Tobias Allander Group

Clinical Virology and Virus Discovery

The group is based at the Department of Clinical Microbiology at Karolinska University Hospital, and the research is focused on developing efficient diagnostic methods for virus infections. We have a special interest in respiratory tract infections, but also study gastroenteritis viruses and chronic virus infections.

A main activity is identification of unknown viruses and clinical characterization of newly discovered viruses. The group has identified two novel human viruses, human bocavirus (HBoV) and KI polyomavirus (KIPyV). We have further established a relationship between human bocavirus and acute respiratory disease in infants and children. HBoV analysis is now routinely provided to health care

Virus discovery is done by combining a specially designed virus purification protocol with high-throughput sequencing and bioinformatics, in collaboration with the genome sequencing group at the Department of Cell- and Molecular Biology, Karolinska Institutet. We screen a wide variety of clinical samples for unknown viruses, from upper respiratory tract secretions to tumors.

Virus infections impose a huge disease burden on humanity. Diagnosing infectious agents and searching for the cause for diseases with unknown aetiology is fundamental for many aspects of clinical medicine.


Virome characterisation from Guthrie cards in children who later developed acute lymphoblastic leukaemia.
Bogdanovic G, Pou C, Barrientos-Somarribas M, Bjerkner A, Honkaniemi E, Allander T, et al
Br. J. Cancer 2016 Oct;115(8):1008-1014

Viremic co-infections in children with allogeneic haematopoietic stem cell transplantation are predominated by human polyomaviruses.
Koskenvuo M, Rahiala J, Sadeghi M, Waris M, Vuorinen T, Lappalainen M, et al
Infect Dis (Lond) 2016 Jul;():1-10

Polyomaviruses BK, JC, KI, WU, MC, and TS in children with allogeneic hematopoietic stem cell transplantation.
Rahiala J, Koskenvuo M, Sadeghi M, Waris M, Vuorinen T, Lappalainen M, et al
Pediatr Transplant 2016 May;20(3):424-31

Human bocavirus 1 may suppress rhinovirus-associated immune response in wheezing children.
Lukkarinen H, Söderlund-Venermo M, Vuorinen T, Allander T, Hedman K, Simell O, et al
J. Allergy Clin. Immunol. 2014 Jan;133(1):256-8.e1-4

Children with multiple viral respiratory infections are older than those with single viruses.
Rotzén-Östlund M, Eriksson M, Tiveljung Lindell A, Allander T, Zweygberg Wirgart B, Grillner L
Acta Paediatr. 2014 Jan;103(1):100-4

Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing.
Lysholm F, Wetterbom A, Lindau C, Darban H, Bjerkner A, Fahlander K, et al
PLoS ONE 2012 ;7(2):e30875

Human bocavirus-the first 5 years.
Jartti T, Hedman K, Jartti L, Ruuskanen O, Allander T, Söderlund-Venermo M
Rev. Med. Virol. 2012 Jan;22(1):46-64

Life-threatening respiratory tract disease with human bocavirus-1 infection in a 4-year-old child.
Edner N, Castillo-Rodas P, Falk L, Hedman K, Söderlund-Venermo M, Allander T
J. Clin. Microbiol. 2012 Feb;50(2):531-2

Respiratory viruses, a common microbiological finding in neutropenic children with fever.
Lindblom A, Bhadri V, Söderhäll S, Ohrmalm L, Wong M, Norbeck O, et al
J. Clin. Virol. 2010 Mar;47(3):234-7

Merkel cell polyomavirus in respiratory tract secretions.
Goh S, Lindau C, Tiveljung-Lindell A, Allander T
Emerging Infect. Dis. 2009 Mar;15(3):489-91

Development and implementation of a molecular diagnostic platform for daily rapid detection of 15 respiratory viruses.
Tiveljung-Lindell A, Rotzén-Ostlund M, Gupta S, Ullstrand R, Grillner L, Zweygberg-Wirgart B, et al
J. Med. Virol. 2009 Jan;81(1):167-75

Human bocavirus and acute wheezing in children.
Allander T, Jartti T, Gupta S, Niesters H, Lehtinen P, Osterback R, et al
Clin. Infect. Dis. 2007 Apr;44(7):904-10

Identification of a third human polyomavirus.
Allander T, Andreasson K, Gupta S, Bjerkner A, Bogdanovic G, Persson M, et al
J. Virol. 2007 Apr;81(8):4130-6

Cloning of a human parvovirus by molecular screening of respiratory tract samples.
Allander T, Tammi M, Eriksson M, Bjerkner A, Tiveljung-Lindell A, Andersson B
Proc. Natl. Acad. Sci. U.S.A. 2005 Sep;102(36):12891-6


Group Members

Senior researcher

Tobias Allander

Organizational unit: Tobias Allander group

Annelie BjerknerAssociated
Lena GrillnerAssociated
Anne KellyAssociated
Maria Rotzén ÖstlundAssociated
Benita Zweygberg WirgartAssociated