Stefan Skare´s research group

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Neuroradiology – MRI physics

The research group consists of MR physicists at Karolinska University Hospital and GE Healthcare, and develops new imaging methods for brain MRI. The research consists of software development of new acquisition methods (a.k.a. pulse sequences) and image reconstruction methods for brain MRI, with integration in a clinical environment. A criteria for our research projects are that they should also be implemented in the clinical routine, and today about 20% of the clinical MR images at the Dept. of Neuroradiology are acquired with in-house developed software. The methods developed may also come to good use for other departments and hospitals.

Research projects

MRI is a slow imaging modality, where each image series typically takes several minutes to acquire. This requires that the patient is capable of remaining still during the data acquisition, and a complete MR exam takes between 30-60 min. Our research group have two major R&D projects to address this fundamental problem in MRI. One project is about acceleration techniques (SMS - simultaneous multi-slice) for 2D pulse sequences that are used clinically. This aims to reduce the imaging time for each series in the MR exam, which implies less risk of head motion as well as shorter MR examinations overall. The other, and the most central, project for the group is prospective (and retrospective) motion correction for the range of MR image contrasts that are used clinically. This will allow patients to freely move their head during the MR examination without loss in the diagnostic image quality or confidence. This is of particular interest for brain MRI of children, where the goal is also to significantly reduce the number of MR examinations with the patient under general anesthesia (GA).

Selected publications

Collapsed fat navigators for brain 3D rigid body motion.
Engström M, Mårtensson M, Avventi E, Norbeck O, Skare S
Magn Reson Imaging 2015 Oct;33(8):984-91

Properties of a 2D fat navigator for prospective image domain correction of nodding motion in brain MRI.
Skare S, Hartwig A, Mårtensson M, Avventi E, Engström M
Magn Reson Med 2015 Mar;73(3):1110-9

On the signal-to-noise ratio efficiency and slab-banding artifacts in three-dimensional multislab diffusion-weighted echo-planar imaging.
Engström M, Mårtensson M, Avventi E, Skare S
Magn Reson Med 2015 Feb;73(2):718-25

Diffusion-weighted 3D multislab echo planar imaging for high signal-to-noise ratio efficiency and isotropic image resolution.
Engström M, Skare S
Magn Reson Med 2013 Dec;70(6):1507-14

Clinical multishot DW-EPI through parallel imaging with considerations of susceptibility, motion, and noise.
Skare S, Newbould R, Clayton D, Albers G, Nagle S, Bammer R
Magn Reson Med 2007 May;57(5):881-90

Group members

Johan BerglundAssistant professor
Ola NorbeckGraduate Student
Henric RydénGraduate Student
Stefan SkareAssociated, Research team leader
Tim SprengerAssociated

Clinical NeuroscienceNeuroradiology