/p21 Complexes

Lecona E; Rojas LA; Bonasio R; Johnston A; Fernandez-Capetillo O; Reinberg D
Article: CELL CYCLE. 2013;12(12):1948-1954

INK4a/ARF limits the expansion of cells suffering from replication stress

Monasor A; Murga M; Lopez-Contreras AJ; Navas C; Gomez G; Pisano DG; Fernandez-Capetillo O
Article: CELL. 2013;153(6):1266-1280

53BP1 Mediates Productive and Mutagenic DNA Repair through Distinct Phosphoprotein Interactions

Callen E; Di Virgilio M; Kruhlak MJ; Nieto-Soler M; Wong N; Chen H-T; Faryabi RB; Polato F; Santos M; Starnes LM; Wesemann DR; Lee J-E; Tubbs A; Sleckman BP; Daniel JA; Ge K; Alt FW; Fernandez-Capetillo O; Nussenzweig MC; Nussenzweig A
Article: CELL REPORTS. 2013;3(4):1105-1116

A Proteomic Characterization of Factors Enriched at Nascent DNA Molecules

Lopez-Contreras AJ; Ruppen I; Nieto-Soler M; Murga M; Rodriguez-Acebes S; Remeseiro S; Rodrigo-Perez S; Rojas AM; Mendez J; Munoz J; Fernandez-Capetillo O
Article: CELL. 2013;152(3):620-632

Identification of Early Replicating Fragile Sites that Contribute to Genome Instability

Barlow JH; Faryabi RB; Callen E; Wong N; Malhowski A; Chen HT; Gutierrez-Cruz G; Sun H-W; McKinnon P; Wright G; Casellas R; Robbiani DF; Staudt L; Fernandez-Capetillo O; Nussenzweig A
Article: CELL STEM CELL. 2013;12(1):88-100

Cyclin-Dependent Kinase Inhibitor p21 Controls Adult Neural Stem Cell Expansion by Regulating Sox2 Gene Expression

Angeles Marques-Torrejon M; Porlan E; Banito A; Gomez-Ibarlucea E; Lopez-Contreras AJ; Fernandez-Capetillo O; Vidal A; Gil J; Torres J; Farinas I
Article: MOLECULAR CELL. 2012;46(2):125-135

BRCA1 Functions Independently of Homologous Recombination in DNA Interstrand Crosslink Repair

Bunting SF; Callen E; Kozak ML; Kim JM; Wong N; Lopez-Contreras AJ; Ludwig T; Baer R; Faryabi RB; Malhowski A; Chen H-T; Fernandez-Capetillo O; D'Andrea A; Nussenzweig A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2012;209(3):455-461

An extra allele of Chk1 limits oncogene-induced replicative stress and promotes transformation

Lopez-Contreras AJ; Gutierrez-Martinez P; Specks J; Rodrigo-Perez S; Fernandez-Capetillo O
Article: JOURNAL OF CLINICAL INVESTIGATION. 2012;122(1):241-252

Oncogenic stress sensitizes murine cancers to hypomorphic suppression of ATR

Schoppy DW; Ragland RL; Gilad O; Shastri N; Peters AA; Murga M; Fernandez-Capetillo O; Diehl JA; Brown EJ
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2011;18(12):1331-1335

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

Murga M; Campaner S; Lopez-Contreras AJ; Toledo LI; Soria R; Montana MF; D'Artista L; Schleker T; Guerra C; Garcia E; Barbacid M; Hidalgo M; Amati B; Fernandez-Capetillo O
Article: EMBO REPORTS. 2011;12(10):1032-1038

Lac operator repeats generate a traceable fragile site in mammalian cells

Jacome A; Fernandez-Capetillo O
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2011;18(6):721-727

A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations

Toledo LI; Murga M; Zur R; Soria R; Rodriguez A; Martinez S; Oyarzabal J; Pastor J; Bischoff JR; Fernandez-Capetillo O
Article: PLOS GENETICS. 2010;6(12):e1001234

Histone H2A C-Terminus Regulates Chromatin Dynamics, Remodeling, and Histone H1 Binding

