Our research develops the knowledge area of sexual, reproductive and perinatal health (human reproduction and the beginning of life).
Photo: iStockThe research is translational and organized in three subgroups/areas: Experimental research, Clinical trials and Global Reproductive Health. Our main vision is to improve management and access to sexual and reproductive health in a global perspective and translate our research into clinical praxis and policy; from bench to bed to the hands of women
Marie Klingberg Allvin research group
The research is focused on issues related to the clinical work of midwives. The philosophy of science as well as the design of the projects is thus generally based on caring and public health science, but also to some extent on social and medical science.
The unit is also engaged in international research projects and education in Asia, Africa and South America, as well as in student-teacher exchange programmes such as Erasmus and Linnaeus-Palme.
Each year 64 midwives graduate at the Division, and many PhD students are supervised. Several courses are given, focusing on different target groups such as doctorial level courses, master's level courses, elective courses and commissioned education.
| Research area | Research group leader |
|---|---|
| Sexual Reproductive Health and Rights Research | Marie Klingberg Allvin |
Our focus is to explore the basics of female reproductive sciences at the molecular level to understand fertility and its associated disorders with the intention of translating the knowledge to clinical applications. The experimental group consists clinicians, embryologists, molecular biologists, biotechnologist and bioinformaticians.
Studies on human embryo implantation in managing infertility and fertility
Studies on endometrial receptivity – two sides of a coin: management of infertility and new strategies for fertility control. Understanding endometrial receptivity is vital in managing infertility and regulating fertility. We study the cellular and molecular aspects of endometrial function, particularly, endometrial mesenchymal cells and its niche factors on endometrial regeneration. Knowledge on the above is important in finding solution for infertility due to thin endometrium. We also have ongoing studies on embryo quality and development, with the intention to develop non-invasive methods for embryo quality assessment in assisted reproduction. We are studying different types of RNAs expressed in human embryos aa well as in the embryo spent media of healthy and compromised quality of embryos.
Understanding the aetiology of endometriosis and the link to ovarian cancer development
Endometriosis is a gynaecologic disorder with poorly understood aetiology, affecting 10-15% of women causing pelvic inflammation, chronic pain and infertility. The most widely accepted theory on the aetiology of endometriosis is Sampson’s retrograde menstruation. Endometrium consists of a variety of cells expressing markers relevant to attachment, adhesion, migration and stemness. Inappropriately shed endometrial cells during menstruation reach the peritoneal cavity, where they are able to adhere and establish endometriotic implants/lesions. We study the role of different endometrial cell types in the aetiology of endometriosis and its relation to ovarian cancer.
Bromocriptine on uterine adenomyosis
Clinical trial conducted by our group on the effect of bromocriptine on adenomyosis showed a significant reduction with the symptoms. Now, we are studying the possible molecules and the related pathways involved in improving the symptoms at endometrial level.
Our research wet lab is located at BioClinicum.
Researchers and Postdocs
PhD students
