Nils-Göran Larsson Group

The mitochondrion is a key player in cellular function and dysfunctional mitochondria have been implicated in a number of disorders as well as in the process of normal ageing. Our knowledge of mitochondria is, however, still limited. How is the number and the funciton of mitochondra regulated? What happens in a cell with dysfunctional mitochondria?

Research Techniques

  • Production and analysis of genetically modified mouse models
  • Methods in molecular biology such as analysis of DNA, RNA and proteins.
  • Microscopy.

External Funding

  • Swedish Research Council
  • Knut and Alice Wallenberg Foundation
  • Parkinsonfonden

Members of the group

Group leader

Professor/senior physician

Nils-Göran Larsson

Organizational unit: Nils-Göran Larsson's Group

Group Members

Camilla KoolmeisterResearch coordinator
Eva BerglundResearch coordinator
Nils-Göran LarssonProfessor/senior physician
Oleksandr LytovchenkoPostdoc
Olga LytovchenkoAssociated
Roberta FilogranaPostdoc
Seungmin LeeAssistant professor
Shan JiangPostdoc
Susanne VirdingBiomedical scientist

Selected Publications

Complementation between polymerase- and exonuclease-deficient mitochondrial DNA polymerase mutants in genomically engineered flies.
Bratic A, Kauppila T, Macao B, Grönke S, Siibak T, Stewart J, et al
Nat Commun 2015 Nov;6():8808

SLIRP stabilizes LRPPRC via an RRM-PPR protein interface.
Spåhr H, Rozanska A, Li X, Atanassov I, Lightowlers R, Chrzanowska-Lightowlers Z, et al
Nucleic Acids Res. 2016 Aug;44(14):6868-82

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA.
Kühl I, Miranda M, Posse V, Milenkovic D, Mourier A, Siira S, et al
Sci Adv 2016 Aug;2(8):e1600963

Hierarchical RNA Processing Is Required for Mitochondrial Ribosome Assembly.
Rackham O, Busch J, Matic S, Siira S, Kuznetsova I, Atanassov I, et al
Cell Rep 2016 Aug;16(7):1874-90

COX7A2L Is a Mitochondrial Complex III Binding Protein that Stabilizes the III2+IV Supercomplex without Affecting Respirasome Formation.
Pérez-Pérez R, Lobo-Jarne T, Milenkovic D, Mourier A, Bratic A, García-Bartolomé A, et al
Cell Rep 2016 Aug;16(9):2387-98