Vogler C; Huber C; Waldmann T; Ettig R; Braun L; Izzo A; Daujat S; Chassignet I; Joaquin Lopez-Contreras A; Fernandez-Capetillo O; Dundr M; Rippe K; Laengst G; Schneider R
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2010;207(5):973-981

Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8

Santos MA; Huen MSY; Jankovic M; Chen H-T; Lopez-Contreras AJ; Klein IA; Wong N; Barbancho JLR; Fernandez-Capetillo O; Nussenzweig MC; Chen J; Nussenzweig A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(16):7491-7496

Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair

Kumar A; Fernandez-Capetillo O; Carrera AC
Article: CELL. 2010;141(2):243-254

53BP1 Inhibits Homologous Recombination in Brca1-Deficient Cells by Blocking Resection of DNA Breaks

Bunting SF; Callen E; Wong N; Chen H-T; Polato F; Gunn A; Bothmer A; Feldhahn N; Fernandez-Capetillo O; Cao L; Xu X; Deng C-X; Finkel T; Nussenzweig M; Stark JM; Nussenzweig A
Article: NATURE COMMUNICATIONS. 2010;1:3

Sirt1 improves healthy ageing and protects from metabolic syndrome-associated cancer

Herranz D; Munoz-Martin M; Canamero M; Mulero F; Martinez-Pastor B; Fernandez-Capetillo O; Serrano M
Article: JOURNAL OF CELL BIOLOGY. 2010;188(5):639-652

ATR suppresses telomere fragility and recombination but is dispensable for elongation of short telomeres by telomerase

McNees CJ; Tejera AM; Martinez P; Murga M; Mulero F; Fernandez-Capetillo O; Blasco MA
Article: NATURE CELL BIOLOGY. 2010;12(1):54-59

Cdk2 suppresses cellular senescence induced by the c-myc oncogene

Campaner S; Doni M; Hydbring P; Verrecchia A; Bianchi L; Sardella D; Schleker T; Perna D; Tronnersjo S; Murga M; Fernandez-Capetillo O; Barbacid M; Larsson L-G; Amati B
Article: JOURNAL OF CELL BIOLOGY. 2009;187(6):773-780

Overall Cdk activity modulates the DNA damage response in mammalian cells

Cerqueira A; Santamaria D; Martinez-Pastor B; Cuadrado M; Fernandez-Capetillo O; Barbacid M
Article: CANCER RESEARCH. 2009;69(22):8726-8732

p27^KiP1 Stabilization Is Essential for the Maintenance of Cell Cycle Arrest in Response to DNA Damage

Cuadrado M; Gutierrez-Martinez P; Swat A; Nebreda AR; Fernandez-Capetillo O
Article: GENES & DEVELOPMENT. 2009;23(17):2060-2075

Increased telomere fragility and fusions resulting from TRF1 deficiency lead to degenerative pathologies and increased cancer in mice

Martinez P; Thanasoula M; Munoz P; Liao C; Tejera A; McNees C; Flores JM; Fernandez-Capetillo O; Tarsounas M; Blasco MA
Article: NATURE. 2009;460(7259):1149-1153

A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity

Marion RM; Strati K; Li H; Murga M; Blanco R; Ortega S; Fernandez-Capetillo O; Serrano M; Blasco MA
Article: NATURE GENETICS. 2009;41(8):891-898

A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging

Murga M; Bunting S; Montana MF; Soria R; Mulero F; Canamero M; Lee Y; McKinnon PJ; Nussenzweig A; Fernandez-Capetillo O
Article: MOLECULAR AND CELLULAR BIOLOGY. 2009;29(16):4341-4351

p38 Mitogen-Activated Protein Kinase- and HuR-Dependent Stabilization of p21^Cip1 mRNA Mediates the G₁/S Checkpoint

Lafarga V; Cuadrado A; Lopez de Silanes I; Bengoechea R; Fernandez-Capetillo O; Nebreda AR
Article: PLOS ONE. 2009;4(5):e5475

