Anna Wredenberg Group


Anna Wredenberg

Organizational unit: Anna Wredenberg's Group

Metabolism is the complex network of chemical transformations within a
living cell, required to sustain its viability. Mitochondria play a
central role within most eukaryotic cells, by combining many different
metabolic pathways, such as glucose and lipid metabolism, steroid and
haem synthesis or apoptosis and calcium buffering.
The Wredenberg group is interested in how mitochondrial dysfunction
effects the rest of the cell, with a specific focus on energy
Mitochondria are an organelle network within the majority of eukaryotic
cells that undergo dynamic and complex changes of motility, shape and
metabolism in response to environmental stimuli and energetic
requirements. Understanding these processes, their signals and
molecular basis is essential in order to appreciate the defects
involved in a range of inborn errors of metabolism, but also how
mitochondrial function influences common diseases, such as heart
disease, diabetes, cancers, neurodegeneration or autoimmune diseases.

Mitochondria contain their own genome, a small, circular DNA molecule
(mtDNA), situated in multiple copies within mitochondria. The
Wredenberg group is interested in understanding what regulates
mitochondrial RNA turnover, and how these RNAs are targeted for
degradation. We use the fruit fly, Drosophila melanogaster, as a model
system to understand regulatory mechanisms of mtDNA, what regulates
mitochondrial RNA metabolism, what regulates RNA processing, turnover
and how mitochondrial transcription is linked to translation. For this
the group either silences factors of interest by RNA interference, or
by generating genetically modified fly lines. Flies are then analysed
by a range of molecular biological and biochemical techniques in order
to understand the molecular mechanisms at hand.

Anna Wredenberg is a clinician at the Centre for Inherited Metabolic
Diseases at the Karolinska University Hospital, Stockholm, Sweden,
which has specialised on rare genetic diseases involving mitochondrial
dysfunction. Advances in sequencing technology has enabled us to
rapidly diagnose many known inborn errors of metabolism, but has also
lead to a surge in novel disease-candidates, where pathogenicity needs
to be validated.
The Wredenberg group attempts to understand the molecular basis of
disease formation, using primary patient cells or reprogrammed neuronal
stem cells in order to investigate metabolic derangements in disease
progression. Generating disease-specific fly models allows for the
investigation of patient-relevant metabolic disturbances in an in vivo

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