Research group - Qiang Pan-Hammarström

We focus on two main areas of research: Immunogenetics and Cancer Genetics.

Current projects

Regulation of immunoglobulin class switch recombination in human B cells

The project is aimed at understanding the complex molecular mechanisms involved in DNA editing, repair and recombination during immunoglobulin class switch recombination (CSR) and somatic hypermutation (SHM) and their involvement in the pathophysiological processes leading to immunodeficiency, genome instability and cancer development in humans.

Induced pluripotent stems cells  a platform for personalized diagnosis and therapy in patients with primary immunodeficiency

The project is aimed at reprogramming the fibroblasts or peripheral blood B cells derived from IgA deficient (IgAD) patients into pluripotent stem (iPS) cells and to re-differentiate these iPS cells into antibody-producing B cells. If successful, this study may provide a potentially curative treatment in patients with IgA deficiency. They will also provide a methodological platform for studies aimed at replacing cells in patients with a variety of other primary immunodeficiency diseases as well as autoimmune and neurological disorders associated with these diseases.

Discovery of therapeutic targets in B cell lymphoma by next generation sequencing

The project is aimed at identifying potentially treatable molecular targets in mature B cell lymphomas (with focus on diffuse large B cell lymphomas and mantle cell lymphomas) by high-throughput, next generation-sequencing omic- technologies such as whole genome and exome sequencing and RNA-seq.

Our research is supported by the Swedish Research Council (VR), the Swedish Cancer Society (Cancerfonden) and the European Research Council (ERC).

Research group leader Qiang Pan-Hammarström

Professor

Qiang Pan Hammarström

Phone: +46-(0)8-524 835 92
Organizational unit: Division of Clinical Immunology
E-mail: Qiang.Pan-Hammarstrom@ki.se

Group members

Rozina CaridhaLaboratory coordinator
Longyun ChenAssociated
Likun DuPostdoc
Wei LiAssociated
Hui LiuAssociated
Qiang Pan HammarströmProfessor
Mohammad PirmoradianPostdoc
Rosa RomanoPostdoc
Xiaofei YePhD student

Alumni

Click here to view list of alumni

 

Research techniques

  • DNA sequencing, including whole exome and whole genome sequencing
  • Molecular cloning
  • PCR/realtime PCR
  • Cell culture
  • Generating iPSCs.

External funding

The Swedish Research Council, Cancerfonden, European Research Council (ERC), Barncancerfonden (Swedish Children Cancer Fund), The Swedish Foundation for International Cooperation in Research and Higher Education (STINT)

Postdoc positions available

For possible postdoc or PhD student positions, please contact Prof. Qiang Pan-Hammarström directly.

Selected publications

Common variants at PVT1, ATG13-AMBRA1, AHI1 and CLEC16A are associated with selective IgA deficiency.
Bronson P, Chang D, Bhangale T, Seldin M, Ortmann W, Ferreira R, et al
Nat. Genet. 2016 Nov;48(11):1425-1429

Genetic basis of PD-L1 overexpression in diffuse large B-cell lymphomas.
Georgiou K, Chen L, Berglund M, Ren W, de Miranda N, Lisboa S, et al
Blood 2016 Jun;127(24):3026-34

Frequent alterations in cytoskeleton remodelling genes in primary and metastatic lung adenocarcinomas.
Wu K, Zhang X, Li F, Xiao D, Hou Y, Zhu S, et al
Nat Commun 2015 Dec;6():10131

Aberrant recombination and repair during immunoglobulin class switching in BRCA1-deficient human B cells.
Björkman A, Qvist P, Du L, Bartish M, Zaravinos A, Georgiou K, et al
Proc. Natl. Acad. Sci. U.S.A. 2015 Feb;112(7):2157-62

B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity.
Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon K, Resch W, et al
Cell 2014 Dec;159(7):1524-37

Exome sequencing reveals novel mutation targets in diffuse large B-cell lymphomas derived from Chinese patients.
de Miranda N, Georgiou K, Chen L, Wu C, Gao Z, Zaravinos A, et al
Blood 2014 Oct;124(16):2544-53

A regulatory role for the cohesin loader NIPBL in nonhomologous end joining during immunoglobulin class switch recombination.
Enervald E, Du L, Visnes T, Björkman A, Lindgren E, Wincent J, et al
J. Exp. Med. 2013 Nov;210(12):2503-13

New facets of antibody deficiencies.
Liadaki K, Sun J, Hammarström L, Pan-Hammarström Q
Curr. Opin. Immunol. 2013 Oct;25(5):629-38

DNA repair genes are selectively mutated in diffuse large B cell lymphomas.
de Miranda N, Peng R, Georgiou K, Wu C, Falk Sörqvist E, Berglund M, et al
J. Exp. Med. 2013 Aug;210(9):1729-42

Nurture your scientific curiosity early in your research career.
Jagodic M, Stridh P, Gad A, Paine A, Udekwu K, Sjöholm L, et al
Nat. Genet. 2013 Feb;45(2):116-8

Cernunnos influences human immunoglobulin class switch recombination and may be associated with B cell lymphomagenesis.
Du L, Peng R, Björkman A, Filipe de Miranda N, Rosner C, Kotnis A, et al
J. Exp. Med. 2012 Feb;209(2):291-305

Cancer geneticsImmunology