Limited Role of Murine ATM in Oncogene-Induced Senescence and p53-Dependent Tumor Suppression

Efeyan A; Murga M; Martinez-Pastor B; Ortega-Molina A; Soria R; Collado M; Fernandez-Capetillo O; Serrano M
Article: CELL CYCLE. 2008;7(8):980-983

Why cells respond differently to DNA damage - A chromatin perspective

Fernandez-Capetillo O; Murga M
Article: GENES & DEVELOPMENT. 2008;22(3):297-302

ATR signaling can drive cells into senescence in the absence of DNA breaks

Toledo LI; Murga M; Gutierrez-Martinez P; Soria R; Fernandez-Capetillo O
Article: JOURNAL OF CELL BIOLOGY. 2007;178(7):1101-1108

Global chromatin compaction limits the strength of the DNA damage response

Murga M; Jaco I; Fan Y; Soria R; Martinez-Pastor B; Cuadrado M; Yang S-M; Blasco MA; Skoultchi AI; Fernandez-Capetillo O
Article: CLINICAL & TRANSLATIONAL ONCOLOGY. 2007;9(4):216-220

Genomic instability:: on the birth and death of cancer

Murga M; Fernandez-Capetillo O
Article: JOURNAL OF CELL BIOLOGY. 2007;176(5):581-592

RAD51C deficiency in mice results in early prophase I arrest in males and sister chromatid separation at metaphase II in females

Kuznetsov S; Pellegrini M; Shuda K; Fernandez-Capetillo O; Liu Y; Martin BK; Burkett S; Southon E; Pati D; Tessarollo L; West SC; Donovan PJ; Nussenzweig A; Sharan SK
Article: CELL DIVISION. 2006;1(1):7

"ATR activation in response to ionizing radiation: still ATM territory"

Cuadrado M; Martinez-Pastor B; Fernandez-Capetillo O
Article: JOURNAL OF CELL BIOLOGY. 2006;172(6):823-834

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

Kruhlak MJ; Celeste A; Dellaire G; Fernandez-Capetillo O; Müller WG; McNally JG; Bazett-Jones DP; Nussenzweig A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2006;203(2):297-303

ATM regulates ATR chromatin loading in response to DNA double-strand breaks

Cuadrado M; Martinez-Pastor B; Murga M; Toledo LI; Gutierrez-Martinez P; Lopez E; Fernandez-Capetillo O
Article: NATURE CELL BIOLOGY. 2005;7(7):675-685

Role of Nbs1 in the activation of the Atm kinase revealed in humanized mouse models

Difilippantonio S; Celeste A; Fernandez-Capetillo O; Chen HT; San Martin BR; Van Laethem F; Yang YP; Petukhova GV; Eckhaus M; Feigenbaum L; Manova K; Kruhlak M; Camerini-Otero RD; Sharan S; Nussenzweig M; Nussenzweig A
Article: BLOOD. 2005;105(5):1992-1999

Neuropilin-1 regulates attachment in human endothelial cells independently of vascular endothelial growth factor receptor-2

Murga M; Fernandez-Capetillo O; Tosato G
Article: CELL CYCLE. 2005;4(1):177-182

Specific association of mouse MDC1/NFBD1 with NBS1 at sites of DNA-damage

Lee AC; Fernandez-Capetillo O; Pisupati V; Jackson SP; Nussenzweig A
Article: NATURE GENETICS. 2005;37(1):41-47

Silencing of unsynapsed meiotic chromosomes in the mouse

Turner JMA; Mahadevaiah SK; Fernandez-Capetillo O; Nussenzweig A; Xu XL; Deng CX; Burgoyne PS
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2004;199(12):1671-1677

Phosphorylation of histone H2B at DNA double-strand breaks

Fernandez-Capetillo O; Allis CD; Nussenzweig A
Article: JOURNAL OF CELL BIOLOGY. 2003;163(1):15-20

H2AX regulates meiotic telomere clustering

Fernandez-Capetillo O; Liebe B; Scherthan H; Nussenzweig A
Article: CELL CYCLE. 2003;2(5):426-427

Focusing on Foci H2AX and the Recruitment of DNA-Damage Response Factors

Fernandez-Capetillo O; Celeste A; Nussenzweig A
Article: CELL. 2003;114(3):371-383

H2AX haploinsufficiency modifies genomic stability and tumor susceptibility

Celeste A; Difilippantonio S; Difilippantonio MJ; Fernandez-Capetillo O; Pilch DR; Sedelnikova OA; Eckhaus M; Ried T; Bonner WM; Nussenzweig A
Article: NATURE CELL BIOLOGY. 2003;5(7):675-679

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks

Celeste A; Fernandez-Capetillo O; Kruhlak MJ; Pilch DR; Staudt DW; Lee A; Bonner RF; Bonner WM; Nussenzweig A
Article: DEVELOPMENTAL CELL. 2003;4(4):497-508

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis

Fernandez-Capetillo O; Mahadevaiah SK; Celeste A; Romanienko PJ; Camerini-Otero RD; Bonner WM; Manova K; Burgoyne P; Nussenzweig A
Article: NATURE CELL BIOLOGY. 2002;4(12):993-997

DNA damage-induced G₂-M checkpoint activation by histone H2AX and 53BP1

Fernandez-Capetillo O; Chen HT; Celeste A; Ward I; Romanienko PJ; Morales JC; Naka K; Xia ZF; Camerini-Otero RD; Motoyama N; Carpenter PB; Bonner WM; Chen JJ; Nussenzweig A
Article: SCIENCE. 2002;296(5569):922-927

Genomic instability in mice lacking histone H2AX

Celeste A; Petersen S; Romanienko PJ; Fernandez-Capetillo O; Chen HT; Sedelnikova OA; Reina-San-Martin B; Coppola V; Meffre E; Difilippantonio MJ; Redon C; Pilch DR; Olaru A; Eckhaus M; Camerini-Otero RD; Tessarollo L; Livak F; Manova K; Bonner WM; Nussenzweig MC; Nussenzweig A
Article: JOURNAL OF COMPARATIVE NEUROLOGY. 2000;417(3):263-274

Immunocytochemical localization of the metabotropic glutamate receptor mGluR4a in the piriform cortex of the rat

Benítez R; Fernández-Capetillo O; Lázaro E; Mateos JM; Osorio A; Elezgarai I; Bilbao A; Lingenhoehl K; Van der Putten H; Hampson DR; Kuhn R; Knöpfel T; Grandes P
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Editorial comment: FRONTIERS IN PHARMACOLOGY. 2022;13:873197

Alkylating Agent-Induced Toxicity and Melatonin-Based Therapies

Egea J; Lopez-Munoz F; Fernandez-Capetillo O; Reiter RJ; Romero A
Review: REVISTA ESPANOLA DE QUIMIOTERAPIA. 2021;34(6):525-555

Overview of virus and cancer relationships. Position paper

Bouza E; Martin Jimenez M; Alemany L; Arribas J; Banares R; Begona Barragan M; Eiros Bouza JM; Felip E; Fernandez-Capetillo O; Gracia D; Lopez-Velez R; Bautista Mollar J; Munoz P; Paz-Ares L; Torne A; Tovar J; Valencia E; Palomo E
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(16):8796

Coordinating DNA Replication and Mitosis through Ubiquitin/SUMO and CDK1

Galarreta A; Valledor P; Fernandez-Capetillo O; Lecona E
Review: NATURE REVIEWS CANCER. 2018;18(9):586-595

Targeting ATR in cancer

Lecona E; Fernandez-Capetillo O
Corrigendum: NATURE. 2016;539(7629):456

Replication fork stability confers chemoresistance in BRCA-deficient cells (vol 535, pg 382, 2016)

Chaudhuri AR; Callen E; Ding X; Gogola E; Duarte AA; Lee J-E; Wong N; Lafarga V; Calvo JA; Panzarino NJ; John S; Day A; Crespo AV; Shen B; Starnes LM; de Ruiter JR; Daniel JA; Konstantinopoulos PA; Cortez D; Cantor SB; Fernandez-Capetillo O; Ge K; Jonkers J; Rottenberg S; Sharan SK; Nussenzweig A
Editorial comment: CELL CYCLE. 2016;15(6):775-776

The (elusive) role of the SMC5/6 complex

Fernandez-Capetillo O
Editorial comment: ONCOTARGET. 2015;6(33):34045-34046

Reducing genomic instability in iPSCs

Ruiz S; Fernandez-Capetillo O
Review: METHODS IN MOLECULAR BIOLOGY. 2015;1267:413-437

Modeling the study of DNA damage responses in mice.

Specks J; Nieto-Soler M; Lopez-Contreras AJ; Fernandez-Capetillo O
Other: NATURE. 2015;517(7532):111-113

Hopes for the year ahead.

Fernández-Capetillo Ó; Yan N; Dionne J; Bassett D; Sebastian S; Hendon C; Schlichting H; Baker M
Review: EXPERIMENTAL CELL RESEARCH. 2014;329(1):26-34

Replication stress and cancer: It takes two to tango

Lecona E; Fernandez-Capetillo O
Editorial comment: CELL. 2014;159(2):225-226

When the Going Gets Tough: Scientists' Personal Challenges

Lengerke C; Fernandez-Capetillo O; Tolic-Norrelykke I; Barna M; Coleman T; Zamboni D
Editorial comment: MOLECULAR CELL. 2014;55(6):803-804

The Maternal Side of Fanconi Anemia

Ruiz S; Fernandez-Capetillo O
Corrigendum: BIOLOGY OPEN. 2014;3(3):231

Late-replicating CNVs as a source of new genes (vol 2, pg 1402, 2013)

Juan D; Rico D; Marques-Bonet T; Fernandez-Capetillo O; Valencia A
Editorial comment: CELL. 2013;155(5):979-980

Naked Replication Forks Break apRPArt

Fernandez-Capetillo O; Nussenzweig A
Corrigendum: BIOLOGY OPEN. 2013;2(12)

Late-replicating CNVs as a source of new genes (vol 2, pg 1402, 2013)

Juan D; Rico D; Marques-Bonet T; Fernandez-Capetillo O; Valencia A
Letter: DNA REPAIR. 2011;10(10):1000-1001

CGK733 does not inhibit ATM or ATR kinase activity in H460 human lung cancer cells

Choi S; Toledo LI; Fernandez-Capetillo O; Bakkenist CJ
Review: MOLECULAR ONCOLOGY. 2011;5(4):368-373

Targeting ATR and Chk1 kinases for cancer treatment: A new model for new (and old) drugs

Toledo LI; Murga M; Fernandez-Capetillo O
Editorial comment: EMBO JOURNAL. 2011;30(6):991-993

Genomic instability in iPS: time for a break

Blasco MA; Serrano M; Fernandez-Capetillo O
Review: DNA REPAIR. 2010;9(12):1249-1255

The ATR barrier to replication-born DNA damage

Lopez-Contreras AJ; Fernandez-Capetillo O
Corrigendum: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(24):11145

Nuclear phosphoinositide 3-kinase β controls double-strand break DNA repair (vol 107, pg 7491, 2010)

Kumar A; Fernandez-Capetillo O; Carrera AC
Review: EMBO REPORTS. 2010;11(1):32-36

Intrauterine programming of ageing

Fernandez-Capetillo O
Editorial comment: MOLECULAR CELL. 2008;31(3):303-304

ATM breaks into heterochromatin

Fernandez-Capetillo O; Nussenzweig A
Review: DNA REPAIR. 2004;3(8-9):959-967

H2AX: the histone guardian of the genome

Fernandez-Capetillo O; Lee A; Nussenzweig M; Nussenzweig A
Editorial comment: NATURE GENETICS. 2004;36(7):672-674

Aging counts on chromosomes

Fernandez-Capetillo O; Nussenzweig A
Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(6):1427-1428

Linking histone deacetylation with the repair of DNA breaks

Fernandez-Capetillo O; Nussenzweig A
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